93 results on '"Xie, Mingjie"'
Search Results
2. Association between the mean perfusion pressure and the risk of acute kidney injury in critically ill patients with sepsis: a retrospective cohort study
- Author
-
Li, Ling, Qin, Shuangwen, Lu, Xiuhong, Huang, Liuyun, Xie, Mingjie, and Huang, Debin
- Published
- 2024
- Full Text
- View/download PDF
3. New insights into the influences of firework combustion on molecular composition and formation of sulfur- and halogen-containing organic compounds
- Author
-
Yan, Caiqing, Chen, Haibiao, Xu, Fei, Fu, Qinglong, Zhou, Ying, Zhou, Ruizhi, Li, Ruiyu, Zheng, Mei, Xie, Mingjie, Jiang, Bin, Zhang, Zhisheng, Meng, He, Cui, Min, Yang, Lingxiao, Zhou, Xuehua, and Chen, Bing
- Published
- 2024
- Full Text
- View/download PDF
4. Direct radiative forcing of light-absorbing carbonaceous aerosols in China
- Author
-
Yang, Liu, Mao, Yuhao, Liao, Hong, Xie, Mingjie, and Zhang, Ying
- Published
- 2024
- Full Text
- View/download PDF
5. Size-resolved light-absorbing organic carbon and organic molecular markers in Nanjing, east China: Seasonal variations and sources
- Author
-
Feng, Wei, Shao, Zhijuan, Wang, Qin'geng, and Xie, Mingjie
- Published
- 2023
- Full Text
- View/download PDF
6. The Number of Lymph Nodes Examined is Associated with Survival Outcomes of Neuroendocrine Tumors of the Jejunum and Ileum (siNET): Development and Validation of a Prognostic Model Based on SEER Database
- Author
-
Wang, Peng, Chen, Erlin, Xie, Mingjie, Xu, Wei, Ou, Chaoyang, Zhou, Zhou, Niu, Yuanjie, Song, Wei, Ni, Qingfeng, and Zhu, Jianwei
- Published
- 2022
- Full Text
- View/download PDF
7. Inhibition of BTK improved APAP-induced liver injury via suppressing proinflammatory macrophages activation by restoring mitochondrion function
- Author
-
Guo, Huiting, Xie, Mingjie, Liu, Weixia, Chen, Shiwei, Ye, Bingjue, Yao, Jiping, Xiao, Zhengyun, Zhou, Cheng, and Zheng, Min
- Published
- 2022
- Full Text
- View/download PDF
8. Collocated speciation of PM2.5 using tandem quartz filters in northern nanjing, China: Sampling artifacts and measurement uncertainty
- Author
-
Yang, Li, Shang, Yue, Hannigan, Michael P., Zhu, Rui, Wang, Qin'geng, Qin, Chao, and Xie, Mingjie
- Published
- 2021
- Full Text
- View/download PDF
9. Evaluating coarse PM composition and sources based on bulk and molecular speciation of PM2.5 and PM10 in Nanjing, East China
- Author
-
Cui, Wangnan, Wang, Zishu, Feng, Wei, Qin, Chao, Liao, Hong, Wang, Yuhang, and Xie, Mingjie
- Published
- 2025
- Full Text
- View/download PDF
10. The relevance of pyroptosis in the pathogenesis of liver diseases
- Author
-
Guo, Huiting, Xie, Mingjie, Zhou, Cheng, and Zheng, Min
- Published
- 2019
- Full Text
- View/download PDF
11. The role of HBV-induced autophagy in HBV replication and HBV related-HCC
- Author
-
Xie, Mingjie, Yang, Zhenggang, Liu, Yanning, and Zheng, Min
- Published
- 2018
- Full Text
- View/download PDF
12. Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo
- Author
-
Yao, Hangping, Lu, Xiangyun, Chen, Qiong, Xu, Kaijin, Chen, Yu, Cheng, Minghui, Chen, Keda, Cheng, Linfang, Weng, Tianhao, Shi, Danrong, Liu, Fumin, Wu, Zhigang, Xie, Mingjie, Wu, Haibo, Jin, Changzhong, Zheng, Min, Wu, Nanping, Jiang, Chao, and Li, Lanjuan
- Published
- 2020
- Full Text
- View/download PDF
13. Analysis of Air Pollutants and Their Potential Sources in Eastern Xinjiang, Northwestern Inland China, from 2018 to 2022.
- Author
-
Zhang, Yuanyuan, Xu, Hui, Zhang, Yunhui, Luo, Jie, Chen, Fuyao, Cao, Bo, and Xie, Mingjie
- Subjects
AIR analysis ,PARTICULATE matter ,AIR pollutants ,COAL combustion ,AIR masses ,POLLUTANTS ,AIR pollution - Abstract
Air pollution in the developed regions of eastern China has been intensively investigated in the past decade. However, there is a relative dearth of air pollution studies on the northwest of inland China (e.g., Xinjiang). In this work, hourly measurement data of six criteria air pollutants (PM
2.5 , PM10 , CO, NO2 , O3 , and SO2 ) for the past five years (2018–2022) from Hami and Turpan cities of eastern Xinjiang were analyzed to reveal air pollution characteristics and the distribution of potential sources. Hami and Turpan had the highest AQI values in winter due to increased coal combustion for domestic heating and unfavorable meteorological conditions. The slight elevations of AQI values in spring were caused by frequent dust storms. PM10 was the most frequent main pollutant in both Hami (63.1%) and Turpan (74.1%), followed by PM2.5 and O3 . Except for O3 , PM2.5 , PM10 , SO2 , NO2 , and CO exhibited a generally decreasing pattern in annual average values. But the annual average concentrations of PM10 in Hami (83.5 μg·m−3 ) and Turpan (139 μg·m−3 ) in 2022 were still higher than those in eastern China. Diurnal and monthly variations of the six criteria pollutants were influenced by a combination of emission sources and meteorological conditions. The air masses in eastern Xinjiang mainly originated from the west and north and were affected by both inter-regional and intra-regional transport. Analysis of the distribution of potential sources showed that local emissions strongly impacted particulate matter pollution in winter, while regional transport played a dominant role in other seasons. O3 showed a broad distribution of potential sources across all four seasons. Considering that the trend that O3 pollution increased year by year, eastern Xinjiang might face a similar pollution situation as eastern China, i.e., the combined pollution of particulate matter and O3 . [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
14. Time‐Resolved Measurements of PM2.5 Chemical Composition and Brown Carbon Absorption in Nanjing, East China: Diurnal Variations and Organic Tracer‐Based PMF Analysis.
- Author
-
Feng, Wei, Wang, Xinyue, Shao, Zhijuan, Liao, Hong, Wang, Yuhang, and Xie, Mingjie
- Subjects
TIME-resolved measurements ,PARTICULATE matter ,BIOMASS burning ,ABSORPTION coefficients ,LIGHT absorption ,SUMMER - Abstract
To understand diurnal variations in PM2.5 composition and aerosol extract absorption, PM2.5 samples were collected at intervals of 2 hr from 8:00 to 20:00 and 6 hr from 20:00 to 8:00 (the next day) in northern Nanjing, China, during the winter and summer of 2019–2020 and analyzed for bulk components, organic tracers, and light absorption of water and methanol extracts—a proxy measure of brown carbon (BrC). Diurnal patterns of measured species reflected the influences of primary emissions and atmospheric processes. Light absorption coefficients of water (Abs365,w) and methanol extracts (Abs365,m) at 365 nm shared a similar diurnal profile peaking at 18:00–20:00, generally following changes in biomass burning tracers. However, Abs365,w, Abs365,m, and their normalizations to organic aerosols increased at 14:00–16:00, earlier than that of levoglucosan in the late afternoon, which was attributed to secondarily formed BrC. The methanol extracts showed a less drastic decrease in light absorption at night than the water extracts and elevated absorption efficiency during 2:00–8:00. This is due to the fact that the water‐insoluble OC has a longer lifetime and stronger light absorption than the water‐soluble OC. According to the source apportionment results solved by positive matrix factorization (PMF), biomass burning and secondary formation were the major BrC sources in northern Nanjing, with an average total relative contribution of about 90%. Compared to previous studies, diurnal source cycles were added to the PMF simulations in this work by using time‐resolved speciation data, which avoided misclassification of BrC sources. Plain Language Summary: Light‐absorbing organic carbon (OC), also known as "brown carbon", plays an important role in influencing the Earth's radiative balance. Filter samples of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) were collected at a resolution of 2 hr from 8:00 to 20:00 and a resolution of 6 hr from 20:00 to 8:00 (the next day) in northern Nanjing, China, during the winter and summer of 2019 and 2020. To understand the diurnal variations of BrC and its sources, each sample was analyzed for bulk components (OC, elemental carbon, and water‐soluble ions), organic molecular markers, and light absorption by BrC, and a receptor model was used to identify potential BrC sources based on PM2.5 composition data. We found that diurnal variations of BrC generally followed changes in concentrations of levoglucosan‐a tracer of biomass burning; the increase in BrC absorption in the early afternoon was caused by secondary formation of BrC chromophores; biomass burning and secondary formation were the main sources of BrC. Time‐resolved measurements of PM2.5 components were rarely used to investigate the diurnal variations of BrC and its sources, which is very important for modeling the climate impact of BrC. Key Points: Diurnal variations in PM2.5 bulk components and organic tracers reflect diurnal cycles of sourcesLight absorption of water and methanol extracts of PM2.5 exhibited a similar diurnal profile that followed changes in levoglucosanShort‐term and high time‐resolved data of organic tracers should be used for source apportionment to avoid misclassification [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
15. Gas/particle partitioning of n-alkanes, PAHs and oxygenated PAHs in urban Denver
- Author
-
Xie, Mingjie, Hannigan, Michael P., and Barsanti, Kelley C.
