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305 results on '"Maguire, Jonathon L."'

7. Haemoglobin thresholds to define anaemia from age 6 months to 65 years: estimates from international data sources

Author

Braat, Sabine, Fielding, Katherine L, Han, Jiru, Jackson, Victoria E, Zaloumis, Sophie, Xu, Jessica Xu Hui, Moir-Meyer, Gemma, Blaauwendraad, Sophia M, Jaddoe, Vincent W V, Gaillard, Romy, Parkin, Patricia C, Borkhoff, Cornelia M, Keown-Stoneman, Charles D G, Birken, Catherine S, Maguire, Jonathon L, Bahlo, Melanie, Davidson, Eliza M, and Pasricha, Sant-Rayn

Published
2024
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24. Changes in Pediatric Movement Behaviors During the COVID-19 Pandemic by Stages of Lockdown in Ontario, Canada: A Longitudinal Cohort Study.

Author

Patel, Priya, Li, Xuedi, Keown-Stoneman, Charles D.G., Vanderloo, Leigh M., Kinlin, Laura M., Maguire, Jonathon L., and Birken, Catherine S.

Subjects
COVID-19 pandemic, STAY-at-home orders, SCREEN time, CHILD behavior, COHORT analysis
Abstract

Background: Children's movement behaviors have been affected by the COVID-19 pandemic; however, little is known regarding movement behavior patterns over time by government-issued lockdowns. Our primary objective was to evaluate how children's movement behaviors changed by stages of lockdown/reopening in Ontario, Canada, from 2020 to 2021. Methods: A longitudinal cohort study with repeated measures of exposure and outcomes was conducted. The exposure variables were dates from before and during COVID-19 when child movement behavior questionnaires were completed. Lockdown/reopening dates were included as knot locations in the spline model. The outcomes were daily screen, physical activity, outdoor, and sleep time. Results: A total of 589 children with 4805 observations were included (53.1% boys, 5.9 [2.6] y). On average, screen time increased during the first and second lockdowns and decreased during the second reopening. Physical activity and outdoor time increased during the first lockdown, decreased during the first reopening, and increased during the second reopening. Younger children (<5 y) had greater increases in screen time and lower increases in physical activity and outdoor time than older children (≥5 y). Conclusions: Policy makers should consider the impact of lockdowns on child movement behaviors, especially in younger children. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Randomized Trial of Oral Iron and Diet Advice versus Diet Advice Alone in Young Children with Nonanemic Iron Deficiency

Author

Stoneman, Charles Keown, Malhi, Tarandeep, Thompson, Julia, Kowal, Christine, Mason, Dalah, Thompson, Laurie, Barozzino, Tony, Campbell, Douglas, Chisamore, Brian, Danayan, Karoon, Do, Anh, Jacobson, Sheila, Kadar, Paul, Lau, Eddy, Naymark, Sharon, Peer, Michael, Perlmutar, Marty, Persaud, Nav, Saunderson, Janet, Sgro, Michael, Wong, Peter, Zajdman, Michael, Parkin, Patricia C., Borkhoff, Cornelia M., Macarthur, Colin, Abdullah, Kawsari, Birken, Catherine S., Fehlings, Darcy, Koroshegyi, Christine, Maguire, Jonathon L., Mamak, Eva, Mamdani, Muhammad, Thorpe, Kevin E., Zlotkin, Stanley H., and Zuo, Fei

Published
2021
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27. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

Author

Jolliffe, David A, Camargo, Carlos A, Jr, Sluyter, John D, Aglipay, Mary, Aloia, John F, Ganmaa, Davaasambuu, Bergman, Peter, Bischoff-Ferrari, Heike A, Borzutzky, Arturo, Damsgaard, Camilla T, Dubnov-Raz, Gal, Esposito, Susanna, Gilham, Clare, Ginde, Adit A, Golan-Tripto, Inbal, Goodall, Emma C, Grant, Cameron C, Griffiths, Christopher J, Hibbs, Anna Maria, Janssens, Wim, Khadilkar, Anuradha Vaman, Laaksi, Ilkka, Lee, Margaret T, Loeb, Mark, Maguire, Jonathon L, Majak, Paweł, Mauger, David T, Manaseki-Holland, Semira, Murdoch, David R, Nakashima, Akio, Neale, Rachel E, Pham, Hai, Rake, Christine, Rees, Judy R, Rosendahl, Jenni, Scragg, Robert, Shah, Dheeraj, Shimizu, Yoshiki, Simpson-Yap, Steve, Trilok-Kumar, Geeta, Urashima, Mitsuyoshi, and Martineau, Adrian R

