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16 results on '"Vascular Medicine"'

1. Practical Recommendations for Optimal Thromboprophylaxis in Patients with COVID-19: A Consensus Statement Based on Available Clinical Trials

Author

Konstantinos G. Kyriakoulis, Evangelos Dimakakos, Ioannis G. Kyriakoulis, Mariella Catalano, Alex C. Spyropoulos, Sam Schulman, James Douketis, Anna Falanga, Anthony Maraveyas, Dan-Mircea Olinic, Jill Belch, Grigorios Gerotziafas, Konstantinos Syrigos, Anastasios Kollias, and COVID-19 Thrombosis Collaborative Group, Endorsed by VAS-European Independent Foundation in Angiology/Vascular Medicine, UEMS Division of Angiology/Vascular Medicine/and ESVM-European Society of Vascular Medicine and Supported by the Balkan Working Group

Subjects
anticoagulation, COVID-19, COVID-19 therapeutics, dosage, mortality, thromboprophylaxis, Medicine
Abstract

Coronavirus disease 2019 (COVID-19) has been shown to be strongly associated with increased risk for venous thromboembolism events (VTE) mainly in the inpatient but also in the outpatient setting. Pharmacologic thromboprophylaxis has been shown to offer significant benefits in terms of reducing not only VTE events but also mortality, especially in acutely ill patients with COVID-19. Although the main source of evidence is derived from observational studies with several limitations, thromboprophylaxis is currently recommended for all hospitalized patients with acceptable bleeding risk by all national and international guidelines. Recently, high quality data from randomized controlled trials (RCTs) further support the role of thromboprophylaxis and provide insights into the optimal thromboprophylaxis strategy. The aim of this statement is to systematically review all the available evidence derived from RCTs regarding thromboprophylaxis strategies in patients with COVID-19 in different settings (either inpatient or outpatient) and provide evidence-based guidance to practical questions in everyday clinical practice. Clinical questions accompanied by practical recommendations are provided based on data derived from 20 RCTs that were identified and included in the present study. Overall, the main conclusions are: (i) thromboprophylaxis should be administered in all hospitalized patients with COVID-19, (ii) an optimal dose of inpatient thromboprophylaxis is dependent upon the severity of COVID-19, (iii) thromboprophylaxis should be administered on an individualized basis in post-discharge patients with COVID-19 with high thrombotic risk, and (iv) thromboprophylaxis should not be routinely administered in outpatients. Changes regarding the dominant SARS-CoV-2 variants, the wide immunization status (increasing rates of vaccination and reinfections), and the availability of antiviral therapies and monoclonal antibodies might affect the characteristics of patients with COVID-19; thus, future studies will inform us about the thrombotic risk and the optimal therapeutic strategies for these patients.

Published
2022
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3. T-13-20: Adults with severe or moderately severe haemophilia B receiving etranacogene dezaparvovec in the HOPE-B phase 3 trial experience a stable increase in mean Factor IX activity levels and durable haemostatic protection after 24 months' follow-up.

Author

Pipe, S. W., Leebeek, F. W.G., Recht, M., Key4 University of of North Carolina, Chapel Hill, USA, N. S., Lattimore5 Oregon Health & Science University, Portland, USA, S., Castaman6 Center for Bleeding Disorders and Coagulation,Careggi University Hospital, Florence, Italy, G., Coppens7 Department of Vascular Medicine, AmsterdamCardiovascular Sciences, Amsterdam UMC, University ofAmsterdam, Amsterdam, Netherlands, M., Cooper, D., Gut, R., Slawka, S., Verweij, S., Dolmetsch, R., Li, Y., Monahan, P. E., and Miesbach, W.

Published
2023
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6. Association of Accuracy, Conclusions, and Reporting Completeness With Acceptance by Radiology Conferences and Journals

