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429 results on '"Wu, Y.-L."'

6. Osimertinib versus platinum–pemetrexed for patients with EGFR T790M advanced NSCLC and progression on a prior EGFR-tyrosine kinase inhibitor: AURA3 overall survival analysis

Author

Papadimitrakopoulou, V.A., Mok, T.S., Han, J.-Y., Ahn, M.-J., Delmonte, A., Ramalingam, S.S., Kim, S.W., Shepherd, F.A., Laskin, J., He, Y., Akamatsu, H., Theelen, W.S.M.E., Su, W.-C., John, T., Sebastian, M., Mann, H., Miranda, M., Laus, G., Rukazenkov, Y., and Wu, Y.-L.

Published
2020
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11. EFFICIENT UAV FLIGHT PLANNING FOR LOD2 CITY MODEL IMPROVEMENT.

Author

Wu, Y.-L., Alsadik, B., Oude Elberink, S., and Vosselman, G.

Subjects
FLIGHT planning (Aeronautics), URBAN renewal, URBAN planning, BUILDING repair, POINT cloud
Abstract

Geometric errors in LoD2 building models can be caused by the modeling algorithm but are often related to the quality of input data. One approach to tackling the modeling errors caused by the quality of input data is to collect additional data with a UAV and remodel the buildings. However, no flight planning approach exists specifically designed for efficient data recollection for model improvement. In this paper, we propose an innovative flight planning approach for this purpose. Contrary to the conventional method that recollects the data covering the entire building roof, our approach only collects the data over the erroneous region and uses it to improve the erroneous model part later. Our algorithm utilizes the existing LiDAR survey data to automatically detect model errors and design the camera networks by considering the roof geometry. We optimize the trajectory that connects the viewpoints with a genetic algorithm and develops an obstacle avoidance function with ray-casting to ensure a collision-free path. The proposed flight plan is implemented in a real-world scene. Our result shows an improved point cloud created through dense image matching with the collected UAV image data. The generated point cloud is successfully used for creating partial building models for improving the original models. [ABSTRACT FROM AUTHOR]

Published
2023
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15. PHGDH promotes the proliferation and differentiation of primary chicken myoblasts.

Author

Chen, L., Wu, Y. L., Ding, H., Xie, K. Z., Zhang, T., Zhang, G. X., and Wang, J. Y.

Subjects
*MYOBLASTS, *CHICKENS, *MUSCLE growth, *GENE expression, *PROTEIN expression, *WESTERN immunoblotting
Abstract

1. Chicken primary myoblasts (CPMs) are precursors that form muscle fibres. The proliferation and differentiation of CPMs is an essential stage in muscle development. Previous RNA-seq analysis showed that phosphoglycerate dehydrogenase (PHGDH) is a differentially expressed gene in chicken muscle tissue at different growth stages. Therefore, the following study explored the effect of PHGDH on the proliferation and differentiation of CPMs. 2. The effect on the proliferation of CPMs by RT–qPCR, CCK-8, and EdU assays after the overexpression and knockdown of PHGDH was evaluated. RT–qPCR, western blotting, and indirect immunofluorescence were used to detect the effect of PHGDH on the differentiation of the CPMs. The expression was observed at different time points for differentiation induced by the CPMs. 3. The results showed that PHGDH significantly promoted proliferation and differentiation in CPMs. The results showed that overexpression of PHGDH significantly upregulated CPM proliferation, while knockdown had the opposite effect. Marker genes showed that overexpression of PHGDH significantly upregulated the expression of P21, MYOG and MYOD genes, significantly downregulated the expression of the MSTN gene and promoted the expression of the MYHC protein. In contrast, PHGDH knockdown had the opposite effect. 4. Desmin immunofluorescence analysis of myotube differentiation in primary myoblasts showed that overexpression of PHGDH significantly increased the area of myotube differentiation and promoted the proliferation and differentiation of myoblasts. Knockdown of PHGDH had the opposite effect. 5. In summary, PHGDH was shown to play a positive role in regulating myoblast proliferation and differentiation. This provides a theoretical basis for further analysis of the regulatory mechanism of the PHGDH gene in chicken muscle development and for improving poultry production. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Quality of life (QoL) analyses from OPTIMAL (CTONG-0802), a phase III, randomised, open-label study of first-line erlotinib versus chemotherapy in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC)

Author

Chen, G., Feng, J., Zhou, C., Wu, Y.-L., Liu, X.-Q., Wang, C., Zhang, S., Wang, J., Zhou, S., Ren, S., Lu, S., Zhang, L., Hu, C.-P., Hu, C., Luo, Y., Chen, L., Ye, M., Huang, J., Zhi, X., Zhang, Y., Xiu, Q., Ma, J., Zhang, L., and You, C.

Published
2013
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43. On-site in situ high-pressure ultrafast pump–probe spectroscopy instrument.

Author

Wu, Y. L., Yin, X., Hasaien, J. Z. L., Tian, Z. Y., Ding, Yang, and Zhao, Jimin

Subjects
*OPTICAL instruments, *DIAMOND anvil cell, *SPECTROMETRY, *QUANTUM states, *EXCITED states
Abstract

We conceive and construct an on-site in situ high-pressure time-resolved ultrafast optical spectroscopy instrument that facilitates ultrafast pump–probe dynamics measurements under high pressure conditions. We integrate an ultrafast pump–probe spectroscopy system with a diamond anvil cell (DAC) system. Significantly, both the DAC and the sample are fixed within the light path without motion and rotation throughout the whole ultrafast spectroscopy experiment, including tuning and calibrating the pressure. This instrument thus avoids introducing artifacts due to sample motion or rotation, enabling precision high-pressure ultrafast pump–probe dynamics investigations. As a demonstrating example, we compare the effect of on-site in situ conditions with off-site in situ conditions on the ultrafast dynamics of Sr2IrO4 under 0–44.5 GPa high pressure. Our data and analysis show that conventional possible artifacts are greatly reduced by using the on-site in situ layout. Our work helps the high-pressure ultrafast science investigation develop into a promising new area, which enables the exploration of nonequilibrium excited quantum states in the high-pressure regime. [ABSTRACT FROM AUTHOR]

Published
2021
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48. LBA1 Efficacy and safety of adjuvant alectinib vs platinum-based chemotherapy (CT) in patients (pts) from Asia with resected, early-stage ALK+ non-small cell lung cancer (NSCLC): A sub analysis of ALINA.

Author

Ahn, J.S., Wu, Y-L., Dziadziuszko, R., Barlesi, F., Nishio, M., Lee, D.H., Lee, J-S., Zhong, W-Z., Horinouchi, H., Mao, W., Lu, S., Wang, Q., Yang, C-T., Korphaisarn, K., Xu, T., Bu, L., Scalori, A., Petric, P., Redhead, K., and Solomon, B.

Subjects
*NON-small-cell lung carcinoma, *CANCER chemotherapy
Published
2023
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