Search

Your search keyword '"O'Connor, Christopher"' showing total 1,564 results
Start Over Author "O'Connor, Christopher" Search Limiters Academic (Peer-Reviewed) Journals
1,564 results on '"O'Connor, Christopher"'

12. Standardized Definitions for Evaluation of Acute Decompensated Heart Failure Therapies: HF-ARC Expert Panel Paper

Author

Lala, Anuradha, Hamo, Carine E., Bozkurt, Biykem, Fiuzat, Mona, Blumer, Vanessa, Bukhoff, Daniel, Butler, Javed, Costanzo, Maria Rosa, Felker, G. Michael, Filippatos, Gerasimos, Konstam, Marvin A., McMurray, John J.V., Mentz, Robert J., Metra, Marco, Psotka, Mitchell A., Solomon, Scott D., Teerlink, John, Abraham, William T., and O’Connor, Christopher M.

Published
2024
Full Text
View/download PDF

14. Sex-Related Differences in Patient Characteristics, Hemodynamics, and Outcomes of Cardiogenic Shock: INOVA-SHOCK Registry

Author

Epps, Kelly C., Tehrani, Behnam N., Rosner, Carolyn, Bagchi, Pramita, Cotugno, Annunziata, Damluji, Abdulla A., deFilippi, Christopher, Desai, Shashank, Ibrahim, Nasrien, Psotka, Mitchell, Raja, Anika, Sherwood, Matthew W., Singh, Ramesh, Sinha, Shashank S., Tang, Daniel, Truesdell, Alexander G., O’Connor, Christopher, and Batchelor, Wayne

Published
2023
Full Text
View/download PDF

19. Assessment of Biomarkers of Myocardial injury, Inflammation, and Renal Function in Heart Failure With Reduced Ejection Fraction: The VICTORIA Biomarker Substudy

Author

DEFILIPPI, CHRISTOPHER R., ALEMAYEHU, WENDIMAGEGN G., VOORS, ADRIAAN A., KAYE, DAVID, BLAUSTEIN, ROBERT O., BUTLER, JAVED, EZEKOWITZ, JUSTIN A., HERNANDEZ, ADRIAN F., LAM, CAROLYN S.P., ROESSIG, LOTHAR, SELIGER, STEPHEN, SHAH, PALAK, WESTERHOUT, CYNTHIA M., ARMSTRONG, PAUL W., and O'CONNOR, CHRISTOPHER M.

Published
2023
Full Text
View/download PDF

20. Background Medical Therapy and Clinical Outcomes From the VICTORIA Trial

Author

Ezekowitz, Justin A., McMullan, Ciaran J., Westerhout, Cynthia M., Piña, Ileana L., Lopez-Sendon, Jose, Anstrom, Kevin J., Hernandez, Adrian F., Lam, Carolyn S.P., O’Connor, Christopher M., Pieske, Burkert, Ponikowski, Piotr, Roessig, Lothar, Voors, Adriaan A., Koglin, Joerg, Armstrong, Paul W., and Butler, Javed

Published
2023
Full Text
View/download PDF

21. Functional and Symptomatic Clinical Trial Endpoints: The HFC-ARC Scientific Expert Panel

Author

Psotka, Mitchell A., Abraham, William T., Fiuzat, Mona, Filippatos, Gerasimos, Lindenfeld, JoAnn, Ahmad, Tariq, Felker, G. Michael, Jacob, Richard, Kitzman, Dalane W., Leifer, Eric S., Lewis, Eldrin F., Mentz, Robert J., Nkulikiyinka, Richard, Ni, Wei, Schaber, Daniel E., Sharma, Abhinav, Solomon, Scott D., Stockbridge, Norman, Teerlink, John R., Unger, Ellis F., Whellan, David J., Wittes, Janet, Anker, Stefan D., and O’Connor, Christopher M.

Published
2022
Full Text
View/download PDF

22. Optimal medical therapy with or without surgical revascularization and long-term outcomes in ischemic cardiomyopathy

Author

Dabrowski, Rafal, Djokovic, Ljubomir, Drazner, Mark, Haddad, Haissam, Ali, Imtiaz S., Keltai, Matyas, Naik, Ajay, Sopko, George, Golba, Krzysztof, Andersson, Bert, Carson, Peter, Kukulski, Tomasz, Farsky, Pedro S., White, Jennifer, Al-Khalidi, Hussein R., Sueta, Carla A., Rouleau, Jean L., Panza, Julio A., Velazquez, Eric J., and O'Connor, Christopher M.

