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377 results on '"Koh, Tse-Hsien"'

1. Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study

Author

Suphavilai, Chayaporn, Ko, Karrie Kwan Ki, Lim, Kar Mun, Tan, Mei Gie, Boonsimma, Patipan, Chu, Joash Jun Keat, Goh, Sui Sin, Rajandran, Prevena, Lee, Lai Chee, Tan, Kwee Yuen, Shaik Ismail, Bushra Binte, Aung, May Kyawt, Yang, Yong, Sim, Jean Xiang Ying, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, Spruijtenburg, Bram, Chan, Kian Sing, Oon, Lynette Lin Ean, Tan, Ai Ling, Tan, Yen Ee, Wijaya, Limin, Tan, Ban Hock, Ling, Moi Lin, Koh, Tse Hsien, Meis, Jacques F, Tsui, Clement Kin Ming, and Nagarajan, Niranjan

Published
2024
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2. Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales

Author

Marimuthu, Kalisvar, Venkatachalam, Indumathi, Koh, Vanessa, Harbarth, Stephan, Perencevich, Eli, Cherng, Benjamin Pei Zhi, Fong, Raymond Kok Choon, Pada, Surinder Kaur, Ooi, Say Tat, Smitasin, Nares, Thoon, Koh Cheng, Tambyah, Paul Anantharajah, Hsu, Li Yang, Koh, Tse Hsien, De, Partha Pratim, Tan, Thean Yen, Chan, Douglas, Deepak, Rama Narayana, Tee, Nancy Wen Sim, Kwa, Andrea, Cai, Yiying, Teo, Yik-Ying, Thevasagayam, Natascha May, Prakki, Sai Rama Sridatta, Xu, Weizhen, Khong, Wei Xin, Henderson, David, Stoesser, Nicole, Eyre, David W., Crook, Derrick, Ang, Michelle, Lin, Raymond Tzer Pin, Chow, Angela, Cook, Alex R., Teo, Jeanette, and Ng, Oon Tek

Published
2022
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3. Sequence Types and Antimicrobial Resistance Profiles of Salmonella Typhimurium in the Food Chain in Singapore.

Author

Lim, Yen Ching, Ong, Kar Hui, Khor, Wei Ching, Chua, Favian Yue Xuan, Lim, Jia Qi, Tan, Li Kiang, Chen, Swaine L., Wong, Wai Kwan, Maiwald, Matthias, Barkham, Timothy, Koh, Tse Hsien, Khoo, Joanna, Chan, Joanne Sheot Harn, and Aung, Kyaw Thu

Subjects
WHOLE genome sequencing, SALMONELLA typhimurium, DRUG resistance in microorganisms, FOOD pathogens, CHICKENS, LACTAMS
Abstract

Salmonella remains a significant foodborne pathogen globally with S. Typhimurium presenting as a frequently occurring serovar. This study aimed to characterize 67 S. Typhimurium isolates from humans, food, farms, and slaughterhouses collected in Singapore from 2016 to 2017. Using whole-genome sequencing analysis, the isolates were found to belong to either ST19 (n = 33) or ST36 (n = 34). ST36 predominated in human intestinal and chicken isolates, while human extra-intestinal and non-chicken food isolates belonged to ST19. Plasmids were predicted in 88.1% (n = 59) of the isolates with the most common incompatibility group profiles being IncFIB(S), IncFII(S) and IncQ1. IncFIB(S) (adjusted p-value < 0.05) and IncFII(S) (adjusted p-value < 0.05) were significantly more prevalent in ST19 isolates, while Col156 (adjusted p-value < 0.05) was more significantly found in ST36 isolates. ST36 isolates exhibited higher resistance to multiple antibiotic classes such as penicillins, phenicols, folate pathway inhibitors, aminoglycosides, β-lactam/β-lactamase inhibitor combinations, tetracyclines, and fluoroquinolones. Phylogenetics analysis suggested potential shared routes of transmission among human, chicken, farm and slaughterhouse environments. Taken together, this study offers a cross-sectional epidemiological insight into the genomic epidemiology and antimicrobial landscape of S. Typhimurium isolates in Singapore, informing strategies for future public health and food safety surveillance. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Author Correction: The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone

Author

Chen, Swaine L., Ding, Ying, Apisarnthanarak, Anucha, Kalimuddin, Shirin, Archuleta, Sophia, Omar, Sharifah Faridah Syed, De, Partha Pratim, Koh, Tse Hsien, Chew, Kean Lee, Atiya, Nadia, Suwantarat, Nuntra, Velayuthan, Rukumani Devi, Wong, Joshua Guo Xian, and Lye, David C.

