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431 results on '"Legnani, Cristina"'

1. More early bleeds associated with high baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study

Author

Testa, Sophie, Dellanoce, Claudia, Paoletti, Oriana, Morandini, Rossella, Tala, Maurizio, Ciampa, Antonio, Gaeta, Martina, Chiarugi, Paolo, Casini, Monica, Guerri, Valentina, Santoro, Rita Carlotta, Iannaccaro, Piergiorgio, Iannone, Angela Maria, Campagna, Maddalena, De Candia, Erica, Alberelli, Maria Adele, Basso, Maria, De Cristofaro, Raimondo, Di Gennaro, Leonardo, Ferretti, Antonietta, Sorrentino, Silvia, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Saliola, Mirella, Faioni, Elena Maria, Avarello, Ilaria, Razzari, Cristina, Chistolini, Antonio, Aprile, Simona Michela, Santoro, Cristina, Serrao, Alessandra, Esteban, Maria del Pilar, Ricca, Sergio, Marietta, Marco, Arletti, Laura, Coluccio, Valeria, Debbia, Giulia, Grisolia, Deborah, Serra, Domizio, Orselli, Alberto, Pescarollo, Alessandra, Verna, Sandra, Di Gregorio, Patrizia, Cassetti, Giuseppina, Molteni, Mauro, Monelli, Mauro, Paparo, Carmelo, Resani, Guido, Di Gregorio, Nicoletta, Grassi, Davide, Lodigiani, Corrado, Banfi, Elena, Ferrazzi, Paola, Librè, Luca, Pacetti, Veronica, Sacco, Clara, Bucciarelli, Paolo, Martinelli, Ida, Abbattista, Maria, Artoni, Andrea, Capecchi, Marco, Gianniello, Francesca, Scimeca, Barbara, Turrini, Anna, Moretta, Francesca, Parise, Giorgio, Zeccardo, Ciro, Fregoni, Vittorio, Balboni, Massimo, Leggio, Federico, Poli, Daniela, Ria, Luigi, Spagnolo, Marina, Dirienzo, Giovanni, Dirienzo, Lavinia, Fuzio, Diana, Donadini, Marco Paolo, Squizzato, Alessandro, Ageno, Walter, Colombo, Giovanna, Galliazzo, Silvia, Gallo, Andrea, Tamborini Permunian, Eleonora, Virano, Alexandra, Falanga, Anna, Barcella, Luca, Gamba, Sara, Lerede, Teresa, Maggioni, Anna, Russo, Laura, Schieppati, Francesca, Zunino, Federica, Barillari, Giovanni, Bertone, Antonella, Poz, Alessandra, Venturelli, Ugo, Serricchio, Giuseppina, Brevi, Francesca, Palareti, Gualtiero, Legnani, Cristina, Cini, Michela, Antonucci, Emilia, Tripodi, Armando, and Tosetto, Alberto

Published
2024
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6. Thrombotic events associated with low baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study

