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209 results on '"Lei, Guanghua"'

1. Physical Distancing Measures and Walking Activity in Middle-aged and Older Residents in Changsha, China, During the COVID-19 Epidemic Period: Longitudinal Observational Study

Author

Wang, Yilun, Zhang, Yuqing, Bennell, Kim, White, Daniel Kenta, Wei, Jie, Wu, Ziying, He, Hongyi, Liu, Shaohui, Luo, Xianghang, Hu, Shuo, Zeng, Chao, and Lei, Guanghua

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundPhysical distancing measures taken to contain COVID-19 transmission may substantially reduce physical activity levels and cause individuals to adopt a more sedentary lifestyle. ObjectiveThe objective of this study is to determine if there was any change in daily steps, an important component of daily physical activity, and examine risk factors for frequent low daily steps during the COVID-19 epidemic. MethodsWe used data collected from the Step Study, a population-based longitudinal study of walking activity among residents aged ≥40 years in Changsha, China. Daily steps were collected via a smartphone linked to WeChat, a social networking platform. We plotted mean daily steps and the prevalence of low daily steps (≤1500 steps/day) 30 days before (reference period) and 30 days after (epidemic period) January 21, 2020 (date of the first COVID-19 case diagnosed in Changsha), and compared it with the same corresponding period from 2019. We examined the association of risk factors with the prevalence of frequent low daily steps (≤1500 steps/day for ≥14 days) using logistic regression. ResultsAmong 3544 participants (mean age 51.6 years; n=1226 females, 34.6%), mean daily steps dropped from 8097 to 5440 and the prevalence of low daily steps increased from 3% (2287/76,136 person-day) to 18.5% (12,951/70,183 person-day) during the reference and epidemic periods, respectively. No such phenomenon was observed during the corresponding period in 2019. Older age (P for interaction=.001) and female sex (P for interaction

Published
2020
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9. A Survey of the Current Status of Surgical Treatment of Hemophilic Osteoarthropathy in China Mainland 17 Grade A General Hospitals

Author

XU Yiming, PENG Huiming, LYU Shuaijie, TONG Peijian, LI Hu, CHEN Fenyong, WANG Haibin, YANG Qi, CHEN Bin, YUAN Zhen, BI Rongxiu, FENG Jianmin, JIANG Wenxue, ZHOU Zongke, FAN Meng, LI Xiang, LEI Guanghua, and WENG Xisheng

Subjects
hemophilia, hemophilic osteoarthropathy, surgery, questionnaire survey, Medicine
Abstract

Objective To understand the current status of surgical treatment for hemophilia osteoarthropathy (HO) in China.Methods Using an online questionnaire, select domestic hospitals that partici-pated in the compilation of the 'Guideline for perioperative management of hemophilia patients undergoing orthopaedic surgery in China ', in addition to members of the National Joint Surgery Group, and the Orthopedic Branch of the Chinese Medical Association for targeted investigation and analysis.Results A total of 17 domestic hospitals were included, all of which were general hospitals. Hospitals that started HO surgery treatment before 2000 accounted for 35.29%. A total of 3057 surgical cases of HO were reported by those hospitals. The most commonly performed surgical procedures were hip and knee joint replacement. The most commonly used coagulation factor replacement regimen was recombinant coagulation factor preparation. Ten hospitals reported finding patients with transfusion-related infectious diseases. Bleeding and hematoma formation were the most frequently reported surgical complications. Excessive length of hospital stay and high economic costs were the most frequently reported problems.Conclusions Surgical treatment for HO in 17 hospitals is mainly carried out in some large comprehensive medical centers in the eastern region. Compared with the patient base, the popularity and number of surgeries are still relatively insufficient. It is necessary to further standardize the treatment system by standardizing factor replacement and strengthening rehabilitation to improve surgical treatment outcomes.

Published
2023
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27. Current progress and trends in musculoskeletal research: Highlights of NSFC-CUHK academic symposium on bone and joint degeneration and regeneration

Author

Tuan, Rocky S., Zhang, Yingze, Chen, Lin, Guo, Quanyi, Yung, Patrick SH., Jiang, Qing, Lai, Yuxiao, Yu, Jiakuo, Luo, Jian, Xia, Jiang, Xu, Chenjie, Lei, Guanghua, Su, Jiacan, Luo, Xianghang, Zou, Weiguo, Qu, Jing, Song, Bing, Zhao, Xin, Ouyang, Hongwei, Li, Gang, Ding, Changhai, Wan, Chao, Chan, Barbara P., Yang, Liu, Xiao, Guozhi, Shi, Dongquan, Xu, Jiankun, Cheung, Louis WH., Bai, Xiaochun, Xie, Hui, Xu, Ren, Li, Zhong Alan, Chen, Di, and Qin, Ling

Published
2022
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40. Association Between Hyperuricemia and Ultrasound‐Detected Hand Synovitis.