Published
2021
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7. Acquisition of Plasmid with Carbapenem-Resistance Gene [bla.sub.KPC2] in Hypervirulent Klebsiella pneumoniae, Singapore

Author

Chen, Yahua, Marimuthu, Kalisvar, Teo, Jeanette, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, De Wang, Liang, Prakki, Sai Rama Sridatta, Xu, Weizhen, Tan, Yi Han, Nguyen, Lan Chi, Koh, Tse Hsien, Ng, Oon Tek, and Gan, Yunn-Hwen

Subjects
Klebsiella infections -- Genetic aspects -- Care and treatment -- Development and progression, Microbial drug resistance -- Genetic aspects, Sentinel surveillance, Plasmids -- Identification and classification, Diseases, Health
Abstract

The rise of multidrug-resistant (MDR) Enterobacteriaceae prompted the World Health Organization to classify carbapenem-resistant Enterobacteriaceae, of which Klebsiella is the most common genus, on the global priority list of antibiotic-resistant [...]

Published
2020
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8. Clinical and Molecular Epidemiology of Carbapenem-Resistant Enterobacteriaceae Among Adult Inpatients in Singapore

Author

Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group, Marimuthu, Kalisvar, Venkatachalam, Indumathi, Khong, Wei Xin, Koh, Tse Hsien, Cherng, Benjamin Pei Zhi, Van La, My, De, Partha Pratim, Krishnan, Prabha Unny, Tan, Thean Yen, Choon, Raymond Fong Kok, Pada, Surinder Kaur, Lam, Choong Weng, Ooi, Say Tat, Deepak, Rama Narayana, Smitasin, Nares, Tan, Eng Lee, Lee, Jia Jun, Kurup, Asok, Young, Barnaby, Sim, Nancy Tee Wen, Thoon, Koh Cheng, Fisher, Dale, Ling, Moi Lin, Peng, Brenda Ang Sze, Teo, Yik-Ying, Hsu, Li Yang, Lin, Raymond Tzer Pin, Ong, Rick Twee-Hee, Teo, Jeanette, and Ng, Oon Tek

Published
2017

9. 2015 Epidemic of Severe Streptococcus agalactiae Sequence Type 283 Infections in Singapore Associated With the Consumption of Raw Freshwater Fish: A Detailed Analysis of Clinical, Epidemiological, and Bacterial Sequencing Data

Author

Singapore Group B Streptococcus Consortium, Kalimuddin, Shirin, Chen, Swaine L., Lim, Cindy T. K., Koh, Tse Hsien, Tan, Thean Yen, Kam, Michelle, Wong, Christopher W., Mehershahi, Kurosh S., Chau, Man Ling, Ng, Lee Ching, Tang, Wen Ying, Badaruddin, Hishamuddin, Teo, Jeanette, Apisarnthanarak, Anucha, Suwantarat, Nuntra, Ip, Margaret, Holden, Matthew T. G., Hsu, Li Yang, and Barkham, Timothy

Published
2017

10. Discovery of the sixth Candida auris clade in Singapore

Author

Suphavilai, Chayaporn, primary, Ko, Karrie K. K., additional, Lim, Kar Mun, additional, Tan, Mei Gie, additional, Boonsimma, Patipan, additional, Chu, Joash Jun Keat, additional, Goh, Sui Sin, additional, Rajandran, Prevena, additional, Lee, Lai Chee, additional, Tan, Kwee Yuen, additional, Shaik Ismail, Bushra, additional, Aung, May Kyawt, additional, Yang, Yong, additional, Sim, Jean Xiang Ying, additional, Venkatachalam, Indumathi, additional, Cherng, Benjamin Pei Zhi, additional, Spruijtenburg, Bram, additional, Chan, Kian Sing, additional, Oon, Lynette Lin Ean, additional, Tan, Ai Ling, additional, Tan, Yen Ee, additional, Wijaya, Limin, additional, Tan, Ban Hock, additional, Ling, Moi Lin, additional, Koh, Tse Hsien, additional, Meis, Jacques F., additional, Tsui, Clement Kin Ming, additional, and Nagarajan, Niranjan, additional