Published
2022
Full Text
View/download PDF

23. A Standardized and Regionalized Network of Care for Cardiogenic Shock

Author

Tehrani, Behnam N., Sherwood, Matthew W., Rosner, Carolyn, Truesdell, Alexander G., Ben Lee, Seiyon, Damluji, Abdulla A., Desai, Mehul, Desai, Shashank, Epps, Kelly C., Flanagan, Michael C., Howard, Edward, Ibrahim, Nasrien, Kennedy, Jamie, Moukhachen, Hala, Psotka, Mitchell, Raja, Anika, Saeed, Ibrahim, Shah, Palak, Singh, Ramesh, Sinha, Shashank S., Tang, Daniel, Welch, Timothy, Young, Karl, deFilippi, Christopher R., Speir, Alan, O’Connor, Christopher M., and Batchelor, Wayne B.

Published
2022
Full Text
View/download PDF

27. Elucidating the water–anatase TiO2(101) interface structure using infrared signatures and molecular dynamics.

Author

O'Connor, Christopher R., Calegari Andrade, Marcos F., Selloni, Annabella, and Kimmel, Greg A.

Subjects
*MOLECULAR dynamics, *INTERFACE structures, *HYDROGEN bonding, *INFRARED spectroscopy, *MONOMOLECULAR films, *ATOMS
Abstract

The structure and dynamics of water on solid surfaces critically affect the chemistry of materials in ambient and aqueous environments. Here, we investigate the hydrogen bonding network of water adsorbed on the majority (101) surface of anatase TiO2, a widely used photocatalyst, using polarization- and azimuth-resolved infrared spectroscopy combined with neural network potential molecular dynamics simulations. Our results show that one monolayer of water saturates the undercoordinated titanium (Ti5c) sites, forming one-dimensional chains of molecule hydrogen bonded to surface undercoordinated bridging oxygen (O2c) atoms. As the coverage increases, water adsorption on O2c sites leads to significant restructuring of the water monolayer and the formation of a two-dimensional hydrogen bond network characterized by tightly bound pairs of water molecules on adjacent Ti5c and O2c sites. This structural motif likely persists at ambient conditions, influencing the reactions occurring there. The results reported here provide critical details of the structure of the water–anatase (101) interface that were previously hypothesized but unconfirmed experimentally. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

32. Dose-limiting, adverse event–associated bradycardia with β-blocker treatment of atrial fibrillation in the GENETIC-AF trial

Author

Abraham, William T., Piccini, Jonathan P., Dufton, Christopher, Carroll, Ian A., Healey, Jeffrey S., O’Connor, Christopher M., Marshall, Debra, Aleong, Ryan, van Veldhuisen, Dirk J., Rienstra, Michiel, Wilton, Stephen B., White, Michel, Sauer, William H., Anand, Inder S., Huebler, Sophia P., Connolly, Stuart J., and Bristow, Michael R.

Published
2022
Full Text
View/download PDF

34. A well-defined supported Pt nanoparticle catalyst for heterogeneous catalytic surface science.

Author

Kim, Taek-Seung, O'Connor, Christopher R., Le, Samantha L., and Reece, Christian

Abstract

Our ability to rationalise the activity of heterogeneous catalytic materials relies on a precise understanding of both the structure and composition of the catalyst under reaction conditions to resolve active sites. Their highly dynamic nature means that catalysis suffers from an observer effect, where the act of measuring activity and/or structure will modify the structure itself. Herein, we present a well-defined catalyst consisting of 2 nm Pt nanoparticles supported on SiO2 that can be dynamically modified and regenerated without irreversibly changing the underlying structure or activity of the catalyst. Using in situ diffuse reflectance infrared Fourier transform spectroscopy and transmission electron microscopy we identify that the catalyst is resistant to oxidative and reductive treatments, but irreversibly restructures in reactive environments (CO + O2) at moderate pressures and temperatures. We show that by using transient pressure pulse experiments it is possible to minimise the restructuring in reactive environments, which when coupled with kinetic modelling can be used to identify site and state dependent activity while simultaneously quantifying the number of active sites. The well-defined nature of this 2 nm Pt/SiO2 catalyst means it can be utilised to gain molecular insight into catalytic processes and act as a new material for use in heterogeneous catalytic surface science. Further, the rapid restructuring of the catalyst during CO oxidation demonstrates that it is not a benign characterisation tool for comparison of catalysts. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. The Impact of Depression on Outcomes in Patients With Heart Failure and Reduced Ejection Fraction Treated in the GUIDE-IT Trial

