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1. Modification of the third phase in the framework for vertebrate species persistence in urban mosaic environments

Author

Downs, Colleen T., Alexander, Jarryd, Brown, Mark, Chibesa, Moses, Ehlers Smith, Yvette C., Gumede, S. Thobeka, Hart, Lorinda, Josiah, Kyrone K., Kalle, Riddhika, Maphalala, Machawe, Maseko, Mfundo, McPherson, Shane, Ngcobo, Samukelisiwe P., Patterson, Lindsay, Pillay, Kerushka, Price, Cormac, Raji, Islamiat Abidemi, Ramesh, Tharmalingam, Schmidt, Warren, Senoge, Ntaki D., Shivambu, Tinyiko C., Shivambu, Ndivhuwo, Singh, Nikisha, Singh, Preshnee, Streicher, Jarryd, Thabethe, Vuyisile, Thatcher, Harriet, Widdows, Craig, Wilson, Amy-Leigh, Zungu, Manqoba M., and Ehlers Smith, David A.

Published
2021
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2. Correction to: Modification of the third phase in the framework for vertebrate species persistence in urban mosaic environments

Author

Downs, Colleen T., Alexander, Jarryd, Brown, Mark, Chibesa, Moses, Ehlers Smith, Yvette C., Gumede, S. Thobeka, Hart, Lorinda, Josiah, Kyrone K., Kalle, Riddhika, Maphalala, Machawe, Maseko, Mfundo, McPherson, Shane, Ngcobo, Samukelisiwe P., Patterson, Lindsay, Pillay, Kerushka, Price, Cormac, Raji, Islamiat Abidemi, Ramesh, Tharmalingam, Schmidt, Warren, Senoge, Ntaki D., Shivambu, Tinyiko C., Shivambu, Ndivhuwo, Singh, Nikisha, Singh, Preshnee, Streicher, Jarryd, Thabethe, Vuyisile, Thatcher, Harriet, Widdows, Craig, Wilson, Amy-Leigh, Zungu, Manqoba M., and Ehlers Smith, David A.

Published
2021
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3. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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4. Improved Survival Among all Interferon-α-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders

Author

Cozen, Myrna L, Ryan, James C, Shen, Hui, Cheung, Ramsey, Kaplan, David E, Pocha, Christine, Brau, Norbert, Aytaman, Ayse, Schmidt, Warren N, Pedrosa, Marcos, Anand, Bhupinderjit S, Chang, Kyong-Mi, Morgan, Timothy, and Monto, Alexander

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hepatitis, Emerging Infectious Diseases, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Infectious Diseases, Rare Diseases, Substance Misuse, Clinical Research, Liver Disease, Hepatitis - C, Clinical Trials and Supportive Activities, Cancer, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Infection, Good Health and Well Being, Adult, Cohort Studies, Female, Hepatitis C, Humans, Interferon-alpha, Liver Cirrhosis, Male, Middle Aged, Proportional Hazards Models, Ribavirin, United States, United States Department of Veterans Affairs, Hepatitis C therapy, Cirrhosis, Hepatocellular carcinoma, Survival, Gastroenterology & Hepatology, Clinical sciences
Abstract

BackgroundAs the era of interferon-alpha (IFN)-based therapy for hepatitis C ends, long-term treatment outcomes are now being evaluated.AimTo more fully understand the natural history of hepatitis C infection by following a multisite cohort of patients.MethodsPatients with chronic HCV were prospectively enrolled in 1999-2000 from 11 VA medical centers and followed through retrospective medical record review.ResultsA total of 2211 patients were followed for an average of 8.5 years after enrollment. Thirty-one percent of patients received HCV antiviral therapy, 15 % with standard IFN/ribavirin only, 16 % with pegylated IFN/ribavirin, and 26.7 % of treated patients achieved sustained virologic response (SVR). Cirrhosis developed in 25.8 % of patients. Treatment nonresponders had a greater than twofold increase in the hazard of cirrhosis and hepatocellular carcinoma, compared to untreated patients, whereas SVR patients were only marginally protected from cirrhosis. Nearly 6 % developed hepatocellular carcinoma, and 27.1 % died during the follow-up period. Treated patients, regardless of response, had a significant survival benefit compared to untreated patients (HR 0.58, CI 0.46-0.72). Improved survival was also associated with college education, younger age, lower levels of alcohol consumption, and longer duration of medical service follow-up-factors typically associated with treatment eligibility.ConclusionsAs more hepatitis C patients are now being assessed for all-oral combination therapy, these results highlight that patient compliance and limiting harmful behaviors contribute a significant proportion of the survival benefit in treated patients and that the long-term clinical benefits of SVR may be less profound than previously reported.

