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3. Impaired Sleep Quality in COPD Is Associated With Exacerbations The CanCOLD Cohort Study

Author

Shorofsky, Matthew, Bourbeau, Jean, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Tan, Wan C, Aaron, Shawn D, Sin, Don D, Road, Jeremy, Chapman, Kenneth R, O’Donnell, Denis E, Maltais, François, Hernandez, Paul, Walker, Brandie L, Marciniuk, Darcy, Kaminska, Marta, FitzGerald, J Mark, Sin, DD, Marciniuk, DD, O'Donnell, DE, Cowie, Robert, Aaron, Shawn, Maltais, F, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C, Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, and Clemens, Ron

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Sleep Research, Lung, Behavioral and Social Science, Clinical Research, Chronic Obstructive Pulmonary Disease, Respiratory, Aged, Cohort Studies, Disease Progression, Dyspnea, Female, Health Services, Humans, Male, Middle Aged, Proportional Hazards Models, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Sleep, Sleep Wake Disorders, Sputum, Time Factors, acute exacerbation of chronic bronchitis, COPD, sleep medicine, Canadian Respiratory Research Network, CanCOLD Collaborative Research group, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundCOPD increases susceptibility to sleep disturbances, which may in turn predispose to increased respiratory symptoms. The objective of this study was to evaluate, in a population-based sample, the relationship between subjective sleep quality and risk of COPD exacerbations.MethodsData were obtained from the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. Participants with COPD who had completed 18 months of follow-up were included. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and a three-factor analysis. Symptom-based (dyspnea or sputum change ≥ 48 h) and event-based (symptoms plus medication or unscheduled health services use) exacerbations were assessed. Association of PSQI with exacerbation rate was assessed by using negative binomial regression. Exacerbation-free survival was also assessed.ResultsA total of 480 participants with COPD were studied, including 185 with one or more exacerbations during follow-up and 203 with poor baseline sleep quality (PSQI score > 5). Participants with subsequent symptom-based exacerbations had higher median baseline PSQI scores than those without (6.0 [interquartile range, 3.0-8.0] vs 5.0 [interquartile range, 2.0-7.0]; P = .01), and they were more likely to have baseline PSQI scores > 5 (50.3% vs 37.3%; P = .01). Higher PSQI scores were associated with increased symptom-based exacerbation risk (adjusted rate ratio, 1.09; 95% CI, 1.01-1.18; P = .02) and event-based exacerbation risk (adjusted rate ratio, 1.10; 95% CI, 1.00-1.21; P = .048). The association occurred mainly in those with undiagnosed COPD. Strongest associations were with Factor 3 (sleep disturbances and daytime dysfunction). Time to symptom-based exacerbation was shorter in participants with poor sleep quality (adjusted hazard ratio, 1.49; 95% CI, 1.09-2.03).ConclusionsHigher baseline PSQI scores were associated with increased risk of COPD exacerbation over 18 months' prospective follow-up.

Published
2019

5. Impaired Sleep Quality in COPD Is Associated With Exacerbations: The CanCOLD Cohort Study

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Ferguson, Nancy, Haynes, Nancy, Chuang, Junior, Li, Licong, Bayat, Selva, Wong, Amanda, Alavi, Zoe, Peng, Catherine, Zhao, Bin, Scott-Hsiung, Nathalie, Nadirshaw, Tasha, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Walker, Brandie, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Shorofsky, Matthew, Kimoff, John, Jen, Rachel, Malhotra, Atul, Ayas, Najib, Aaron, Shawn D., Sin, Don D., O’Donnell, Denis E., Maltais, François, Walker, Brandie L., and Kaminska, Marta

Published
2019
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7. EFFECTIVENESS OF BENRALIZUMAB AFTER 12 MONTHS OF TREATMENT IN CANADIANS WITH SEVERE ASTHMA

Author

PENZ, ERIKA D, primary, KAYANIYIL, SHEENA, additional, LANCASTER, BRETT, additional, LEE, JASON, additional, TOURIN, OLGA, additional, RAMESH, WARREN, additional, WALKER, BRANDIE L, additional, KHAN HAZARATOOLA, IRFAN I, additional, SUSSMAN, GORDON, additional, FRANCOEUR, BRUNO, additional, THAWER, AMIN, additional, FERA, THARWAT A, additional, BELAK, ZENON A, additional, SEBASTIAN, JUSTIN C, additional, DHAWAN, VIVEK, additional, and MBUAGBAW, LAWRENCE, additional

