13 results on '"Korteweg, Tijmen"'
Search Results
2. Case report of the broad spectrum of late complications in an adult patient with univentricular physiology palliated by the Fontan circulation.
- Author
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Nederend, Marieke, Egorova, Anastasia D, Vliegen, Hubert W, Roest, Arno A W, Ruijter, Bastian N, Korteweg, Tijmen, Ninaber, Maarten K, Zeppenfeld, Katja, Hazekamp, Mark G, Kiès, Philippine, and Jongbloed, Monique R M
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CONGENITAL heart disease ,VENA cava inferior ,VENA cava superior ,PULMONARY circulation ,CARDIAC patients ,TRANSPOSITION of great vessels - Abstract
Background At the most severe end of the spectrum of congenital heart disease are patients with an univentricular physiology. They comprise a heterogeneous group of congenital heart malformations that have the common characteristic that the cardiac morphology is not equipped for sustaining a biventricular circulation. Case summary Here, we present a case of an adult patient after Fontan palliation, illustrative of the complex clinical course and the broad spectrum of complications that can be encountered during follow-up, highlighting the need for a multidisciplinary approach in the clinical care for these patients. Discussion During the surgical Fontan procedure, the inferior vena cava is connected to the pulmonary circulation, after prior connection of the superior vena cava to the pulmonary arterial circulation. The resulting cavopulmonary connection, thus lacking a subpulmonic ventricle, provides non-pulsatile passive flow of oxygen-poor blood from the systemic venous circulation into the lungs, and the functional monoventricle pumps the oxygen-rich pulmonary venous return blood into the aorta. With an operative mortality of <5% and current 30-year survival rates up to 85%, the adult population of patients with a Fontan circulation is growing. This increase in survival is, however, inevitably accompanied by long-term complications affecting multiple organ systems, resulting in decline in cardiovascular performance. Conclusion For optimal treatment, the evaluation in a multidisciplinary team is mandatory, using the specific expertise of the team members to timely detect and address late complications and to support quality of life. [ABSTRACT FROM AUTHOR]
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- 2022
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3. MRI criteria for dissemination in space in patients with clinically isolated syndromes: a multicentre follow-up study
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Korteweg, Tijmen, Tintoré, Mar, Uitdehaag, Bernard, Rovira, Alex, Frederiksen, Jette, Miller, David, Fernando, Kryshani, Filippi, Massimo, Agosta, Federica, Rocca, Maria, Fazekas, Franz, Enzinger, Christian, Matthews, Paul, Parry, Allyson, Polman, Chris, Montalban, Xavier, and Barkhof, Frederik
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- 2006
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4. Feasibility of Velocity‐Selective Arterial Spin Labeling in Breast Cancer Patients for Noncontrast‐Enhanced Perfusion Imaging.
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Franklin, Suzanne L., Voormolen, Nora, Bones, Isabell K., Korteweg, Tijmen, Wasser, Martin N. J. M., Dankers, Henrike G., Cohen, Daniele, van Stralen, Marijn, Bos, Clemens, and van Osch, Matthias J. P.