- Published
- 2014
- Full Text
- View/download PDF
16. Concentrations and source insights for trace elements in fine and coarse particulate matter
- Author
-
Clements, Nicholas, Eav, Jenny, Xie, Mingjie, Hannigan, Michael P., Miller, Shelly L., Navidi, William, Peel, Jennifer L., Schauer, James J., Shafer, Martin M., and Milford, Jana B.
- Published
- 2014
- Full Text
- View/download PDF
17. Molecular Characterization of Brown Carbon Chromophores in Atmospherically Relevant Samples and Their Gas‐Particle Distribution and Diurnal Variation in the Atmosphere.
- Author
-
Xing, Chong, Wan, Yibei, Wang, Qiongqiong, Kong, Shaofei, Huang, Xiangpeng, Ge, Xinlei, Xie, Mingjie, and Yu, Huan
- Subjects
CARBONACEOUS aerosols ,CHROMOPHORES ,TANDEM mass spectrometry ,RADIATION chemistry ,ATMOSPHERIC radiation ,POLYCYCLIC aromatic hydrocarbons - Abstract
By developing a nontarget tandem mass spectrometry experiment workflow, we identified the most probable structures of 100 brown carbon (BrC) chromophores in five types of atmospherically relevant samples including ambient aerosols, biomass burning aerosols, road tunnel aerosols, toluene secondary organic aerosol and rainwater. These chromophores were classified into nine groups, that is, 31 nitrophenols, 12 benzoic acids, 11 oxygenated polycyclic aromatic hydrocarbons, 10 phenols, 10 aryl amides/amines, 9 phenylpropene derivatives, 9 coumarins and flavonoids, 5 pyridines, and 3 nitrobenzoic acids. Among them, aryl amides/amine chromophores, which were mostly found in rainwater, were reported for the first time. The identified chromophores accounted for 20.9%–83.5% of total light absorption over 300–400 nm wavelength or total ion intensity in the 5 types of samples. We identified the characteristic chromophore groups in each sample type and identical chromophores among different sample types, especially between the source samples and ambient aerosols. Gas‐particle distribution and diurnal variation of 13 BrC compounds in the atmosphere were measured by an online high‐resolution chemical ionization mass spectrometer equipped with a Filter Inlet for Gases and Aerosols. It was found that gas‐particle distribution of BrC compounds was dictated by their functional group, oxygen and carbon atom numbers. The BrC compounds containing nitro‐group had higher nighttime concentrations, while those without nitro‐group had higher daytime concentrations. Plain Language Summary: Brown carbon chromophores absorb near‐ultraviolet and visible light and thus influence atmospheric radiation and atmospheric chemistry. By developing a nontarget tandem mass spectrometry experiment workflow, we identified the most probable structures of a large diversity of brown carbon (BrC) chromophores in atmospherically relevant samples like ambient aerosols, biomass burning aerosols, road tunnel aerosols, secondary organic aerosol and rainwater. The similarity and difference of BrC chromophores in these samples were investigated, with a focus on exploring the source of the chromophores in ambient aerosols. For the first time, an online high‐resolution chemical ionization mass spectrometer was applied to measure gas‐particle distribution and diurnal variation of BrC chromophores in the atmosphere. Key Points: We developed a nontarget tandem mass spectrometry experiment workflow to identify the most probable structures of brown carbon (BrC) chromophoresWe identified 100 BrC chromophores in five types of atmospheric samples, among which 33 chromophores was reported for the first timeFilter Inlet for Gases and Aerosols‐chemical ionization mass spectrometer was applied to measure gas‐particle distribution and diurnal variation of BrC chromophores in the atmosphere [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
18. Phthalates and alternative plasticizers and potential for contact exposure from children’s backpacks and toys
- Author
-
Xie, Mingjie, Wu, Yaoxing, Little, John C, and Marr, Linsey C
- Published
- 2016
- Full Text
- View/download PDF
19. Towards Carbon Neutrality: Carbon Emission Performance of Science and Technology Finance Policy.
- Author
-
Xu, Hong, Liu, Baozhen, Lin, Kai, Zhang, Yunyun, Liu, Bei, and Xie, Mingjie
- Published
- 2022
- Full Text
- View/download PDF
20. Seasonal variations, temperature dependence, and sources of size-resolved PM components in Nanjing, east China.
- Author
-
Xie, Mingjie, Feng, Wei, He, Shuyan, and Wang, Qin'geng
- Subjects
- *
PARTICULATE matter , *SEASONS , *AIR quality , *MATRIX decomposition , *TEMPERATURE , *CARBONACEOUS aerosols , *HUMIDITY - Abstract
• NO3- concentrations in coarse particles show elevations in warm seasons. • Size distributions of semi-volatile species have a dependency on ambient temperatures. • Relative humidity plays a role in driving seasonal changes of PM size distributions. • Heterogeneous formations of secondary salts contribute ∼20% of speciated coarse PM. Size-segregated ambient particulate matter (PM) samples were collected seasonally in suburban Nanjing of east China from 2016 to 2017 and chemically speciated. In both fine (< 2.1 µm, PM 2.1) and coarse (> 2.1 µm, PM >2.1) PM, organic carbon (OC) accounted for the highest fractions (26.9% ± 10.9% and 23.1% ± 9.35%) of all measured species, and NO 3 − lead in average concentrations of water-soluble inorganic ions (WSIIs). The size distributions of measured components were parameterized using geometric mean diameter (GMD). GMD values of NO 3 −, Cl−, OC, and PM for the whole size range varied from < 2.1 µm in winter to > 2.1 μm in warm seasons, which was due to the fact that the size distributions of semi-volatile components (e.g., NH 4 NO 3 , NH 4 Cl, and OC) had a dependency on the ambient temperature. Unlike OC, elemental carbon (EC), and elements, NH 4 +, NO 3 −, and SO 4 2− exhibited an increase trend in GMD values with relative humidity, indicating that the hygroscopic growth might also play a role in driving seasonal changes of PM size distributions. Positive matrix factorization was performed using compositional data of fine and coarse particles, respectively. The secondary formation of inorganic salts contributing to the majority (> 70%) of fine PM and 20.2% ± 19.9% of speciated coarse PM. The remaining coarse PM content was attributed to a variety of dust sources. Considering that coarse and fine PM had comparable mass concentrations, more attention should be paid to local dust emissions in future air quality plans. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
21. Potential underestimation of ambient brown carbon absorption based on the methanol extraction method and its impacts on source analysis.