Published
2021
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28. Timing of Introduction to Solid Food, Growth, and Nutrition Risk in Later Childhood

Author

Cohn, Ronald, Lau, Eddy, Laupacis, Andreas, Parkin, Patricia C., Salter, Michael, Szatmari, Peter, Weir, Shannon, Anderson, Laura N., Borkhoff, Cornelia M., Kowal, Christine, Mason, Dalah, Abdurrahman, Murtala, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Calpin, Caroline, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Constantin, Evelyn, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Kadar, Paul, Kim, Florence, Kiran, Tara, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leduc, Denis, Leung, Fok-Han, Li, Alan, Li, Patricia, Malach, Jessica, Male, Roy, Mascoll, Vashti, Meret, Aleks, Mok, Elise, Moodie, Rosemary, Nader, Maya, Nash, Katherine, Naymark, Sharon, Owen, James, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Raza, Danyaal, Rosenthal, Alana, Rouleau, Katherine, Ruderman, Caroline, Saunderson, Janet, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Treherne, Stephen, Turner, Suzanne, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wong, Peter, Yaremko, John, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Camacho, Charmaine, Dalwadi, Dharma, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Aglipay, Mary, Bayoumi, Imaan, Carsley, Sarah, Cost, Katherine, Eny, Karen, Kim, Theresa, Kinlin, Laura, Omand, Jessica, Vanderhout, Shelley, Vanderloo, Leigh, Allen, Christopher, Boodhoo, Bryan, Chan, Olivia, Dai, David W.H., Hall, Judith, Juni, Peter, Lebovic, Gerald, Pope, Karen, Thorpe, Kevin, Kandel, Rita, Rodrigues, Michelle, Vandenberghe, Hilde, D'Hollander, Curtis J., Keown-Stoneman, Charles D.G., Birken, Catherine S., O'Connor, Deborah L., and Maguire, Jonathon L.

Published
2021
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29. Prospective Cohort Study of Vitamin D and Autism Spectrum Disorder Diagnoses in Early Childhood

Author

Ali, Yamna, Anderson, Laura N., Smile, Sharon, Chen, Yang, Borkhoff, Cornelia M., Koroshegyi, Christine, Lebovic, Gerald, Parkin, Patricia C., Birken, Catherine S., Szatmari, Peter, and Maguire, Jonathon L.

Abstract

Several studies have suggested an association between vitamin D in childhood and autism spectrum disorder. No prospective studies have evaluated whether lower vitamin D levels precede ASD diagnoses -- a necessary condition for causality. The objective of this study was to prospectively evaluate whether vitamin D serum levels in early childhood was associated with incident physician diagnosed ASD. A prospective cohort study was conducted using data from preschool-aged children in the TARGet Kids! practice-based research network in Toronto, Canada, from June 2008 to July 2015. 25-hydroxyvitamin D concentration was measured through blood samples and vitamin D supplementation from parent report. Autism spectrum disorder diagnosis was determined from medical records at follow-up visits. Covariates included age, sex, family history of autism spectrum disorder, maternal ethnicity, and neighborhood household income. Unadjusted and adjusted relative risks and 95% confidence intervals were estimated using Poisson regression with a robust error variance. In this study, 3852 children were included. Autism spectrum disorder diagnosis was identified in 41 children (incidence = 1.1%) over the observation period (average follow-up time = 2.5 years). An association between 25-hydroxyvitamin D concentration and autism spectrum disorder was not identified in the unadjusted (relative risk = 1.04, 95% confidence interval: 0.97, 1.11 per 10 nmol/L increase in 25-hydroxyvitamin D concentration) or adjusted models (adjusted relative risk = 1.06; 95% confidence interval: 0.95, 1.18). An association between vitamin D supplementation in early childhood and autism spectrum disorder was also not identified (adjusted relative risk = 0.86, 95% confidence interval: 0.46, 1.62). Vitamin D in early childhood may not be associated with incident physician diagnoses of autism spectrum disorder.

Published
2019
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32. Underweight in the first 2 years of life and nutrition risk in later childhood: a prospective cohort study.

