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690 results on '"Muñoz, F."'

18. Genetic diversity and geographical genetic diversity in Colombian accessions of Lippia alba (Mill.) N.E. Brown

Author

José Omar Cardona M. and Jaime Eduardo Muñoz F.

Subjects
anthropochory, gd-ggd, mantel analysis, verbena complex, ram, a-2x dna protocol extraction, Agriculture, Agriculture (General), S1-972
Abstract

Bushy matgrass (Lippia alba, Verbenaceae) is a promising plant genetic resource, by their active compounds. The present document studied the molecular genetic diversity and spatial genetic structure of two contrasting populations of L. alba in Colombia. Eight RAM, evaluated total DNA of 59 accessions of non-cultivated plants collected in two Colombia regions, Chicamocha and Sumapaz. The expected average heterozygosity (or average heterozygosity genetic diversity of Nei) for the sample had low value (0.0≤He=0.2467≤0.5). The values of molecular diversity (MD) indicated values in the range of 0.1219 to 0.3425 for seven RAM. The frequency of variants is based on an effective number of alleles [Ae] and expected heterozygosity [He], genetic diversity by locus (hj=1-p2-q2) had maximum values (near 0.5) in the primers ACA, AG, CGA, and CEC. RAM suitably analyzed Lippia alba as an endemic genetic resource. A DNA bank composed of 59 Colombian accessions from Lippia alba was set up. The analysis of the spatial global structure shows that the subpopulation Sumapaz is structured, whilst the subpopulation Chicamocha, is in the structuring process. The results suggest in all cases the need for implementing: a) exchange of gene-seed, (b) gene banks with maximum genetic variability and c) induce genetic diversity.

Published
2019
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27. Assessing the impact on intestinal microbiome and clinical outcomes of antibiotherapy optimisation strategies in haematopoietic stem cell transplant recipients: study protocol for the prospective multicentre OptimBioma study

Author

Lucrecia Yáñez, Silvia Jiménez-Jorge, Clara M Rosso-Fernández, Gema Labrador-Herrera, Nancy Rodríguez-Torres, María Eugenia Pachón-Ibáñez, Younes Smani, Francisco José Márquez-Malaver, Carmen Limón Ramos, Carlos Solano, Lourdes Vázquez-López, Mi Kwon, Joan Manuel Mora Barrios, Manuela Aguilar-Guisado, Ildefonso Espigado, Ariadna Pérez Martínez, Peña-Muñoz F, and Rebeca Bailen Almorox

Subjects
Medicine
Abstract

Introduction Haematopoietic stem cell transplantation (HSCT) is a life-saving treatment for a number of haematological diseases. Graft versus host disease (GVHD) is its main complication and hampers survival. There is strong evidence that intestinal microbiota diversity of the recipient may increase the risk of GVHD worsening survival. Antibiotic regimens used during the early phase of the transplant may influence clinical outcomes by reducing intestinal microbiota diversity. Present guidelines of European Conference on Infections in Leukaemia exhort to optimising antibiotic use in haematological patients including HSCT recipients. The present study aims to investigate if, in HSCT recipients, the optimisation of antibacterial use may preserve intestinal microbiota composition reducing the incidence and severity of acute GVHD and improving relevant clinical outcomes.Methods and analysis This is a prospective longitudinal observational study of two cohorts of HSCT recipients: (1) the intervention cohort includes patients treated in centres in which a predefined strategy of antibiotherapy optimisation is implemented, with the objective of optimising and reducing antibiotic administration according to clinical criteria and (2) the control cohort includes patients treated in centres in which a classic permissive strategy of antibiotic prophylaxis and treatment is used. Adult patient receiving a first HSCT as a treatment for any haematological condition are included. Clinical variables are prospectively recorded and up to five faecal samples are collected for microbiota characterisation at prestablished peritransplant time points. Patients are followed since the preconditioning phase throughout 1-year post-transplant and four follow-up visits are scheduled. Faecal microbiota composition and diversity will be compared between both cohorts along with acute GVHD incidence and severity, severe infections rate, mortality and overall and disease-free survival.Ethics and dissemination The study was approved between 2017 and 2018 by the Ethical Committees of participant centres. Study results will be disseminated through peer-reviewed journals and national and international scientific conferences.Trial registration number NCT03727113