Author

Jiang, Ting, Weng, Qianlin, Zhang, Yuqing, Zhang, Weiya, Doherty, Michael, Sarmanova, Aliya, Yang, Zidan, Yang, Tuo, Li, Jiatian, Liu, Ke, Wang, Yuqing, Obotiba, Abasiama D., Zeng, Chao, Lei, Guanghua, and Wei, Jie

Subjects
JOINTS (Anatomy), BODY mass index, SYNOVITIS, HYPERURICEMIA, ODDS ratio
Abstract

Objective: Although hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population‐based sample. Methods: We performed a cross‐sectional study in Longshan County, Hunan Province, China. Hyperuricemia was defined as a serum urate level >420 μmol/L in men and >360 μmol/L in women. Ultrasound examinations were performed on both hands of 4,080 participants, and both gray‐scale synovitis and the Power Doppler signal (PDS) were assessed using semiquantitative scores (grades 0–3). We evaluated the association of hyperuricemia with hand gray‐scale synovitis (grade ≥2) and PDS (grade ≥1), respectively, adjusting for age, sex, and body mass index. Results: All required assessments for analysis were available for 3,286 participants. The prevalence of hand gray‐scale synovitis was higher among participants with hyperuricemia (30.0%) than those with normouricemia (23.3%), with an adjusted odds ratio (aOR) of 1.28 (95% confidence interval [CI] 1.00–1.62). Participants with hyperuricemia also had a higher prevalence of PDS (aOR 2.36; 95% CI 1.15–4.81). Furthermore, hyperuricemia positively associated, both at the hand and joint levels, with the presence of gray‐scale synovitis (aOR 1.27; 95% CI 1.00–1.60 and adjusted prevalence ratio [aPR] 1.26; 95% CI 1.10–1.44, respectively) and PDS (aOR 2.35; 95% CI 1.15–4.79 and aPR 2.34; 95% CI 1.28–4.30, respectively). Conclusion: This population‐based study provides more evidence for a positive association between hyperuricemia and prevalent hand synovitis. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Weight Loss Induced by Antiobesity Medications and All‐Cause Mortality Among Patients With Knee or Hip Osteoarthritis.

Author

Wei, Jie, Hunter, David, Lane, Nancy E., Wu, Jing, Zeng, Chao, Lei, Guanghua, and Zhang, Yuqing

Subjects
THROMBOEMBOLISM prevention, WEIGHT loss, KNEE osteoarthritis, SECONDARY analysis, RESEARCH funding, HYPERTENSION, VEINS, CAUSES of death, CARDIOVASCULAR diseases risk factors, DESCRIPTIVE statistics, LONGITUDINAL method, ANTIOBESITY agents, TYPE 2 diabetes, HIP osteoarthritis, COMPARATIVE studies, CONFIDENCE intervals, OBESITY, WEIGHT gain
Abstract

Objective: The current guidelines recommend weight loss for patients with overweight or obesity and knee or hip osteoarthritis (OA); however, there is a paucity of data on the relation of weight loss to death among patients with OA. We aimed to examine the relation of the rate of weight loss induced by antiobesity medications over one year to all‐cause mortality among patients with overweight or obesity and knee or hip OA. Methods: Using the IQVIA Medical Research Database, we identified people with overweight or obesity and knee or hip OA. We emulated analyses of a hypothetical target trial to assess the effect of slow‐to‐moderate (2%–10%) or fast (≥10%) weight loss induced by the initiation of antiobesity medications within one year on all‐cause mortality and secondary outcomes over five years' follow‐up. Results: Among 6,524 participants, the five‐year all‐cause mortality rates were 5.3%, 4.0%, and 5.4% for weight gain or stable, slow‐to‐moderate weight loss, and fast weight loss arms, respectively. Compared with the weight gain or stable arm, hazard ratios of all‐cause mortality were 0.72 (95% confidence interval [CI] 0.56–0.92) for the slow‐to‐moderate weight loss arm and 0.99 (95% CI 0.67–1.44) for the fast weight loss arm. We found dose–response protective effects of weight loss on incident hypertension, type 2 diabetes, and venous thromboembolism but a slightly higher risk of cardiovascular disease, albeit not statistically significant, in the fast rate of weight loss arm than in the weight gain or stable arm and no significant relations of weight loss to the risk of cancer. Conclusion: In this population‐based study, a slow‐to‐moderate, but not fast, rate of weight loss induced by antiobesity medications is associated with a lower risk of all‐cause mortality in people with overweight or obesity and knee or hip OA. [ABSTRACT FROM AUTHOR]

Published
2024
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