Author

South, Courtney A., Keown‐Stoneman, Charles D. G., Birken, Catherine S., Malik, Vasanti, Zlotkin, Stanley H., and Maguire, Jonathon L.

Subjects
RISK assessment, LEANNESS, MALNUTRITION, FOOD consumption, RESEARCH funding, BODY mass index, BODY weight, LONGITUDINAL method, STATURE, ODDS ratio, FOOD habits, CONFIDENCE intervals, DISEASE risk factors, CHILDREN
Abstract

Background: Children with underweight in the first 2 years have lower body mass index z‐score (zBMI) and height‐for‐age z‐score (HAZ) in later childhood. It is not known if underweight in the first 2 years is associated with nutrition risk in later childhood. Objective: (1) Determine the relationship between underweight (zBMI < −2) in the first 2 years and nutrition risk measured by the Nutrition Screening for Toddlers and Preschoolers (NutriSTEP) score from 18 months to 5 years. (2) Explore the relationship between underweight in the first 2 years and the NutriSTEP subscores for eating behaviours and dietary intake from 18 months to 5 years. Methods: This was a prospective study, including healthy full‐term children in Canada aged 0–5 years. zBMI was calculated using measured heights and weights and the WHO growth standards. NutriSTEP score was measured using a parent‐completed survey and ranged from 0 to 68. Nutrition risk was defined as a score ≥21. Linear mixed effects models were used. Results: Four thousand nine hundred twenty‐nine children were included in this study. At enrolment, 51.9% of participants were male. The prevalence of underweight children was 8.8%. Underweight in the first 2 years was associated with higher NutriSTEP (0.79, 95% CI: 0.29,1.29), higher eating behaviour subscore (0.24, 95% CI: 0.03, 0.46) at 3 years and higher odds of nutrition risk (OR: 1.39, 95% CI: 1.07,1.82) at 5 years. Conclusions: Children with underweight in the first 2 years had higher nutrition risk in later childhood. Further research is needed to understand the factors which influence these relationships. Key points: In this prospective cohort study of 4929 children aged 0–5 years, children with underweight in the first 2 years of life had higher odds of nutrition risk at 5 years of age compared to children without underweight in the first 2 years (p = 0.02). Further research is needed to understand the factors which influence these relationships. [ABSTRACT FROM AUTHOR]

Published
2024
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37. A Positive Association Between Dietary Intake of Higher Cow's Milk-Fat Percentage and Non−High-Density Lipoprotein Cholesterol in Young Children

Author

Birken, Catherine S., Maguire, Jonathon L., Cohn, Ronald, Lau, Eddy, Laupacis, Andreas, Parkin, Patricia C., Salter, Michael, Szatmari, Peter, Weir, Shannon, Anderson, Laura N., Borkhoff, Cornelia M., Keown-Stoneman, Charles, Kowal, Christine, Mason, Dalah, Abdurrahman, Murtala, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Calpin, Caroline, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Constantin, Evelyn, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Kadar, Paul, Kim, Florence, Kiran, Tara, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leduc, Denis, Leung, Fok-Han, Li, Alan, Li, Patricia, Malach, Jessica, Male, Roy, Mascoll, Vashti, Meret, Aleks, Mok, Elise, Moodie, Rosemary, Nader, Maya, Nash, Katherine, Naymark, Sharon, Owen, James, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Raza, Danyaal, Rosenthal, Alana, Rouleau, Katherine, Ruderman, Caroline, Saunderson, Janet, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Treherne, Stephen, Turner, Suzanne, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wong, Peter, Yaremko, John, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Camacho, Charmaine, Dalwadi, Dharma, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Aglipay, Mary, Bayoumi, Imaan, Carsley, Sarah, Cost, Katherine, Eny, Karen, Kim, Theresa, Kinlin, Laura, Omand, Jessica, Vanderhout, Shelley, Vanderloo, Leigh, Allen, Christopher, Boodhoo, Bryan, Chan, Olivia, Dai, David W.H., Hall, Judith, Juni, Peter, Lebovic, Gerald, Pope, Karen, Thorpe, Kevin, Kandel, Rita, Rodrigues, Michelle, Vandenberghe, Hilde, Wong, Vincent C.H., Omand, Jessica A., and O'Connor, Deborah L.

