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Your search keyword '"Tsuruda, K."' showing total 122 results
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122 results on '"Tsuruda, K."'

1. Applying recommended definition of aggressive prostate cancer: a validation study using high-quality data from the Cancer Registry of Norway.

Author

Robsahm, T. E., Tsuruda, K. M., Hektoen, H. H., Storås, A. H., Cook, M. B., Hurwitz, L. M., and Langseth, H.

Subjects
*REPORTING of diseases, *SENSITIVITY & specificity (Statistics), *PROSTATE tumors
Abstract

The Prostate Cancer Cohort Consortium (PC3) Working Group proposed a definition for aggressive prostate cancer (PC) for aetiologic epidemiologic research. We aimed to validate this definition as well as a second approach utilising only information on stage at diagnosis. First primary PCs diagnosed 2004 − 2009 in the population-based Janus Serum Bank (JSB) cohort were identified by linkage to the population-based Cancer Registry of Norway (CRN) (n = 3568). The CRN and Norwegian Prostate Cancer Registry provided clinicopathological data for these cases. Approach 1 classified PC as aggressive if it was clinically T4, or N1, or M1, or had a Gleason score ≥8 at diagnosis (as proposed). Approach 2 classified PC as aggressive if CRN stage at diagnosis was 'regional spread' or 'distant metastases'. Both approaches were validated by calculating the sensitivity and positive predictive value (PPV) against PC-death within 10 years of diagnosis. Overall, 555 died from PC within 10 years. Approach 1 classified 24.7% of cases as aggressive and 13.6% were unclassified due to missing information. Approach 2 classified 19.6% as aggressive and 29% were unclassified. Sensitivity was highest for Approach 1 (0.76, 95% CI: 0.72 − 0.80 vs 0.69, 95% CI: 0.64 − 0.73), while PPVs were similar for both approaches (0.43, 95% CI: 0.40 − 0.46 and 0.40, 95% CI: 0.36 − 0.44). We observed similarly high sensitivity and higher PPVs than those reported by the PC3 Working Group. The proposed definition of aggressive PC was applicable and valid in the JSB cohort. Stage at diagnosis can be useful if data on cTNM or Gleason score is unavailable. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Preface

Author

Shinagawa, H., Yamamoto, T., Tsuruda, K., and Luhmann, J. G.

Published
1998
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26. High‐speed error‐free wireless data transmission using a terahertz resonant tunnelling diode transmitter and receiver.

Author

Diebold, S., Nishio, K., Nishida, Y., Kim, J.‐Y., Tsuruda, K., Mukai, T., Fujita, M., and Nagatsuma, T.

Abstract

An error‐free wireless transmission of a 9 Gbit/s on–off keying modulated signal as well as a 4 k video signal is demonstrated using resonant tunnelling diodes as active elements in both the transmitter and the receiver. The employed system and the modulation scheme enabling the high data rate are discussed. [ABSTRACT FROM AUTHOR]

Published
2016
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27. LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway.

Author

Hasegawa, H., Yamada, Y., Tsukasaki, K., Mori, N., Tsuruda, K., Sasaki, D., Usui, T., Osaka, A., Atogami, S., Ishikawa, C., Machijima, Y., Sawada, S., Hayashi, T., Miyazaki, Y., and Kamihira, S.

Subjects
LEUKEMIA, LYMPHOMAS, APOPTOSIS, TUMORS, CELL proliferation
Abstract

Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. In this study, we examined the effects of a new inhibitor of deacetylase enzymes, LBH589, on ATLL cells. LBH589 effectively induced apoptosis in ATLL-related cell lines and primary ATLL cells and reduced the size of tumors inoculated in SCID mice. Analyses, including with a DNA microarray, revealed that neither death receptors nor p53 pathways contributed to the apoptosis. Instead, LBH589 activated an intrinsic pathway through the activation of caspase-2. Furthermore, small interfering RNA experiments targeting caspase-2, caspase-9, RAIDD, p53-induced protein with a death domain (PIDD) and RIPK1 (RIP) indicated that activation of RAIDD is crucial and an event initiating this pathway. In addition, LBH589 caused a marked decrease in levels of factors involved in ATLL cell proliferation and invasion such as CCR4, IL-2R and HTLV-1 HBZ-SI, a spliced form of the HTLV-1 basic zipper factor HBZ. In conclusion, we showed that LBH589 is a strong inducer of apoptosis in ATLL cells and uncovered a novel apoptotic pathway initiated by activation of RAIDD. [ABSTRACT FROM AUTHOR]

Published
2011
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32. Time-of-flight neutral mass and velocity spectrometer for atmospheric research.

Author

Fujikawa, N., Tsuruda, K., and Hayakawa, H.

Subjects
*SPECTROMETERS, *ATMOSPHERIC research
Abstract

We have developed a prototype time-of-flight neutral gas mass spectrometer that simultaneously measures the density and the velocity distribution function of each mass species, using the time-of-flight and the two-dimensional spatial distribution of the ionized particles on a charge-coupled device (CCD). We confirmed the feasibility of the velocity distribution measurement in a vacuum chamber using room-temperature Ar gas, by measuring the spatial distribution of the ionized Ar on the CCD and inferring the corresponding velocity distribution of the incident Ar. © 2002 American Institute of Physics. [ABSTRACT FROM AUTHOR]

Published
2002
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48. Three-dimensional computer simulation of ion beam scattering by an electrostatic reflector.

Author

Nakamura, M., Tsuruda, K., and Hayakawa, H.

Subjects
*ION bombardment, *SCATTERING (Physics)
Abstract

A three-dimensional computer model was used to study the scattering of a reflected lithium ion beam by an electrostatic reflector. Results show that for ion gun systems for active space plasma experiment applications, beam scattering of less than 1° can be attained with electrostatic reflectors. [ABSTRACT FROM AUTHOR]

Published
1987
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