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6. Specific consistency score for rational selection of epilepsy resection surgery candidates

Author

Tojima, Maya, primary, Shimotake, Akihiro, additional, Neshige, Shuichiro, additional, Okada, Tadashi, additional, Kobayashi, Katsuya, additional, Usami, Kiyohide, additional, Matsuhashi, Masao, additional, Honda, Masayuki, additional, Takeyama, Hirofumi, additional, Hitomi, Takefumi, additional, Yoshida, Takeshi, additional, Yokoyama, Atsushi, additional, Fushimi, Yasutaka, additional, Ueno, Tsukasa, additional, Yamao, Yukihiro, additional, Kikuchi, Takayuki, additional, Namiki, Takao, additional, Arakawa, Yoshiki, additional, Takahashi, Ryosuke, additional, and Ikeda, Akio, additional

Published
2024
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8. Effort complementarity and role assignments in group contests.

Author

Kobayashi, Katsuya

Subjects
ELASTICITY (Economics), RESOURCE allocation, CONTESTS, PROBABILITY theory
Abstract

This study characterizes role assignments in maximizing a group's winning probability under the influence of the complementarity of group members' efforts in a group contest, in contrast to prize and multiple resource allocations. We use a constant elasticity of substitution effort aggregator function to parameterize the complementarity. While the prize and resource allocation rules depend on the complementarity, the assignment rule does not when multiple roles are assignable to a single group member: All roles are assigned only to the most productive group member. However, when only a single role per group member is assignable, the assignment rule depends on the complementarity: Roles from greater to less importance are assigned to group members in descending order of their productivity under strong complementarity; only the most important role is assigned to the most productive group member and the others have no effect under weak complementarity. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Engagement of cortico-cortical and cortico-subcortical networks in a patient with epileptic spasms: An integrated neurophysiological study

Author

Inoue, Takeshi, Kobayashi, Katsuya, Matsumoto, Riki, Inouchi, Morito, Togo, Masaya, Togawa, Jumpei, Usami, Kiyohide, Shimotake, Akihiro, Matsuhashi, Masao, Kikuchi, Takayuki, Yoshida, Kazumichi, Kawawaki, Hisashi, Sawamoto, Nobukatsu, Kunieda, Takeharu, Miyamoto, Susumu, Takahashi, Ryosuke, and Ikeda, Akio

Published
2020
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11. Impact of Seizure Recurrence on 1-Year Functional Outcome and Mortality in Patients With Poststroke Epilepsy

Author

Yoshimura, Hajime, Tanaka, Tomotaka, Fukuma, Kazuki, Matsubara, Soichiro, Motoyama, Rie, Mizobuchi, Masahiro, Matsuki, Takayuki, Manabe, Yasuhiro, Suzuki, Junichiro, Kobayashi, Katsuya, Shimotake, Akihiro, Nishimura, Kunihiro, Onozuka, Daisuke, Kawamoto, Michi, Koga, Masatoshi, Toyoda, Kazunori, Murayama, Shigeo, Matsumoto, Riki, Takahashi, Ryosuke, Ikeda, Akio, and Ihara, Masafumi

Published
2022
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17. Methotrexate-induced subacute myelopathy: a serious but treatable complication

Author

Miyoshi, Takashi, primary, Kondo, Tadakazu, additional, Nishikori, Momoko, additional, Kitawaki, Toshio, additional, Kobayashi, Katsuya, additional, Fujimoto, Masakazu, additional, Yoshinaga, Noriyoshi, additional, Oka, Satoshi, additional, Asagoe, Kohsuke, additional, Imashuku, Shinsaku, additional, and Takaori-Kondo, Akifumi, additional

Published
2023
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21. Entropy of monopoles from percolating cluster in quenched SU(2) QCD

Author

Ishiguro, Katsuya, Chernodub, M. N., Kobayashi, Katsuya, and Suzuki, Tsuneo

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

The length distribution and the monopole action of the infrared monopole clusters are studied numerically in quenched SU(2) QCD. We determine the effective entropy of the monopole currents which turns out to be a descending function of the blocking scale, indicating that the effective degrees of freedom of the extended monopoles are getting smaller as the blocking scale increases., Comment: 3 pages, 3 figures, uses espcrc2.sty; Lattice2003(topology)

Published
2003
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22. Numerical determination of monopole entropy in pure SU(2) QCD

