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It has been controversial whether the matching of learning styles with teaching environment has improved the teaching effects. This paper constructs matching modes by choosing Sternberg's three learning styles (liberal leaning, internal scope and global level) and adopts curriculum comprehensiveness and instructing modes. The research, based on data of off-line teaching collected from 456 college students in China, finds that: (1) direct effect: three learning styles have significant effects on eight dimensions of learners' cognitive information processing (CIP); (2) matching effect: the alignment of learners' liberal leaning and instructing modes has a direct impact on the eight dimensions of learners' CIP; the alignment of learners' global level and curriculum characteristics has a direct impact on the 7 dimensions; the alignment of learners' internal scope and instructing modes have no significant direct impact on the 7 dimensions; and (3) moderating effect of the mandatory use of IT (MUIT): MUIT may restrain or strengthen effects of some matching modes on some dimensions of CIP. The key conclusion is that whether personalized instructing based on learners' characteristics can improve teaching results requires the selection of appropriate matching modes. Not all matching modes have matching effects, and matching effect is influenced by MUIT.

ObjectiveTo explore the effect of emotional catharsis on the mental health status， coping style and satisfaction with the intervention among adolescents in Nanchong in the post-pandemic period.MethodsCompletely random sampling method was used to recruit 390 adolescents from 2 general secondary schools， 2 county secondary schools and 2 universities in Nanchong from January 2021 to April 2022. The subjects were divided into study group （n=195） and control group （n=195） by random number table method. The study group received emotional catharsis intervention. The control group received self-regulation and relaxation without any other intervention. Interventions for both groups lasted for 3 months. Before and after the intervention， the mental health status and coping style of the adolescents were assessed using the Symptom Checklist 90 （SCL-90） and the Simplified Coping Style Questionnaire （SCSQ）. Also， the participants rated the satisfaction with the intervention via self-made satisfaction questionnaire after the intervention.ResultsAfter intervention， the total SCL-90 score of study group was lower than that of control group （t=68.312， P

North China has specific regional advantages in the overall economic and social development of China, and water resources are the most prominent factor that affects the sustainable development of this region. This study focuses on the land spatial layout of water-and-land adapted planting in North China. Based on the analysis of agricultural planting structure and water and land resource layout in the current year (2018) of North China, and considering varied population, climate, and socio-economic scenarios and water resource constraints, the study proposes a scheme for optimizing the agricultural planting layout in North China that adapts to local water and land resource conditions. We suggest that the burden on production and supply of commercial grain and other commercial agricultural products in North China should be appropriately reduced. In terms of improving the regional water resource carrying capacity, Hebei Province should alleviate its water shortage through water transfer. Shanxi Province should improve the agricultural water use efficiency through agricultural mechanization and modernization. Shandong Province and Henan Province can moderately fallow the land and improve forest and grass coverage. It is also recommended to optimize the spatial layout of agricultural planting and adjust the planting structure to adapt to water. In shallow groundwater overexploitation areas as well as Tianjin City and the southeast of Hebei Plain where deep groundwater overexploitation is severe, semi-arid land planting systems and structures that adapt to precipitation should be developed, and the specific recuperation period should be determined according to the rate of groundwater recharge.

We collected 599 policies related to medical treatment combination issued by local governments from October 2010 to December 2022 to study the differences and characteristics of medical treatment combination policies in different regions of China. Descriptive statistics and the structural topic model were used to compare medical treatment combination policies in four major economic regions (West, Central, East, Northeast) of China from three dimensions: the number of policies issued, policy types and policy topics. The study shows that: the structure of Chinese local medical treatment combination policy system was not balanced and was characterized by an emphasis on implementation rules rather than standard specifications; the construction of hierarchical diagnosis and treatment service system and the management model of medical treatment combination are hot topics, while the topics such as supporting measures and disease prevention and treatment have not received widespread attention. The construction of medical treatment combination in each region shows diversified exploration. The local government needs to issue relevant policies according to the regional differences, so as to supplement the shortcomings of the policy and promote the improvement of the policy system of the regional medical treatment combination. [ABSTRACT FROM AUTHOR]

