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44 results on '"Olszewski, Dominik"'

1. Asymmetric Isomap for Dimensionality Reduction and Data Visualization

Author

Olszewski, Dominik, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wand, Michael, editor, Malinovská, Kristína, editor, Schmidhuber, Jürgen, editor, and Tetko, Igor V., editor

Published
2024
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6. Clustering-Based Adaptive Self-Organizing Map

Author

Olszewski, Dominik, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Rutkowski, Leszek, editor, Scherer, Rafał, editor, Korytkowski, Marcin, editor, Pedrycz, Witold, editor, Tadeusiewicz, Ryszard, editor, and Zurada, Jacek M., editor

Published
2021
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7. An Adaptive Neighborhood Retrieval Visualizer

Author

Olszewski, Dominik, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, de la Cal, Enrique Antonio, editor, Villar Flecha, José Ramón, editor, Quintián, Héctor, editor, and Corchado, Emilio, editor

Published
2020
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11. An Improved Adaptive Self-Organizing Map

Author

Olszewski, Dominik, Kacprzyk, Janusz, Zadrożny, Sławomir, Kacprzyk, Janusz, Series editor, Trė, Guy de, editor, Grzegorzewski, Przemysław, editor, Owsiński, Jan W., editor, Penczek, Wojciech, editor, and Zadrożny, Sławomir, editor

Published
2016
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12. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Author

Lang, Judith, Bohn, Patrick, Bhat, Hilal, Jastrow, Holger, Walkenfort, Bernd, Cansiz, Feyza, Fink, Julian, Bauer, Michael, Olszewski, Dominik, Ramos-Nascimento, Ana, Duhan, Vikas, Friedrich, Sarah-Kim, Becker, Katrin Anne, Krawczyk, Adalbert, Edwards, Michael J., Burchert, Andreas, Huber, Magdalena, Friebus-Kardash, Justa, Göthert, Joachim R., Hardt, Cornelia, Probst, Hans Christian, Schumacher, Fabian, Köhrer, Karl, Kleuser, Burkhard, Babiychuk, Eduard B., Sodeik, Beate, Seibel, Jürgen, Greber, Urs F., Lang, Philipp A., Gulbins, Erich, and Lang, Karl S.

Published
2020
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13. Asymmetric k-means Clustering of the Asymmetric Self-Organizing Map

Author

Olszewski, Dominik, Kacprzyk, Janusz, Zadrożny, Sławomir, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Tanaka, Yuzuru, editor, Wahlster, Wolfgang, editor, Siekmann, Jörg, editor, Rutkowski, Leszek, editor, Korytkowski, Marcin, editor, Scherer, Rafał, editor, Tadeusiewicz, Ryszard, editor, Zadeh, Lotfi A., editor, and Zurada, Jacek M., editor

Published
2014
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14. An Improved Adaptive Self-Organizing Map

Author

Olszewski, Dominik, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Tanaka, Yuzuru, editor, Wahlster, Wolfgang, editor, Siekmann, Jörg, editor, Rutkowski, Leszek, editor, Korytkowski, Marcin, editor, Scherer, Rafał, editor, Tadeusiewicz, Ryszard, editor, Zadeh, Lotfi A., editor, and Zurada, Jacek M., editor

Published
2014
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16. Employing Self-Organizing Map for Fraud Detection

Author

Olszewski, Dominik, Kacprzyk, Janusz, Zadrożny, Sławomir, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Rutkowski, Leszek, editor, Korytkowski, Marcin, editor, Scherer, Rafał, editor, Tadeusiewicz, Ryszard, editor, Zadeh, Lotfi A., editor, and Zurada, Jacek M., editor

Published
2013
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17. Time Series Visualization Using Asymmetric Self-Organizing Map

Author

Olszewski, Dominik, Kacprzyk, Janusz, Zadrożny, Sławomir, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Tomassini, Marco, editor, Antonioni, Alberto, editor, Daolio, Fabio, editor, and Buesser, Pierre, editor

Published
2013
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18. k-Means Clustering of Asymmetric Data

Author

Olszewski, Dominik, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Corchado, Emilio, editor, Snášel, Václav, editor, Abraham, Ajith, editor, Woźniak, Michał, editor, Graña, Manuel, editor, and Cho, Sung-Bae, editor

Published
2012
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19. An Experimental Study on Asymmetric Self-Organizing Map

Author

Olszewski, Dominik, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Yin, Hujun, editor, Wang, Wenjia, editor, and Rayward-Smith, Victor, editor

Published
2011
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20. Fraud Detection in Telecommunications Using Kullback-Leibler Divergence and Latent Dirichlet Allocation

Author

Olszewski, Dominik, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Dobnikar, Andrej, editor, Lotrič, Uroš, editor, and Šter, Branko, editor

Published
2011
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21. Asymmetric k-Means Algorithm

Author

Olszewski, Dominik, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Dobnikar, Andrej, editor, Lotrič, Uroš, editor, and Šter, Branko, editor