Author

Chernodub, M. N., Ishiguro, Katsuya, Kobayashi, Katsuya, and Suzuki, Tsuneo

Subjects
High Energy Physics - Lattice
Abstract

We study numerically the length distributions of the infrared monopole clusters in pure SU(2) QCD. These distributions are Gaussian for all studied blocking steps of monopoles, lattice volumes and lattice coupling constant. We also investigate the monopole action for the infrared monopole clusters. The knowledge of both the length distribution and the monopole action allows us to determine the effective entropy of the monopole currents. The entropy is a descending function of blocking scale, indicating that the effective degrees of freedom of the extended monopoles are getting smaller as the blocking scale increases., Comment: 17 pages, 19 figures, LaTeX 2e

Published
2003
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25. Periodic discharges plus fast activity on EEG predict worse outcomes in post‐stroke epilepsy

Author

Fukuma, Kazuki, primary, Tojima, Maya, additional, Tanaka, Tomotaka, additional, Kobayashi, Katsuya, additional, Kajikawa, Shunsuke, additional, Shimotake, Akihiro, additional, Kamogawa, Naruhiko, additional, Ikeda, Shuhei, additional, Ishiyama, Hiroyuki, additional, Abe, Soichiro, additional, Morita, Yoshiaki, additional, Nakaoku, Yuriko, additional, Ogata, Soshiro, additional, Nishimura, Kunihiro, additional, Koga, Masatoshi, additional, Toyoda, Kazunori, additional, Matsumoto, Riki, additional, Takahashi, Ryosuke, additional, Ikeda, Akio, additional, and Ihara, Masafumi, additional

Published
2023
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28. Periodic discharges plus fast activity on electroencephalogram predict worse outcomes in poststroke epilepsy.

Author

Fukuma, Kazuki, Tojima, Maya, Tanaka, Tomotaka, Kobayashi, Katsuya, Kajikawa, Shunsuke, Shimotake, Akihiro, Kamogawa, Naruhiko, Ikeda, Shuhei, Ishiyama, Hiroyuki, Abe, Soichiro, Morita, Yoshiaki, Nakaoku, Yuriko, Ogata, Soshiro, Nishimura, Kunihiro, Koga, Masatoshi, Toyoda, Kazunori, Matsumoto, Riki, Takahashi, Ryosuke, Ikeda, Akio, and Ihara, Masafumi

Subjects
STROKE, EPILEPSY, ELECTROENCEPHALOGRAPHY, HEMORRHAGIC stroke, ODDS ratio
Abstract

Objective: Postseizure functional decline is a concern in poststroke epilepsy (PSE). However, data on electroencephalogram (EEG) markers associated with functional decline are scarce. Thus, we investigated whether periodic discharges (PDs) and their specific characteristics are associated with functional decline in patients with PSE. Methods: In this observational study, patients admitted with seizures of PSE and who had scalp EEGs were included. The association between the presence or absence of PDs and postseizure short‐term functional decline lasting 7 days after admission was investigated. In patients with PD, EEG markers were explored for risk stratification of short‐term functional decline, according to the American Clinical Neurophysiology Society's Standardized Critical Care EEG Terminology. The association between EEG markers and imaging findings and long‐term functional decline at discharge and 6 months after discharge, defined as an increase in the modified Rankin Scale score compared with the baseline, was evaluated. Results: In this study, 307 patients with PSE (median age = 75 years, range = 35–97 years, 64% males; hemorrhagic stroke, 47%) were enrolled. Compared with 247 patients without PDs, 60 patients with PDs were more likely to have short‐term functional decline (12 [20%] vs. 8 [3.2%], p <.001), with an adjusted odds ratio (OR) of 4.26 (95% confidence interval [CI] = 1.44–12.6, p =.009). Patients with superimposed fast‐activity PDs (PDs+F) had significantly more localized (rather than widespread) lesions (87% vs. 58%, p =.003), prolonged hyperperfusion (100% vs. 62%, p =.023), and a significantly higher risk of short‐term functional decline than those with PDs without fast activity (adjusted OR = 22.0, 95% CI = 1.87–259.4, p =.014). Six months after discharge, PDs+F were significantly associated with long‐term functional decline (adjusted OR = 4.21, 95% CI = 1.27–13.88, p =.018). Significance: In PSE, PDs+F are associated with sustained neuronal excitation and hyperperfusion, which may be a predictor of postseizure short‐ and long‐term functional decline. [ABSTRACT FROM AUTHOR]