- Author
-
Xu, Zhenqi, Feng, Wei, Wang, Yicheng, Ye, Haoran, Wang, Yuhang, Liao, Hong, and Xie, Mingjie
- Subjects
ABSORPTION coefficients ,BIOMASS burning ,DICHLOROMETHANE ,COAL combustion ,LIGHT absorption ,AEROSOL sampling - Abstract
The methanol extraction method was widely applied to isolate organic carbon (OC) from ambient aerosols, followed by measurements of brown carbon (BrC) absorption. However, undissolved OC fractions will lead to underestimated BrC absorption. In this work, water, methanol (MeOH), MeOH / dichloromethane (MeOH / DCM, 1:1 , v/v), MeOH / DCM (1:2 , v/v), tetrahydrofuran (THF), and N,N-dimethylformamide (DMF) were tested for extraction efficiencies of ambient OC, and the light absorption of individual solvent extracts was determined. Among the five solvents and solvent mixtures, DMF dissolved the highest fractions of ambient OC (up to ∼95 %), followed by MeOH and MeOH / DCM mixtures (<90 %), and the DMF extracts had significantly (p<0.05) higher light absorption than other solvent extracts. This is because the OC fractions evaporating at higher temperatures (>280 ∘) are less soluble in MeOH (∼80 %) than in DMF (∼90 %) and contain stronger light-absorbing chromophores. Moreover, the light absorption of DMF and MeOH extracts of collocated aerosol samples in Nanjing showed consistent temporal variations in winter when biomass burning dominated BrC absorption, while the average light absorption of DMF extracts was more than 2 times greater than the MeOH extracts in late spring and summer. The average light absorption coefficient at 365 nm of DMF extracts was 30.7 % higher (p<0.01) than that of MeOH extracts. Source apportionment results indicated that the MeOH solubility of BrC associated with biomass burning, lubricating oil combustion, and coal combustion is similar to their DMF solubility. The BrC linked with unburned fossil fuels and polymerization processes of aerosol organics was less soluble in MeOH than in DMF, which was likely the main reason for the large difference in time series between MeOH and DMF extract absorption. These results highlight the importance of testing different solvents to investigate the structures and light absorption of BrC, particularly for the low-volatility fraction potentially originating from non-combustion sources. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
22. Aliphatic alkanes and polycyclic aromatic hydrocarbons in atmospheric PM 10 aerosols from Baoji, China: Implications for coal burning
- Author
-
Xie, Mingjie, Wang, Gehui, Hu, Shuyuan, Han, Qingyou, Xu, Yajuan, and Gao, Zhongchao
- Published
- 2009
- Full Text
- View/download PDF
23. Multiple periodic oscillations in the radio light curves of NRAO 530
- Author
-
Xie, MingJie, Wang, JunYi, An, Tao, Zheng, Lin, and Han, Xu
- Published
- 2013
- Full Text
- View/download PDF
24. Antibacterial mechanism of soybean isoflavone on Staphylococcus aureus
- Author
-
Wang, Qian, Wang, Haitao, and Xie, Mingjie
- Published
- 2010
- Full Text
- View/download PDF
25. Collocated Measurements of Light‐Absorbing Organic Carbon in PM2.5: Observation Uncertainty and Organic Tracer‐Based Source Apportionment.
- Author
-
Xie, Mingjie, Peng, Xiang, Shang, Yue, Yang, Li, Zhang, Yuanyuan, Wang, Yuhang, and Liao, Hong
- Subjects
PARTICULATE matter ,LIGHT absorption ,CRYSTAL filters ,WATER-soluble organometallic compounds ,AEROSOLS - Abstract
In this study, collocated filter samples of particulate matter with aerodynamic diameter less than 2.5 μm (PM2.5) from northern Nanjing were extracted using water and methanol, followed by analysis of light absorption. A backup quartz filter was used to correct sampling artifacts caused by adsorption of gaseous organics. The collocated precision of light‐absorbing properties of water‐soluble organic carbon (WSOC) and methanol‐extractable organic carbon (MEOC) were parameterized using correlation coefficient (r), coefficient of divergence (COD), and average relative percent difference (ARPD, %). In general, the light absorption of WSOC and MEOC showed good agreement (r > 0.80, COD < 0.20) between collocated samples. Performing artifact correction is necessary and will increase the heterogeneity between collocated measurements. The duplicate‐derived ARPD values of MEOC absorption were more than 60% higher than those of WSOC absorption. Then, it would be inappropriate to assume a uniform uncertainty fraction (e.g., ∼10%) for WSOC and MEOC absorption in future studies on their climate effects and source apportionment. To apportion artifact‐corrected absorption of aerosol extracts to specific emission sources or formation pathways, positive matrix factorization was performed by using concentration data of selected bulk species and organic molecular markers. Among the nine identified factor/sources, the biomass burning factor had the highest average contributions to the absorption of both WSOC (31.6%) and MEOC (48.0%), followed by dust resuspension and coal combustion factors. Unlike combustion‐related primary emissions, the factors containing influences from atmospheric processing (e.g., secondary nitrate) contributed more fractions of WSOC absorption than MEOC absorption. Key Points: Collocated measurements provide an approach to estimate uncertainties in light‐absorbing properties of solvent‐extractable organic carbonIgnoring the adsorption of gaseous organics onto filter medium will lead to significant overestimation of brown carbon absorptionAerosol sources influenced by aging processes contributed more fractions of aqueous extracts absorption than methanol extracts absorption [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
26. Measurements, Gas/Particle Partitioning, and Sources of Nonpolar Organic Molecular Markers at a Suburban Site in the West Yangtze River Delta, China.
- Author
-
Gou, Yafeng, Qin, Chao, Liao, Hong, and Xie, Mingjie
- Subjects
URETHANE foam ,ALKANES ,HYDROCARBONS ,VAPOR pressure ,SUMMER ,DELTAS - Abstract
This study seeks to understand the ambient levels, gas/particle partitioning, and sources of nonpolar organic molecular makers (OMMs) at a suburban site in Nanjing, China. Particle‐ and gas‐phase OMMs were collected using a medium volume sampler equipped with two quartz filters in series and a polyurethane foam (PUF)/XAD‐4/PUF (PXP) adsorbent sandwich. More than 100 pairs of filter and PXP samples were collected diurnally from September 2018 to September 2019. The concentration profiles of total n‐alkanes and polycyclic aromatic hydrocarbons were peaking at n‐C12–n‐C17 homologs (9.98 ± 5.43–38.4 ± 17.7 ng m−3) and naphthalene (92.5 ± 56.7 ng m−3), respectively, followed by decreasing concentrations with further increases in molecular weight. Three artifact correction methods with different pre‐assumptions on relative contributions of evaporation loss to backup filter measurements were used to separate particle‐ and gas‐phase OMMs. The resulting particle‐phase fractions showed significant differences for OMMs with vapor pressure <10−9 atm at 298.15 K. Absorptive gas/particle partitioning coefficients of OMMs were empirically calculated based on measurements and theoretically predicted for comparison. The results obtained under the three artifact correction methods suggested growing importance of evaporation loss with decreased vapor pressure. Positive matrix factorization (PMF) was performed for source apportionment using total (PMFtotal) and particle‐phase (PMFparticle) OMMs data, respectively. Besides eliminating the influence of gas/particle partitioning, the involvements of more volatile species and gaseous OMMs data improved the identification of specific emission sources, supporting the usage of total OMMs data over a wide vapor pressure range for PMF source apportionment. Key Points: The particulate fractions of organic molecular markers attained their minima in summer, when the total concentrations increasedEvaporation loss might be the main sampling artifact of particulate organics when the vapor pressure is lower than 10−10 atmTotal concentrations of organic molecular markers over a wide vapor pressure range should be used for positive matrix factorization analysis [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
27. Gas–particle partitioning of polyol tracers at a suburban site in Nanjing, east China: increased partitioning to the particle phase.
- Author
-
Qin, Chao, Gou, Yafeng, Wang, Yuhang, Mao, Yuhao, Liao, Hong, Wang, Qin'geng, and Xie, Mingjie
- Subjects
POLYOLS ,PHASE partition ,HENRY'S law ,HYDROPHILIC compounds ,VAPOR pressure ,ORGANIC compounds - Abstract
Gas–particle partitioning of water-soluble organic compounds plays a significant role in influencing the formation, transport, and lifetime of organic aerosols in the atmosphere, but is poorly characterized. In this work, gas- and particle-phase concentrations of isoprene oxidation products (C5-alkene triols and 2-methylterols), levoglucosan, and sugar polyols were measured simultaneously at a suburban site of the western Yangtze River Delta in east China. All target polyols were primarily distributed into the particle phase (85.9 %–99.8 %). Given the uncertainties in measurements and vapor pressure predictions, a dependence of particle-phase fractions on vapor pressures cannot be determined. To explore the impact of aerosol liquid water on gas–particle partitioning of polyol tracers, three partitioning schemes (Cases 1–3) were proposed based on equilibriums of gas vs. organic and aqueous phases in aerosols. If particulate organic matter (OM) is presumed as the only absorbing phase (Case 1), the measurement-based absorptive partitioning coefficients (Kp,OMm) of isoprene oxidation products and levoglucosan were more than 10 times greater than predicted values (Kp,OMt). The agreement between Kp,OMm and Kp,OMt was substantially improved when solubility in a separate aqueous phase was included, whenever water-soluble and water-insoluble OM partitioned into separate (Case 2) or single (Case 3) liquid phases, suggesting that the partitioning of polyol tracers into the aqueous phase in aerosols should not be ignored. The measurement-based effective Henry's law coefficients (KH,em) of polyol tracers were orders of magnitude higher than their predicted values in pure water (KH,wt). Due to the moderate correlations between log(KH,em/KH,wt) and molality of sulfate ions, the gap between KH,em and KH,wt of polyol tracers could not be fully parameterized by the equation defining "salting-in" effects and might be ascribed to mechanisms of reactive uptake, aqueous phase reaction, "like-dissolves-like" principle, etc. These study results also partly reveal the discrepancy between observation and modeling of organic aerosols. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