Published
2020
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31. Oral immunotherapy for food allergy: A Spanish guideline. Egg and milk immunotherapy Spanish guide (ITEMS GUIDE). Part 2: Maintenance phase of cow milk (CM) and egg oral immunotherapy (OIT), special treatment dosing schedules. Models of dosing schedules of OIT with CM and EGG

Author

Martorell, A., Alonso, E., Echeverría, L., Escudero, C., García-Rodríguez, R., Blasco, C., Bone, J., Borja-Segade, J., Bracamonte, T., Claver, A., Corzo, J.L., De la Hoz, B., Del Olmo, R., Dominguez, O., Fuentes-Aparicio, V., Guallar, I., Larramona, H., Martín-Muñoz, F., Matheu, V., Michavila, A., Ojeda, I., Ojeda, P., Piquer, M., Poza, P., Reche, M., Río, P. Rodríguez del, Rodríguez, M., Ruano, F., Sánchez-García, S., Terrados, S., Valdesoiro, L., and Vazquez-Ortiz, M.

Published
2017
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33. Oral immunotherapy for food allergy: A Spanish guideline. Immunotherapy egg and milk Spanish guide (items guide). Part I: Cow milk and egg oral immunotherapy: Introduction, methodology, rationale, current state, indications contraindications and oral immunotherapy build-up phase

Author

Martorell, A., Alonso, E., Echeverría, L., Escudero, C., García-Rodríguez, R., Blasco, C., Bone, J., Borja-Segade, J., Bracamonte, T., Claver, A., Corzo, J.L., De la Hoz, B., Del Olmo, R., Dominguez, O., Fuentes-Aparicio, V., Guallar, I., Larramona, H., Martín-Muñoz, F., Matheu, V., Michavila, A., Ojeda, I., Ojeda, P., Piquer, M., Poza, P., Reche, M., Rodríguez del Río, P., Rodríguez, M., Ruano, F., Sánchez-García, S., Terrados, S., Valdesoiro, L., and Vazquez-Ortiz, M.

Published
2017
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37. Genetic diversity of bocachico Prochilodus magdalenae in the department of Sucre

Author

Darwin Hernández H,, Orlando Navarro M, and Jaime Muñoz F

Subjects
Microsatélites amplificados al azar, Recursos genéticos, Peces endémicos., Agriculture, Agriculture (General), S1-972, Animal culture, SF1-1100
Abstract

Therefore the objective of the present study was to characterize genetically wild and cultivated populations of P. magdalenae, using molecular markers type RAMs in the area of the lower San Jorge, in the Department of Sucre. For this, DNA was extracted and PCR amplified with seven primers RAMs, in a sample of 80 wild specimens from four sites and 40 cultured specimens from two companies the. All primers RAMs were polymorphic with values ranging from 93,33% in the CA primer to 99,17% in AG, this primer had the highest He value (0,469 ± 0,005), while the CCA primer had the lowest value (0,321 ± 0,010). In the wild populations of P. magdalenae the SBA site was the most diverse (He: 0,194 ± 0,028) and the CAI site was the least diverse (0,150 ± 0,029), with an He average of 0,167 ± 0,019, that was lower than the average often cultivated population (He: 0,194 ± 0,002). The analysis of the population structure reflects greater variation within that between the populations with moderate and high FST values, indicating low gene flow between sites and between wild and cultivated populations, that is evidenced in dendrograms. It is concluded that this genetic structure can be due to natural or artificial physiographic barriers and that the greater diversity in the cultivated population can be due to an adequate reproductive management or endogamy effects in the wild population.

Published
2017
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