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The systematic technique used to detect and analyze crime patterns and trends is called crime analysis and prevention. The proposed model will be able to predict regions that have a high chance of crime occurrence. Crime data specialists can assist police officers in stopping crime more quickly. Our goal is to develop methods that can forecast homicide activities based on demographic and economic data from a specific area. In this project, we use a classification and clustering algorithm to build an effective crime prediction model. Support vector networks, multivariate time-series data, and artificial neural networks are some of the prediction approaches that can be used to test the efficiency of prediction models. We use multiple algorithms for classification and clustering and then we compare with accuracy. To measure the out-oftraining effectiveness of classifiers, we use a ten-fold cross-validation approach. [ABSTRACT FROM AUTHOR]

Abstract: The role of vascular endothelial growth factor (VEGF) on cathepsin L expression was investigated in human glioblastoma cells (U87MG). Our results demonstrate the transcriptional upregulation of cathepsin L expression by VEGF. Transient transfection of U87MG cells with VEGF expression vector significantly increased cathepsin L activity. These results were further corroborated by a parallel increase in the mRNA levels and promoter activity of cathepsin L by VEGF. By deletion analysis, we identified a 47 base pair VEGF response element (VRE) in human cathepsin L promoter. Site directed mutagenesis studies demonstrated that both SP-1 and AP-4 motifs present in this region contribute to VEGF responsiveness. These results prove for the first time that over-expression of VEGF in human glioblastoma cells induces cathepsin L expression at the transcriptional level. This mechanism could be involved in the enhanced tumorogenic potential of these cells. [Copyright &y& Elsevier]

Mounier-Kuhn syndrome is a congenital abnormality characterized by tracheobronchomegaly as a result of atrophy or absence of elastic fibers and thinning of smooth muscle layer in trachea and main bronchi. The usual presentation is one of recurrent respiratory tract infections with a broad spectrum of functional impairment ranging from minimal disease with preservation of lung function to severe disease in the form of bronchiectasis. We describe a case of an elderly man who presented with a recurrent respiratory infection who was subsequently diagnosed as Mounier-Kuhn syndrome.

Pulmonary alveolar microlithiasis (PAM) is a rare idiopathic disease characterized by microliths in the lungs which is usually asymptomatic and often diagnosed incidentally. Here we discuss a case of a young woman while evaluating for surgery presented with an abnormal chest X ray of bilateral diffuse nodular opacities. Patient was completely asymptomatic. High resolution CT scan revealed crazy paving pattern, black pleura sign, and pleural calcification typical findings of pulmonary alveolar microlithiasis. CT guided lung biopsy confirmed the diagnosis. [ABSTRACT FROM AUTHOR]