28. The complex roles of neutrophils in APAP‐induced liver injury.
- Author
-
Guo, Huiting, Chen, Shiwei, Xie, Mingjie, Zhou, Cheng, and Zheng, Min
- Subjects
LIVER injuries ,NEUTROPHILS ,LIVER failure - Abstract
Acetaminophen (APAP) is a widely applied drug for the alleviation of pain and fever, which is also a dose‐depedent toxin. APAP‐induced acute liver injury has become one of the primary causes of liver failure which is an increasingly serious threat to human health. Neutrophils are the major immune cells in human serving as the first barrier against the invasion of pathogen. It has been reported that neutrophils patriciate in the occurrence and development of APAP‐induced liver injury. However, evolving evidences suggest that neutrophils also contribute to tissue repair and actively orchestrate resolution of inflammation. Here, we addressed the complex roles in APAP‐induced liver injury on the basis of brief introduction of neutrophil's activation, recruitment and migration. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
29. Research on benefit evaluation method of pumped storage power station.
- Author
-
Xie, Mingjie, Gong, Chuanzheng, Chen, Tongfa, Pan, Ligang, Wang, Qingran, Zhang, Kailin, Chu, Hongchen, and Yang, Kai
- Published
- 2021
- Full Text
- View/download PDF
30. Neddylation inhibitor MLN4924 has anti‐HBV activity via modulating the ERK‐HNF1α‐C/EBPα‐HNF4α axis.
- Author
-
Xie, Mingjie, Guo, Huiting, Lou, Guohua, Yao, Jiping, Liu, Yanning, Sun, Yi, Yang, Zhenggang, and Zheng, Min
- Subjects
VIRAL antigens ,HEPATITIS B virus ,TRANSCRIPTION factors ,EXTRACELLULAR signal-regulated kinases ,HEPATOCELLULAR carcinoma - Abstract
Hepatitis B virus (HBV) infection is a major public health problem. The high levels of HBV DNA and HBsAg are positively associated with the development of secondary liver diseases, including hepatocellular carcinoma (HCC). Current treatment with nucleos(t)ide analogues mainly reduces viral DNA, but has minimal, if any, inhibitory effect on the viral antigen. Although IFN reduces both HBV DNA and HBsAg, the serious associated side effects limit its use in clinic. Thus, there is an urgent demanding for novel anti‐HBV therapy. In our study, viral parameters were determined in the supernatant of HepG2.2.15 cells, HBV‐expressing Huh7 and HepG2 cells which transfected with HBV plasmids and in the serum of HBV mouse models with hydrodynamic injection of pAAV‐HBV1.2 plasmid. RT‐qPCR and Southern blot were performed to detect 35kb mRNA and cccDNA. RT‐qPCR, Luciferase assay and Western blot were used to determine anti‐HBV effects of MLN4924 and the underlying mechanisms. We found that treatment with MLN4924, the first‐in‐class neddylation inhibitor currently in several phase II clinical trials for anti‐cancer application, effectively suppressed production of HBV DNA, HBsAg, 3.5kb HBV RNA as well as cccDNA. Mechanistically, MLN4924 blocks cullin neddylation and activates ERK to suppress the expression of several transcription factors required for HBV replication, including HNF1α, C/EBPα and HNF4α, leading to an effective blockage in the production of cccDNA and HBV antigen. Our study revealed that neddylation inhibitor MLN4924 has impressive anti‐HBV activity by inhibiting HBV replication, thus providing sound rationale for future MLN4924 clinical trial as a novel anti‐HBV therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
31. Chemical composition, structures, and light absorption of N-containing aromatic compounds emitted from burning wood and charcoal in household cookstoves.
- Author
-
Xie, Mingjie, Zhao, Zhenzhen, Holder, Amara L., Hays, Michael D., Chen, Xi, Shen, Guofeng, Jetter, James J., Champion, Wyatt M., and Wang, Qin'geng
- Subjects
LIGHT absorption ,AROMATIC compounds ,CHARCOAL ,CHEMICAL formulas ,CRYSTAL filters ,CHEMICAL properties - Abstract
N-containing aromatic compounds (NACs) are an important group of light-absorbing molecules in the atmosphere. They are often observed in combustion emissions, but their chemical formulas and structural characteristics remain uncertain. In this study, red oakwood and charcoal fuels were burned in cookstoves using the standard water-boiling test (WBT) procedure. Submicron aerosol particles in the cookstove emissions were collected using quartz (Qf) and polytetrafluoroethylene (PTFE) filter membranes positioned in parallel. A backup quartz filter (Qb) was also installed downstream of the PTFE filter to evaluate the effect of sampling artifacts on NAC measurements. Liquid chromatography–mass spectroscopy (LC–MS) techniques identified 17 NAC chemical formulas in the cookstove emissions. The average concentrations of total NACs in Qb samples (0.37±0.31 – 1.79±0.77 µgm-3) were greater than 50 % of those observed in the Qf samples (0.51±0.43 – 3.91±2.06 µgm-3), and the Qb -to- Qf mass ratios of individual NACs had a range of 0.02–2.71, indicating that the identified NACs might have substantial fractions remaining in the gas phase. In comparison to other sources, cookstove emissions from red oak or charcoal fuels did not exhibit unique NAC structural features but had distinct NAC composition. However, before identifying NAC sources by combining their structural and compositional information, the gas-particle partitioning behaviors of NACs should be further investigated. The average contributions of total NACs to the light absorption of organic matter at λ=365 nm (1.10 %–2.57 %) in Qf and Qb samples (10.7 %–21.0 %) are up to 10 times larger than their mass contributions (Qf : 0.31 %–1.01 %; Qb : 1.08 %–3.31 %), so the identified NACs are mostly strong light absorbers. To explain more sample extract absorption, future research is needed to understand the chemical and optical properties of high-molecular-weight (e.g., molecular weight, MW>500 Da) entities in particulate matter. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
32. Study on promotion of interface adhesion by ultrasonic vibration for CFRP/Al alloy joints.
- Author
-
Wang, Hui, Xie, Mingjie, Hua, Lin, Chen, Yizhe, Wu, Min, and Chen, Zhenyan
- Subjects
- *
ADHESION , *CHEMICAL bonds , *CHEMICAL reactions , *BOND strengths , *ADHESIVES , *ADHESIVE joints , *ALUMINUM-lithium alloys - Abstract
Adhesively bonded CFRP/Al joints have been widely used in various engineering fields. However, the poor interface adhesion between the adhesive and the Al adherend limits its further use. In this study, ultrasonic vibration was applied to promote the interface adhesion, and the promotion mechanism was studied in detail. The vibration was exerted on the surface close to the bonding area after the adhesive was applied. According to the bonding strength test, this process improved the bonding strength and repeatability by approximately 32% and 48%, respectively. By comparing the failure behavior without and with ultrasound, it can be seen that ultrasound promotes interface adhesion of the adhesive/Al adherend significantly. Under the application of ultrasonic vibration, a tight microscopic bond was formed at the bonding interface, and a chemical reaction occurred to form chemical bonds. The opening of the epoxy group was promoted to allow Al to react with –O–C to form Al–O–C, because attack of electrophilic Al + on O– of the epoxy group was strengthened by high-frequency impact between the adhesive and the Al adherend at the interface caused by the ultrasonic vibration. It can be seen that the application of ultrasonic vibration during the adhesive bonding process can promote interface adhesion between Al and the adhesive in terms of physics and chemistry, thus significantly improving the performance of the adhesive bond. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
33. Initial Cost Barrier of Ammonia Control in Central China.
- Author
-
Zheng, Mingming, Wang, Yuhang, Bao, Jianguo, Yuan, Lianxin, Zheng, Huang, Yan, Yingying, Liu, Dantong, Xie, Mingjie, and Kong, Shaofei
- Subjects
AMMONIA ,PARTICULATE matter ,SULFUR dioxide ,ATMOSPHERIC aerosols - Abstract
Ammonia control has received increasing attention as a measure to decrease particulate concentrations. Modeling analysis of observation data from central China over the period of September 2015 to August 2016 shows clear asymmetric responses of particulate pH and mass to ammonia emissions. With a change of ±80% of NHx (NH3 + NH4+), the corresponding ΔpH are +0.5 and −3.0, respectively, and the corresponding particulate NH4+ changes are +2.62% and −61.8%, respectively. This asymmetry implies that there is a Critical Total Ammonia Concentration, above which particulate pH and mass are insensitive to ammonia control. Analysis of the observation data suggests that the Critical Total Ammonia Concentration is −25%. The estimated cost for an NHx reduction of 25% is $140 – 320 million for Hubei province, which is the initial cost barrier before ammonia control can effectively affect particulate pH and mass in central China. This cost barrier will increase as NOx and SO2 emissions decrease. Key Points: Only after NHx reduction exceeds 25% can ammonia control effectively reduce the inorganic aerosol massMore NHx reduction will be required to reach the critical point of effective ammonia control as NOx and SO2 emissions decreaseA large enough NHx reduction (60%–80%) renders concurrent reduction of NOx emissions ineffective and even the effect of SO2 emission control is reduced [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
34. PM2.5 elements at an urban site in Yangtze River Delta, China: High time-resolved measurement and the application in source apportionment.