Published
2016

13. Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

Author

Hu, Katherine, Zhu, Zhaowen, Mathahs, Meleah M, Tran, Huy, Bommer, Jerry, Testa, Charles A, and Schmidt, Warren N

Subjects
hepatitis C virus, Dose-Response Relationship, Drug, Molecular Structure, Hepacivirus, Microbial Sensitivity Tests, Viral Nonstructural Proteins, porphyrins, Virus Replication, Antiviral Agents, Structure-Activity Relationship, Humans, Protease Inhibitors, Serine Proteases, hepatitis C genotype, Cells, Cultured, Original Research
Abstract

Background Antiviral actions of tetrapyrroles have been described in a number of systems. Our goal was to evaluate antagonism of the HCV NS3-4A protease by a variety of common porphyrins and characterize structure–activity relationships that may be useful for future drug design of HCV and related Flaviviruses. Methods Using fluorometric assays, common metalloprotoporphyrins (MPP) all inhibited NS3-4A protease with IC50 values in low micromolar ranges [CoPP (1.4 µM) < ZnPP = MnPP = SnPP < CuPP < FePP (6.5 µM) = protoporphyrin]. Results Lineweaver–Burk plots confirmed that MPP: NS3 inhibition was basically competitive. All tested MPPs inhibited HCV genotype 1A, 1B, 2A and 3A recombinant proteases with the same fidelity suggesting wide antagonistic capabilities. However, when the MPPs were tested in cellular incubations with HCV replicons only Zn, Fe and free-base protoporphyrin showed comparable EC50 and IC50 values suggesting that there may be critical differences in MPP uptake and intracellular availability. Meso, deutero, and isohematoporphyrin derivatives, with or without metal substitution, all showed less anti-protease and antiviral activities as compared to protoporphyrins, suggesting that the planar, vinyl side chains are important for protease active site binding. MPPs were also active against three common protease mutants (T54A, A156T, and V36M) with equivalent or better IC50 values as compared to wild type enzyme. Conclusion These findings document the versatility of MPPs as antiviral agents with an expanded sensitivity for HCV genotypes and resistance to some common viral mutations. The results also suggest that further study of MPP structure and function will be useful for the development of new antiviral agents.

Published
2020

18. The Race without A Finish Line: America's Quest for Total Quality. Jossey-Bass Management Series.

Author

Schmidt, Warren H., Finnigan, Jerome P., Schmidt, Warren H., and Finnigan, Jerome P.

Abstract

This book offers a guide to implementing Total Quality Management (TQM) in public and private organizations based on interviews and site visits with 12 award-winning companies. Part 1 provides an overview of TQM, attempts to put the Quality Revolution into perspective, and suggests diagnostic questions to determine whether TQM is appropriate for a specific organization. Part 2 offers a strategic implementation plan based on the key success factors identified as common to all the Baldrige Award winners. These included: (1) establishing supportive organizational roles and structures; (2) using the right tools and processes; (3) implementing long term educational programs; (4) creating meaningful recognition and reward systems; and (5) encouraging complete and regular communication. Part 3 examines the Baldrige and President's Awards and presents their winners. The Malcolm Baldrige National Quality Award and the President's Award for Quality are two national competitions in the United States which have stimulated and focused attention on the Quality Movement. It examines why and how large and small organization competed for these awards, how the competition affected them, what they learned in the process, and how they are maintaining an improvement process since winning their award. Resources at the end of the book provide a glossary of TQM terms, a directory of TQM organizations and centers, and an annotated bibliography of TQM publications. (Contains over 150 references.) (JB)

Published
1992

19. Peginterferon alfa-2b and Ribavirin: Effective in Patients With Hepatitis C Who Failed Interferon alfa/Ribavirin Therapy