Published
2023
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29. A super‐elderly autopsy case of benign adult familial myoclonus epilepsy with a heterozygous mutation

Author

Tojima, Maya, primary, Kobayashi, Katsuya, additional, Hitomi, Takefumi, additional, Ishibashi, Haruka, additional, Yoshii, Daisuke, additional, Sainouchi, Makoto, additional, Ayaki, Takashi, additional, Shimotake, Akihiro, additional, Usami, Kiyohide, additional, Maki, Takakuni, additional, Kakita, Akiyoshi, additional, Takahashi, Ryosuke, additional, and Ikeda, Akio, additional

Published
2023
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30. A super‐elderly autopsy case of benign adult familial myoclonus epilepsy with a heterozygous mutation

Author

70737121, 50402904, 60749555, 80726000, 20829204, 70762334, 90216771, 90212761, Tojima, Maya, Kobayashi, Katsuya, Hitomi, Takefumi, Ishibashi, Haruka, Yoshii, Daisuke, Sainouchi, Makoto, Ayaki, Takashi, Shimotake, Akihiro, Usami, Kiyohide, Maki, Takakuni, Kakita, Akiyoshi, Takahashi, Ryosuke, Ikeda, Akio, 70737121, 50402904, 60749555, 80726000, 20829204, 70762334, 90216771, 90212761, Tojima, Maya, Kobayashi, Katsuya, Hitomi, Takefumi, Ishibashi, Haruka, Yoshii, Daisuke, Sainouchi, Makoto, Ayaki, Takashi, Shimotake, Akihiro, Usami, Kiyohide, Maki, Takakuni, Kakita, Akiyoshi, Takahashi, Ryosuke, and Ikeda, Akio

Published
2023

33. Corrigendum to “Two types of clinical ictal direct current shifts in invasive EEG of intractable focal epilepsy identified by waveform cluster analysis” [Clin. Neurophysiol. 137 (2022) 113–121]

Author

Kajikawa, Shunsuke, primary, Matsuhashi, Masao, additional, Kobayashi, Katsuya, additional, Hitomi, Takefumi, additional, Daifu-Kobayashi, Masako, additional, Kobayashi, Tamaki, additional, Yamao, Yukihiro, additional, Kikuchi, Takayuki, additional, Yoshida, Kazumichi, additional, Kunieda, Takeharu, additional, Matsumoto, Riki, additional, Kakita, Akiyoshi, additional, Namiki, Takao, additional, Tsuda, Ichiro, additional, Miyamoto, Susumu, additional, Takahashi, Ryosuke, additional, and Ikeda, Akio, additional

Published
2022
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34. Association of Cortical Superficial Siderosis with Post‐Stroke Epilepsy

Author

Tanaka, Tomotaka, primary, Fukuma, Kazuki, additional, Abe, Soichiro, additional, Matsubara, Soichiro, additional, Ikeda, Shuhei, additional, Kamogawa, Naruhiko, additional, Ishiyama, Hiroyuki, additional, Hosoki, Satoshi, additional, Kobayashi, Katsuya, additional, Shimotake, Akihiro, additional, Nakaoku, Yuriko, additional, Ogata, Soshiro, additional, Nishimura, Kunihiro, additional, Koga, Masatoshi, additional, Toyoda, Kazunori, additional, Matsumoto, Riki, additional, Takahashi, Ryosuke, additional, Ikeda, Akio, additional, and Ihara, Masafumi, additional

Published
2022
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36. Ictal direct current shifts contribute to defining the core ictal focus in epilepsy surgery

Author

Nakatani, Mitsuyoshi, primary, Inouchi, Morito, additional, Daifu-Kobayashi, Masako, additional, Murai, Tomohiko, additional, Togawa, Jumpei, additional, Kajikawa, Shunsuke, additional, Kobayashi, Katsuya, additional, Hitomi, Takefumi, additional, Kunieda, Takeharu, additional, Hashimoto, Satoka, additional, Inaji, Motoki, additional, Shirozu, Hiroshi, additional, Kanazawa, Kyoko, additional, Iwasaki, Masaki, additional, Usui, Naotaka, additional, Inoue, Yushi, additional, Maehara, Taketoshi, additional, and Ikeda, Akio, additional

Published
2022
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40. Developing an Asymmetry Method for Detecting Postictal Hyperperfusion in Poststroke Epilepsy