- Author
-
Yu, Yiyong, He, Shuyan, Wu, Xilan, Zhang, Chi, Yao, Ying, Liao, Hong, Wang, Qin'geng, and Xie, Mingjie
- Subjects
TIME-resolved measurements ,ENVIRONMENTAL sciences ,TRACE elements ,MATRIX decomposition ,DELTAS ,MEGALOPOLIS ,SANDSTORMS - Abstract
Elemental concentrations of ambient aerosols are commonly sampled over 12–24 h, and the low time resolution puts a great limit on current understanding about the temporal variations and source apportionment based on receptor models. In this work, hourly-resolved concentrations of eighteen elements in PM 2.5 at an urban site in Nanjing, a megacity in Yangtze River Delta of east China, were obtained by using a Xact 625 ambient metals monitor from 12/12/2016 to 12/31/2017. The influence of traffic activities was clearly reflected by the spikes of crustal elements (e.g., Fe, Ca, and Si) in the morning rush hour, and the firework burning and sandstorm events during the sampling periods were tracked by sharp enrichment of Ba, K and Fe, Ca, Si, Ti in PM 2.5 , respectively. To evaluate the advantage of hourly-resolved elements data in identifying impacts from specific emission sources, positive matrix factorization (PMF) analysis was performed with the 1-h data set (PMF 1-h) and 23-h averaged data (PMF 23-h), respectively. The 4- and 6-factor PMF 23-h solutions had similar factor profiles and consistent factor contributions as the corresponding PMF 1-h solutions. However, due to the limit in inter-sample variability, PMF analysis with 23-h average data misclassified some major (e.g., K, Fe, Zn, Ca, and Si) and trace (e.g., Pb) elements in factor profiles, resulting in different absolute factor contributions between PMF 23-h and PMF 1-h solutions. These results suggested the use of high time-resolved data to obtain valid and robust source apportionment results. Image 1 • PM 2.5 elements were measured with 1-h resolution at an urban site in Nanjing city. • Specific local emissions were reflected by the diurnal variations of PM 2.5 elements. • Two pollution episodes were tracked by sharp enrichment of distinct elements. • The 1-h measurements data were preferred over 23-h averages for source apportionment. This study suggests using high time-resolved measurements of PM 2.5 elements for receptor-based source apportionment to obtain robust results. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
35. Iodine speciation and size distribution in ambient aerosols at a coastal new particle formation hotspot in China.
- Author
-
Yu, Huan, Ren, Lili, Huang, Xiangpeng, Xie, Mingjie, He, Jun, and Xiao, Hang
- Subjects
PARTICLE size determination ,TIME-of-flight mass spectrometry ,IODINE ,IODINE compounds ,CHEMICAL formulas ,CHEMICAL speciation - Abstract
Intense new particle formation (NPF) events were observed in the coastal atmosphere during algae growth and farming season at Xiangshan gulf of the east China coast. High nucleation-mode iodine concentrations measured by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS) confirmed that the NPF events were induced by iodine species. Our study provides important information on iodine speciation, size distributions, and its role in NPF in the context of heavy air pollution in China's coastal areas. For the first time, we identified 5 inorganic iodine species, 45 organic iodine compounds (35 molecular formulas), and a group of iodide–organic adducts in aerosols. The concentrations and size distributions of iodine species down to 10 nm were measured during the iodine-induced NPF, continental NPF, and non-NPF days at the coastal site and compared to those at an inland site. The iodine in the above four aerosol sample types were characterized by iodate, aromatic iodine compounds, iodoacetic acid or iodopropenoic acid, and iodide–organic adducts, respectively. Iodide and organic iodine compounds were found in the nucleation-mode particles; however, it is still not clear whether they contributed to nucleation or just new particle growth. Wild algae, as well as farmed algae, could be an important NPF source in China's coastal areas. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
36. Composition and light absorption of N-containing aromatic compounds in organic aerosols from laboratory biomass burning.
- Author
-
Xie, Mingjie, Chen, Xi, Hays, Michael D., and Holder, Amara L.
- Subjects
BIOMASS burning ,ORGANIC compounds ,LIGHT absorption ,VOLATILE organic compounds ,AROMATIC compounds ,MOLECULAR structure - Abstract
This study seeks to understand the compositional details of N-containing aromatic compounds (NACs) emitted during biomass burning (BB) and their contribution to light-absorbing organic carbon (OC), also termed brown carbon (BrC). Three laboratory BB experiments were conducted with two United States pine forest understory fuels typical of those consumed during prescribed fires. During the experiments, submicron aerosol particles were collected on filter media and subsequently extracted with methanol and examined for their optical and chemical properties. Significant correlations (p<0.05) were observed between BrC absorption and elemental carbon (EC)/OC ratios for individual burns data. However, the pooled experimental data indicated that EC/OC alone cannot explain the BB BrC absorption. Fourteen NAC formulas were identified in the BB samples, most of which were also observed in simulated secondary organic aerosol (SOA) from photooxidation of aromatic volatile organic compounds (VOCs) with NOx. However, the molecular structures associated with the identical NAC formula from BB and SOA are different. In this work, the identified NACs from BB are featured by methoxy and cyanate groups and are predominately generated during the flaming phase. The mass concentrations of identified NACs were quantified using authentic and surrogate standards, and their contributions to bulk light absorption of solvent-extractable OC were also calculated. The contributions of identified NACs to organic matter (OM) and BrC absorption were significantly higher in flaming-phase samples than those in smoldering-phase samples, and they correlated with the EC/OC ratio (p<0.05) for both individual burns and pooled experimental data, indicating that the formation of NACs from BB largely depends on burn conditions. The average contributions of identified NACs to overall BrC absorption at 365 nm ranged from 0.087±0.024 % to 1.22±0.54 %, which is 3–10 times higher than their mass contributions to OM (0.023±0.0089 % to 0.18±0.067 %), so the NACs with light absorption identified in this work from BB are likely strong BrC chromophores. Further studies are warranted to identify more light-absorbing compounds to explain the unknown fraction (>98 %) of BB BrC absorption. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
37. Light absorption of organic carbon and its sources at a southeastern U.S. location in summer.
- Author
-
Xie, Mingjie, Chen, Xi, Holder, Amara L., Hays, Michael D., Lewandowski, Michael, Offenberg, John H., Kleindienst, Tadeusz E., Jaoui, Mohammed, and Hannigan, Michael P.
- Subjects
ABSORPTION ,IMBIBITION (Chemistry) ,ORGANIC compounds ,COMBUSTION ,CARBON compounds - Abstract
Abstract Light-absorbing organic carbon (OC), also referred to as "brown carbon" (BrC), has been intensively investigated in atmospheres impacted by biomass burning. However, other BrC sources (e.g., secondary formation in the atmosphere) are rarely studied in ambient aerosols. In the current work, forty-five PM 2.5 filter samples were collected in Research Triangle Park (RTP), NC, USA from June 1st to July 15th, 2013. The bulk carbonaceous components, including OC, elemental carbon (EC), water soluble OC (WSOC), and an array of organic molecular markers were measured; an ultraviolet/visible spectrometer was used to measure the light absorption of methanol extractable OC and WSOC. The average light absorption per OC and WSOC mass of PM 2.5 samples in summer RTP are 0.36 ± 0.16 m
2 gC−1 and 0.29 ± 0.13 m2 gC−1 , respectively, lower than the ambient aerosol samples impacted by biomass burning and/or fossil fuel combustion (0.7–1.6 m2 gC−1 ) from other places. Less than 1% of the aqueous extracts absorption is attributed to the light-absorbing chromophores (nitroaromatic compounds) identified in this work. To identify the major sources of BrC absorption in RTP in the summer, Positive Matrix Factorization (PMF) was applied to a dataset containing optical properties and chemical compositions of carbonaceous components in PM 2.5. The results suggest that the formation of biogenic secondary organic aerosol (SOA) containing organosulfates is an important BrC source, contributing up to half of the BrC absorption in RTP during the summertime. Graphical abstract Image 1 Highlights • BrC absorption in summer at RTP, NC is similar to other Southeastern US locations. • Less than 1% of BrC absorption is attributed to identified nitroaromatic compounds. • Biomass burning is not the dominant source for BrC absorption in summer at RTP, NC. • Biogenic secondary organic aerosol formation is a major BrC source in this work. This study identified a linkage between atmospheric BrC and biogenic SOA formation when biomass burning is not significant in Research Triangle Park, NC during the summer. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
38. Light absorption of organic carbon emitted from burning wood, charcoal, and kerosene in household cookstoves.
- Author
-
Xie, Mingjie, Shen, Guofeng, Holder, Amara L., Hays, Michael D., and Jetter, James J.