Author

Testa, Sophie, Dellanoce, Claudia, Paoletti, Oriana, Morandini, Rossella, Tala, Maurizio, Ciampa, Antonio, Gaeta, Martina, Chiarugi, Paolo, Casini, Monica, Guerri, Valentina, Santoro, Rita Carlotta, Iannaccaro, Piergiorgio, Iannone, Angela Maria, Campagna, Maddalena, De Candia, Erica, Alberelli, Maria Adele, Basso, Maria, De Cristofaro, Raimondo, Di Gennaro, Leonardo, Ferretti, Antonietta, Sorrentino, Silvia, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Saliola, Mirella, Faioni, Elena Maria, Avarello, Ilaria, Razzari, Cristina, Chistolini, Antonio, Aprile, Simona Michela, Santoro, Cristina, Serrao, Alessandra, Esteban, Maria del Pilar, Ricca, Sergio, Marietta, Marco, Arletti, Laura, Coluccio, Valeria, Debbia, Giulia, Grisolia, Deborah, Serra, Domizio, Orselli, Alberto, Pescarollo, Alessandra, Verna, Sandra, Di Gregorio, Patrizia, Cassetti, Giuseppina, Molteni, Mauro, Monelli, Mauro, Paparo, Carmelo, Resani, Guido, Di Gregorio, Nicoletta, Grassi, Davide, Lodigiani, Corrado, Banfi, Elena, Ferrazzi, Paola, Librè, Luca, Pacetti, Veronica, Sacco, Clara, Bucciarelli, Paolo, Martinelli, Ida, Abbattista, Maria, Artoni, Andrea, Capecchi, Marco, Gianniello, Francesca, Scimeca, Barbara, Turrini, Anna, Moretta, Francesca, Parise, Giorgio, Zeccardo, Ciro, Fregoni, Vittorio, Balboni, Massimo, Leggio, Federico, Poli, Daniela, Ria, Luigi, Spagnolo, Marina, Dirienzo, Giovanni, Dirienzo, Lavinia, Fuzio, Diana, Donadini, Marco Paolo, Squizzato, Alessandro, Ageno, Walter, Colombo, Giovanna, Galliazzo, Silvia, Gallo, Andrea, Permunian, Eleonora Tamborini, Virano, Alexandra, Falanga, Anna, Barcella, Luca, Gamba, Sara, Lerede, Teresa, Maggioni, Anna, Russo, Laura, Schieppati, Francesca, Zunino, Federica, Barillari, Giovanni, Bertone, Antonella, Poz, Alessandra, Venturelli, Ugo, Serricchio, Giuseppina, Brevi, Francesca, Palareti, Gualtiero, Legnani, Cristina, Cini, Michela, Antonucci, Emilia, Tripodi, Armando, and Tosetto, Alberto

Published
2024
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8. MORE EARLY BLEEDS ASSOCIATED WITH HIGH BASELINE DIRECT ORAL ANTICOAGULANT LEVELS IN ATRIAL FIBRILLATION: THE MAS STUDY

Author

Palareti, Gualtiero, primary, Testa, Sophie, additional, Legnani, Cristina, additional, Dellanoce, Claudia, additional, Cini, Michela, additional, Paoletti, Oriana, additional, Ciampa, Antonio, additional, Antonucci, Emilia, additional, Poli, Daniela, additional, Morandini, Rossella, additional, Tala, Maurizio, additional, Chiarugi, Paolo, additional, Santoro, Rita Carlotta, additional, Iannone, Angela Maria, additional, De Candia, Erica, additional, Pignatelli, Pasquale, additional, Faioni, Elena Maria, additional, Chistolini, Antonio, additional, Esteban, Maria del Pilar, additional, Marietta, Marco, additional, Tripodi, Armando, additional, and Tosetto, Alberto, additional

Published
2024
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9. D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study

Author

Palareti, Gualtiero, Poli, Daniela, Ageno, Walter, Legnani, Cristina, Antonucci, Emilia, Bucherini, Eugenio, Testa, Sophie, Paoletti, Oriana, Chistolini, Antonio, Serrao, Alessandra, Martinelli, Ida, Bucciarelli, Paolo, Falanga, Anna, Tosetto, Alberto, Sarti, Luca, Mastroiacovo, Daniela, Cosmi, Benilde, Visonà, Adriana, Santoro, Rita Carlotta, Zanatta, Nello, Grandone, Elvira, Bertù, Lorenza, Pengo, Vittorio, Caiano, Lucia, and Prandoni, Paolo

Published
2022
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10. Long‐term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta‐analysis

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S., Kearon, Clive, Weitz, Jeffrey I., Büller, Harry R., Raskob, Gary E., Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A., Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert‐Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A., Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W.A., Gebel, Martin, Grosso, Michael A., Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Published
2021
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12. Sex Differences in Clinical Presentation of Lower Extremity Deep Vein Thrombosis.