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SPIN labels ,BREAST cancer ,CANCER patients ,CONTRAST media ,PERFUSION - Abstract
Background: Dynamic contrast‐enhanced (DCE) MRI is the most sensitive method for detection of breast cancer. However, due to high costs and retention of intravenously injected gadolinium‐based contrast agent, screening with DCE‐MRI is only recommended for patients who are at high risk for developing breast cancer. Thus, a noncontrast‐enhanced alternative to DCE is desirable. Purpose: To investigate whether velocity selective arterial spin labeling (VS‐ASL) can be used to identify increased perfusion and vascularity within breast lesions compared to surrounding tissue. Study Type: Prospective. Population: Eight breast cancer patients. Field Strength/Sequence: A 3 T; VS‐ASL with multislice single‐shot gradient‐echo echo‐planar‐imaging readout. Assessment: VS‐ASL scans were independently assessed by three radiologists, with 3–25 years of experience in breast radiology. Scans were scored on lesion visibility and artifacts, based on a 3‐point Likert scale. A score of 1 corresponded to "lesions being distinguishable from background" (lesion visibility), and "no or few artifacts visible, artifacts can be distinguished from blood signal" (artifact score). A distinction was made between mass and nonmass lesions (based on BI‐RADS lexicon), as assessed in the standard clinical exam. Statistical Tests: Intra‐class correlation coefficient (ICC) for interobserver agreement. Results: The ICC was 0.77 for lesion visibility and 0.84 for the artifact score. Overall, mass lesions had a mean score of 1.27 on lesion visibility and 1.53 on the artifact score. Nonmass lesions had a mean score of 2.11 on lesion visibility and 2.11 on the artifact score. Data Conclusion: We have demonstrated the technical feasibility of bilateral whole‐breast perfusion imaging using VS‐ASL in breast cancer patients. Evidence Level: 1 Technical Efficacy: Stage 1 [ABSTRACT FROM AUTHOR]
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- 2021
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5. Agreement between different input image types in brain atrophy measurement in multiple sclerosis using SIENAX and SIENA
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Neacsu, Veronica, Jasperse, Bas, Korteweg, Tijmen, Knol, Dirk L., Valsasina, Paola, Filippi, Massimo, Barkhof, Frederik, Rovaris, Marco, and Vrenken, Hugo
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- 2008
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6. Successful Thrombectomy via a Surgically Reopened Umbilical Vein for Extended Portal Vein Thrombosis Caused by Portal Vein Embolization prior to Extended Liver Resection.
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Derksen, Wouter J.M., de Jong, Iris E.M., Buis, Carlijn I., Reyntjens, Koen M.E.M., Kater, G. Matthijs, Korteweg, Tijmen, Mazuri, Aryan, and Porte, Robert J.
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PORTAL vein ,UMBILICAL veins ,THROMBOSIS ,LIVER surgery ,PORTAL vein surgery ,LIVER ,THROMBOLYTIC therapy - Abstract
Selective portal vein embolization (PVE) before extended liver surgery is an accepted method to stimulate growth of the future liver remnant. Portal vein thrombosis (PVT) of the main stem and the non-targeted branches to the future liver remnant is a rare but major complication of PVE, requiring immediate revascularization. Without revascularization, curative liver surgery is not possible, resulting in a potentially life-threatening situation. We here present a new surgical technique to revascularize the portal vein after PVT by combining a surgical thrombectomy with catheter-based thrombolysis via the surgically reopened umbilical vein. This technique was successfully applied in a patient who developed thrombosis of the portal vein main stem, as well as the left portal vein and its branches to the left lateral segments after selective right-sided PVE in preparation for an extended right hemihepatectomy. The advantage of this technique is the avoidance of an exploration of hepatoduodenal ligament and a venotomy of the portal vein. The minimal surgical trauma facilitates additional intravascular thrombolytic therapy as well as the future right extended hemihepatectomy. We recommend this technique in patients with extensive PVT in which percutaneous less invasive therapies have been proven unsuccessful. [ABSTRACT FROM AUTHOR]
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- 2020
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7. Reliability of clinical nodal status regarding response to neoadjuvant chemoradiotherapy compared with surgery alone and prognosis in esophageal cancer patients.
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Dijksterhuis, Willemieke P. M., Hulshoff, Jan Binne, van Dullemen, Hendrik M., Kats-Ugurlu, Gursah, Burgerhof, Johannes G. M., Korteweg, Tijmen, Mul, Veronique E. M., Hospers, Geke A. P., and Plukker, John T. M.