Author

Fukuma, Kazuki, primary, Tanaka, Tomotaka, additional, Takaya, Shigetoshi, additional, Tojima, Maya, additional, Kobayashi, Katsuya, additional, Shimotake, Akihiro, additional, Morita, Yoshiaki, additional, Nishimura, Kunihiro, additional, Koga, Masatoshi, additional, Toyoda, Kazunori, additional, Matsumoto, Riki, additional, Takahashi, Ryosuke, additional, Ikeda, Akio, additional, and Ihara, Masafumi, additional

Published
2022
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41. Clinical and imaging features of nonmotor onset seizure in poststroke epilepsy

Author

Fukuma, Kazuki, primary, Ikeda, Shuhei, additional, Tanaka, Tomotaka, additional, Kamogawa, Naruhiko, additional, Ishiyama, Hiroyuki, additional, Abe, Soichiro, additional, Tojima, Maya, additional, Kobayashi, Katsuya, additional, Shimotake, Akihiro, additional, Nakaoku, Yuriko, additional, Nishimura, Kunihiro, additional, Koga, Masatoshi, additional, Toyoda, Kazunori, additional, Matsumoto, Riki, additional, Ikeda, Akio, additional, and Ihara, Masafumi, additional

Published
2022
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42. Clinical significance of ictal magnetoencephalography in patients undergoing epilepsy surgery

Author

Najm, Imad M, Aldosari, Mubarak M, Wang, Z Irene, Katagiri, Masaya, Burgess, Richard C, Hirfanoglu, Tuğba, Bulacio, Juan, Kobayashi, Katsuya, Wang, Shan, Aung, Thandar, Bingaman, William, and Alexopoulos, Andreas V

Subjects
Clinical Relevance, Epilepsy, Neurology, Seizures, Physiology (medical), Humans, Magnetoencephalography, Electroencephalography, Neurology (clinical), Magnetic Resonance Imaging, Sensory Systems
Abstract

© 2022 International Federation of Clinical NeurophysiologyObjective: The significance of ictal magnetoencephalography (MEG) is not well appreciated. We evaluated the relationships between ictal MEG, MRI, intracranial electroencephalography (ICEEG), surgery and postoperative seizure outcome. Methods: A total of 45 patients (46 cases) with ictal MEG who underwent epilepsy surgery was included. We examined the localization of each modality, surgical resection area and seizure freedom after surgery. Results: Twenty-one (45.7%) out of 46 cases were seizure-free at more than 6 months follow-up. Median duration of postoperative follow-up was 16.5 months. The patients in whom ictal, interictal single equivalent current dipole (SECD) and MRI lesion localization were completely included in the resection had a higher chance of being seizure-free significantly (p < 0.05). Concordance between ictal and interictal SECD localizations was significantly associated with seizure-freedom. Concordance between MRI lesion and ictal SECD, concordance between ictal ICEEG and ictal and interictal SECD, as well as concordance between ictal ICEEG and MRI lesion were significantly associated with seizure freedom. Conclusions: Ictal MEG can contribute useful information for delineating the resection area in epilepsy surgery. Significance: Resection should include ictal, interictal SECDs and MRI lesion localization, when feasible. Concordant ictal and interictal SECDs on MEG can be a favorable predictor of seizure freedom.

Published
2022

43. Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential

Author

20829204, 70737121, 80726000, 40625084, 90598921, 40456885, 90216771, 90212761, Togo, Masaya, Matsumoto, Riki, Usami, Kiyohide, Kobayashi, Katsuya, Takeyama, Hirofumi, Nakae, Takuro, Shimotake, Akihiro, Kikuchi, Takayuki, Yoshida, Kazumichi, Matsuhashi, Masao, Kunieda, Takeharu, Miyamoto, Susumu, Takahashi, Ryosuke, Ikeda, Akio, 20829204, 70737121, 80726000, 40625084, 90598921, 40456885, 90216771, 90212761, Togo, Masaya, Matsumoto, Riki, Usami, Kiyohide, Kobayashi, Katsuya, Takeyama, Hirofumi, Nakae, Takuro, Shimotake, Akihiro, Kikuchi, Takayuki, Yoshida, Kazumichi, Matsuhashi, Masao, Kunieda, Takeharu, Miyamoto, Susumu, Takahashi, Ryosuke, and Ikeda, Akio