Author

Cosmi, Benilde, Borgese, Laura, Legnani, Cristina, Sartori, Michelangelo, and Palareti, Gualtiero

Subjects
LEG, OUTPATIENT services in hospitals, VENOUS thrombosis, SEX distribution, FIBRIN fibrinogen degradation products, RETROSPECTIVE studies, HOSPITAL emergency services, DESCRIPTIVE statistics, COMPARATIVE studies, ALGORITHMS, SYMPTOMS
Abstract

Background: Differences between men and women in the clinical features and extent of lower limb deep vein thrombosis (DVT) may influence DVT diagnostic algorithms involving pretest clinical probability (PTP) assessment, D-dimer, and compression ultrasonography (CUS). Aims: To assess differences in DVT clinical presentation between men and women and their effect on PTP and D-dimer. Methods: We conducted a retrospective study in outpatients referred for suspected DVT of the lower limbs to our vascular emergency department from January 2005 to December 2019. Patients underwent PTP assessment with the Wells score, D-dimer testing, and CUS. Results: More women were referred for suspected DVT than men (M/F: 1,785/2,821; F: 61.4%; p < 0.0001). Women were older than men (median age: 71 vs. 67 years; p = 0.0001), DVT was diagnosed in 436 patients (9.4%) but in more men than women (M: 210 [11.8%] vs. F: 226 [8%]; p = 0.0002), with more proximal DVT in men than women (M: 131 7.3% vs. F: 124 [4.4%]; p = 0.00021). PTP was more likely in men (355 [19.9%]) than women (455 [16.2%]) (p = 0.0011); more men had swelling in the entire limb, increased calf circumference by >3 cm compared with the contralateral limb, and pitting edema, than women. D-dimer levels (available in 65% of patients) were more frequently positive in women with DVT than in men (94.6% vs. 85.7%; p = 0.016). However, a positive D-dimer and/or likely PTP was similarly frequent in men (92%) and women (96%) with DVT. Conclusions: More women than men are referred for suspected DVT, and men have a higher prevalence of proximal DVT. However, current algorithms for DVT diagnosis perform similarly in men and in women. [ABSTRACT FROM AUTHOR]

Published
2024
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13. LOW LEVELS OF DIRECT ORAL ANTICOAGULANTS AT STEADY STATE IN ATRIAL FIBRILLATION PATIENTS WHO LATER DEVELOP THROMBOTIC COMPLICATIONS; THE PROSPECTIVE MAS (MEASURE AND SEE) STUDY

Author

Testa, Sophie, primary, Palareti, Gualtiero, additional, LEGNANI, CRISTINA, additional, Dellanoce, Claudia, additional, Cini, Michela, additional, Paoletti, Oriana, additional, Ciampa, Antonio, additional, Antonucci, Emilia, additional, Poli, Daniela, additional, Morandini, Rossella, additional, Tala, Maurizio, additional, Chiarugi, Paolo, additional, Santoro, Rita Carlotta, additional, Iannone, Angela Maria, additional, De Candia, Erica, additional, Pignatelli, Pasquale, additional, Faioni, Elena, additional, Chistolini, Antonio, additional, Esteban, Maria Del Pilar, additional, Marietta, Marco, additional, Tripodi, Armando, additional, and Tosetto, Alberto, additional

Published
2023
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19. COVID-19 pandemic affects the ability of negative D-dimer to identify venous thromboembolism patients at low risk of recurrence: insights from the Apidulcis study

Author

Palareti, Gualtiero, Legnani, Cristina, Poli, Daniela, Ageno, Walter, Pengo, Vittorio, Testa, Sophie, Tosetto, Alberto, Prandoni, Paolo, De Candia, Erica, De Candia E (ORCID:0000-0003-0942-2819), Palareti, Gualtiero, Legnani, Cristina, Poli, Daniela, Ageno, Walter, Pengo, Vittorio, Testa, Sophie, Tosetto, Alberto, Prandoni, Paolo, De Candia, Erica, and De Candia E (ORCID:0000-0003-0942-2819)

Abstract

N/A

Published
2023

21. Evaluation of Coaguchek®Pro II coagulation testing device performance to assess direct oral anticoagulant action. The DOAC-CHECK study

Author

Legnani, Cristina, primary, Cini, Michela, additional, Testa, Sophie, additional, Tosetto, Alberto, additional, Dellanoce, Claudia, additional, Bellesso, Stefania, additional, Carli, Giuseppe, additional, Nichele, Ilaria, additional, Lissandrini, Laura, additional, Zorzi, Serena, additional, Antonucci, Emilia, additional, and Palareti, Gualtiero, additional