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CANCER patients ,COMBINED modality therapy ,ESOPHAGEAL tumors ,TUMOR classification ,TREATMENT effectiveness ,PROPORTIONAL hazards models ,DESCRIPTIVE statistics ,CHEMORADIOTHERAPY - Abstract
Background: Clinical nodal (cN) staging is a key element in treatment decisions in patients with esophageal cancer (EC). The reliability of cN status regarding the effect on response and survival after neoadjuvant chemoradiotherapy (nCRT) with esophagectomy was evaluated in determining the up- and downstaged pathological nodal (pN) status after surgery alone. Material and methods: From a prospective database, we included all 395 EC patients who had surgery with curative intent with or without nCRT between 2000 and 2015. All patients were staged by a standard pretreatment protocol: 16-64 mdCT, 18 F-FDG-PET or 18 F-FDG-PET/CT and EUS ± FNA. After propensity score matching on baseline clinical tumor and nodal (cT/N) stage and histopathology, a surgery-alone and nCRT group (each N = 135) were formed. Clinical and pathological N stage was scored as equal (cN = pN), downstaged (cN > pN) or upstaged (cN < pN). Prognostic impact on disease free survival (DFS) was assessed with multivariable Cox regression analysis (factors with p value <.1 on univariable analysis). Results: The surgery-alone and nCRT group did not differ in cT/N status. Pathologic examination revealed equal staging (32 vs. 27%), nodal up (43 vs. 16%) and downstaging (25 vs. 56%), respectively (p <.001). Nodal up-staging was common in cT3-4a tumors and adenocarcinomas in the surgery-alone group, while nodal downstaging was found in half of cT1-2 and cT3-4 regardless of tumortype after nCRT. Prognostic factors for DFS were pN (p =.002) and lymph-angioinvasion (p =.016) in surgery-alone, and upper abdominal cN metastases (p =.012) and lymph node ratio (p =.034) in the nCRT group. Conclusions: Despite modern staging methods, correct cN staging remains difficult in EC. Nodal overstaging (cN > pN) occurred more often than understaging impeding an adequate assessment of pathologic complete response and prognosis after nCRT. Preoperative assessment of true nodal response after nCRT in EC remains difficult with clinical nodal upstaging (16% vs. 43%) and downstaging (56% vs. 25%) after nCRT and surgery alone, respectively. [ABSTRACT FROM AUTHOR]
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- 2019
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8. Unenhanced CT imaging is highly sensitive to exclude pheochromocytoma: a multicenter study.
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Buitenwerf, Edward, Korteweg, Tijmen, Visser, Anneke, Haag, Charlotte M. S. C., Feelders, Richard A., Timmers, Henri J. L. M., Canu, Letizia, Haak, Harm R., Bisschop, Peter H. L. T., Eekhoff, Elisabeth M. W., Corssmit, Eleonora P. M., Krak, Nanda C., Rasenberg, Elise, van den Bergh, Janneke, Stoker, Jaap, Greuter, Marcel J. W., Dullaart, Robin P. F., Links, Thera P., and Kerstens, Michiel N.
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PHEOCHROMOCYTOMA , *COMPUTED tomography , *ADRENAL tumors , *TUMOR diagnosis , *PREOPERATIVE care - Abstract
Background: A substantial proportion of all pheochromocytomas is currently detected during the evaluation of an adrenal incidentaloma. Recently, it has been suggested that biochemical testing to rule out pheochromocytoma is unnecessary in case of an adrenal incidentaloma with an unenhanced attenuation value =10 Hounsfield Units (HU) at computed tomography (CT). Objectives: We aimed to determine the sensitivity of the 10 HU threshold value to exclude a pheochromocytoma. Methods: Retrospective multicenter study with systematic reassessment of preoperative unenhanced CT scans performed in patients in whom a histopathologically proven pheochromocytoma had been diagnosed. Unenhanced attenuation values were determined independently by two experienced radiologists. Sensitivity of the 10 HU threshold was calculated, and interobserver consistency was assessed using the intraclass correlation coefficient (ICC). Results: 214 patients were identified harboring a total number of 222 pheochromocytomas. Maximum tumor diameter was 51 (39-74) mm. The mean attenuation value within the region of interest was 36 ± 10 HU. Only one pheochromocytoma demonstrated an attenuation value =10 HU, resulting in a sensitivity of 99.6% (95% CI: 97.5-99.9). ICC was 0.81 (95% CI: 0.75-0.86) with a standard error of measurement of 7.3 HU between observers. Conclusion: The likelihood of a pheochromocytoma with an unenhanced attenuation value =10 HU on CT is very low. The interobserver consistency in attenuation measurement is excellent. Our study supports the recommendation that in patients with an adrenal incidentaloma biochemical testing for ruling out pheochromocytoma is only indicated in adrenal tumors with an unenhanced attenuation value >10 HU. [ABSTRACT FROM AUTHOR]
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- 2018
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9. A three-year, multi-parametric MRI study in patients at presentation with CIS.