Published
2023
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12. SG-APSIC1097: The impact of COVID-19 on the incidence of carbapenem-resistant Enterobacterales (CRE) in Singapore: An interrupted time-series analysis

Author

Ong, Chong Hui Clara, primary, Cheng, Thoon Koh, additional, Pada, Surinder Kaur M S, additional, Narayana, Deepak Rama, additional, Ooi, Say Tat, additional, Smitasin, Nares, additional, Fong, Kok Choon Raymond, additional, Koh, Tse Hsien, additional, Cherng, Pei Zhi Benjamin, additional, Lin, Raymond, additional, Pratim, De Partha, additional, Yang, Hsu Li, additional, Teo, Jeanette, additional, Ng, Oon Tek, additional, Venkatachalam, Indumathi, additional, and Marimuthu, Kalisvar, additional

Published
2023
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14. Impact of COVID-19 pandemic on carbapenem-resistant Enterobacterales incidence in the South-East Asia region: an observational study

Author

Linn, Kyaw Zaw, primary, Sutjipto, Stephanie, additional, Ng, Oon Tek, additional, Teo, Jeanette, additional, Cherng, Benjamin Pei Zhi, additional, Tan, Thean Yen, additional, Pada, Surinder Kaur, additional, Ooi, Say Tat, additional, Smitasin, Nares, additional, Thoon, Koh Cheng, additional, Huan, Xiaowei, additional, De, Partha Pratim, additional, Chan, Douglas, additional, Tee, Nancy Wen Sim, additional, Ang, Michelle, additional, Hsu, Li Yang, additional, Lin, Raymond Tzer Pin, additional, Ng, Tong Yong, additional, Deepak, Rama Narayana, additional, Koh, Tse Hsien, additional, Apisarnthanarak, Anucha, additional, Ponnampalavanar, Sasheela, additional, Venkatachalam, Indumathi, additional, and Marimuthu, Kalisvar, additional

Published
2023
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17. Clonal serotype 1c multidrug-resistant Shigella flexneri detected in multiple institutions by sentinel-site sequencing

Author

Ko, Karrie K. K., primary, Chu, Joash Jun Keat, additional, Lim, Kar Mun, additional, Yingtaweesittikul, Hatairat, additional, Huang, Wenjie, additional, Tan, Shireen Yan Ling, additional, Goh, Kenneth Choon Meng, additional, Tan, Si Huei, additional, Ng, Tong Yong, additional, Maiwald, Matthias, additional, Chia, Jonathan Wei Zhong, additional, Cao, Delphine Yanhong, additional, Tan, Yen Ee, additional, Sim, James Heng Chiak, additional, Koh, Tse Hsien, additional, Nagarajan, Niranjan, additional, and Suphavilai, Chayaporn, additional

Published
2022
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18. Characterisation of Salmonella enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore

Author

Aung, Kyaw Thu, Khor, Wei Ching, Ong, Kar Hui, Tan, Wei Ling, Wong, Zhi Ning, Oh, Jia Quan, Wong, Wai Kwan, Tan, Brian Zi Yan, Maiwald, Matthias, Tee, Nancy Wen Sim, Barkham, Timothy, Koh, Tse Hsien, Dalsgaard, Anders, Chen, Swaine L., Schlundt, Joergen, Ng, Lee Ching, Aung, Kyaw Thu, Khor, Wei Ching, Ong, Kar Hui, Tan, Wei Ling, Wong, Zhi Ning, Oh, Jia Quan, Wong, Wai Kwan, Tan, Brian Zi Yan, Maiwald, Matthias, Tee, Nancy Wen Sim, Barkham, Timothy, Koh, Tse Hsien, Dalsgaard, Anders, Chen, Swaine L., Schlundt, Joergen, and Ng, Lee Ching