Abstract

The medial parietal cortices are components of the default mode network (DMN), which are active in the resting state. The medial parietal cortices include the precuneus and the dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences in the connectivity in the medial parietal cortices, and these differences have not yet been precisely elucidated. Electrophysiological connectivity is essential for understanding cortical function or functional differences. Since little is known about electrophysiological connections from the medial parietal cortices in humans, we evaluated distinct connectivity patterns in the medial parietal cortices by constructing a standardized connectivity map using cortico-cortical evoked potential (CCEP). This study included nine patients with partial epilepsy or a brain tumor who underwent chronic intracranial electrode placement covering the medial parietal cortices. Single-pulse electrical stimuli were delivered to the medial parietal cortices (38 pairs of electrodes). Responses were standardized using the z-score of the baseline activity, and a response density map was constructed in the Montreal Neurological Institutes (MNI) space. The precuneus tended to connect with the inferior parietal lobule (IPL), the occipital cortex, superior parietal lobule (SPL), and the dorsal premotor area (PMd) (the four most active regions, in descending order), while the dPCC tended to connect to the middle cingulate cortex, SPL, precuneus, and IPL. The connectivity pattern differs significantly between the precuneus and dPCC stimulation (p<0.05). Regarding each part of the medial parietal cortices, the distributions of parts of CCEP responses resembled those of the functional connectivity database. Based on how the dPCC was connected to the medial frontal area, SPL, and IPL, its connectivity pattern could not be explained by DMN alone, but suggested a mixture of DMN and the frontoparietal cognitive network. These findings improve our

Published
2022

44. Ictal direct current shifts contribute to defining the core ictal focus in epilepsy surgery

Author

70737121, 50402904, 90212761, Nakatani, Mitsuyoshi, Inouchi, Morito, Daifu-Kobayashi, Masako, Murai, Tomohiko, Togawa, Jumpei, Kajikawa, Shunsuke, Kobayashi, Katsuya, Hitomi, Takefumi, Kunieda, Takeharu, Hashimoto, Satoka, Inaji, Motoki, Shirozu, Hiroshi, Kanazawa, Kyoko, Iwasaki, Masaki, Usui, Naotaka, Inoue, Yushi, Maehara, Taketoshi, Ikeda, Akio, 70737121, 50402904, 90212761, Nakatani, Mitsuyoshi, Inouchi, Morito, Daifu-Kobayashi, Masako, Murai, Tomohiko, Togawa, Jumpei, Kajikawa, Shunsuke, Kobayashi, Katsuya, Hitomi, Takefumi, Kunieda, Takeharu, Hashimoto, Satoka, Inaji, Motoki, Shirozu, Hiroshi, Kanazawa, Kyoko, Iwasaki, Masaki, Usui, Naotaka, Inoue, Yushi, Maehara, Taketoshi, and Ikeda, Akio

Abstract

Identifying the minimal and optimal epileptogenic area to resect and cure is the goal of epilepsy surgery. To achieve this, EEG analysis is recognized as the most direct way to detect epileptogenic lesions from spatiotemporal perspectives. Although ictal direct-current shifts (icDCs; below 1 Hz) and ictal high-frequency oscillations (icHFOs; above 80 Hz) have received increasing attention as good indicators that can add more specific information to the conventionally defined seizure-onset zone, large cohort studies on postoperative outcomes are still lacking. This work aimed to clarify whether this additional information, particularly icDCs which is assumed to reflect extracellular potassium concentration, really improve postoperative outcomes. To assess the usefulness in epilepsy surgery, we collected unique EEG datasets recorded with a longer time constant of 10 sec using an alternate current amplifier. 61 patients [15 with mesial temporal lobe epilepsy and 46 with neocortical epilepsy] who had undergone invasive presurgical evaluation for medically refractory seizures at five institutes in Japan, were retrospectively enrolled in this study. Among intracranially implanted electrodes, the two core electrodes of both icDCs and icHFOs were independently identified by board-certified clinicians based on unified methods. The occurrence patterns, such as their onset time, duration, and amplitude (power) were evaluated to extract the features of both icDCs and icHFOs. Additionally, we examined whether the resection ratio of the core electrodes of icDCs and icHFOs independently correlated with favorable outcomes. A total of 53 patients with 327 seizures were analyzed for wide-band EEG analysis, and 49 patients were analyzed for outcome analysis. icDCs were detected in the seizure-onset zone more frequently than icHFOs among both patients (92% vs. 71%) and seizures (86% vs. 62%). Additionally, icDCs significantly preceded icHFOs in patients exhibiting both biomarkers, and