Published
2023
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8. Short-term air pollution exposure and exacerbation events in mild to moderate COPD: a case-crossover study within the CanCOLD cohort

Author

Ross, Bryan A, primary, Doiron, Dany, additional, Benedetti, Andrea, additional, Aaron, Shawn D, additional, Chapman, Kenneth, additional, Hernandez, Paul, additional, Maltais, François, additional, Marciniuk, Darcy, additional, O'Donnell, Denis E, additional, Sin, Don D, additional, Walker, Brandie L, additional, Tan, Wan, additional, and Bourbeau, Jean, additional

Published
2023
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9. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, D.D., Marciniuk, D.D., O'Donnell, D.E., Hernandez, Paul, Chapman, Kenneth R., Cowie, Robert, Aaron, Shawn, Maltais, F., Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Baglole, Carole, Jabet, Carole, Mancino, Palmina, Fortier, Yvan, Sin, Don, Tam, Sheena, Road, Jeremy, Comeau, Joe, Png, Adrian, Coxson, Harvey, Kirby, Miranda, Leipsic, Jonathon, Hague, Cameron, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Duquette, Jean-Francois, Benedetti, Andrea, Jensen, Denis, O'Donnell, Denis, Lo, Christine, Cheng, Sarah, Fung, Cindy, Haynes, Nancy, Chuang, Junior, Zheng, Liyun, Latreille, David, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Cowie, Ann, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, McNeil, Matthew, Whelan, Kate, Maltais, Francois, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Gupta, Nisha, Pinto, Lancelot, Li, Pei Zhi, Aaron, Shawn D., Marciniuk, Darcy D., Maltais, François, O'Donnell, Denis E., and Walker, Brandie L.

Published
2016
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12. Dyspnoea and symptom burden in mild–moderate COPD: the Canadian Cohort Obstructive Lung Disease Study

Author

Cherian, Mathew, primary, Jensen, Dennis, additional, Tan, Wan C., additional, Mursleen, Sara, additional, Goodall, Emma C., additional, Nadeau, Gilbert A., additional, Awan, Amnah M., additional, Marciniuk, Darcy D., additional, Walker, Brandie L., additional, Aaron, Shawn D., additional, O'Donnell, Denis E., additional, Chapman, Kenneth R., additional, Maltais, François, additional, Hernandez, Paul, additional, Sin, Don D., additional, Benedetti, Andrea, additional, and Bourbeau, Jean, additional

Published
2021
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16. The effects of marijuana smoking on lung function in older people

Author

Tan, Wan C., primary, Bourbeau, Jean, additional, Aaron, Shawn D., additional, Hogg, James C., additional, Maltais, François, additional, Hernandez, Paul, additional, Marciniuk, Darcy D., additional, Chapman, Kenneth R., additional, To, Teresa, additional, FitzGerald, J. Mark, additional, Walker, Brandie L., additional, Road, Jeremy, additional, Zheng, Liyun, additional, Zhou, Guohai, additional, Yau, Trevor, additional, Benedetti, Andrea, additional, O'Donnell, Denis, additional, and Sin, Don D., additional

Published
2019
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19. The COPD Assessment Test: Can It Discriminate Across COPD Subpopulations?

Author

Gupta, Nisha, Pinto, Lancelot, Benedetti, Andrea, Li, Pei Zhi, Tan, Wan C., Aaron, Shawn D., Chapman, Kenneth R., FitzGerald, J. Mark, Hernandez, Paul, Marciniuk, Darcy D., Maltais, François, O'Donnell, Denis E., Sin, Don, Walker, Brandie L., Bourbeau, Jean, O'Donnell, Denis E, and Canadian Respiratory Research Network and the CanCOLD Collaborative Research Group

