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To solve the problem of poor stability of additive flame retardant waterborne polyurethane， a series of waterborne polyurethane with flame retardant properties was synthesized by prepolymer method using aliphatic polyisocyanate， polyether polyol， and flame retardant phosphorus-containing polyol as raw materials. The flame retardant waterborne polyurethane was applied to the dipping process of microfiber synthetic leather base （microfiber base）. Its effects on the mechanics， quality， flame retardant， and thermal decomposition properties of microfiber base were discussed. The results show that with the increase of phosphorus-containing flame retardant polyol content， the combustion rate decreases from 115.00 mm/min to 60.79 mm/min， and the limiting oxygen index increases from 21.00% to 24.20%. After different concentrations of phosphorus-nitrogen flame retardants were sprayed on the surface of microfiber base， microfiber base appears self-extinguishing phenomenon during combustion， and the limiting oxygen index increases to 27.00%. Compared with the microfiber base without flame retardant treatment，the peak heat release rate and total heat release rate of the microfiber base after flame retardant treatment are reduced by 42.29% and 20.01%， respectively. The test analyses of SEM and Raman spectroscopy reveal that the graphitization degree of the carbon layer is improved and the surface structure becomes more compact after flame retardant finishing， suggesting that the flame retardant plays a crucial role by using the condensed phase flame retardant mechanism.

Background Coronary heart disease (CHD) is one of the major public health burdens in the world. Although treatment strategies have been developed, but CHD remains a leading cause of morbidity and mortality worldwide. The diagnosis of CHD mainly relies on coronary angiography or contrast-enhanced computed tomography. However, due to the lack of equipment in primary hospitals, early diagnosis and prognosis judgment are relatively difficult. Therefore, the search for relatively simple and easy-to-obtain laboratory indicators is conducive to providing basis for primary care physicians to diagnose and treat CHD. Objective To investigate the correlation of serum interleukin-6 (IL-6) and fasting blood glucose (FPG) levels with the degree and clinical classification of coronary stenosis, number of lesions and adverse cardiovascular events in patients with CHD. Methods CHD patients admitted to the Fifth Affiliated Hospital of Xinjiang Medical University from September to November 2020 were included as the study objects, and their general data and laboratory test results were collected. According to Gensini score criteria, the patients were divided into the mild stenosis group (group A, Gensini score≤33.25 points, n=40) and moderate and severe stenosis group (group B, Gensini score>33.25 points, n=40) based on the Gensini scoring criteria. According to the results of coronary angiography results, patients were divided into the single-vessel lesion group (n=28), double-vessel lesion group (n=21) and multi-vessel lesion group (number of lesion branch≥3, n=31) based on the number of lesions. According to the clinical classification, patients were divided into stable angina group (n=34) and acute coronary syndrome group (n=46). Spearman rank correlation analysis was used to explore the relationship of serum IL-6, FPG with relevant data of patients. Survival curves of patients were plotted using the Kaplan-Meier method, and the comparison of survival curves was performed by Log-rank test. Univariate and multivariate Cox proportional hazard regression analyses were used to explore the factors influencing the risk of adverse cardiovascular events in patients with CHD. The receiver operating characteristic (ROC) curve of IL-6 predicting the occurrence of adverse events was plotted. Results IL-6 and FPG in group A were lower than those in group B, IL-6 in the multi-vessel lesion group was higher than that in the single-vessel lesion group, FPG was higher than that in double-vessel lesion group, and IL-6 and FPG in acute coronary syndrome group was higher than that in stable angina group, with statistical significance (P45.8 ng/L group (n=39) and IL-6≤45.8 ng/L group (n=41) according to the median IL-6 expression level (45.8 ng/L), and the upper limit of normal FPG (6.1 mmol/L) was used as the grouping standard to divide the patients into FPG>6.1 mmol/L group (n=36) and FPG≤6.1 mmol/L group (n=44). Log-rank test results showed that the incidence of adverse cardiovascular events in IL-6>45.8 ng/L group was higher than that in IL-6≤45.8 ng/L group (76.9% vs. 36.6%; χ2=16.075, P < 0.001), FPG>6.1 mmol/L group had a higher incidence of adverse cardiovascular events than FPG≤6.1 mmol/L group (69.4% vs. 45.5%; χ2=4.292, P=0.038). Multivariate Cox proportional hazard regression analysis showed that IL-6 was a significant factor in adverse cardiovascular events in patients with CHD (HR=2.396, 95%CI=1.203-6.054, P