Author

Poynard, Thierry, Colombo, Massimo, Bruix, Jordi, Schiff, Eugene, Terg, Ruben, Flamm, Steven, Moreno-Otero, Ricardo, Carrilho, Flair, Schmidt, Warren, Berg, Thomas, McGarrity, Thomas, Heathcote, E. Jenny, Gonçales, Fernando, Diago, Moises, Craxi, Antonio, Silva, Marcelo, Bedossa, Pierre, Mukhopadhyay, Pabak, Griffel, Louis, Burroughs, Margaret, Brass, Clifford, and Albrecht, Janice

Published
2009
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28. Emricasan to prevent new decompensation in patients with NASH-related decompensated cirrhosis

Author

Frenette, Catherine, primary, Kayali, Zeid, additional, Mena, Edward, additional, Mantry, Parvez S., additional, Lucas, Kathryn J., additional, Neff, Guy, additional, Rodriguez, Miguel, additional, Thuluvath, Paul J., additional, Weinberg, Ethan, additional, Bhandari, Bal R., additional, Robinson, James, additional, Wedick, Nicole, additional, Chan, Jean L., additional, Hagerty, David T., additional, Kowdley, Kris V., additional, Corey, Kathleen, additional, Bernstein, David, additional, Noureddin, Mazen, additional, Kemmer, Nyingi, additional, DeLemos, Andrew, additional, Pyrsopoulos, Nikolaos, additional, Lee, William, additional, Ghabril, Marwan, additional, Scanga, Andrew, additional, McKenzie, Mark, additional, Lawitz, Eric, additional, Figueroa-Diaz, Viviana, additional, Simonetto, Douglas, additional, Frederick, Richard, additional, Brown, Kimberly, additional, Therapondos, George, additional, Sheikh, Aasim, additional, Brandman, Danielle, additional, Stein, Lance, additional, Ankoma-Sey, Victor, additional, Bhamidimarri, Kalyan, additional, Landis, Charles, additional, Fortune, Brett, additional, Vargas, Hugo, additional, Abdelmalek, Manal, additional, Freilich, Bradley, additional, Rockey, Don, additional, Vierling, John, additional, Tatum, Harvey, additional, Curry, Michael, additional, Shiffman, Mitchell, additional, Bambha, Kiran, additional, Ghalib, Reem, additional, Stratton, Amy, additional, Anwar, Nadeem, additional, Caldwell, Stephen, additional, Koteish, Ayman, additional, Siddiqui, Mohammad, additional, Saab, Sammy, additional, Shah, Nikunj, additional, Kohli, Anita, additional, Rinella, Mary, additional, Sarkar, Souvik, additional, Torres, Dawn, additional, Verna, Elizabeth, additional, Ravendhran, Ravi, additional, Reynolds, Justin, additional, Thomason, Ray, additional, Kim, Ray, additional, Membreno, Fernando, additional, Jakab, Sofia, additional, Gonzalez, Stevan, additional, Keaveny, Andrew, additional, Pan, Jen-Jung, additional, Gill, Satinder, additional, Huang, Jonathan, additional, Strobel, James, additional, Wieland, Amanda, additional, Morelli, Giuseppe, additional, Amankonah, Thomas, additional, Roytman, Marina, additional, Schmidt, Warren, additional, Abrams, Gary, additional, and Patel, Bhaktasharan, additional

Published
2021
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31. Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships

Author

Hu,Katherine, Zhu,Zhaowen, Mathahs,Meleah M, Tran,Huy, Bommer,Jerry, Testa,Charles A, Schmidt,Warren N, Hu,Katherine, Zhu,Zhaowen, Mathahs,Meleah M, Tran,Huy, Bommer,Jerry, Testa,Charles A, and Schmidt,Warren N