Abstract

Salmonella enteritidis is a major foodborne pathogen worldwide. In this study, a total of 276 S. enteritidis isolates, collected between 2016 and 2017 from human, food and farm/slaughterhouse samples, were studied to enhance the understanding of the epidemiology of human salmonellosis in Singapore. Results showed all 276 isolates belonged either to ST1925 (70.3%) or ST11 (29.7%), with ST11 being significantly more frequent in extra-intestinal isolates and chicken isolates. Food isolates, most of which were from poultry, showed the highest prevalence of resistance (33–37%) against beta-lactams or beta-lactams/beta-lactamase inhibitor combination (ampicillin, piperacillin and ampicillin/sulbactam). The analysis showed the detection of genes associated with resistance to aminoglycoside genes (99.6%), tetracycline (55.1%), and beta-lactams (14.9%) of all isolates. Nine types of plasmids were found in 266 isolates; the most common incompatibility group profiles were IncFIB(S)-IncFII(S)-IncX1 (72.2%) and IncFIB(S)-IncFII(S) (15.8%). Most plasmid harbouring isolates from chicken (63.6%, 14/22) and from human (73.8%, 175/237) shared the same plasmid profile (IncFIB(S)-IncFII(S)-IncX1). SNP analysis showed clustering of several isolates from poultry food products and human isolates, suggesting phylogenetic relatedness among these isolates. Lastly, this study provides important epidemiological insights on the application of phenotypic and next-generation sequencing (NGS) tools for improved food safety and public health surveillance and outbreak investigation of S. enteritidis.

Published
2022

20. Characterisation of Salmonella Enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore

Author

Aung, Kyaw Thu, primary, Khor, Wei Ching, additional, Ong, Kar Hui, additional, Tan, Wei Ling, additional, Wong, Zhi Ning, additional, Oh, Jia Quan, additional, Wong, Wai Kwan, additional, Tan, Brian Zi Yan, additional, Maiwald, Matthias, additional, Tee, Nancy Wen Sim, additional, Barkham, Timothy, additional, Koh, Tse Hsien, additional, Dalsgaard, Anders, additional, Chen, Swaine L., additional, Schlundt, Joergen, additional, and Ng, Lee Ching, additional

Published
2022
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26. Antimicrobial drug resistance in Singapore hospitals

Author

Hsu, Li-Yang, Tan, Thean-Yen, Jureen, Roland, Koh, Tse-Hsien, Krishnan, Prabha, Lin, Raymond Tzer-Pin, Tee, Nancy Wen-Sin, and Tambyah, Paul Ananth

Subjects
Hospital patients -- Health aspects, Hospital patients -- Surveys, Drug resistance in microorganisms -- Surveys, Drug resistance in microorganisms -- Research
Abstract

A new national antimicrobial resistance surveillance program in Singapore public hospitals that uses WHONET detected high levels of methicillin resistance among Staphylococcus aureus (35.3%), carbapenem resistance among Acinetobacter spp. (49.6%), [...]

Published
2007

34. Elimination of Extracellular Adenosine Triphosphate for the Rapid Prediction of Quantitative Plate Counts in 24 h Time-Kill Studies against Carbapenem-Resistant Gram-Negative Bacteria

Author

Cai, Yiying, primary, Ng, Jonathan J., additional, Leck, Hui, additional, Teo, Jocelyn Q., additional, Goh, Jia-Xuan, additional, Lee, Winnie, additional, Koh, Tse-Hsien, additional, Tan, Thuan-Tong, additional, Lim, Tze-Peng, additional, and Kwa, Andrea L., additional

Published
2020
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39. Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

Author

Boulouis, Caroline, primary, Sia, Wan Rong, additional, Gulam, Muhammad Yaaseen, additional, Teo, Jocelyn Qi Min, additional, Png, Yi Tian, additional, Phan, Thanh Kha, additional, Mak, Jeffrey Y. W., additional, Fairlie, David P., additional, Poon, Ivan K. H., additional, Koh, Tse Hsien, additional, Bergman, Peter, additional, Lim, Chwee Ming, additional, Wang, Lin-Fa, additional, Kwa, Andrea Lay Hoon, additional, Sandberg, Johan K., additional, and Leeansyah, Edwin, additional

