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34 results on '"Makeyeva, Galina A."'

3. Effect of Low-Dose Aspirin on the Course of Age-Related Macular Degeneration

Author

Robman, Liubov D., primary, Wolfe, Rory, additional, Woods, Robyn L., additional, Thao, Le Thi Phuong, additional, Makeyeva, Galina A., additional, Hodgson, Lauren A. B., additional, Lepham, Y-Anh, additional, Jachno, Kim, additional, Phung, James, additional, Maguire, Emily, additional, Luong, Henry, additional, Trevaks, Ruth E., additional, Ward, Stephanie A., additional, Fitzgerald, Sharyn M., additional, Orchard, Suzanne G., additional, Lacaze, Paul, additional, Storey, Elsdon, additional, Abhayaratna, Walter P., additional, Nelson, Mark R., additional, Guymer, Robyn H., additional, and McNeil, John J., additional

Published
2024
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4. Baseline characteristics and age-related macular degeneration in participants of the “ASPirin in Reducing Events in the Elderly” (ASPREE)-AMD trial

Author

Robman, Liubov D., Phuong Thao, Le Thi, Guymer, Robyn H., Wolfe, Rory, Woods, Robyn L., Hodgson, Lauren AB., Phung, James, Makeyeva, Galina A., Le-Pham, Y-Anh, Orchard, Suzanne G., Suleiman, Jewhara, Maguire, Emily, Trevaks, Ruth E., Ward, Stephanie A., Riaz, Moeen, Lacaze, Paul, Storey, Elsdon, Abhayaratna, Walter P., Nelson, Mark R., Ernst, Michael E., Reid, Christopher M., and McNeil, John J.

Published
2020
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6. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study

Author

Robman, Liubov, Guymer, Robyn, Woods, Robyn, Ward, Stephanie, Wolfe, Rory, Phung, James, Hodgson, Lauren, Makeyeva, Galina, Aung, Khin Zaw, Gilbert, Tom, Lockery, Jessica, Le-Pham, Y-Anh, Orchard, Suzanne, Storey, Elsdon, Abhayaratna, Walter, Reid, Daniel, Ernst, Michael E., Nelson, Mark, Reid, Christopher, and McNeil, John

Published
2017
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7. Hyperpigmentary abnormalities in age-related macular degeneration: association with progression and impact on visual sensitivity.

Author

Kai Lyn Goh, Kumar, Himeesh, Hadoux, Xavier, Jannaud, Maxime, Abbott, Carla, Hodgson, Lauren, Robman, Luba, Makeyeva, Galina, Van Wijngaarden, Peter, Guymer, Robyn, and Zhichao Wu

Abstract

Background/aims To investigate the additional prognostic value of quantifying the extent of colour fundus photography (CFP)-defined hyperpigmentary abnormalities (HPAs) compared with their presence alone for predicting progression to late-stage age-related macular degeneration (AMD) and to understand their association with visual sensitivity in individuals with intermediate AMD. Methods 140 participants with bilateral large drusen underwent multimodal imaging and microperimetry at baseline and then every 6 months for up to 3 years. Baseline CFPs were graded for the presence of HPAs and their extent was quantified. Optical coherence tomography (OCT) scans were used to quantify drusen volume. Predictive models for progression to late AMD (including OCT signs of atrophy) were developed using either HPA presence or extent. The association between HPA extent with mean visual sensitivity (both overall and sector based) was also evaluated. All models were adjusted for the confounders of baseline age and drusen volume. Results The predictive performance for late AMD development was not significantly different for HPA presence or extent (p=0.92). Increasing HPA extent in each sector, but not its overall extent in an eye, was associated with reduced sector-based visual sensitivity (p<0.001 and p=0.671, respectively). Conclusion In a cohort with bilateral large drusen, quantifying HPA extent did not improve the prediction of late AMD development compared with presence alone. HPA extent was associated with more local, rather than generalised, reductions in visual sensitivity. These findings suggest that quantification of HPA extent adds little to the prediction of AMD progression, but that it provides an imaging biomarker of visual dysfunction. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Hyperpigmentary abnormalities in age-related macular degeneration: association with progression and impact on visual sensitivity

Author

Goh, Kai Lyn, Kumar, Himeesh, Hadoux, Xavier, Jannaud, Maxime, Abbott, Carla, Hodgson, Lauren, Robman, Luba, Makeyeva, Galina, Van Wijngaarden, Peter, Guymer, Robyn, and Wu, Zhichao

