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Whilst no disease-modifying-therapies (DMTs) are currently available for Huntington’s disease (HD), the investigational drugs most advanced in clinical development are administered intrathecally, requiring additional resources in HD clinics. We investigated the impact of upcoming DMTs for HD on healthcare systems and the implications of possible resource capacity gaps on access to care.The capacity to perform intrathecal drug administrations was assessed in 35 HD specialist centres from nine countries. Interviews with >170 healthcare professionals were performed and resources available in each HD centre were compared to the predicted amount of future resources that the estimated eligible patient population would need.Only 20% of participating HD teams currently have the required resources to perform intrathecal injec- tions: a skilled ‘proceduralist’, one or more nurses to assist in the procedure, and the appropriate space. When considering all resources available in the hospital, only 17% of HD-specialist clinics are estimated to have enough capacity to serve the eligible population. When simulating the additional referral-in of patients from non-HD-specialised clinics, only 6% of HD clinics have enough capacity.To ensure adequate care, capacity-constrained healthcare systems will need to plan adequately and ensure providers have sufficient training and resources to deliver new intrathecally administered DMTs.kopano.mukelabai@roche.com

The United Nations Global Compact (UNGC) is one of the most important corporate social responsibility initiatives; its aim is to align companies’ strategies and operations with principles that involve human rights, labor, the environment, and anti-corruption. After approximately 15 years of research on the UNGC, we provide a systematic literature review on this topic. We start with a keyword search of 96 papers on the UNGC. We then code these papers based on a deductive–inductive approach and classify them by year of publication, publication outlet, research focus, methodology, and underpinning theory. We frame and summarize the debate on the five main topics of UNGC literature, namely motivations driving the companies toward UNGC adoption, weaknesses, impacts, contextual factors affecting adoption, and contextual factors affecting performance. For each of the five streams of research, we identify several factors or variables that enrich the knowledge of it. Building on these findings, we identify various research gaps and develop a set of hypotheses for future empirical validation that are grounded on prominent theoretical frameworks, such as the stakeholder theory (in combination with the Human Resource Management literature) and the signal theory.