Published
2019
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38. Higher Body Mass Index Is Associated with Iron Deficiency in Children 1 to 3 Years of Age

Author

Aglipay, Mary, Anderson, Laura N., Dai, David W.H., Keown-Stoneman, Charles, Kowal, Christine, Mason, Dalah, Abdurrahman, Murtala, Anderson, Barbara, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bayoumi, Imaan, Bergeron, Sylvie, Bhagat, Dimple, Blanchette, Nicholas, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Brown, Anne, Bugera, Jennifer, Calpin, Caroline, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Constantin, Evelyn, Culbert, Ellen, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Dorey, Michael, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Hatch, Hailey, Hughes, Teresa, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Jasuja, Mona, Kadar, Paul, Kiran, Tara, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Lau, Eddy, Leduc, Denis, Leung, Fok-Han, Li, Alan, Li, Patricia, Loo, Jennifer, Louis, Joanne, Mahmoud, Sarah, Malach, Jessica, Male, Roy, Mascoll, Vashti, Meret, Aleks, Mok, Elise, Moodie, Rosemary, Morinis, Julia, Nader, Maya, Nash, Katherine, Naymark, Sharon, Owen, James, Parry, Jane, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Rana, Jesleen, Raza, Danyaal, Rosenthal, Alana, Rouleau, Katherine, Saunderson, Janet, Saxena, Rahul, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Treherne, Stephen, Turner, Suzanne, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wong, Peter, Wormsbecker, Anne, Yaremko, John, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Camacho, Charmaine, Dalwadi, Dharma, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Sypes, Emma E., Parkin, Patricia C., Birken, Catherine S., Carsley, Sarah, MacArthur, Colin, Maguire, Jonathon L., and Borkhoff, Cornelia M.

Published
2019
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39. Xylitol for the prevention of acute otitis media episodes in children aged 1-5 years: a randomised controlled trial.

Author

Persaud, Navindra, Azarpazhooh, Amir, Stoneman, Charles Keown, Birken, Catherine S., Isaranuwatchai, Wanrudee, Maguire, Jonathon L., Mamdani, Muhammad, Allen, Christopher, Mason, Dalah, Kowal, Christine, Jaleel, Mateenah, Bazeghi, Farnaz, Thorpe, Kevin E., Laupacis, Andreas, and Parkin, Patricia C.

Subjects
OTITIS media, ACUTE otitis media, XYLITOL, RANDOMIZED controlled trials, COVID-19 pandemic, EMERGENCY room visits
Published
2024
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48. Association of birthweight with diabetes, hypertension, and ischemic heart disease in young adulthood: a retrospective cohort study.

Author

Yoshida-Montezuma, Yulika, Keown-Stoneman, Charles D.G., Birken, Catherine S., Maguire, Jonathon L., Brown, Hilary K., and Anderson, Laura N.

Subjects
MYOCARDIAL ischemia, CORONARY disease, YOUNG adults, BIRTH weight, COHORT analysis
Abstract

Birthweight has been associated with diabetes in a reverse J-shape (highest risk at low birthweight and moderately high risk at high birthweight) and inversely associated with hypertension in adulthood with inconsistent evidence for cardiovascular disease. There is a lack of population-based studies examining the incidence of cardiometabolic outcomes in young adults born with low and high birthweights. To evaluate the association between birthweight and diabetes, hypertension, and ischemic heart disease (IHD) in young adulthood, we conducted a retrospective cohort study of 874,904 singletons born in Ontario, Canada, from 1994 to 2002, identified from population-based health administrative data. Separate Cox regression models examined birthweight in association with diabetes, hypertension, and IHD adjusting for confounders. Among adults 18–26 years, the diabetes incidence rate was 18.15 per 100,000 person-years, hypertension was 15.80 per 100,000 person-years, and IHD was 1.85 per 100,000 person-years. Adjusted hazard ratios (AHR) for the hazard of diabetes with low (<2500g) and high (>4000g), compared with normal (2500–4000g) birthweight, were 1.46 (95% CI 1.28, 1.68) and 1.09 (0.99, 1.21), respectively. AHR for hypertension with low and high birthweight were 1.34 (1.15, 1.56) and 0.86 (0.77, 0.97), respectively. AHR for IHD with low and high birthweight were 1.28 (0.80, 2.05) and 0.97 (0.71, 1.33), respectively. Overall, birthweight was associated with diabetes in young adults in a reverse J-shape and inversely with hypertension. There was insufficient evidence of an association with IHD. Further evidence is needed to understand the causal mechanisms between birthweight and cardiometabolic diseases in young adults. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Validation of Parent-reported Gestational Age Categories for Children Less Than 6 Years of Age.