- Subjects
LIGHT absorption ,CARBON sequestration ,COMBUSTION ,BIOMASS ,SPECTROPHOTOMETRY - Abstract
Household cookstove emissions are an important source of carbonaceous aerosols globally. The light-absorbing organic carbon (OC), also termed brown carbon (BrC), from cookstove emissions can impact the Earth's radiative balance, but is rarely investigated. In this work, PM 2.5 filter samples were collected during combustion experiments with red oak wood, charcoal, and kerosene in a variety of cookstoves mainly at two water boiling test phases (cold start CS, hot start HS). Samples were extracted in methanol and extracts were examined using spectrophotometry. The mass absorption coefficients (MAC λ , m 2 g −1 ) at five wavelengths (365, 400, 450, 500, and 550 nm) were mostly inter-correlated and were used as a measurement proxy for BrC. The MAC 365 for red oak combustion during the CS phase correlated strongly to the elemental carbon (EC)/OC mass ratio, indicating a dependency of BrC absorption on burn conditions. The emissions from cookstoves burning red oak have an average MAC λ 2–6 times greater than those burning charcoal and kerosene, and around 3–4 times greater than that from biomass burning measured in previous studies. These results suggest that residential cookstove emissions could contribute largely to ambient BrC, and the simulation of BrC radiative forcing in climate models for biofuel combustion in cookstoves should be treated specifically and separated from open biomass burning. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
39. First long-term and near real-time measurement of trace elements in China's urban atmosphere: temporal variability, source apportionment and precipitation effect.
- Author
-
Chang, Yunhua, Huang, Kan, Xie, Mingjie, Deng, Congrui, Zou, Zhong, Liu, Shoudong, and Zhang, Yanlin
- Subjects
TRACE elements ,ATMOSPHERE ,METEOROLOGICAL precipitation ,NONFERROUS metals ,POLLUTION - Abstract
Atmospheric trace elements, especially metal species, are an emerging environmental and health concern with insufficient understanding of their levels and sources in Shanghai, the most important industrial megacity in China. Here we continuously performed a 1 year (from March 2016 to February 2017) and hourly resolved measurement of 18 elements in fine particles (PM
2:5 ) at the Shanghai urban center with an Xact multi-metals monitor and several collocated instruments. Mass concentrations (mean±1σ; ngm-3 ) determined by Xact ranged from detection limits (nominally 0.1 to 20 ngm-3 ) to 15 µgm-3 . Element-related oxidized species comprised an appreciable fraction of PM2:5 during all seasons, accounting for 8.3% on average. As a comparison, the atmospheric elements concentration level in Shanghai was comparable with that in other industrialized cities in East Asia but 1 or 2 orders of magnitude higher than at sites in North America and Europe. Positive matrix factorization (PMF) was applied to identify and apportion the sources of the elements in the PM2:5 mass. Five different factors were resolved (notable elements and relative contribution in parentheses): traffic-related (Ca, Fe, Ba, Si; 46%), shipping (V, Ni; 6%), nonferrous metal smelting (Ag, Cd, Au; 15%), coal combustion (As, Se, Hg, Pb; 18%) and ferrous metal smelting (Cr, Mn, Zn; 15%). The contribution from the exhaust and non-exhaust vehicle emissions, i.e., the traffic-related factor shows a strong bimodal diurnal profile with average concentration over 2 times higher during the rush hour than during nighttime. The shipping factor was firmly identified because V and Ni, two recognized tracers of shipping emissions, are almost exclusively transported from the East China Sea and their ratio (around 3.2) falls within the variation range of V= Ni ratios in particles emitted from heavy oil combustion. Interestingly, nearly half of the K was derived from coal combustion with high mineral affinity (elements associated with aluminosilicates, carbonates and other minerals in coal ash). The contributions of nonferrous metal smelting to the trace elements are consistent with a newly developed emission inventory. Although the precipitation scavenging effect on the mass concentration of the trace elements varied among different species and sources, precipitation could effectively lower the concentration of the trafficand coal combustion-related trace elements. Therefore, water spray to simulate natural types of precipitation could be one of the abatement strategies to facilitate the reduction of ambient PM2:5 trace elements in the urban atmosphere. Collectively, our findings in this study provide baseline levels and sources of trace elements with high detail, which are needed for developing effective control strategies to reduce the high risk of acute exposure to atmospheric trace elements in China's megacities. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
40. Inhibitory effects of silybin on the efflux pump of methicillin-resistant Staphylococcus aureus.
- Author
-
Wang, Di, Xie, Kunpeng, Zou, Dan, Meng, Meizhu, and Xie, Mingjie
- Subjects
STAPHYLOCOCCUS aureus ,CIPROFLOXACIN ,REVERSE transcriptase polymerase chain reaction ,DRUG resistance in bacteria ,EFFLUX (Microbiology) - Abstract
Bacterial multidrug resistance efflux systems serve an important role in antimicrobial resistance. Thus, identifying novel and effective efflux pump inhibitors that are safe with no adverse side effects is urgently required. Silybin is a flavonolignan component of the extract from the milk thistle seed. To order to investigate the mechanism by which silybin inhibits the efflux system of methicillin-resistant Staphylococcus aureus (MRSA), antimicrobial susceptibility testing and the double-plate method were used to evaluate the effect of silybin on MRSA41577. The ability of silybin to inhibit the efflux of ciprofloxacin from MRSA was evaluated by performing a fluorescence assay. Reverse transcription-quantitative polymerase chain reaction analysis revealed that silybin reduced the expression of the quinolone resistance protein NorA (norA) and quaternary ammonium resistance proteins A/B (qacA/B) efflux genes in MRSA. This suggested that silybin may effectively inhibit the efflux system of MRSA41577. Compared with the control, MRSA41577 treated with silybin for 16 h exhibited a 36 and 49% reduction in the expression of norA and qacA/B, respectively. Inhibition of the expression of these genes by silybin restored the sensitivity of MRSA41577 to antibiotics, indicating that efflux pump inhibitors, which act by inhibiting the efflux system of MRSA, may disrupt the MRSA resistance to antibiotics, rendering the bacteria sensitive to these drugs. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
41. Characterization of organic nitrogen in aerosols at a forest site in the southern Appalachian Mountains.
- Author
-
Chen, Xi, Xie, Mingjie, Hays, Michael D., Edgerton, Eric, Schwede, Donna, and Walker, John T.
- Subjects
ATMOSPHERIC aerosols ,NITROGEN ,MOUNTAIN forests ,ATMOSPHERIC chemistry ,STRATOSPHERIC aerosols - Abstract
This study investigates the composition of organic particulate matter in PM
2.5 in a remote montane forest in the southeastern US, focusing on the role of organic nitrogen (N) in sulfur-containing secondary organic aerosol (nitrooxy-organosulfates) and aerosols associated with biomass burning (nitro-aromatics). Bulk water-soluble organic N (WSON) represented ∼ 14 % w∕w of water-soluble total N (WSTN) in PM2.5 on average across seasonal measurement campaigns conducted in the spring, summer, and fall of 2015. The largest contributions of WSON to WSTN were observed in spring ( ∼ 18 % w∕w) and the lowest in the fall ( ∼ 10 % w∕w). On average, identified nitro-aromatic and nitrooxy-organosulfate compounds accounted for a small fraction of WSON, ranging from ∼ 1 % in spring to ∼ 4 % in fall, though were observed to contribute as much as 28 % w∕w of WSON in individual samples that were impacted by local biomass burning. The highest concentrations of oxidized organic N species occurred during summer (average of 0.65 ng N m−3 ) along with a greater relative abundance of higher-generation oxygenated terpenoic acids, indicating an association with more aged aerosol. The highest concentrations of nitro-aromatics (e.g., nitrocatechol and methyl-nitrocatechol), levoglucosan, and aged SOA tracers were observed during fall, associated with aged biomass burning plumes. Nighttime nitrate radical chemistry is the most likely formation pathway for nitrooxy-organosulfates observed at this low NOx site (generally < 1 ppb). Isoprene-derived organosulfate (MW216, 2-methyltetrol derived), which is formed from isoprene epoxydiols (IEPOX) under low NOx conditions, was the most abundant individual organosulfate. Concentration-weighted average WSON ∕ WSOC ratios for nitro-aromatics + organosulfates + terpenoic acids were 1 order of magnitude lower than the overall aerosol WSON ∕ WSOC ratio, indicating the presence of other uncharacterized higher-N-content species. Although nitrooxy-organosulfates and nitro-aromatics contributed a small fraction of WSON, our results provide new insight into the atmospheric formation processes and sources of these largely uncharacterized components of atmospheric organic N, which also helps to advance the atmospheric models to better understand the chemistry and deposition of reactive N. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
42. Evaluating the influence of constant source profile presumption on PMF analysis of PM2.5 by comparing long- and short-term hourly observation-based modeling.