Published
2022

46. Two types of clinical ictal direct current shifts in invasive EEG of intractable focal epilepsy identified by waveform cluster analysis

Author

Kajikawa, Shunsuke, primary, Matsuhashi, Masao, additional, Kobayashi, Katsuya, additional, Hitomi, Takefumi, additional, Daifu-Kobayashi, Masako, additional, Kobayashi, Tamaki, additional, Yamao, Yukihiro, additional, Kikuchi, Takayuki, additional, Yoshida, Kazumichi, additional, Kunieda, Takeharu, additional, Matsumoto, Riki, additional, Kakita, Akiyoshi, additional, Namiki, Takao, additional, Tsuda, Ichiro, additional, Miyamoto, Susumu, additional, Takahashi, Ryosuke, additional, and Ikeda, Akio, additional

Published
2022
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47. Enhanced phase-amplitude coupling of human electrocorticography selectively in the posterior cortical region during rapid eye movement sleep

Author

Togawa, Jumpei, primary, Matsumoto, Riki, additional, Usami, Kiyohide, additional, Matsuhashi, Masao, additional, Inouchi, Morito, additional, Kobayashi, Katsuya, additional, Hitomi, Takefumi, additional, Nakae, Takuro, additional, Shimotake, Akihiro, additional, Yamao, Yukihiro, additional, Kikuchi, Takayuki, additional, Yoshida, Kazumichi, additional, Kunieda, Takeharu, additional, Miyamoto, Susumu, additional, Takahashi, Ryosuke, additional, and Ikeda, Akio, additional

Published
2022
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49. Association of Cortical Superficial Siderosis with Post‐Stroke Epilepsy.

Author

Tanaka, Tomotaka, Fukuma, Kazuki, Abe, Soichiro, Matsubara, Soichiro, Ikeda, Shuhei, Kamogawa, Naruhiko, Ishiyama, Hiroyuki, Hosoki, Satoshi, Kobayashi, Katsuya, Shimotake, Akihiro, Nakaoku, Yuriko, Ogata, Soshiro, Nishimura, Kunihiro, Koga, Masatoshi, Toyoda, Kazunori, Matsumoto, Riki, Takahashi, Ryosuke, Ikeda, Akio, and Ihara, Masafumi

Subjects
EPILEPSY, CEREBRAL amyloid angiopathy, STROKE patients, STROKE, HEMOSIDERIN, LOGISTIC regression analysis
Abstract

Objective: To assess whether post‐stroke epilepsy (PSE) is associated with neuroimaging findings of hemosiderin in a case–control study, and whether the addition of hemosiderin markers improves the risk stratification models of PSE. Methods: We performed a post‐hoc analysis of the PROgnosis of POST‐Stroke Epilepsy study enrolling PSE patients at National Cerebral and Cardiovascular Center, Osaka, Japan, from November 2014 to September 2019. PSE was diagnosed when one unprovoked seizure was experienced >7 days after the index stroke, as proposed by the International League Against Epilepsy. As controls, consecutive acute stroke patients with no history or absence of any late seizure or continuing antiseizure medications at least 3 months after stroke were retrospectively enrolled during the same study period. We examined cortical microbleeds and cortical superficial siderosis (cSS) using gradient‐echo T2*‐weighted images. A logistic regression model with ridge penalties was tuned using 10‐fold cross‐validation. We added the item of cSS to the existing models (SeLECT and CAVE) for predicting PSE and evaluated performance of new models. Results: The study included 180 patients with PSE (67 women; median age 74 years) and 1,183 controls (440 women; median age 74 years). The cSS frequency was higher in PSE than control groups (48.9% vs 5.7%, p < 0.0001). Compared with the existing models, the new models with cSS (SeLECT‐S and CAVE‐S) demonstrated significantly better predictive performance of PSE (net reclassification improvement 0.63 [p = 0.004] for SeLECT‐S and 0.88 [p = 0.001] for CAVE‐S at the testing data). Interpretation: Cortical superficial siderosis was associated with PSE, stratifying stroke survivors at high risk of PSE. ANN NEUROL 2023;93:357–370 [ABSTRACT FROM AUTHOR]

Published
2023
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