Published
2011
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25. High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections

Author

Olszewski, Dominik; https://orcid.org/0000-0001-5389-4034, Georgi, Fanny; https://orcid.org/0000-0002-4803-5099, Murer, Luca, Andriasyan, Vardan, Kuttler, Fabien; https://orcid.org/0000-0003-2575-1989, Petkidis, Anthony, Witte, Robert, Yakimovich, Artur, Fischer, Lucy, Rozanova, Alina, Yamauchi, Yohei, Turcatti, Gerardo; https://orcid.org/0000-0003-0139-223X, Greber, Urs F; https://orcid.org/0000-0003-2278-120X, Olszewski, Dominik; https://orcid.org/0000-0001-5389-4034, Georgi, Fanny; https://orcid.org/0000-0002-4803-5099, Murer, Luca, Andriasyan, Vardan, Kuttler, Fabien; https://orcid.org/0000-0003-2575-1989, Petkidis, Anthony, Witte, Robert, Yakimovich, Artur, Fischer, Lucy, Rozanova, Alina, Yamauchi, Yohei, Turcatti, Gerardo; https://orcid.org/0000-0003-0139-223X, and Greber, Urs F; https://orcid.org/0000-0003-2278-120X

Abstract

Viruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- or antiviral effects we conducted arrayed high-content image-based multi-cycle infection screens of 1,280 mainly FDA-approved compounds with three human viruses, rhinovirus (RV), influenza A virus (IAV), and herpes simplex virus (HSV) differing in genome organization, composition, presence of an envelope, and tropism. Based on Z’-factors assessing screening quality and Z-scores ranking individual compounds, we identified potent inhibitors and enhancers of infection: the RNA mutagen 5-Azacytidine against RV-A16; the broad-spectrum antimycotic drug Clotrimazole inhibiting IAV-WSN; the chemotherapeutic agent Raltitrexed blocking HSV-1; and Clobetasol enhancing HSV-1. Remarkably, the topical antiseptic compound Aminacrine, which is clinically used against bacterial and fungal agents, inhibited all three viruses. Our data underscore the versatility and potency of image-based, full cycle virus propagation assays in cell-based screenings for antiviral agents.

Published
2022

28. Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern

Author

Murer, Luca, primary, Volle, Romain, additional, Andriasyan, Vardan, additional, Petkidis, Anthony, additional, Gomez-Gonzalez, Alfonso, additional, Yang, Liliane, additional, Meili, Nicole, additional, Suomalainen, Maarit, additional, Bauer, Michael, additional, Policarpo Sequeira, Daniela, additional, Olszewski, Dominik, additional, Georgi, Fanny, additional, Kuttler, Fabien, additional, Turcatti, Gerardo, additional, and Greber, Urs F., additional

Published
2022
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31. Arrayed multicycle drug screens identify broadly acting chemical inhibitors for repurposing against SARS-CoV-2

Author

Murer, Luca, primary, Volle, Romain, additional, Andriasyan, Vardan, additional, Meili, Nicole, additional, Yang, Liliane, additional, Sequeira, Daniela, additional, Gomez-Gonzalez, Afonso, additional, Petkidis, Anthony, additional, Olszewski, Dominik, additional, Bauer, Michael, additional, Suomalainen, Maarit, additional, Kuttler, Fabien, additional, Turcatti, Gerardo, additional, and Greber, Urs F., additional

Published
2021
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32. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Author

Lang, Judith; https://orcid.org/0000-0001-5352-106X, Bohn, Patrick, Bhat, Hilal, Jastrow, Holger, Walkenfort, Bernd, Cansiz, Feyza, Fink, Julian, Bauer, Michael; https://orcid.org/0000-0002-8156-4603, Olszewski, Dominik, Greber, Urs F; https://orcid.org/0000-0003-2278-120X, et al, Lang, Judith; https://orcid.org/0000-0001-5352-106X, Bohn, Patrick, Bhat, Hilal, Jastrow, Holger, Walkenfort, Bernd, Cansiz, Feyza, Fink, Julian, Bauer, Michael; https://orcid.org/0000-0002-8156-4603, Olszewski, Dominik, Greber, Urs F; https://orcid.org/0000-0003-2278-120X, and et al

Abstract

Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are unclear. Here we show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs). In MVBs, acid ceramidase (aCDase) converts ceramide into sphingosine and increases the formation of sphingosine-rich intraluminal vesicles (ILVs). Once HSV-1 particles reach MVBs, sphingosine-rich ILVs bind to HSV-1 particles, which restricts fusion with the limiting endosomal membrane and prevents cellular infection. Lack of aCDase in macrophage cultures or in Asah1−/− mice results in replication of HSV-1 and Asah1−/− mice die soon after systemic or intravaginal inoculation. The treatment of macrophages with sphingosine enhancing compounds blocks HSV-1 propagation, suggesting a therapeutic potential of this pathway. In conclusion, aCDase loads ILVs with sphingosine, which prevents HSV-1 capsids from penetrating into the cytosol.

