Search

The design and self-assembly of six new supramolecular complexes are described. These assemblies incorporate two new bispyridyl cavitand building blocks and were prepared in excellent yields.

m- or p-diiodobenzene undergoes selective double coupling reactions with arylboronic acids and esters. Results show that diiodobenzenes are the best choice of electrophile if double coupling is desired, whereas selective coupling can be obtained through reactions of dibromobenzenes with arylaboronic acids.

Antibiotics are among the most important interventions in healthcare. Resistance of bacteria to antibiotics threatens the effectiveness of treatment. Systematic reviews of antibiotic treatments often do not address resistance to antibiotics even when data are available in the original studies. This omission creates a skewed view, which emphasizes short-term efficacy and ignores the long-term consequences to the patient and other people. We offer a framework for addressing antibiotic resistance in systematic reviews. We suggest that the data on background resistance in the original trials should be reported and taken into account when interpreting results. Data on emergence of resistance (whether in the body reservoirs or in the bacteria causing infection) are important outcomes. Emergence of resistance should be taken into account when interpreting the evidence on antibiotic treatment in randomized controlled trials or systematic reviews. [ABSTRACT FROM AUTHOR]