- Author
-
Xie, Mingjie, Lu, Xinyu, Ding, Feng, Cui, Wangnan, Zhang, Yuanyuan, and Feng, Wei
- Subjects
MATRIX decomposition ,QUALITY control ,COVID-19 pandemic ,AIR quality ,SANDSTORMS ,GENETIC speciation ,CARBONACEOUS aerosols ,SAMPLE size (Statistics) - Abstract
Hourly PM 2.5 speciation data have been widely used as an input of positive matrix factorization (PMF) model to apportion PM 2.5 components to specific source-related factors. However, the influence of constant source profile presumption during the observation period is less investigated. In the current work, hourly concentrations of PM 2.5 water-soluble inorganic ions, bulk organic and elemental carbon, and elements were obtained at an urban site in Nanjing, China from 2017 to 2020. PMF analysis based on observation data during specific pollution (firework combustion, sandstorm, and winter haze) and emission-reduction (COVID-19 pandemic) periods was compared with that using the whole 4-year data set (PMF whole). Due to the lack of data variability, event-based PMF solutions did not separate secondary sulfate and nitrate. But they showed better performance in simulating average concentrations and temporal variations of input species, particularly for primary source markers, than the PMF whole solution. After removing event data, PMF modeling was conducted for individual months (PMF month) and the 4-year period (PMF 4-year), respectively. PMF month solutions reflected varied source profiles and contributions and reproduced monthly variations of input species better than the PMF 4-year solution, but failed to capture seasonal patterns of secondary salts. Additionally, four winter pollution days were selected for hour-by-hour PMF simulations, and three sample sizes (500, 1000, and 2000) were tested using a moving window method. The results showed that using short-term observation data performed better in reflecting immediate changes in primary sources, which will benefit future air quality control when primary PM emissions begin to increase. [Display omitted] • PMF analysis using short-term speciation data can capture spikes of source markers. • Long-term modeling is useful for evaluating seasonal patterns of secondary sources. • Continuous PMF source apportionment is proposed based on hourly measurement data. • Short-term PMF analysis can reflect immediate changes in primary sources. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
43. Impact of Gas/Particle Partitioning of Semivolatile Organic Compounds on Source Apportionment with Positive Matrix Factorization.
- Author
-
Xie, Mingjie, Hannigan, Michael P., and Barsanti, Kelley C.
- Subjects
- *
SEMIVOLATILE organic compounds , *GASES , *FACTORIZATION , *STATISTICAL bootstrapping , *CARBONACEOUS aerosols , *QUARTZ fibers , *GAS chromatography/Mass spectrometry (GC-MS) - Abstract
To quantify and minimize the influence of gas/particle (G/P) partitioning on receptor-based source apportionment using particle-phase semivolatile organic compound (SVOC) data, positive matrix factorization (PMF) coupled with a bootstrap technique was applied to three data sets mainly composed of "measured-total" (measured ? particle- + gas-phase), "particle-only" (measured particle-phase) and "predicted-total" J (measured particle-phase + predicted gas-phase) SVOC5 to apportion carbonaceous J aerosols. Particle-(PM25) and gas-phase SVOC5 were collected using quartz fiber filters followed by PUF/XAD-4/PUF adsorbents and measured using gas chromatography-mass spectrometry (GC-MS). Concentrations of gas-phase SVOC5 were also predicted " from their particle-phase concentrations using absorptive partitioning theory. Five factors were resolved for each data set, and the factor profiles were generally consistent across the three PMF solutions. Using a previous source apportionment study at the same receptor site, those five factors were linked to summertime biogenic emissions (odd n-alkane factor), unbumed fossil fuels (light SVOC factor), road dust and/or cooking (n-alkane factor), motor vehicle emissions (PAH factor), and lubricating oil combustion (sterane factor). The "measured-total" solution was least influenced by G/P partitioning and used as reference. Two out of the five factors (odd n-alkane and PAH factors) exhibited consistent contributions for "particle-only" vs "measured-total" and " "predicted-total" vs "measured-total" solutions. Factor contributions of light SVOC and n-alkane factors were more consistent for "predicted-total" vs "measured-total" than "particle-only" vs "measured-total" solutions. The remaining factor (sterane factor) underestimated the contribution by around 50% from both "particle-only" and "predicted-total" solutions. The results of this study confirm that when measured gas-phase SVOCs are not available, "predicted-total" SVOCs should be used to decrease the influence of G/P partitioning on receptorbased source apportionment. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
44. Positive matrix factorization of a 32-month series of daily PM2.5 speciation data with incorporation of temperature stratification
- Author
-
Xie, Mingjie, Piedrahita, Ricardo, Dutton, Steven J., Milford, Jana B., Hemann, Joshua G., Peel, Jennifer L., Miller, Shelly L., Kim, Sun-Young, Vedal, Sverre, Sheppard, Lianne, and Hannigan, Michael P.
- Subjects
- *
DATA analysis , *POLYCYCLIC aromatic hydrocarbons , *BIOMARKERS , *TEMPERATURE effect , *STATISTICAL correlation , *HYDROCARBONS , *ALKANOIC acids , *ALKANES - Abstract
Abstract: This study presents source apportionment results for PM2.5 from applying positive matrix factorization (PMF) to a 32-month series of daily PM2.5 compositional data from Denver, CO, including concentrations of sulfate, nitrate, bulk elemental carbon (EC) and organic carbon (OC), and 51 organic molecular markers (OMMs). An optimum 8-factor solution was determined primarily based on the interpretability of the PMF results and rate of matching factors from bootstrapped PMF solutions with those from the base case solution. These eight factors were identified as inorganic ion, n-alkane, EC/sterane, light n-alkane/polycyclic aromatic hydrocarbon (PAH), medium alkane/alkanoic acid, PAH, winter/methoxyphenol and summer/odd n-alkane. The inorganic ion factor dominated the reconstructed PM2.5 mass (sulfate + nitrate + EC + OC) in cold periods (daily average temperature <10 °C; 43.7% of reconstructed PM2.5 mass) whereas the summer/odd n-alkane factor dominated in hot periods (>20 °C; 53.1%). The two factors had comparable relative contributions of 26.5% and 27.1% in warm periods with temperatures between 10 °C and 20 °C. Each of the seven factors resolved in a previous study (Dutton et al., 2010b) using a 1-year data set from the same location matches one factor from the current work based on comparing factor profiles. Six out of the seven matched pairs of factors are linked to similar source classes as suggested by the strong correlations between factor contributions (r = 0.89–0.98). Temperature-stratified source apportionment was conducted for three subsets of the data in the current study, corresponding to the cold, warm and hot periods mentioned above. The cold period (7-factor) solution exhibited a similar distribution of reconstructed PM2.5 mass as the full data set solution. The factor contributions of the warm period (7-factor) solution were well correlated with those from the full data set solution (r = 0.76–0.99). However, the reconstructed PM2.5 mass was distributed more to inorganic ion, n-alkane and medium alkane/alkanoic acid factors in the warm period solution than in the full data set solution. For the hot period (6-factor) solution, PM2.5 mass distribution was quite different from that of the full data set solution, as illustrated by regression slopes as low as 0.2 and as high as 4.8 of each matched pair of factors across the two solutions. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
45. Intra-urban spatial variability of PM2.5-bound carbonaceous components
- Author
-
Xie, Mingjie, Coons, Teresa L., Dutton, Steven J., Milford, Jana B., Miller, Shelly L., Peel, Jennifer L., Vedal, Sverre, and Hannigan, Michael P.
- Subjects
- *
SPATIAL variation , *ATMOSPHERIC carbon dioxide , *PUBLIC health , *ATMOSPHERIC aerosols , *ENVIRONMENTAL monitoring , *INTERSTATE Highway System , *UNIFORMITY - Abstract
Abstract: The Denver Aerosol Sources and Health (DASH) study was designed to evaluate associations between PM2.5 species and sources and adverse human health effects. The DASH study generated a five-year (2003–2007) time series of daily speciated PM2.5 concentration measurements from a single, special-purpose monitoring site in Denver, CO. To evaluate the ability of this site to adequately represent the short term temporal variability of PM2.5 concentrations in the five county Denver metropolitan area, a one year supplemental set of PM2.5 samples was collected every sixth day at the original DASH monitoring site and concurrently at three additional sites. Two of the four sites, including the original DASH site, were located in residential areas at least 1.9 km from interstate highways. The other two sites were located within 0.3 km of interstate highways. Concentrations of elemental carbon (EC), organic carbon (OC), and 58 organic molecular markers were measured at each site. To assess spatial variability, site pairs were compared using the Pearson correlation coefficient (r) and coefficient of divergence (COD), a statistic that provides information on the degree of uniformity between monitoring sites. Bi-weekly co-located samples collected from July 2004 to September 2005 were also analyzed and used to estimate the uncertainty associated with sampling and analytical measurement for each species. In general, the two near-highway sites exhibited higher concentrations of EC, OC, polycyclic aromatic hydrocarbons (PAHs), and steranes than did the more residential sites. Lower spatial heterogeneity based on r and COD was inferred for all carbonaceous species after considering their divergence and lack of perfect correlations in co-located samples. Ratio–ratio plots combined with available gasoline- and diesel-powered motor vehicle emissions profiles for the region suggested a greater impact to high molecular weight (HMW) PAHs from diesel-powered vehicles at the near-highway sites and a more uniformly distributed impact to ambient hopanes from gasoline-powered motor vehicles at all four sites. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
46. Intra-urban spatial variability and uncertainty assessment of PM2.5 sources based on carbonaceous species
- Author
-
Xie, Mingjie, Coons, Teresa L., Hemann, Joshua G., Dutton, Steven J., Milford, Jana B., Peel, Jennifer L., Miller, Shelly L., Kim, Sun-Young, Vedal, Sverre, Sheppard, Lianne, and Hannigan, Michael P.