Author

Palumbo, Alexandra M., Kirkwood, David, Borkhoff, Cornelia M., Keown-Stoneman, Charles D. G., Muraca, Giulia M., Fuller, Anne, Birken, Catherine S., Maguire, Jonathon L., Brown, Hilary K., and Anderson, Laura N.

Abstract

Background: Preterm birth is an important outcome or exposure in epidemiologic research. When administrative data on measured gestational age is not available, parent-reported gestational age can be obtained from questionnaires, which is subject to potential bias. To our knowledge, few studies have assessed the validity of parentreported gestational age categories, including commonly defined categories of preterm birth. Methods: We used linked data from primarily healthy children <6 years of age in TARGet Kids! in Toronto, Canada, and ICES administrative healthcare data from April 2011 to March 2020. We assessed the criterion validity of questionnaire-based parent-reported gestational age by calculating sensitivity and specificity for term (=37 weeks), late preterm (34-36 weeks), and moderately preterm (32-33 weeks) gestational age categories, using administrative healthcare records of gestational age as the criterion standard. We conducted subgroup analyses for various parent and socioeconomic factors that may influence recall. Results: Of the 4684 participants, 97.3% correctly classified the gestational age category according to administrative healthcare data. Parent-reported gestational age sensitivity ranged from 83.7% to 98.5% and specificity ranged from 88.3% to 99.8%, depending on category. For each subgroup characteristic, sensitivity and specificity were all =70%. Lower educational attainment, lower family income, father reporting, =1 year since birth, =2 children, lower parent age, and reported gestational diabetes and/or hypertension were associated with slightly lower sensitivity and/or specificity. Conclusions: In this linked cohort, parent-reported gestational age categories had high accuracy. Criterion validity varied minimally among some parent and socioeconomic factors. Our findings can inform future quantitative bias analyses. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Timing of introduction to solid food, eczema and wheezing in later childhood: a longitudinal cohort study.

Author

D'Hollander, Curtis J., Keown-Stoneman, Charles D. G., Birken, Catherine S., O'Connor, Deborah L., Maguire, Jonathon L., TARGet Kids! collaboration, Allen, Christopher, Anderson, Laura N., D'Annunzio, Danielle, Jaleel, Mateenah, McFarlane, Natricha Levy, Omand, Jessica A., Thadani, Sharon, Aglipay, Mary, Bayoumi, Imaan, Borkhoff, Cornelia M., Carsley, Sarah, Charach, Alice, Cost, Katherine, and Fuller, Anne

Subjects
WHEEZE, COHORT analysis, ECZEMA, GENERALIZED estimating equations, LONGITUDINAL method
Abstract

Background: The timing of introduction to solid food has been associated with eczema and wheezing in childhood. Our aim was to determine whether differences persist within the recommended 4 to 6 month age range. Methods: A longitudinal cohort study with repeated measures was conducted among children from birth to 10 years of age who were participating in the TARGet Kids! practice based research network in Toronto, Canada. The primary exposure was the timing of introduction to infant cereal as the first solid food. The primary outcome was eczema and the secondary outcome was wheezing collected by parent report using the validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Multinomial generalized estimating equations were used and effect modification by family history of asthma and breastfeeding duration were explored. Results: Of the 7843 children included, the mean (standard deviation) age of introduction to infant cereal was 5.7 (1.9) months. There was evidence for family history of asthma and breastfeeding duration to be effect modifiers in the eczema (P = 0.04) and wheezing (P = 0.05) models. Introduction to infant cereal at 4 vs. 6 months of age was associated with higher odds of eczema (OR 1.62; 95% CI: 1.12, 2.35; P = 0.01) among children without a family history of asthma who were not breastfeeding when solid foods were introduced. Introduction to infant cereal at 4 vs. 6 months of age was associated with a higher odds of wheezing (OR 1.31; 95% CI: 1.13, 1.52; P <.001) among children without a family history of asthma who were breastfeeding when solid foods were introduced. There was little evidence of an association among the remaining strata for either outcome. Conclusion: The findings of this study support recommendations to introduce solid food around 6 months of age. [ABSTRACT FROM AUTHOR]

Published
2023
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