150 results on '"Shen, Jingkang"'
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2. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors
3. Designing of novel ERRγ inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives
4. Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction
5. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma
6. Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups
7. Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site
8. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor
9. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors
10. Stereoselective addition of Grignard reagents to (2-methyl-5-tert-butyl)phenyl 1-thio-β-D-ribopentodialdo-1,4-furanoside derivative
11. Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity
12. Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic
13. Discovery of 1H‑Imidazo[4,5‑b]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
14. Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design
15. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors
16. Synthesis and biological evaluation of 6H-pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization
17. Discovery of pyrazole as C-terminus of selective BACE1 inhibitors
18. Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors
19. Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors
20. (N,N-Diisopropylcarbamoyloxy)-methyl p-tolyl sulfone: preparation and application for the syntheses of 1,2-diols
21. Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists
22. Discovery of benzhydrylpiperazine derivatives as CB 1 receptor inverse agonists via privileged structure-based approach
23. Aromatic β-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists
24. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
25. Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
26. Discovery of Novel 2‑Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors.
27. Illudalic acid as a potential LAR inhibitor: Synthesis, SAR, and preliminary studies on the mechanism of action
28. MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules
29. Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis.
30. One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation
31. Design, synthesis, and evaluation of Leu∗Ala hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors
32. MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation
33. DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks
34. Molecular modeling studies of [4-(3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine-based CDK4 inhibitors.
35. BSSF: a fingerprint based ultrafast binding site similarity search and function analysis server
36. Rational Design and Evaluation of 6‑(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1H)‑ones as Polypharmacological Inhibitors of BET and Kinases.
37. Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.
38. Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.
39. Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study.
40. Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors.
41. A one-pot synthesis of omarigliptin and its analogues through stabilized beta -amino ketone intermediate.
42. Stereoselective and Regioselective Preparation of C-Pentopyranosides and Formal Synthesis of Omarigliptin.
43. Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer.
44. Ga(OTf)3-promoted synthesis of functionalized 2-carbonyl-imidazo[1,2-a]pyridines derived from ethyl α-benzotriazolyl-α-morpholinoacetate.
45. Fragment-Based Drug Discoveryof 2-Thiazolidinonesas BRD4 Inhibitors: 2. Structure-Based Optimization.
46. Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke–Blackburn–Bienaymé reaction and their Hsp90 inhibitory activity.
47. Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation.
48. A Chemical Tuned Strategyto Develop Novel IrreversibleEGFR-TK Inhibitors with Improved Safety and Pharmacokinetic Profiles.
49. Discovery and Optimizationof 4,5-Diarylisoxazolesas Potent Dual Inhibitors of Pyruvate Dehydrogenase Kinase and HeatShock Protein 90.
50. Highly Stereoselective Nucleophilic Addition of Difluoromethyl-2-pyridyl Sulfone to Sugar Lactones and Efficient Synthesis of Fluorinated 2-Ketoses.
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