Oxygen and nutrient deprivation are common features of solid tumors. Although abnormal alternative splicing (AS) has been found to be an important driving force in tumor pathogenesis and progression, the regulatory mechanisms of AS that underly the adaptation of cancer cells to harsh microenvironments remain unclear. Here, we found that hypoxia- and nutrient deprivation-induced asparagine endopeptidase (AEP) specifically cleaved DDX3X in a HIF1A-dependent manner. This cleavage yields truncated carboxyl-terminal DDX3X (tDDX3X-C), which translocates and aggregates in the nucleus. Unlike intact DDX3X, nuclear tDDX3X-C complexes with an array of splicing factors and induces AS events of many premRNAs; for example, enhanced exon skipping (ES) in exon 2 of the classic tumor suppressor PRDM2 leads to a frameshift mutation of PRDM2. Intriguingly, the isoform ARRB1-[DELTA]exon 13 binds to glycolytic enzymes and regulates glycolysis. By utilizing in vitro assays, glioblastoma organoids, and animal models, we revealed that AEP/tDDX3X-C promoted tumor malignancy via these isoforms. More importantly, high AEP/tDDX3X-C/ARRB1- [DELTA]exon 13 in cancerous tissues was tightly associated with poor patient prognosis. Overall, our discovery of the effect of AEP-cleaved DDX3X switching on alternative RNA splicing events identifies a mechanism in which cancer cells adapt to oxygen and nutrient shortages and provides potential diagnostic and/or therapeutic targets., Introduction In the tumor microenvironment, cells often face a certain degree of oxygen and nutrient deprivation. Cancer cells strive to survive and proliferate in this harsh environment in multiple ways, [...]

The effects of different preparation techniques (aqueous enzymatic extraction, aqueous extraction, cold pressing, hot pressing and organic solvent extraction) on the physical and chemical properties, nutritional components and oxidation stability of tiger nut oil from the cultivar ‘Zhongyousha 1’ grown in Xinjiang were investigated. The results showed that organic solvent extraction gave the highest extraction rate (88.31%), and there were significant differences in the physicochemical properties of tiger nut oils prepared by different processes (P < 0.05). Oleic acid accounted for 76.04% of the total fatty acids in the oil prepared by aqueous extraction, which was 1.72–2.34 percentage points higher than that obtained with other preparation processes (P < 0.05). Different preparation techniques had significant effects on the lipid concomitant content and oxidation stability of tiger nut oil (P < 0.05). The oil obtained by organic solvent extraction had the highest contents of tocopherol (370.67 mg/kg), total phenol (168.59 mg/100 g) and phytosterol (271.26 mg/100 g), while the content of squalene was highest (162.04 mg/kg) in the oil obtained by aqueous extraction. The cold pressed oil had the highest oxidation stability index (24.15 h) indicating good oxidation stability. Correlation analysis indicated that the oxidation stability of tiger nut oil was positively correlated with unsaturated fatty acid and oleic acid (r = 0.72, r = 0.48), and the antioxidant capacity (1,1-diphenyl-2-picrylhydrazyl and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) free radical scavenging rate) of polar components was significantly positively correlated with total phenol content (r = 0.91, r = 0.96, P < 0.05). The results of principal component analysis (PCA) revealed that the cold pressed oil was similar to the oil obtained aqueous enzymatic extraction, while the oils prepared by organic solvent extraction, hot pressing and aqueous extraction were differentiated well. These results can provide a theoretical basis for the development of high-quality tiger nut oil.