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381 results on '"Nakagawa, Masahiro"'

3. Evolutionary histories of breast cancer and related clones

Author

Nishimura, Tomomi, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Sakurai, Takaki, Kataoka, Tatsuki R., Kondoh, Eiji, Chigusa, Yoshitsugu, Kawai, Masahiko, Sawada, Morio, Inoue, Takuya, Takeuchi, Yasuhide, Maeda, Hirona, Baba, Satoko, Shiozawa, Yusuke, Saiki, Ryunosuke, Nakagawa, Masahiro M., Nannya, Yasuhito, Ochi, Yotaro, Hirano, Tomonori, Nakagawa, Tomoe, Inagaki-Kawata, Yukiko, Aoki, Kosuke, Hirata, Masahiro, Nanki, Kosaku, Matano, Mami, Saito, Megumu, Suzuki, Eiji, Takada, Masahiro, Kawashima, Masahiro, Kawaguchi, Kosuke, Chiba, Kenichi, Shiraishi, Yuichi, Takita, Junko, Miyano, Satoru, Mandai, Masaki, Sato, Toshiro, Takeuchi, Kengo, Haga, Hironori, Toi, Masakazu, and Ogawa, Seishi

Published
2023
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4. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Author

Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, and Seno, Hiroshi

Published
2023
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7. Summary of Japanese clinical practice guidelines for head and neck cancer - 2022 update edited by the Japan society for head and neck cancer

Author

Homma, Akihiro, Ando, Mizuo, Hanai, Nobuhiro, Harada, Hiroyuki, Honma, Yoshitaka, Kanda, Tomonori, Kano, Satoshi, Kawakita, Daisuke, Kiyota, Naomi, Kizawa, Yoshiyuki, Nakagawa, Masahiro, Ogawa, Takenori, Shinomiya, Hirotaka, Shinozaki, Takeshi, Suzuki, Motoyuki, Tsuji, Tetsuya, Yasuda, Koichi, Zenda, Sadamoto, Kodaira, Takeshi, Kirita, Tadaaki, and Nibu, Ken-ichi

Published
2024
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8. Potential for expanding indications and curability criteria of endoscopic resection for early gastric cancer in elderly patients: results from a Japanese multicenter prospective cohort study

Author

Sekiguchi, Masau, Suzuki, Haruhisa, Takizawa, Kohei, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Toya, Yosuke, Nakagawa, Masahiro, Toyonaga, Takashi, Takemura, Kenichi, Hirasawa, Kingo, Matsuda, Mitsuru, Yamamoto, Hironori, Tsuji, Yosuke, Hashimoto, Satoru, Maeda, Yuki, Oyama, Tsuneo, Takenaka, Ryuta, Yamamoto, Yoshinobu, Shimazu, Taichi, Ono, Hiroyuki, Tanabe, Satoshi, Kondo, Hitoshi, Iishi, Hiroyasu, Ninomiya, Motoki, and Oda, Ichiro

Published
2024
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9. Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, and Ogawa, Seishi

Published
2023
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10. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Mashimo, Yumi, Ishigooka, Masahiro, Fukase, Kazutoshi, Mizuguchi, Yasuhiko, Suzuki, Haruhisa, Ono, Hiroyuki, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Toya, Yosuke, Nakagawa, Masahiro, Toyonaga, Takashi, Takemura, Kenichi, Hirasawa, Kingo, Matsuda, Mitsuru, Yamamoto, Hironori, Tsuji, Yosuke, Hashimoto, Satoru, Yuki, Maeda, Oyama, Tsuneo, Takenaka, Ryuta, Yamamoto, Yoshinobu, Naito, Yuji, Yamamoto, Katsumi, Kobayashi, Nozomu, Kawahara, Yoshiro, Hirano, Masaaki, Koizumi, Shigeto, Hori, Shinichiro, Tajika, Masahiro, Hikichi, Takuto, Yao, Kenshi, Yokoi, Chizu, Ohnita, Ken, Hisanaga, Yasuhiro, Sumiyoshi, Tetsuya, Kitamura, Shinji, Tanaka, Hisao, Shimoda, Ryo, Shimazu, Taichi, Takizawa, Kohei, Tanabe, Satoshi, Kondo, Hitoshi, Iishi, Hiroyasu, Ninomiya, Motoki, and Oda, Ichiro