- Subjects
- *
ATMOSPHERIC carbon dioxide , *SPATIAL variation , *UNCERTAINTY , *BIOMARKERS , *LUBRICATING oils , *SOLUTION (Chemistry) , *EMISSIONS (Air pollution) - Abstract
Abstract: To identify the sources of PM2.5 – bound carbonaceous species and examine the spatial variability of source contributions in the Denver metropolitan area, positive matrix factorization (PMF) was applied to one year of every sixth day ambient PM2.5 compositional data, including elemental carbon (EC), organic carbon (OC), and 32 organic molecular markers, from four sites (two residential and two near-traffic). Statistics (median, inner quantiles and 5th – 95th percentiles range) of factor contributions, expressed as reconstructed carbonaceous mass (EC + OC), were estimated from PMF solutions of replicate datasets generated by using a stationary block bootstrap technique. A seven-factor solution was resolved for a set of data pooled across the four sites, as it gave the most interpretable results and had the highest rate of neural network factor matching (76.9%). Identified factors were primarily associated with high plant wax, summertime emission, diesel vehicle emission, fossil fuel combustion, motor vehicle emission, lubricating oil combustion and wood burning. Pearson correlation coefficients (r) and coefficients of divergence (COD) were used to assess spatial variability of factor contributions. The summertime emission factor exhibited the highest spatial correlation (r = 0.74 – 0.88) and lowest CODs (0.32 – 0.38) among all resolved factors; while the three traffic dominated factors (diesel vehicle emission, motor vehicle emission and lubricating oil combustion) showed lower correlations (r = 0.47 – 0.55) and higher CODs (0.41 – 0.53) on average. Average total EC and OC mass were apportioned to each factor and showed a similar distribution across the four sites. Modeling uncertainties were defined as the 5th – 95th percentile range of the factor contributions derived from valid bootstrap PMF solutions, and were highly correlated with the median factor contribution in each factor (r = 0.77 – 0.98). Source apportionment was also performed on site specific datasets; the results exhibited similar factor profiles and temporal variation in factor contribution as those obtained for the pooled dataset, indicating that the four sites are primarily influenced by similar types of sources. On the other hand, differences were observed in absolute factor contributions between PMF solutions for the pooled versus site-specific datasets, likely due to the large uncertainties in EC and OC factor profiles derived from the site specific datasets with limited numbers of observations. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
47. Selected water-soluble organic compounds found in size-resolved aerosols collected from urban, mountain and marine atmospheres over East Asia.
- Author
-
WANG, GEHUI, KAWAMURA, KIMITAKA, XIE, MINGJIE, HU, SHUYUAN, LI, JIANJUN, ZHOU, BIANHONG, CAO, JUNJI, and AN, ZHISHENG
- Subjects
ORGANIC compounds ,AEROSOLS ,CARBOXYLIC acids ,SUCCINIC acid ,PHTHALIC acid ,MARINE ecology - Abstract
BSTRACT Primary (i.e. sugars and sugar-alcohols) and secondary (i.e. carboxylic acids) water-soluble organic compounds (WSOCs) in size-segregated aerosols from the urban and mountain atmosphere of China and from the marine atmosphere in the outflow region of East Asia were characterized on a molecular level. Levoglucosan is the most abundant compound among the quantified WSOCs in the urban and mountain atmosphere, whose concentration at the urban site was 1-2 orders of magnitude higher than that at the mountain and marine sites. In contrast, malic, succinic and phthalic acids were dominant among the measured WSOCs at the marine site. In the urban air, sugars except levoglucosan gave a bimodal size distribution with a large peak in fine range (<2.1 μm) and a small peak in coarse range (≥2.1 μm) during winter, being opposite to those in spring. In contrast, these WSOCs at the mountain and marine sites dominated in the coarse range but diminished and even disappeared in the fine range. Geometric mean diameters (GMDs) of the measured WSOCs in the fine mode at the urban site were larger in winter than in spring. Levoglucosan and carboxylic acids except for azelaic and benzoic acids showed a larger GMD in the coarse mode at the marine site probably due to an increased hygroscopic growth. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
48. Polar organic and inorganic markers in PM10 aerosols from an inland city of China — Seasonal trends and sources
- Author
-
Xie, Mingjie, Wang, Gehui, Hu, Shuyuan, Gao, Shixiang, Han, Qingyou, Xu, Yajuan, and Feng, Jianfang
- Subjects
- *
AEROSOLS , *BIOMARKERS , *ORGANIC compounds , *BIOMASS burning , *PARTICULATE matter , *ALKANOIC acids , *SUGARS , *AIR pollution - Abstract
Abstract: Polar organic compounds and elements were quantified in PM10 aerosols collected in urban and rural areas of Baoji, an inland city of China, during winter and spring 2008. Concentrations of biomass burning markers and high molecular weight n-alkanoic acids (HMW, >C22:0) were heavily increased in winter. In contrast, sugars presented in higher levels in the spring, among which sucrose was the most abundant with an average of 219ngm−3 in winter and 473ngm−3 in spring respectively. This suggests enhanced biotic activity in the warm season, whereas no obvious trend was observed for sugar alcohols, concentrations of the three sugar alcohols in spring were only 0.94–2.3 times as those in winter, indicating a second pathway of their formation other than fungal spores in cold season. Major crustal elements (i.e., Fe, K, Mn and Ti) in PM10 aerosols were also observed in larger concentrations in spring samples than those in winter due to an enhancement of coarse particles from soil minerals. By using principal component analysis (PCA) and positive matrix factorization (PMF), sources and their contributions to the PM components were also investigated in this study. Four factors were extracted with both models, and the sources represented by different factors were based on the highest loaded marker species as follows: factor 1, soil and road dust (Fe, Sr and Ti); factor 2, biomass burning (levoglucosan, galactosan and syringic acid); factor 3, microbial emissions (fructose and sucrose); and factor 4, fossil fuel combustion and fungal spores influence (Pb, Zn, arabitol and mannitol). The high correlation between PM10 and factor 1 suggested that PM10 pollution in Baoji was dominated by soil and dust re-suspension. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
- View/download PDF
49. Water-soluble organic compounds in PM2.5 and size-segregated aerosols over Mount Tai in North China Plain.
- Author
-
Wang, Gehui, Kawamura, Kimitaka, Umemoto, Nobuhiko, Xie, Mingjie, Hu, Shuyuan, and Wang, Zifa
- Published
- 2009
- Full Text
- View/download PDF
50. Recommendations for HCHO and SO 2 Retrieval Settings from MAX-DOAS Observations under Different Meteorological Conditions.
- Author
-
Javed, Zeeshan, Tanvir, Aimon, Bilal, Muhammad, Su, Wenjing, Xia, Congzi, Rehman, Abdul, Zhang, Yuanyuan, Sandhu, Osama, Xing, Chengzhi, Ji, Xiangguang, Xie, Mingjie, Liu, Cheng, and Wang, Yuhang
- Subjects
TRACE gases ,ROOT-mean-squares ,OPTICAL spectroscopy ,LIGHT absorption - Abstract
Recently, the occurrence of fog and haze over China has increased. The retrieval of trace gases from the multi-axis differential optical absorption spectroscopy (MAX-DOAS) is challenging under these conditions. In this study, various reported retrieval settings for formaldehyde (HCHO) and sulfur dioxide (SO
2 ) are compared to evaluate the performance of these settings under different meteorological conditions (clear day, haze, and fog). The dataset from 1st December 2019 to 31st March 2020 over Nanjing, China, is used in this study. The results indicated that for HCHO, the optimal settings were in the 324.5–359 nm wavelength window with a polynomial order of five. At these settings, the fitting and root mean squared (RMS) errors for column density were considerably improved for haze and fog conditions, and the differential slant column densities (DSCDs) showed more accurate values compared to the DSCDs between 336.5 and 359 nm. For SO2 , the optimal settings for retrieval were found to be at 307–328 nm with a polynomial order of five. Here, root mean square (RMS) and fitting errors were significantly lower under all conditions. The observed HCHO and SO2 vertical column densities were significantly lower on fog days compared to clear days, reflecting a decreased chemical production of HCHO and aqueous phase oxidation of SO2 in fog droplets. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.