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Rocca, Maria A., Agosta, Federica, Sormani, Maria P., Fernando, Kryshani, Tintorè, Mar, Korteweg, Tijmen, Tortorella, Paola, Miller, David H., Thompson, Alan, Rovira, Alex, Montalban, Xavier, Polman, Chris, Barkhof, Frederik, and Filippi, Massimo
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MAGNETIC resonance imaging ,BRAIN damage ,MULTIPLE sclerosis ,MAGNETIC resonance ,NEUROLOGY - Abstract
To define the extent of overall brain damage in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) and to identify non-conventional magnetic resonance (MR) metrics predictive of evolution to definite MS. Brain conventional and magnetization transfer (MT) MRI scans were obtained from 208 CIS patients and 55 matched healthy controls, recruited in four centres. Patients were assessed clinically at the time of MRI acquisition and after a median period of 3.1 years from disease onset. The following measures were derived: T2, T1 and gadolinium (Gd)- enhancing lesion volumes (LV), normalized brain volume (NBV), MTR histogram-derived quantities of the normal-appearing white matter (NAWM) and grey matter (GM). During the follow-up, 43 % of the patients converted to definite MS. At baseline, a significant inter-centre heterogeneity was detected for T2 LV (p = 0.003), T1 LV (p = 0.006), NBV (p < 0.001) and MTR histogram-derived metrics (p < 0.001). Pooled average MTR values differed between CIS patients and controls for NAWM (p = 0.003) and GM (p = 0.01). Gdactivity and positivity of International Panel (IP) criteria for disease dissemination in space (DIS), but not NAWM and GM MTR and NBV, were associated with evolution to definite MS. The final multivariable model retained only MRI IP criteria for DIS (p = 0.05; HR = 1.66, 95 % CI = 1.00–2.77) as an independent predictor of evolution to definite MS. Although irreversible tissue injury is present from the earliest clinical stages of MS, macroscopic focal lesions but not "diffuse" brain damage measured by MTR are associated to an increased risk of subsequent development of definite MS in CIS patients. [ABSTRACT FROM AUTHOR]
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- 2008
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10. Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosis.
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Rovaris, Marco, Judica, Elda, Sastre-Garriga, Jaume, Rovira, Alex, Sormani, Maria Pia, Benedetti, Beatrice, Korteweg, Tijmen, De Stefano, Nicola, Khaleeli, Zhaleh, Montalban, Xavier, Barkhof, Frederik, Miller, David H., Polman, Chris, Thompson, Alan J., and Filippi, Massimo
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CEREBROSPINAL fluid ,AIDS patients ,MEDICAL imaging systems ,HLA histocompatibility antigens ,VIRUS diseases ,SPINAL cord - Abstract
Although the mechanisms underlying the accumulation of disability in primary progressive (PP) multiple sclerosis (MS) are still unclear, a major role seems to be played by 'occult' tissue damage. We investigated whether conventional and magnetization transfer (MT) MRI may provide complementary information for the assessment of PPMS severity. Conventional and MT MRI scans from 226 PPMS patients and 84 healthy controls were collected for centralized analysis. The expanded disability status scale (EDSS) score was rated at the time of MRI acquisition. T2 lesion volume, normalized brain volume (NBV) and cervical cord cross-sectional area (CSA) were measured. Magnetization transfer ratio (MTR) histograms from whole brain tissue, normal-appearing white matter and grey matter (NAGM) were also obtained. Mean NBV, CSA and MTR histogram-derived metrics showed significant inter-centre heterogeneity. After correcting for the acquisition centre, pooled average MTR and histogram peak height values were different between PPMS patients and controls for all tissue classes (P-values between 0.03 and 0.0001). More severe brain and cord atrophy and MT MRI-detectable NAGM damage were found in patients who required walking aids than in those who did not (P-values: 0.03, <0.001 and 0.016). A composite score of NBV, CSA, whole brain and NAGM MTR histogram peak height z-scores was correlated with patients' EDSS (r = 0.37, P < 0.001). Magnetization transfer MRI might provide information complementary to that given by conventional MRI when assessing PPMS severity. Sequence-related variability of measurements makes the standardization of MT MRI acquisition essential for the design of multicentre studies. [ABSTRACT FROM AUTHOR]
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- 2008
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11. Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX.