Published
2022
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31. Rationale and design of a study on D-dimer use to stratify patients after a first unprovoked venous thromboembolism for their risk of recurrence: extended low-dose Apixaban given only to patients with positive D-dimer results

Author

Palareti, Gualtiero, primary, Prandoni, Paolo, additional, Legnani, Cristina, additional, Antonucci, Emilia, additional, Zorzi, Serena, additional, Tosetto, Alberto, additional, Bertù, Lorenza, additional, Testa, Sophie, additional, Pengo, Vittorio, additional, Ageno, Walter, additional, Martinelli, Ida, additional, Cosmi, Benilde, additional, Bucherini, Eugenio, additional, and Poli, Daniela, additional

Published
2022
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32. Long-term Risk of Recurrent Venous Thromboembolism Among Patients Receiving Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S, Kearon, Clive, Weitz, Jeffrey I, Büller, Harry R, Raskob, Gary E, Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A, Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert-Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A, Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W A, Gebel, Martin, Grosso, Michael A, Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Subjects
cardiovascular diseases, equipment and supplies
Abstract

BACKGROUND The long-term risk for recurrent venous thromboembolism (VTE) during extended anticoagulation for a first unprovoked VTE is uncertain. OBJECTIVES To determine the incidence of recurrent VTE during extended anticoagulation up to 5 years in patients with a first unprovoked VTE. METHODS MEDLINE, EMBASE, and the Cochrane CENTRAL were searched to identify randomized trials and prospective cohort studies reporting recurrent VTE among patients with a first unprovoked VTE who were to receive anticoagulation for a minimum of 6 additional months after completing ≥ 3 months of initial treatment. Unpublished data on number of recurrent VTE and person-years, obtained from authors of included studies, were used to calculate study-level incidence rate, and random-effects meta-analysis was used to pool results. RESULTS Twenty-six studies and 15, 603 patients were included in the analysis. During 11, 631 person-years of follow-up, the incidence of recurrent VTE and fatal pulmonary embolism per 100 person-years was 1.41 (95% CI, 1.03-1.84) and 0.09 (0.04-0.16), with 5-year cumulative incidences of 7.1% (3.0%-13.2%) and 1.2% (0.4%-4.6%), respectively. The incidence of recurrent VTE was 1.08 (95% CI, 0.77-1.44) with direct oral anticoagulants and 1.55 (1.01-2.20) with vitamin K antagonists. The case-fatality rate of recurrent VTE was 4.9% (95% CI, 2.2%-8.7%). CONCLUSIONS In patients with a first unprovoked VTE, the long-term risk of recurrent VTE during extended anticoagulation is low but not negligible. Thus, clinicians and patients should be aware of this risk and take appropriate and timely action in case of suspicion of recurrent VTE. Estimates from this study can be used to advise patients on what to expect while receiving extended anticoagulation, and estimate the net clinical benefit of extended treatment to guide long-term management of unprovoked VTE.

Published
2021

42. Thrombophilia testing in the real-world clinical setting of thrombosis centres taking part in the Italian Start 2-Register

Author

Legnani, Cristina, Palareti, Gualtiero, Antonucci, Emilia, Poli, Daniela, Cosmi, Benilde, Falanga, Anna, Mastroiacovo, Daniela, Testa, Sophie, Paoletti, Oriana, Morandini, Rossella, Marcucci, Rossella, Maggini, Niccolò, Guazzaloca, Giuliana, Lerede, Teresa, Barcella, Luca, Bucherini, Eugenio, Chiarugi, Paolo, Grandone, Elvira, Colaizzo, Donatella, Pengo, Vittorio, Pignatelli, Pasquale, Pastori, Daniele, Piana, Antonietta, Cibecchini, Francesco, Martini, Giuliana, Bradamante, Salvatore, Masciocco, Lucilla, Paparo, Carmelo, Ageno, Walter, Colombo, Giovanna, Vasselli, Claudio, Toma, Andrea, Visonà, Adriana, Tonello, Diego, Legnani, C., Palareti, G., Antonucci, E., Poli, D., Cosmi, B., Falanga, A., Mastroiacovo, D., and Testa, S.