Published
2020
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40. Determining the Development of Persisters in Extensively Drug-Resistant Acinetobacter baumannii upon Exposure to Polymyxin B-Based Antibiotic Combinations Using Flow Cytometry

Author

Wong, Fiona Hui-Sian, primary, Cai, Yiying, additional, Leck, Hui, additional, Lim, Tze-Peng, additional, Teo, Jocelyn Qi-Min, additional, Lee, Winnie, additional, Koh, Tse Hsien, additional, Tan, Thuan Tong, additional, Tan, Kar Wai, additional, and Kwa, Andrea Lay-Hoon, additional

Published
2020
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50. One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia

Author

Barkham, Timothy, Zadoks, Ruth N., Azmai, Mohammad Noor Amal, Baker, Stephen, Bich, Vu Thi Ngoc, Chalker, Victoria, Chau, Man Ling, Dance, David, Deepak, Rama Narayana, Doorn, H. Rogier Van, Gutierrez, Ramona A., Holmes, Mark A., Huong, Lan Nguyen Phu, Koh, Tse Hsien, Martins, Elisabete, Mehershahi, Kurosh, Newton, Paul, Ng, Lee Ching, Phuoc, Nguyen Ngoc, Sangwichian, Ornuma, Sawatwong, Pongpun, Surin, Uraiwan, Tan, Thean Yen, Tang, Wen Ying, Thuy, Nguyen Vu, Turner, Paul, Vongsouvath, Manivanh, Zhang, Defeng, WhistlerI, Toni, Chen, Swaine L., Barkham, Timothy, Zadoks, Ruth N., Azmai, Mohammad Noor Amal, Baker, Stephen, Bich, Vu Thi Ngoc, Chalker, Victoria, Chau, Man Ling, Dance, David, Deepak, Rama Narayana, Doorn, H. Rogier Van, Gutierrez, Ramona A., Holmes, Mark A., Huong, Lan Nguyen Phu, Koh, Tse Hsien, Martins, Elisabete, Mehershahi, Kurosh, Newton, Paul, Ng, Lee Ching, Phuoc, Nguyen Ngoc, Sangwichian, Ornuma, Sawatwong, Pongpun, Surin, Uraiwan, Tan, Thean Yen, Tang, Wen Ying, Thuy, Nguyen Vu, Turner, Paul, Vongsouvath, Manivanh, Zhang, Defeng, WhistlerI, Toni, and Chen, Swaine L.

Abstract

Background: In 2015, Singapore had the first and only reported foodborne outbreak of invasive disease caused by the group B Streptococcus (GBS; Streptococcus agalactiae). Disease, predominantly septic arthritis and meningitis, was associated with sequence type (ST)283, acquired from eating raw farmed freshwater fish. Although GBS sepsis is well-described in neonates and older adults with co-morbidities, this outbreak affected non-pregnant and younger adults with fewer co-morbidities, suggesting greater virulence. Before 2015 ST283 had only been reported from twenty humans in Hong Kong and two in France, and from one fish in Thailand. We hypothesised that ST283 was causing region-wide infection in Southeast Asia. Methodology/Principal findings: We performed a literature review, whole genome sequencing on 145 GBS isolates collected from six Southeast Asian countries, and phylogenetic analysis on 7,468 GBS sequences including 227 variants of ST283 from humans and animals. Although almost absent outside Asia, ST283 was found in all invasive Asian collections analysed, from 1995 to 2017. It accounted for 29/38 (76%) human isolates in Lao PDR, 102/139 (73%) in Thailand, 4/13 (31%) in Vietnam, and 167/739 (23%) in Singapore. ST283 and its variants were found in 62/62 (100%) tilapia from 14 outbreak sites in Malaysia and Vietnam, in seven fish species in Singapore markets, and a diseased frog in China. Conclusions: GBS ST283 is widespread in Southeast Asia, where it accounts for a large proportion of bacteraemic GBS, and causes disease and economic loss in aquaculture. If human ST283 is fishborne, as in the Singapore outbreak, then GBS sepsis in Thailand and Lao PDR is predominantly a foodborne disease. However, whether transmission is from aquaculture to humans, or vice versa, or involves an unidentified reservoir remains unknown. Creation of cross-border collaborations in human and animal health are needed to complete the epidemiological picture.

Published
2019

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