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Jasperse, Bas, Valsasina, Paola, Neacsu, Veronica, Knol, Dirk L., De Stefano, Nicola, Enzinger, Christian, Smith, Stephen M., Ropele, Stefan, Korteweg, Tijmen, Giorgio, Antonio, Anderson, Valerie, Polman, Chris H., Filippi, Massimo, Miller, David H., Rovaris, Marco, Barkhof, Frederik, Vrenken, Hugo, and Magnetic Imaging in Multiple Sclerosis (MAGNIMS) study group
- Abstract
Purpose: To investigate intercenter agreement of brain volume (change) measurement in multiple sclerosis (MS) using structural image evaluation using normalization of atrophy (SIENA) and the cross-sectional version of SIENA (SIENAX) with additional manual editing to correct for inadequate brain extraction.Materials and Methods: Baseline and follow-up T1-weighted MR images of 20 MS patients were dispatched to five centers. Each center performed fully-automated and manually-edited analyses for SIENAX, yielding normalized brain volume (NBV), and SIENA, yielding percentage brain volume change (PBVC). Intercenter agreement was assessed with the concordance correlation coefficient (CCC).Results: Intercenter agreement was perfect for fully automated NBV and PBVC (both CCC = 1.0), and remained substantial upon manual editing (CCC = 0.94 for NBV, CCC = 0.95 for PBVC). Mean NBV values for each center decreased significantly after manual editing (overall mean NBV = 1605.3 cm(3) vs. 1651.1 cm(3) without manual editing; t = -4.58, P < 0.001). Total variance in PBVC decreased significantly by a factor of 1.8 after manual editing (sigma(2) = 2.82 before, and sigma(2) = 1.54 after manual editing, P < 0.05).Conclusion: Substantial intercenter agreement was found for manually-edited SIENAX and SIENA, suggesting that measurements from multiple centers may be pooled. Manual editing reduces overestimation of NBV, and is likely to increase statistical power for PBVC. [ABSTRACT FROM AUTHOR]- Published
- 2007
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12. Assessment and correction of B1-induced errors in magnetization transfer ratio measurements.
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Ropele, Stefan, Filippi, Massimo, Valsasina, Paola, Korteweg, Tijmen, Barkhof, Frederik, Tofts, Paul S., Samson, Rebecca, Miller, David H., and Fazekas, Franz
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The magnetization transfer ratio (MTR) is strongly related to the field strength ( B
1 ) of the saturation pulse. B1 variations therefore can result in significant MTR variations and can affect histogram analysis, particularly if data from a large volume of interest are included. A multicenter study was performed to determine the typical range of B1 errors and the corresponding MTR variations in brain tissue of healthy volunteers. Seven subjects were included at each center resulting in a total cohort of 28 subjects. Additionally, numerical simulations were done to study this relationship more generally for pulsed saturation. It could be demonstrated, both theoretically and empirically, that for typical B1 errors there is a linear relationship between B1 error and the corresponding MTR change. In addition, for proton density-weighted sequences, this relationship seems to be largely independent of the underlying relaxation properties. Mean B1 errors in the entire brain were typically in the range between -3% and -7%. Due to different coil characteristics, significant MTR differences between different scanners and sites were observed. Using a simple correction scheme that is based on a linear regression analysis between MTR and B1 data it was possible to reduce the intersubject variation by ∼50%. Furthermore, interscanner variation could be reduced such that no significant differences between scanners could be detected. The correction scheme may be useful when investigating MTR as an outcome measure in single or multicenter studies. Magn Reson Med 53:134-140, 2005. © 2004 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]- Published
- 2005
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13. Relating Functional Reorganisation in Multiple Sclerosis to Clinical Measures in a Multi-Centre Study.
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Wegner, Christiane, Agosta, Frederica, Barkhof, Frederick, Beckmann, Christian, Ciccarelli, Olga, De Stefano, Nicola, Fazekas, Franz, Filippi, Massimo, Gass, Achim, Hirsch, Jochen, Johansen-Berg, Heidi, Kappos, Ludwig, Korteweg, Tijmen, Mancini, Laura, Manfredonia, Francesco, Marino, Silvia, Miller, David H., Montalban, Xavier, Palace, Jacqueline, and Polman, Chris
- Published
- 2006
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