Remote sensing technology is widely used to obtain evapotranspiration (ETa), but whether it can distinguish the differences in farmland energy balance components and ETa under different irrigation methods has not been studied. We used Landsat 8 data as the primary dataset to drive the METRIC model and inverted the surface parameters and ETa of the Shiyang River Basin from 2014 to 2018. After improving the METRIC model using Ta obtained by the regression method instead of interpolation to calculate the net radiation flux (Rn), R2 was improved from 0.45 to 0.53, and the RMSE was reduced from 61 W/m2 to 51 W/m2. The ETa estimation results on satellite overpass days performed well, with R2 equal to 0.93 and RMSE equal to 0.48 mm when compared with the Eddy covariance method (EC) observations. Subsequently, the different growth stages and daily average ETa estimates of maize were compared with three observations (water balance, WB; Bowen ratio and energy balance method, BREB; and EC). The daily estimates of ETa correlate well with the observations of BREB (R2BI = 0.82, R2DI = 0.92; RMSEBI = 0.46 mm/day, RMSEDI = 0.32 mm/day) and EC (R2BI = 0.85, R2DI = 0.92; RMSEBI = 0.45 mm/day, RMSEDI = 0.34 mm/day), and the estimation for drip irrigation was found to be better than for border irrigation. The total accuracy of the ETa estimation on the five-year overpass day of maize farmland reached R2 = 0.93 and RMSE = 0.48 mm. With sufficient remote sensing data, the 4-year average ETa of maize was 31 mm lower for DI than for BI, and the mean value of ETa obtained from the three observation methods was 40 mm. The METRIC model can be used to distinguish ETa differences between the two irrigation methods in maize farmlands. [ABSTRACT FROM AUTHOR]

It has been controversial whether the matching of learning styles with teaching environment has improved the teaching effects. This paper constructs matching modes by choosing Sternberg's three learning styles (liberal leaning, internal scope and global level) and adopts curriculum comprehensiveness and instructing modes. The research, based on data of off-line teaching collected from 456 college students in China, finds that (a) direct effect: three learning styles have significant effects on eight dimensions of learners' cognitive information processing (CIP); (b) matching effect: the alignment of learners' liberal leaning and instructing modes has a direct impact on the eight dimensions of learners' CIP; the alignment of learners' global level and curriculum characteristics has a direct impact on the 7 dimensions; the alignment of learners' internal scope and instructing modes have no significant direct impact on the 7 dimensions; (c) moderating effect of the mandatory use of IT (MUIT): MUIT may restrain or strengthen effects of some matching modes on some dimensions of CIP. The key conclusion is that whether personalized instructing based on learners' characteristics can improve teaching results requires the selection of appropriate matching modes. Not all matching modes have matching effects, and matching effect is influenced by MUIT. [ABSTRACT FROM AUTHOR]

This study aims to explore the difference between on-line and off-line teaching and comprehensively evaluate the of elearning system operation effect as both technology-mediated learning and an open information system. This study develops “process-situation-result” (PSR) network, a comprehensive learning system evaluation model. It empirically analyzes the PSR models under off-line and on-line teaching, as well as the intermediary role of e-learning situation in the impact of e-learning process on elearning results. The results show: (1) Learners' perception of e-learning situation is obviously different between off-line and on-line teaching. (2) The eight dimensions of e-learning process have no significant direct impact on e-learning outcome Except in on-line teaching groups, SF (getting self-feedback) has a significantly positive influence. In off-line teaching, GA (gaining attention), IO (informing learner of the objectives), and PG (providing learning guidance) have indirect effects on e-learning. (3) GA, IO and PG have a direct impact on e-learning situation in both on-line and off-line teaching, and only RK (Stimulating recall of prior knowledge) has an impact only in on-line teaching. The other four dimensions have no direct impact on e-learning We provide a theoretical framework for the integration of technology and teaching, on-line teaching and off-line teaching. [ABSTRACT FROM AUTHOR]

Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with abnormal intracellular [Ca.sup.2+] handling. Diastolic [Ca.sup.2+] release from the sarcoplasmic reticulum via "leaky" ryanodine receptors (RyR2s) is hypothesized to contribute to arrhythmogenesis in AF, but the molecular mechanisms are incompletely understood. Here, we have shown that mice with a genetic gain-of-function defect in Ryr2 (which we termed [Ryr2.sup.R176Q/+] mice) did not exhibit spontaneous AF but that rapid atrial pacing unmasked an increased vulnerability to AF in these mice compared with wild-type mice. Rapid atrial pacing resulted in increased [Ca.sup.2+]/calmodulin-dependent protein kinase II (CaMKII) phosphorylation of RyR2, while both pharmacologic and genetic inhibition of CaMKII prevented AF inducibility in [Ryr2.sup.R176Q/+] mice. This result suggests that AF requires both an arrhythmogenic substrate (e.g., RyR2 mutation) and enhanced CaMKII activity. Increased CaMKII phosphorylation of RyR2 was observed in atrial biopsies from mice with atrial enlargement and spontaneous AF, goats with lone AF, and patients with chronic AF. Genetic inhibition of CaMKII phosphorylation of RyR2 in [Ryr2.sup.S2814A] knockin mice reduced AF inducibility in a vagotonic AF model. Together, these findings suggest that increased RyR2-dependent [Ca.sup.2+] leakage due to enhanced CaMKII activity is an important downstream effect of CaMKII in individuals susceptible to AF induction., Introduction Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a significant contributor to cardiovascular morbidity and possibly mortality. Emerging evidence suggests an important role for abnormal [...]

[Ca.sup.2+] overload and reactive oxygen species can injure mitochondria during ischemia and reperfusion. We hypothesized that mitochondrial injury occurs during cardiac resuscitation, causing release of cytochrome c to the cytosol and bloodstream while activating apoptotic pathways. Plasma cytochrome c was measured using reverse-phase HPLC and Western immunoblotting in rats subjected to 4 or 8 min of untreated ventricular fibrillation and 8 min of closed-chest resuscitation followed by 240 min of postresuscitation hemodynamic observation. A sham group served as control. Plasma cytochrome c rose progressively to levels 10-fold higher than in sham rats 240 min after resuscitation (P < 0.01), despite reversal of whole body ischemia (decreases in arterial lactate). Cytochrome c levels were inversely correlated with left ventricular stroke work (r = -0.40, P = 0.02). Western immunoblotting of left ventricular tissue demonstrated increased levels of 17-kDa cleaved caspase-3 fragments in the cytosol. Plasma cytochrome c was then serially measured in 12 resuscitated rats until the rat died or cytochrome c returned to baseline. In three survivors, cytochrome c rose slightly to [less than or equal to] 2 [micro]g/ml and returned to baseline within 96 h. In nine nonsurvivors, cytochrome c rose progressively to significantly higher maximal levels [4.6 (SD 2.0) vs. 1.6 (SD 0.3) [micro]g/ml, P = 0.029] and at faster rates [0.7 (SD 0.5) vs. 0.1 (SD 0.1) [micro]g * [ml.sup.-1] * [h.sup.-1], P = 0.046] than in survivors. Plasma cytochrome c may represent a novel in vivo marker of mitochondrial injury after resuscitation from cardiac arrest that relates inversely with survival outcome. apoptosis; biological markers; cardiopulmonary resuscitation; myocardial ischemia; ventricular fibrillation

The non-invasive identification of novel renal fibrosis biomarkers needs to be further studied. We collected urine samples from 77 biopsy-proven CKD patients and 15 healthy controls. The expression of urinary TREM-1 and TREM-2 was measured and the correlation with renal function parameter and pathological indicators was performed. The receiver operating characteristic (ROC) curve for the diagnosis of renal fibrosis was calculated. The protein expression of TREM-1 and TREM-2 in kidney tissues was measured. The TREM-1/TREM-2 ratio was decreased in CKD patients and correlated with serum creatinine, estimated glomerular filtration rate and cystatin c. Further, the TREM-1/TREM-2 ratio was significantly decreased in moderate-severe fibrosis patients compared with none-mild renal fibrosis. TREM-1/TREM-2 ratio was correlated with the score of tubulointerstitial fibrosis (TIF) and the score of glomerular sclerosis. The ROC curve showed that the urinary TREM-1/TREM-2 ratio can diagnosemoderate-severe renal fibrosis at a cut-off value of 1.338 with a sensitivity of 86.4% and specificity of 81.8%. In human moderate-severe fibrosis kidney tissue, the protein expression of TREM-1 was lower and the TREM-2 was higher than none-mild fibrosis kidney tissue. Urinary TREM-1/TREM-2 ratio was a potential biomarker for the diagnosis of renal fibrosis in CKD patients. [ABSTRACT FROM AUTHOR]