Published
2023
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15. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Kanzaki, Hiromitsu, Inoue, Shuntaro, Miyake, Muneaki, Ohmori, Masayasu, Takeuchi, Yoji, Tani, Yasuhiro, Harada, Nobuyuki, Agatsuma, Nobukazu, Okada, Keijirou, Ikenouchi, Maiko, Nakatani, Yasuki, Uenoyama, Yoshito, Yamashita, Yukitaka, Ishikawa, Shigenao, Inaba, Tomoki, Miyahara, Koji, Moritou, Yuki, Nakagawa, Masahiro, Kitae, Hiroaki, Ishida, Tsugitaka, Naito, Yuji, Nishio, Akiyoshi, Shimatani, Masaaki, Kato, Ryo, Taki, Shinya, Mandai, Koichiro, Sanada, Kasumi, Nakase, Kojiro, Nebiki, Hiroko, Saito, Shunsuke, Wakatsuki, Toshiyuki, Nishimura, Naoyuki, Yamasaki, Yasushi, Uedo, Noriya, Akamatsu, Takuji, Kagawa, Tomo, Higashi, Reiji, Dohi, Osamu, Furukawa, Masanori, Takahashi, Yu, Inoue, Takuya, Tanaka, Shouichi, Takenaka, Ryuta, Iguchi, Mikitaka, Kawamura, Takuji, Tsuzuki, Takao, Yamasaki, Tomoaki, Yamashina, Takeshi, Nasu, Junichiro, Mannami, Tomohiko, Yamauchi, Atsushi, Matsueda, Kazuhiro, Aizawa, Shigeyuki, Mitsuhashi, Toshiharu, and Okada, Hiroyuki

Published
2022
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19. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Author

Makishima, Hideki, Saiki, Ryunosuke, Nannya, Yasuhito, Korotev, Sophia, Gurnari, Carmelo, Takeda, June, Momozawa, Yukihide, Best, Steve, Krishnamurthy, Pramila, Yoshizato, Tetsuichi, Atsuta, Yoshiko, Shiozawa, Yusuke, Iijima-Yamashita, Yuka, Yoshida, Kenichi, Shiraishi, Yuichi, Nagata, Yasunobu, Kakiuchi, Nobuyuki, Onizuka, Makoto, Chiba, Kenichi, Tanaka, Hiroko, Kon, Ayana, Ochi, Yotaro, Nakagawa, Masahiro M., Okuda, Rurika, Mori, Takuto, Yoda, Akinori, Itonaga, Hidehiro, Miyazaki, Yasushi, Sanada, Masashi, Ishikawa, Takayuki, Chiba, Shigeru, Tsurumi, Hisashi, Kasahara, Senji, Muller-Tidow, Carsten, Takaori-Kondo, Akifumi, Ohyashiki, Kazuma, Kiguchi, Toru, Matsuda, Fumihiko, Jansen, Joop H., Polprasert, Chantana, Blombery, Piers, Kamatani, Yoichiro, Miyano, Satoru, Malcovati, Luca, Haferlach, Torsten, Kubo, Michiaki, Cazzola, Mario, Kulasekararaj, Austin G., Godley, Lucy A., Maciejewski, Jaroslaw P., and Ogawa, Seishi

Published
2022
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20. Risk factors for intraoperative and delayed perforation related with gastric endoscopic submucosal dissection.

Author

Mimura, Takuya, Yamamoto, Yoshinobu, Suzuki, Haruhisa, Takizawa, Kohei, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Kudara, Norihiko, Nakagawa, Masahiro, Mashimo, Yumi, Ishigooka, Masahiro, Fukase, Kazutoshi, Shimazu, Taichi, Ono, Hiroyuki, Tanabe, Satoshi, Kondo, Hitoshi, and Iishi, Hiroyasu

Subjects
ENDOSCOPIC surgery, BODY mass index, SURGICAL emergencies, DISSECTION, LONGITUDINAL method, STOMACH cancer, INTESTINAL perforation
Abstract

Background and Aim: Perforation is one of the most important complications of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Several studies have examined risk factors for intraoperative and delayed perforations, but most were retrospective analyses with small numbers of patients. Methods: This study represents a secondary analysis of a Japanese multicenter prospective cohort study. We investigated the factors associated with each type of perforation using 9015 patients with 9975 EGCs undergoing ESD between July 2010 and June 2012. Results: Intraoperative perforation occurred in 198 patients (2.2%) with 203 lesions (2.0%), necessitating emergency surgery for four lesions (0.04% [2.0%, 4/203]). Delayed perforation occurred in another 37 patients (0.4%) with 42 lesions (0.4%), requiring emergency surgery for 12 lesions (0.12% [28.6%, 12/42]). Factors showing significant independent correlations with intraoperative perforation were upper or middle third of the stomach; remnant stomach or gastric tube; procedure time ≥100 min; tumor size >35 mm; body mass index (BMI) < 18.5 kg/m2; and ≥72 years. Factors showing significant independent correlations with delayed perforation were procedure time ≥60 min; BMI < 18.5 kg/m2; ≥75 years; ulceration; and tumor size >20 mm. Intraoperative perforation occurred most frequently at the greater curvature in the upper third of the stomach (7.9%), whereas delayed perforation occurred most frequently at the greater curvature in the middle third (1.2%). Conclusion: This multicenter prospective cohort study clarified the risk and risk factors of intraoperative and delayed perforation related to ESD for EGCs, providing information to help endoscopists reduce perforation. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis

Author

Saiki, Ryunosuke, Momozawa, Yukihide, Nannya, Yasuhito, Nakagawa, Masahiro M., Ochi, Yotaro, Yoshizato, Tetsuichi, Terao, Chikashi, Kuroda, Yutaka, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Niida, Atsushi, Imoto, Seiya, Matsuda, Koichi, Morisaki, Takayuki, and Murakami, Yoshinori

Subjects
Medical research, Medicine, Experimental, Hematopoiesis -- Research, Myeloproliferative disorders -- Genetic aspects -- Development and progression -- Risk factors, Single nucleotide polymorphisms -- Research, Cardiovascular diseases -- Genetic aspects -- Development and progression -- Risk factors, Cancer -- Genetic aspects -- Development and progression -- Risk factors, Copy number variations -- Research, Biological sciences, Health
Abstract

Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases. Previous studies of CH analyzed either single-nucleotide variants and indels (SNVs/indels) or copy number alterations (CNAs), but not both. Here, using a combination of targeted sequencing of 23 CH-related genes and array-based CNA detection of blood-derived DNA, we have delineated the landscape of CH-related SNVs/indels and CNAs in 11,234 individuals without HM from the BioBank Japan cohort, including 672 individuals with subsequent HM development, and studied the effects of these somatic alterations on mortality from HM and cardiovascular disease, as well as on hematological and cardiovascular phenotypes. The total number of both types of CH-related lesions and their clone size positively correlated with blood count abnormalities and mortality from HM. CH-related SNVs/indels and CNAs exhibited statistically significant co-occurrence in the same individuals. In particular, co-occurrence of SNVs/indels and CNAs affecting DNMT3A, TET2, JAK2 and TP53 resulted in biallelic alterations of these genes and was associated with higher HM mortality. Co-occurrence of SNVs/indels and CNAs also modulated risks for cardiovascular mortality. These findings highlight the importance of detecting both SNVs/indels and CNAs in the evaluation of CH. Analysis of single-nucleotide variants and copy number alterations gives a more complete picture of clonal hematopoiesis and its impact on hematological malignancy and cardiovascular disease., Author(s): Ryunosuke Saiki [sup.1] , Yukihide Momozawa [sup.2] , Yasuhito Nannya [sup.1] , Masahiro M. Nakagawa [sup.1] [sup.3] , Yotaro Ochi [sup.1] , Tetsuichi Yoshizato [sup.1] , Chikashi Terao [sup.4] [...]

Published
2021
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25. Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia

Author

Ueno, Hiroo, Yoshida, Kenichi, Shiozawa, Yusuke, Nannya, Yasuhito, Iijima-Yamashita, Yuka, Kiyokawa, Nobutaka, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Isobe, Tomoya, Seki, Masafumi, Kimura, Shunsuke, Makishima, Hideki, Nakagawa, Masahiro M., Kakiuchi, Nobuyuki, Kataoka, Keisuke, Yoshizato, Tetsuichi, Nishijima, Dai, Deguchi, Takao, Ohki, Kentaro, Sato, Atsushi, Takahashi, Hiroyuki, Hashii, Yoshiko, Tokimasa, Sadao, Hara, Junichi, Kosaka, Yoshiyuki, Kato, Koji, Inukai, Takeshi, Takita, Junko, Imamura, Toshihiko, Miyano, Satoru, Manabe, Atsushi, Horibe, Keizo, Ogawa, Seishi, and Sanada, Masashi

Published
2020
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27. Long-term outcomes after non-curative endoscopic submucosal dissection for early gastric cancer according to hospital volumes in Japan: a multicenter propensity-matched analysis

Author

Dohi, Osamu, Hatta, Waku, Gotoda, Takuji, Naito, Yuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Oka, Shiro, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Shimoda, Ryo, Yoshida, Motoyuki, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Aoyagi, Hiroyuki, and Shimosegawa, Tooru

Published
2019
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28. Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling

Author

Watatani, Yosaku, Sato, Yasuharu, Miyoshi, Hiroaki, Sakamoto, Kana, Nishida, Kenji, Gion, Yuka, Nagata, Yasunobu, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Zhao, Lanying, Ochi, Yotaro, Takeuchi, Yasuhide, Takeda, June, Ueno, Hiroo, Kogure, Yasunori, Shiozawa, Yusuke, Kakiuchi, Nobuyuki, Yoshizato, Tetsuichi, Nakagawa, Masahiro M., Nanya, Yasuhito, Yoshida, Kenichi, Makishima, Hideki, Sanada, Masashi, Sakata-Yanagimoto, Mamiko, Chiba, Shigeru, Matsuoka, Ryota, Noguchi, Masayuki, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Kitagawa, Junichi, Nakamura, Nobuhiko, Tsurumi, Hisashi, Miyazaki, Tatsuhiko, Kito, Yusuke, Miyano, Satoru, Shimoda, Kazuya, Takeuchi, Kengo, Ohshima, Koichi, Yoshino, Tadashi, Ogawa, Seishi, and Kataoka, Keisuke

Published
2019
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29. Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer?

Author

Hatta, Waku, Gotoda, Takuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Oka, Shiro, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Shimoda, Ryo, Yoshida, Motoyuki, Dohi, Osamu, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Aoyagi, Hiroyuki, Nakamura, Tomohiro, Nakaya, Naoki, Shimosegawa, Tooru, and Masamune, Atsushi

Published
2019
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33. Molecular pathogenesis of disease progression in MLL-rearranged AML

Author

Kotani, Shinichi, Yoda, Akinori, Kon, Ayana, Kataoka, Keisuke, Ochi, Yotaro, Shiozawa, Yusuke, Hirsch, Cassandra, Takeda, June, Ueno, Hiroo, Yoshizato, Tetsuichi, Yoshida, Kenichi, Nakagawa, Masahiro M., Nannya, Yasuhito, Kakiuchi, Nobuyuki, Yamauchi, Takuji, Aoki, Kosuke, Shiraishi, Yuichi, Miyano, Satoru, Maeda, Takahiro, Maciejewski, Jaroslaw P., Takaori-Kondo, Akifumi, Ogawa, Seishi, and Makishima, Hideki

Published
2019
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34. Age-related remodelling of oesophageal epithelia by mutated cancer drivers

Author

Yokoyama, Akira, Kakiuchi, Nobuyuki, Yoshizato, Tetsuichi, Nannya, Yasuhito, Suzuki, Hiromichi, Takeuchi, Yasuhide, Shiozawa, Yusuke, Sato, Yusuke, Aoki, Kosuke, Kim, Soo Ki, Fujii, Yoichi, Yoshida, Kenichi, Kataoka, Keisuke, Nakagawa, Masahiro M., Inoue, Yoshikage, Hirano, Tomonori, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Nishikawa, Yoshitaka, Amanuma, Yusuke, Ohashi, Shinya, Aoyama, Ikuo, Horimatsu, Takahiro, Miyamoto, Shin’ichi, Tsunoda, Shigeru, Sakai, Yoshiharu, Narahara, Maiko, Brown, J. B., Sato, Yoshitaka, Sawada, Genta, Mimori, Koshi, Minamiguchi, Sachiko, Haga, Hironori, Seno, Hiroshi, Miyano, Satoru, Makishima, Hideki, Muto, Manabu, and Ogawa, Seishi

Published
2019
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35. Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation

Author

Yoshizato, Tetsuichi, Nannya, Yasuhito, Atsuta, Yoshiko, Shiozawa, Yusuke, Iijima-Yamashita, Yuka, Yoshida, Kenichi, Shiraishi, Yuichi, Suzuki, Hiromichi, Nagata, Yasunobu, Sato, Yusuke, Kakiuchi, Nobuyuki, Matsuo, Keitaro, Onizuka, Makoto, Kataoka, Keisuke, Chiba, Kenichi, Tanaka, Hiroko, Ueno, Hiroo, Nakagawa, Masahiro M., Przychodzen, Bartlomiej, Haferlach, Claudia, Kern, Wolfgang, Aoki, Kosuke, Itonaga, Hidehiro, Kanda, Yoshinobu, Sekeres, Mikkael A., Maciejewski, Jaroslaw P., Haferlach, Torsten, Miyazaki, Yasushi, Horibe, Keizo, Sanada, Masashi, Miyano, Satoru, Makishima, Hideki, and Ogawa, Seishi

Published
2017
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37. Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study