Abstract

Katherine Hu, 1, 2 Zhaowen Zhu, 1, 2 Meleah M Mathahs, 1, 2 Huy Tran, 1, 2 Jerry Bommer, 3, 4 Charles A Testa, 5 Warren N Schmidt 1, 2 1Department of Internal Medicine and Research Service, Veterans Affairs Medical Center, Iowa City, IA 52246, USA; 2Department of Internal Medicine of the Roy G. And Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA; 3Frontier Scientific, Logan, UT 84321, USA; 4Echelon Biosciences Inc, Salt Lake City, UT 84108, USA; 5Curza, Provo, UT and Cambridge, MA, USACorrespondence: Warren N SchmidtDepartment of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4553 JCP, Iowa City, IA 52242, USATel +1 319 353-7048Fax +1 319 356-7918Email warren-schmidt@uiowa.eduBackground: Antiviral actions of tetrapyrroles have been described in a number of systems. Our goal was to evaluate antagonism of the HCV NS3-4A protease by a variety of common porphyrins and characterize structure–activity relationships that may be useful for future drug design of HCV and related Flaviviruses.Methods: Using fluorometric assays, common metalloprotoporphyrins (MPP) all inhibited NS3-4A protease with IC 50 values in low micromolar ranges [CoPP (1.4 μM) < ZnPP = MnPP = SnPP < CuPP < FePP (6.5 μM) = protoporphyrin].Results: Lineweaver–Burk plots confirmed that MPP: NS3 inhibition was basically competitive. All tested MPPs inhibited HCV genotype 1A, 1B, 2A and 3A recombinant proteases with the same fidelity suggesting wide antagonistic capabilities. However, when the MPPs were tested in cellular incubations with HCV replicons only Zn, Fe and free-base protoporphyrin showed comparable EC 50 and IC 50 values suggesting that there may be critical differences in MPP uptake and intracellular availability. Meso, deutero, and isohematoporphyrin derivatives, with or without metal substitution, all showed less anti-protease and antiviral activities as compared to protop

Published
2020

33. Hepatitus C virus viremia in HIV-infected individuals with negative HCV antibody tests

Author

George, Sarah L., Gebhardt, Jenny, Klinzman, Donna, Foster, Mathew B., Patrick, Kevin D., Schmidt, Warren N., Alden, Beth, Pfaller, Michael A., and Stapleton, Jack T.

Subjects
Immunological research -- Analysis, Immunological research -- Statistics, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Hepatitis C virus -- Causes of, Hepatitis C virus -- Care and treatment, Hepatitis C virus -- Prevention, Hepatitis C virus -- Health aspects, RNA -- Genetic aspects, Diabetes -- Health aspects, Health
Abstract

Research has been conducted on the hepatitis C virus (HCV) viremia. The characterization of this infection has been carried out via testing HIV-positive persons and HIV-negative control subjects with diabetes for the HCV antibody presence and HCV RNA and the results demonstrate that hepatitis C virus infection occurs more often among HIV-infected persons.

Published
2002

35. Ombitasvir/paritaprevir/ritonavir and dasabuvir±ribavirin for chronic HCV infection in US veterans with psychiatric disorders

Author

Fuchs, Michael, primary, Monto, Alexander, additional, Bräu, Norbert, additional, Charafeddine, Mariem, additional, Schmidt, Warren, additional, Kozal, Michael, additional, Naggie, Susanna, additional, Cheung, Ramsey, additional, Schnell, Gretja, additional, Yu, Yao, additional, Richards, Kristine, additional, Mullally, Victoria, additional, Cohen, Daniel E., additional, and Toro, Doris, additional

Published
2020
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38. Zinc protoporphyrin binding to telomerase complexes and inhibition of telomerase activity.

Author

Zhaowen Zhu, Huy Tran, Huy, Mathahs, Meleah M., Fink, Brian D., Albert, John A., Moninger, Thomas O., Meier, Jeffery L., Ming Li, and Schmidt, Warren N.

Subjects
TELOMERASE, TELOMERASE reverse transcriptase, BIOFLUORESCENCE, ZINC-finger proteins, CONFOCAL fluorescence microscopy, DNA synthesis, CELL imaging
Abstract