Author

CHOUAIRI, FOUAD, FUERY, MICHAEL A., MULLAN, CLANCY W., CARABALLO, CESAR, SEN, SOUNOK, MAULION, CHRISTOPHER, WILKINSON, SAMUEL T., SURTI, TORAL, MCCULLOUGH, MEGAN, MILLER, P. ELLIOTT, PACOR, JUSTIN, LEIFER, ERIC S., FELKER, G. MICHAEL, VELAZQUEZ, ERIC J., FIUZAT, MONA, O'CONNOR, CHRISTOPHER M., JANUZZI, JAMES L, DESAI, NIHAR R., and AHMAD, TARIQ

Published
2021
Full Text
View/download PDF

45. Intercountry Differences in Guideline-Directed Medical Therapy and Outcomes Among Patients With Heart Failure

Author

Fuery, Michael A., Chouairi, Fouad, Januzzi, James L., Moe, Gordon W., Caraballo, Cesar, McCullough, Megan, Miller, P. Elliott, Reinhardt, Samuel W., Clark, Katherine, Oseran, Andrew, Milner, Aidan, Pacor, Justin, Kahn, Peter A., Singh, Avinainder, Ravindra, Neal, Guha, Avirup, Vadlamani, Lina, Kulkarni, Neeti S., Fiuzat, Mona, Felker, G. Michael, O’Connor, Christopher M., Ahmad, Tariq, Ezekowitz, Justin, and Desai, Nihar R.

Published
2021
Full Text
View/download PDF

46. SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes

Author

Schaub, Jennifer A., AlAkwaa, Fadhl M., McCown, Phillip J., Naik, Abhijit S., Nair, Viji, Eddy, Sean, Menon, Rajasree, Otto, Edgar A., Demeke, Dawit, Hartman, John, Fermin, Damian, O'Connor, Christopher L., Subramanian, Lalita, Bitzer, Markus, Harned, Roger, Ladd, Patricia, Pyle, Laura, Pennathur, Subramaniam, Inoki, Ken, Hodgin, Jeffrey B., Brosius, Frank C., III, Nelson, Robert G., Kretzler, Matthias, and Bjornstad, Petter

Subjects
Hypoglycemic agents -- Usage -- Physiological aspects, Type 2 diabetes -- Drug therapy -- Complications and side effects, Pediatric research, Diabetic nephropathies -- Risk factors -- Development and progression -- Prevention, Health care industry
Abstract

The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometric data were collected from research kidney biopsies donated by young persons with type 2 diabetes (T2D), aged 12 to 21 years, and healthy controls (HCs). Participants with T2D were obese and had higher estimated glomerular filtration rates and mesangial and glomerular volumes than HCs. Ten T2D participants had been prescribed SGLT2i (T2Di[+]) and 6 not (T2Di[-]). Transcriptional profiles showed SGLT2 expression exclusively in the proximal tubular (PT) cluster with highest expression in T2Di(-) patients. However, transcriptional alterations with SGLT2i treatment were seen across nephron segments, particularly in the distal nephron. SGLT2i treatment was associated with suppression of transcripts in the glycolysis, gluconeogenesis, and tricarboxylic acid cycle pathways in PT, but had the opposite effect in thick ascending limb. Transcripts in the energy-sensitive mTORC1-signaling pathway returned toward HC levels in all tubular segments in T2Di(+), consistent with a diabetes mouse model treated with SGLT2i. Decreased levels of phosphorylated S6 protein in proximal and distal tubules in T2Di(+) patients confirmed changes in mTORC1 pathway activity. We propose that SGLT2i treatment benefits the kidneys by mitigating diabetes-induced metabolic perturbations via suppression of mTORC1 signaling in kidney tubules., Introduction The incedence of youth-onset type 2 diabetes (T2D) is rapidly rising among children and adolescents globally (1). It is associated with a more severe clinical course than youth-onset type [...]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results