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The aims of this study were to compare the detection rates of gastrointestinal follicular lymphoma lesions by video capsule endoscopy (VCE) and double-balloon endoscopy (DBE), and to determine the pathologic diagnostic yields of DBE-directed biopsies. A total of 27 consecutive patients were enrolled. No significant difference in detection rateswas observed in 12 patients who underwent total enteroscopy at both VCE and DBE. Pathologic diagnostic yields stratified by location were 91% in the proximal duodenum at esophagogastroduodenoscopy, 88% in the jejunum at antegrade DBE, 52% in the ileum at retrograde DBE, and 57% in the terminal ileum at colonoscopy. VCE and DBE were helpful in determining treatment in 44% of patients. [ABSTRACT FROM AUTHOR]

Similarly, whilst most pancreatic cancer, including metastatic lesion has hypovascular pattern, metastatic tumours from Paget's disease has an isovascular pattern, suggesting that sweat gland adenocarcinoma may have a different contrast pattern from that of gastrointestinal adenocarcinoma. Endoscopic ultrasonography (EUS) showed hypoechoic masses in the head (Fig 1c) and body of the pancreas with irregular borders, unclear tumor boundaries, and relatively homogeneous internal echoes. Gastrointestinal: Pancreatic metastasis from extramammary Paget's disease diagnosed by endoscopic ultrasound-guided fine-needle biopsy. [Extracted from the article]

p27 is regarded as a cyclin-dependent kinase inhibitor of the G1-to-S cell cycle progression by suppressing the kinase activity of cyclin/cyclin-dependent kinase complex. This study aimed to investigate p27 expression in the normal endometrium and endometrioid adenocarcinoma of the uterine corpus and the correlation of its expression with cell proliferation and clinicopathological parameters. Tissue samples of 127 endometrioid adenocarcinomas and 15 normal endometria were used in the study. Immunohistochemical staining for detecting p27 and Ki-67 was performed by the labelled streptavidin-biotin method on formalin-fixed and paraffin-embedded tissue samples. The expression was given as the labelling index, which indicates the percentage of positive nuclei. p27 staining was observed in the nuclei of the glandular cells in the functional layer of the secretory phase endometrium, whereas it was negative in those of the proliferative phase. In endometrioid adenocarcinomas, the labelling index of p27 expression paradoxically increased more significantly in the higher histological grades and was correlated with that of Ki-67. The high level of p27 expression was associated with clinicopathological parameters such as FIGO stage, lymph node metastasis, lymphovascular space involvement and myometrial invasion. High p27 expression was linked to higher grades of endometrioid adenocarcinoma, cell proliferation and some clinical prognostic factors. These results indicate that p27 might be an indicator of poor prognosis. [ABSTRACT FROM AUTHOR]