Zinc protoporphyrin (ZnPP), a naturally occurring metalloprotoporphyrin (MPP), is currently under development as a chemotherapeutic agent although its mechanism is unclear. When tested against other MPPs, ZnPP was the most effective DNA synthesis and cellular proliferation inhibitor while promoting apoptosis in telomerase positive but not telomerase negative cells. Concurrently, ZnPP down-regulated telomerase expression and was the best overall inhibitor of telomerase activity in intact cells and cellular extracts with IC50 and EC50 values of ca 2.5 and 6 µM, respectively. The natural fluorescence properties of ZnPP enabled direct imaging in cellular fractions using non-denaturing agarose gel electrophoresis, western blots, and confocal fluorescence microscopy. ZnPP localized to large cellular complexes (>600 kD) that contained telomerase and dysskerin as confirmed with immunocomplex mobility shift, immunoprecipitation, and immunoblot analyses. Confocal fluorescence studies showed that ZnPP co-localized with telomerase reverse transcriptase (TERT) and telomeres in the nucleus of synchronized S-phase cells. Zn PP also co-localized with TERT in the perinuclear regions of log phase cells but did not co-localize with telomeres on the ends of metaphase chromosomes, a site known to be devoid of telomerase complexes. Overall, these results suggest that ZnPP does not bind to telomeric sequences per se, but alternatively, interacts with other structural components of the telomerase complex to inhibit telomerase activity. In conclusion, ZnPP actively interferes with telomerase activity in neoplastic cells, thus promoting pro-apoptotic and anti-proliferative properties. These data support further development of natural or synthetic protoporphyrins for use as chemotherapeutic agents to augment current treatment protocols for neoplastic disease. [ABSTRACT FROM AUTHOR]

Published
2021
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43. Prospective Multicenter Study of Eligibility for Antiviral Therapy Among 4,084 U.S. Veterans with Chronic Hepatitis C Virus Infection

Author

Bini, Edmund J., Bräu, Norbert, Currie, Sue, Shen, Hui, Anand, Bhupinderjit S., Hu, Ke-Qin, Jeffers, Lennox, Ho, Samuel B., Johnson, David, Schmidt, Warren N., King, Paul, Cheung, Ramsey, Morgan, Timothy R., Awad, Joseph, Pedrosa, Marcos, Chang, Kyong-Mi, Aytaman, Ayse, Simon, Franz, Hagedorn, Curt, Moseley, Richard, Ahmad, Jawad, Mendenhall, Charles, Waters, Bradford, Strader, Doris, Sasaki, Anna W., Rossi, Stephen, and Wright, Teresa L.

Published
2005

48. Values and the American manager: an update updated

Author

Posner, Barry Z. and Schmidt, Warren H.

Subjects
Corporations -- Social aspects, Executives -- Beliefs, opinions and attitudes, Social values -- Research, Corporate culture -- Social aspects, Business, Business, general
Abstract

'The direction and vitality of corporate America and its managers cannot be fully understood without knowing more about the values and visions of the men and women who manage it' is as true today as it was ten years ago when we originally reported on a nationwide survey of managers and their values. This study, involving 1,500 managers, replicates our earlier research and reveals that certain values are enduring (such as what we look for in leader), while other values are changing (such as how we balance personal and work demands). (Reprinted by permission of the publisher.)

Published
1992

49. The values of business and federal government executives: more different than alike

Author

Posner, Barry Z. and Schmidt, Warren H.

Subjects
Executives -- Ethical aspects, Business ethics -- Research, Government executives -- Ethical aspects, Business, Government, Human resources and labor relations, Research, Ethical aspects
Abstract

A nationwide sample of executives from business [Mathematical Expression Omitted] and the federal government provided the database for comparing managerial values across these two sectors. Business and government executives differed in the importance they attached to a variety of organizational goals, stakeholders, and personal traits. They also differed in their outlook on future trends and how they handled tradeoffs between work and personal demands. While there were broad areas of disagreement, also noted were some areas of specific agreement on executives' values across the public and private sector. Implications for organizations and future research are suggested., Managerial values are crucial to an understanding of organizational behavior. Indeed, some have claimed that the direction and vitality of 'America cannot be fully understood without knowing more about the [...]

Published
1996

50. The values of American managers then and now

Author

Schmidt, Warren H. and Posner, Barry Z.

Subjects
American Management Association -- Surveys, Executives -- Surveys, Values -- Surveys, Management -- Surveys, Business, general, Surveys
Abstract

37 American managers have a greater interest in values today than they had 10 years ago. They also report more interest in quality and a higher regard for customers, according [...]

Published
1992

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