Author

Robert A, Frank, Nicholas, Fabiano, Zachary, Hallgrimson, Daniël A, Korevaar, Jérémie F, Cohen, Patrick M, Bossuyt, Mariska M G, Leeflang, David, Moher, Matthew D F, McInnes, Lee, Treanor, Jean-Paul, Salameh, Trevor A, McGrath, Anahita Dehmoobad, Sharifabadi, Almohannad, Atyani, Sakib, Kazi, Jade, Choo-Foo, Nabil, Asraoui, Mostafa, Alabousi, Winston, Ha, Ross, Prager, Paul, Rooprai, Alex, Pozdnyakov, Susan, John, Heba, Osman, Nayaar, Islam, Nicole, Li, Isabelle D, Gauthier, Marissa, Absi, Noëmie, Kraaijpoel, Sanam, Ebrahimzadeh, John D, Port, Jaap, Stoker, Jeffrey S, Klein, Mark, Schweitzer, VU University medical center, Graduate School, Pulmonology, APH - Personalized Medicine, APH - Methodology, Epidemiology and Data Science, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, Amsterdam Reproduction & Development (AR&D), Radiology and Nuclear Medicine, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Humans, Radiology, Nuclear Medicine and imaging, diagnostic accuracy, meta-research, Prospective Studies, Periodicals as Topic, Radiology, Publication Bias, STARD, conclusion positivity, Retrospective Studies
Abstract

Background: Preferential publication of studies with positive findings can lead to overestimation of diagnostic test accuracy (i.e. publication bias). Understanding the contribution of the editorial process to publication bias could inform interventions to optimize the evidence guiding clinical decisions. Purpose/Hypothesis: To evaluate whether accuracy estimates, abstract conclusion positivity, and completeness of abstract reporting are associated with acceptance to radiology conferences and journals. Study Type: Meta-research. Population: Abstracts submitted to radiology conferences (European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and International Society for Magnetic Resonance in Medicine (ISMRM)) from 2008 to 2018 and manuscripts submitted to radiology journals (Radiology, Journal of Magnetic Resonance Imaging [JMRI]) from 2017 to 2018. Primary clinical studies evaluating sensitivity and specificity of a diagnostic imaging test in humans with available editorial decisions were included. Assessment: Primary variables (Youden's index [YI > 0.8 vs. 0.8; CI = 0.70–1.35), conclusion positivity (OR = 1.21 for positive conclusions; CI = 0.75–1.90) or STARD for Abstracts adherence (OR = 0.96 per unit increase in reported items; CI = 0.82–1.18). Manuscripts with positive abstract conclusions were less likely to be accepted by radiology journals (OR = 0.45; CI = 0.24–0.86), while YI (OR = 0.85; CI = 0.56–1.29) and STARD for Abstracts adherence (OR = 1.06; CI = 0.87–1.30) showed no significant association. Positive conclusions were present in 86.7% of submitted conference abstracts and 90.2% of journal manuscripts. Data Conclusion: Diagnostic test accuracy studies with positive findings were not preferentially accepted by the evaluated radiology conferences or journals. Evidence Level: 3. Technical Efficacy: Stage 2.

Published
2022

14. Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-{kappa}B pathway

Author

Xian, Wang [Institute of Vascular Medicine, Peking University Third Hospital, Peking University, Beijing 100083 (China) and Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100083 (China)]

Published
2007
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16. ACCF/ACR/AIUM/ASE/ASN/ICAVL/SCAI/SCCT/SIR/SVM/SVS/SVU [corrected] 2012 appropriate use criteria for peripheral vascular ultrasound and physiological testing part I: arterial ultrasound and physiological testing: a report of the American College of Cardiology Foundation appropriate use criteria task force, American College of Radiology, American Institute of Ultrasound in Medicine, American Society of Echocardiography, American Society of Nephrology, Intersocietal Commission for the Accreditation of Vascular Laboratories, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Interventional Radiology, Society for Vascular Medicine, Society for Vascular Surgery, [corrected] and Society for Vascular Ultrasound. [corrected].

Author

Mohler ER 3rd, Gornik HL, Gerhard-Herman M, Misra S, Olin JW, Zierler RE, American College of Cardiology Foundation (ACCF), American College of Radiology (ACR), American Institute of Ultrasound in Medicine (AIUM), American Society of Echocardiography (ASE), American Society of Nephrology (ASN), Intersocietal Commission for the Accreditation of Vascular Laboratories (ICAVL), Society for Cardiovascular Angiography and Interventions (SCAI), Society of Cardiovascular Computed Tomography (SCCT), Society for Interventional Radiology (SIR), Society for Vascular Medicine (SVM), Society for Vascular Surgery (SVS), Mohler, Emile R 3rd, Gornik, Heather L, and Gerhard-Herman, Marie

Published
2012
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