Subjects
Haemostasis And Thrombosis, Recurrent event, Incidence, anticoagulant, Bleeding, Thrombosis, Venous Thromboembolism, Italy, thrombofilia, Humans, Thrombophilia, VTE, thrombosis, Prospective Studies, Anticoagulant therapy, Factor Xa Inhibitors, Follow-Up Studies
Abstract

Background - Even though it rarely influences venous thromboembolism (VTE) treatment and the fact that it is generally discouraged, thrombophilia testing is still largely prescribed. We assessed: 1) whether/how frequently Italian thrombosis centres requested thrombophilia testing; 2) what results were obtained; and 3) if the results affected treatment and clinical results. Materials and methods - We examined data from 4,826 VTE patients enrolled by 19 clinical centres participating in the START 2-Register. Results - 57.2% of patients were tested. Numbers varied widely among centres (2.9-99.7%). Thrombophilic alterations were recorded in 18.2% of patients and the percentage of positive results was inversely correlated with that of patients tested. Significantly less patients with deep vein thrombosis (DVT) were tested, whereas more were tested when the event was idiopathic, presenting as isolated pulmonary embolism (PE), or in unusual sites. Patients with thrombophilic alterations were younger, more frequently treated with direct oral anticoagulants (DOACs), with lower mortality and less frequently discontinued anticoagulation. DOACs were more frequently prescribed in patients with heterozygous Factor V (FV) Leiden or prothrombin mutations, whereas vitamin K antagonists were preferred in patients with inhibitor deficiencies, combined alterations or antiphospholipid syndrome (APLS). There was no difference in duration of treatment among those with or without alterations, though more APLS patients received an extended treatment course. Bleeding and thrombotic complications occurred with a similar and fairly low incidence in patients with or without thrombophilic alterations. Discussion - Although general testing for thrombophilia in VTE patients is currently discouraged, more than half of the VTE patients included in the START2-Register were tested. However, there were marked differences in practice between Italian thrombosis centres. About 60% of all patients with alterations were treated with DOACs, confirming that DOACs can be a useful option for treatment of thrombophilic VTE patients, with the exclusion of those with APLS. IMTIPRO Sr © SIMTIPRO Srl

Published
2021

44. Management and Outcomes of Isolated Distal Deep Vein Thromboses: A Questionable Trend toward Long-Lasting Anticoagulation Treatment. Results from the START-Register

Author

Palareti, Gualtiero, additional, Legnani, Cristina, additional, Antonucci, Emilia, additional, Testa, Sophie, additional, Mastroiacovo, Daniela, additional, Cosmi, Benilde, additional, Poli, Daniela, additional, Bucherini, Eugenio, additional, Dentali, Francesco, additional, Fontanella, Andrea, additional, Mumoli, Nicola, additional, Imberti, Davide, additional, Falanga, Anna, additional, Ageno, Walter, additional, and Pomero, Fulvio, additional

Published
2021
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45. Long-term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta-analysis

Author

HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S, Kearon, Clive, Weitz, Jeffrey I, Büller, Harry R, Raskob, Gary E, Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A, Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert-Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A, Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W A, Gebel, Martin, Grosso, Michael A, Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, Fergusson, Dean, HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S, Kearon, Clive, Weitz, Jeffrey I, Büller, Harry R, Raskob, Gary E, Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A, Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert-Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A, Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W A, Gebel, Martin, Grosso, Michael A, Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Published
2021

50. D-dimer testing to determine the duration of anticoagulation therapy

Author

Palareti, Gualtiero; Cosmi, Benilde; Legnani, Cristina, Tosetto, Alberto; Brusi, Carlotta; Lorio, Alfonso, Pengo, Vittorio; Ghirarduzzi, Angelo, Lensing, Anthonie W.A.; Tripodi, Armando, and Pattacini, Corrado; Testa, Sophie

Subjects
Anticoagulants (Medicine) -- Dosage and administration, Thrombophlebitis -- Drug therapy
Abstract

D-dimer levels are tested to assess the optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism. It is evaluated that patients with abnormal D-dimer have a recurrence of venous thromboembolism after the discontinuation of anticoagulation but reduces on its resumption whereas for patients with normal D-dimer level, the optimal course of anticoagulation is not clearly established.

Published
2006

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