Subjects
OBSTRUCTIVE lung diseases, QUESTIONNAIRES, COMORBIDITY, DISEASE exacerbation, CIGARETTE smokers, DISEASES, COMPARATIVE studies, FUNCTIONAL assessment, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, QUALITY of life, RESEARCH, RESEARCH evaluation, RISK assessment, EVALUATION research, TREATMENT effectiveness
Abstract

Background: The COPD Assessment Test (CAT) is a valid disease-specific questionnaire measuring health status. However, knowledge concerning its use regarding patient and disease characteristics remains limited. Our main objective was to assess the degree to which the CAT score varies and can discriminate between specific patient population groups.Methods: The Canadian Cohort Obstructive Lung Disease (CanCOLD) is a random-sampled, population-based, multicenter, prospective cohort that includes subjects with COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] classifications 1 to 3). The CAT questionnaire was administered at three visits (baseline, 1.5 years, and 3 years). The CAT total score was determined for sex, age groups, smoking status, GOLD classification, exacerbations, and comorbidities.Results: A total of 716 subjects with COPD were included in the analysis. The majority of subjects (72.5%) were not previously diagnosed with COPD. The mean FEV1/FVC ratio was 61.1 ± 8.1%, with a mean FEV1 % predicted of 82.3 ± 19.3%. The mean CAT scores were 5.8 ± 5.0, 9.6 ± 6.7, and 16.1 ± 10.0 for GOLD 1, 2, and 3+ classifications, respectively. Higher CAT scores were observed in women, current smokers, ever-smokers, and subjects with a previous diagnosis of COPD. The CAT was also able to distinguish between subjects who experience exacerbations vs those who had no exacerbation.Conclusions: These results suggest that the CAT, originally designed for use in clinically symptomatic patients with COPD, can also be used in individuals with mild airflow obstruction and newly diagnosed COPD. In addition, the CAT was able to discriminate between sexes and subjects who experience frequent and infrequent exacerbations.Trial Registry: ClinicalTrials.gov; No.: NCT00920348; Study ID No.: IRO-93326. [ABSTRACT FROM AUTHOR]

Published
2016
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20. Cigarette Smoke Modulates Expression of Human Rhinovirus-Induced Airway Epithelial Host Defense Genes

Author

Proud, David, primary, Hudy, Magdalena H., additional, Wiehler, Shahina, additional, Zaheer, Raza S., additional, Amin, Minaa A., additional, Pelikan, Jonathan B., additional, Tacon, Claire E., additional, Tonsaker, Tabitha O., additional, Walker, Brandie L., additional, Kooi, Cora, additional, Traves, Suzanne L., additional, and Leigh, Richard, additional

Published
2012
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22. Identification of a Novel Route of Iron Transcytosis across the Mammalian Blood-Brain Barrier.

Author

Muroo, Iku, Ujiie, Maki, Walker, Brandie L., Tiong, Jacqueline W.C., Vitalis, Timothy Z., Karkan, Delara, Gabathuler, Reinhard, Moise, Alexander R., and Jefferies, Wilfred A.

Subjects
BLOOD-brain barrier, TRANSFERRIN, IRON in the body, ALZHEIMER'S disease, NEUROPHYSIOLOGY, BRAIN
Abstract

OBJECTIVE:: This study was undertaken to assess the role of p97 (also known as melanotransferrin) in the transfer of iron into the brain, because the passage of most large molecules is limited by the presence of the blood-brain barrier, including that of the serum iron transporter transferrin. METHODS:: To study the function of the soluble form of p97, we followed the uptake of radioiodinated and 55Fe loaded p97 and transferrin by the brain during a 24-hour period. RESULTS:: We show that the soluble form of p97 has the ability to transcytose across the murine blood-brain barrier, and its transcytosis can be inhibited in a specific manner. We also provide evidence that p97 transports iron into the brain more efficiently than transferrin. CONCLUSIONS:: These data support the idea that p97 is an important iron transporter across the blood-brain barrier in normal physiology and possibly in neurodegenerative diseases, such as Alzheimer disease, in which iron homeostasis in the brain becomes disrupted.Microcirculation (2003) 10, 457-462. doi:10.1038/sj.mn.7800213 [ABSTRACT FROM AUTHOR]

Published
2003
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