Published
2020

35. Identification of Broad Anti-Coronavirus Chemical Agents for Repurposing Against SARS-CoV-2 and Variants of Concern

Author

Murer, Luca, primary, Volle, Romain, additional, Andriasyan, Vardan, additional, Petkidis, Anthony, additional, Gomez-Gonzalez, Alfonso, additional, Yang, Liliane, additional, Meili, Nicole, additional, Suomalainen, Maarit, additional, Bauer, Michael, additional, Sequeira, Daniela, additional, Olszewski, Dominik, additional, Georgi, Fanny, additional, Kuttler, Fabien, additional, Turcatti, Gerardo, additional, and Greber, Urs, additional

Published
2021
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38. Detection of Alpha, Beta, Gamma, and Unclassified Human Papillomaviruses in Cervical Cancer Samples From Mexican Women

Author

Flores-Miramontes, María Guadalupe, primary, Olszewski, Dominik, additional, Artaza-Irigaray, Cristina, additional, Willemsen, Anouk, additional, Bravo, Ignacio G., additional, Vallejo-Ruiz, Verónica, additional, Leal-Herrera, Yelda Aurora, additional, Piña-Sánchez, Patricia, additional, Molina-Pineda, Andrea, additional, Cantón-Romero, Juan Carlos, additional, Martínez-Silva, María Guadalupe, additional, Jave-Suárez, Luis Felipe, additional, and Aguilar-Lemarroy, Adriana, additional

Published
2020
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39. Genetic variability in E6, E7 and L1 genes of Human Papillomavirus 62 and its prevalence in Mexico

Author

Artaza-Irigaray, Cristina, primary, Flores-Miramontes, María Guadalupe, additional, Olszewski, Dominik, additional, Magaña-Torres, María Teresa, additional, López-Cardona, María Guadalupe, additional, Leal-Herrera, Yelda Aurora, additional, Piña-Sánchez, Patricia, additional, Jave-Suárez, Luis Felipe, additional, and Aguilar-Lemarroy, Adriana, additional

Published
2017
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41. Asymmetric $$k$$ -Means Clustering of the Asymmetric Self-Organizing Map.

Author

Olszewski, Dominik

Subjects
K-means clustering, CLUSTER analysis (Statistics), MACHINE learning, CENTROID, MAPS
Abstract

An asymmetric approach to clustering of the asymmetric self-organizing map is proposed. The clustering is performed using an improved asymmetric version of the well-known $$k$$ -means algorithm. The improved asymmetric $$k$$ -means algorithm is the second proposal of this paper. As a result, we obtain a two-stage fully asymmetric data analysis technique. In this way, we maintain the methodological consistency of the both utilized methods, because they are both formulated in asymmetric versions, and consequently, they both properly adjust to asymmetric relationships in analyzed data. The results of our experiments on real data confirm the effectiveness of the proposed approach. [ABSTRACT FROM AUTHOR]

Published
2016
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43. κ-clustering for asymmetric dissimilarities.

Author

Olszewski, Dominik

Subjects
INFORMATION asymmetry, ALGORITHMS, CLUSTER analysis (Statistics), FEATURE extraction, NON-Euclidean geometry
Abstract

In this paper, an asymmetric version of the kcentroids clustering algorithm is proposed. The asymmetry arises from the use of the asymmetric dissimilarities in the k-centroids algorithm. Application of the asymmetric measures of dissimilarity is motivated by the basic nature of the k-centroids algorithm, which uses dissimilarities in the asymmetric manner. It finds the minimal dissimilarity between an object being currently allocated, and one of the clusters centroids. Clusters centroids are treated as the dominant points governing the asymmetric relationships in the entire cluster analysis. The results of the experimental study on real and simulated data have shown the superiority of the asymmetric dissimilarities employed for the κ-centroids method over their symmetric counterparts. [ABSTRACT FROM AUTHOR]

Published
2011

44. Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease

Author

Lang, Judith, Bohn, Patrick, Bhat, Hilal, Jastrow, Holger, Walkenfort, Bernd, Cansiz, Feyza, Fink, Julian, Bauer, Michael, Olszewski, Dominik, Ramos-Nascimento, Ana, Duhan, Vikas, Friedrich, Sarah-Kim, Becker, Katrin Anne, Krawczyk, Adalbert, Edwards, Michael J., Burchert, Andreas, Huber, Magdalena, Friebus-Kardash, Justa, Göthert, Joachim R., Hardt, Cornelia, Probst, Hans Christian, Schumacher, Fabian, Köhrer, Karl, Kleuser, Burkhard, Babiychuk, Eduard B., Sodeik, Beate, Seibel, Jürgen, Greber, Urs F., Lang, Philipp A., Gulbins, Erich, and Lang, Karl S.

Subjects
570 Life sciences, biology, 610 Medicine & health, 3. Good health

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