Author

Hatta, Waku, Gotoda, Takuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Yoshifuku, Yoshikazu, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Yamanouchi, Kohei, Yoshida, Motoyuki, Dohi, Osamu, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Hayashi, Yoshiaki, Nakamura, Tomohiro, Nakaya, Naoki, and Shimosegawa, Tooru

Published
2018
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38. Survival Benefit of Additional Surgery After Non-curative Endoscopic Submucosal Dissection for Early Gastric Cancer: A Propensity Score Matching Analysis

Author

Suzuki, Sho, Gotoda, Takuji, Hatta, Waku, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Yoshifuku, Yoshikazu, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Yamanouchi, Kohei, Yoshida, Motoyuki, Dohi, Osamu, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Hayashi, Yoshiaki, and Shimosegawa, Tooru

Published
2017
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41. Long-term oncological outcomes of submucosal manipulation during non-curative endoscopic submucosal dissection for submucosal invasive gastric cancer: a multicenter retrospective study in Japan

Author

Ito, Hirotaka, Gotoda, Takuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Yoshifuku, Yoshikazu, Hoteya, Shu, Nakagawa, Masahiro, Hatta, Waku, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Shimoda, Ryo, Yoshida, Motoyuki, Dohi, Osamu, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Hayashi, Yoshiaki, Nakaya, Naoki, Nakamura, Tomohiro, and Shimosegawa, Tooru

Published
2017
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43. Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

Author

Kono, Yoshiyasu, Matsubara, Minoru, Toyokawa, Tatsuya, Takenaka, Ryuta, Suzuki, Seiyu, Nasu, Junichirou, Yoshioka, Masao, Nakagawa, Masahiro, Mizuno, Motowo, Sakae, Hiroyuki, Abe, Makoto, Gotoda, Tatsuhiro, Miura, Ko, Kanzaki, Hiromitsu, Iwamuro, Masaya, Hori, Keisuke, Tsuzuki, Takao, Kita, Masahide, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Published
2017
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47. Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling.

Author

Yogo, Akitada, Masui, Toshihiko, Takaishi, Shigeo, Masuo, Kenji, Chen, Ru, Kasai, Yosuke, Nagai, Kazuyuki, Anazawa, Takayuki, Watanabe, Sadanori, Sakamoto, Satoko, Watanabe, Akira, Inagaki, Ryosaku, Nakagawa, Masahiro M., Ogawa, Seishi, Seno, Hiroshi, Uemoto, Shinji, and Hatano, Etsuro

Abstract

Bile duct cancer (BDC) frequently invades the nerve fibers, making complete surgical resection difficult. A single tumor mass contains cells of variable malignancy and cell‐differentiation states, with cancer stem cells (CSCs) considered responsible for poor clinical outcomes. This study aimed to investigate the contribution of autosynthesized dopamine to CSC‐related properties in BDC. Sphere formation assays using 13 commercially available BDC cell lines demonstrated that blocking dopamine receptor D1 (DRD1) signaling promoted CSC‐related anchorage‐independent growth. Additionally, we newly established four new BDC patient‐derived organoids (PDOs) and found that blocking DRD1 increased resistance to chemotherapy and enabled xenotransplantation in vivo. Single‐cell analysis revealed that the BDC PDO cells varied in their cell‐differentiation states and responses to dopamine signaling. Further, DRD1 inhibition increased WNT7B expression in cells with bile duct‐like phenotype, and it induced proliferation of other cell types expressing Wnt receptors and stem cell‐like signatures. Reagents that inhibited Wnt function canceled the effect of DRD1 inhibition and reduced cell proliferation in BDC PDOs. In summary, in BDCs, DRD1 is a crucial protein involved in autonomous CSC proliferation through the regulation of endogenous WNT7B. As such, inhibition of the DRD1 feedback signaling may be a potential treatment strategy for BDC. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Efficacy and feasibility of docetaxel, cisplatin, and 5-fluorouracil induction chemotherapy for locally advanced head and neck squamous cell carcinoma classified as clinical nodal stage N2c, N3, or N2b with supraclavicular lymph node metastases

Author

Izawa, Naoki, Onozawa, Yusuke, Hikosaka, Tomomi, Hamauchi, Satoshi, Tsushima, Takahiro, Todaka, Akiko, Machida, Nozomu, Haraguchi, Yutaka, Ogawa, Hirofumi, Nishimura, Tetsuo, Nakagawa, Masahiro, Fuke, Tomohito, Iida, Yoshiyuki, Kamijo, Tomoyuki, Onitsuka, Tetsuro, Boku, Narikazu, Yasui, Hirofumi, and Yokota, Tomoya

Published
2015
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