Abstract

Background/aimsTo investigate the additional prognostic value of quantifying the extent of colour fundus photography (CFP)-defined hyperpigmentary abnormalities (HPAs) compared with their presence alone for predicting progression to late-stage age-related macular degeneration (AMD) and to understand their association with visual sensitivity in individuals with intermediate AMD.Methods140 participants with bilateral large drusen underwent multimodal imaging and microperimetry at baseline and then every 6 months for up to 3 years. Baseline CFPs were graded for the presence of HPAs and their extent was quantified. Optical coherence tomography (OCT) scans were used to quantify drusen volume. Predictive models for progression to late AMD (including OCT signs of atrophy) were developed using either HPA presence or extent. The association between HPA extent with mean visual sensitivity (both overall and sector based) was also evaluated. All models were adjusted for the confounders of baseline age and drusen volume.ResultsThe predictive performance for late AMD development was not significantly different for HPA presence or extent (p=0.92). Increasing HPA extent in each sector, but not its overall extent in an eye, was associated with reduced sector-based visual sensitivity (p<0.001 and p=0.671, respectively).ConclusionIn a cohort with bilateral large drusen, quantifying HPA extent did not improve the prediction of late AMD development compared with presence alone. HPA extent was associated with more local, rather than generalised, reductions in visual sensitivity. These findings suggest that quantification of HPA extent adds little to the prediction of AMD progression, but that it provides an imaging biomarker of visual dysfunction.

Published
2024
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19. Prospective Longitudinal Evaluation of Nascent Geographic Atrophy in Age-Related Macular Degeneration

Author

Wu, Zhichao, primary, Luu, Chi D., additional, Hodgson, Lauren A.B., additional, Caruso, Emily, additional, Tindill, Nicole, additional, Aung, Khin Zaw, additional, McGuinness, Myra B., additional, Makeyeva, Galina, additional, Chen, Fred K., additional, Chakravarthy, Usha, additional, Arnold, Jennifer J., additional, Heriot, Wilson J., additional, Durkin, Shane R., additional, and Guymer, Robyn H., additional

Published
2020
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22. Development and validation of a deep‐learning algorithm for the detection of neovascular age‐related macular degeneration from colour fundus photographs

Author

Keel, Stuart, primary, Li, Zhixi, additional, Scheetz, Jane, additional, Robman, Liubov, additional, Phung, James, additional, Makeyeva, Galina, additional, Aung, KhinZaw, additional, Liu, Chi, additional, Yan, Xixi, additional, Meng, Wei, additional, Guymer, Robyn, additional, Chang, Robert, additional, and He, Mingguang, additional

Published
2019
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25. Age-Related Macular Degeneration in Ethnically Diverse Australia: Melbourne Collaborative Cohort Study

Author

Robman, Liubov D., primary, Islam, Fakir M. A., additional, Chong, Elaine W. T., additional, Adams, Madeleine K. M., additional, Simpson, Julie A., additional, Aung, Khin Zaw, additional, Makeyeva, Galina A., additional, Hopper, John L., additional, English, Dallas R., additional, Giles, Graham G., additional, Baird, Paul N., additional, and Guymer, Robyn H., additional

Published
2015
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26. Dietary Patterns and Their Associations with Age-Related Macular Degeneration

Author

Amirul Islam, Fakir M., primary, Chong, Elaine W., additional, Hodge, Allison M., additional, Guymer, Robyn H., additional, Aung, Khin Zaw, additional, Makeyeva, Galina A., additional, Baird, Paul N., additional, Hopper, John L., additional, English, Dallas R., additional, Giles, Graham G., additional, and Robman, Liubov D., additional

Published
2014
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27. Proof of concept, randomized, placebo-controlled study of the effect of simvastatin on the course of age-related macular degeneration

Author

Guymer, Robyn H, Baird, Paul N, Varsamidis, Mary, Busija, Lucy, Dimitrov, Peter N, Aung, Khin Zaw, Makeyeva, Galina A, Richardson, Andrea J, Lim, Lyndell, Robman, Liubov D, Guymer, Robyn H, Baird, Paul N, Varsamidis, Mary, Busija, Lucy, Dimitrov, Peter N, Aung, Khin Zaw, Makeyeva, Galina A, Richardson, Andrea J, Lim, Lyndell, and Robman, Liubov D

Published
2013

30. Static and Flicker Perimetry in Age-Related Macular Degeneration

Author

Luu, Chi D., primary, Dimitrov, Peter N., additional, Wu, Zhichao, additional, Ayton, Lauren N., additional, Makeyeva, Galina, additional, Aung, Khin-Zaw, additional, Varsamidis, Mary, additional, Robman, Luba, additional, Vingrys, Algis J., additional, and Guymer, Robyn H., additional

Published
2013
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31. THE PREVALENCE AND RISK FACTORS OF EPIRETINAL MEMBRANES

Author

Aung, Khin Z., primary, Makeyeva, Galina, additional, Adams, Madeleine K., additional, Chong, Elaine W.-T., additional, Busija, Lucy, additional, Giles, Graham G., additional, English, Dallas R., additional, Hopper, John, additional, Baird, Paul N., additional, Guymer, Robyn H., additional, and Robman, Liubov D., additional

Published
2013
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