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19. Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

Author

Wormser, David, Angelantonio, Emanuele Di, Kaptoge, Stephen, Wood, Angela M, Gao, Pei, Sun, Qi, Walldius, Göran, Selmer, Randi, Verschuren, WM Monique, Bueno-de-Mesquita, H Bas, Engström, Gunnar, Ridker, Paul M, Njølstad, Inger, Iso, Hiroyasu, Holme, Ingar, Giampaoli, Simona, Tunstall-Pedoe, Hugh, Gaziano, J Michael, Brunner, Eric, Kee, Frank, Tosetto, Alberto, Meisinger, Christa, Brenner, Hermann, Ducimetiere, Pierre, Whincup, Peter H, Tipping, Robert W, Ford, Ian, Cremer, Peter, Hofman, Albert, Wilhelmsen, Lars, Clarke, Robert, Boer, Ian H de, Jukema, J Wouter, Ibañez, Alejandro Marín, Lawlor, Debbie A, DʼAgostino, Ralph B, Rodriguez, Beatriz, Casiglia, Edoardo, Stehouwer, Coen DA, Simons, Leon A, Nietert, Paul J, Barrett-Connor, Elizabeth, Panagiotakos, Demosthenes B, Björkelund, Cecilia, Strandberg, Timo E, Wassertheil-Smoller, Sylvia, Blazer, Dan G, Meade, Tom W, Welin, Lennart, Svärdsudd, Kurt, Woodward, Mark, Nissinen, Aulikki, Kromhout, Daan, Jørgensen, Torben, Tilvis, Reijo S, Guralnik, Jack M, Rosengren, Annika, Taylor, James O, Kiechl, Stefan, Dagenais, Gilles R, Gerry, F, Fowkes, R, Wallace, Robert B, Khaw, Kay-Tee, Shaffer, Jonathan A, Visser, Marjolein, Kauhanen, Jussi, Salonen, Jukka T, Gallacher, John, Ben-Shlomo, Yoav, Kitamura, Akihiko, Sundström, Johan, Wennberg, Patrik, Kiyohara, Yutaka, Daimon, Makoto, de la Cámara, Agustin Gómez, Cooper, Jackie A, Onat, Altan, Devereux, Richard, Mukamal, Kenneth J, Dankner, Rachel, Knuiman, Matthew W, Crespo, Carlos J, Gansevoort, Ron T, Goldbourt, Uri, Nordestgaard, Børge G, Shaw, Jonathan E, Mussolino, Michael, Nakagawa, Hidaeki, Fletcher, Astrid, Kuller, Lewis H, Gillum, Richard F, Gudnason, Vilmundur, Assmann, Gerd, Wald, Nicholas, Jousilahti, Pekka R, Greenland, Philip, Trevisan, Maurizio, Ulmer, Hanno, Butterworth, Adam S, Folsom, Aaron R, Davey-Smith, George, Hu, Frank B, Danesh, John, Tipping, Robert W, Ford, Charles E, Simpson, Lara M, Walldius, Göran, Jungner, Ingmar, Folsom, Aaron R, Demerath, Ellen W, Franceschini, Nora, Lutsey, Pamela L, Panagiotakos, Demosthenes B, Pitsavos, Christos, Chrysohoou, Christina, Stefanadis, Christodoulos, Shaw, Jonathan E, Atkins, Robert, Zimmet, Paul Z, Barr, Elizabeth LM, Knuiman, Matthew W, Whincup, Peter H, Wannamethee, S Goya, Morris, Richard W, Willeit, Johann, Kiechl, Stefan, Weger, Siegfried, Oberhollenzer, Friedrich, Wald, Nicholas, Ebrahim, Shah, Lawlor, Debbie A, Gallacher, John, Ben-Shlomo, Yoav, Yarnell, John WG, Casiglia, Edoardo, Tikhonoff, Valérie, Greenland, Philip, Shay, Christina M, Garside, Daniel B, Nietert, Paul J, Sutherland, Susan E, Bachman, David L, Keil, Julian E, de Boer, Ian H, Kizer, Jorge R, Psaty, Bruce M, Mukamal, Kenneth J, Nordestgaard, Børge G, Tybjærg-Hansen, Anne, Jensen, Gorm B, Schnohr, Peter, Giampaoli, Simona, Palmieri, Luigi, Panico, Salvatore, Pilotto, Lorenza, Vanuzzo, Diego, de la Cámara, Agustin Gómez, Simons, Leon A, Simons, Judith, McCallum, John, Friedlander, Yechiel, Gerry, F, Fowkes, R, Price, Jackie F, Lee, Amanda J, Taylor, James O, Guralnik, Jack M, Phillips, Caroline L, Wallace, Robert B, Kohout, Frank J, Cornoni-Huntley, Joan C, Guralnik, Jack M, Blazer, Dan G, Guralnik, Jack M, Phillips, Caroline L, Phillips, Caroline L, Guralnik, Jack M, Khaw, Kay-Tee, Wareham, Nicholas J, Brenner, Hermann, Schöttker, Ben, Müller, Heiko, Rothenbacher, Dietrich, Wennberg, Patrik, Jansson, Jan-Håkan, Nissinen, Aulikki, Donfrancesco, Chiara, Giampaoli, Simona, Woodward, Mark, Vartiainen, Erkki, Jousilahti, Pekka R, Harald, Kennet, Salomaa, Veikko, DʼAgostino, Ralph B, Vasan, Ramachandran S, Fox, Caroline S, Pencina, Michael J, Daimon, Makoto, Oizumi, Toshihide, Kayama, Takamasa, Kato, Takeo, Bladbjerg, Else-Marie, Jørgensen, Torben, Møller, Lars, Jespersen, Jørgen, Dankner, Rachel, Chetrit, Angela, Lubin, Flora, Svärdsudd, Kurt, Eriksson, Henry, Welin, Lennart, Lappas, Georgios, Rosengren, Annika, Lappas, Georgios, Welin, Lennart, Svärdsudd, Kurt, Eriksson, Henry, Lappas, Georgios, Bengtsson, Calle, Lissner, Lauren, Björkelund, Cecilia, Cremer, Peter, Nagel, Dorothea, Strandberg, Timo E, Salomaa, Veikko, Tilvis, Reijo S, Miettinen, Tatu A, Tilvis, Reijo S, Strandberg, Timo E, Kiyohara, Yutaka, Arima, Hisatomi, Doi, Yasufumi, Ninomiya, Toshiharu, Rodriguez, Beatriz, Dekker, Jacqueline M, Nijpels, Giel, Stehouwer, Coen DA, Hu, Frank B, Sun, Qi, Rimm, Eric B, Willett, Walter C, Iso, Hiroyasu, Kitamura, Akihiko, Yamagishi, Kazumasa, Noda, Hiroyuki, Goldbourt, Uri, Vartiainen, Erkki, Jousilahti, Pekka R, Harald, Kennet, Salomaa, Veikko, Kauhanen, Jussi, Salonen, Jukka T, Kurl, Sudhir, Tuomainen, Tomi-Pekka, Poppelaars, Jan L, Deeg, Dorly JH, Visser, Marjolein, Meade, Tom W, De Stavola, Bianca Lucia, Hedblad, Bo, Nilsson, Peter, Engström, Gunnar, Verschuren, WM Monique, Blokstra, Anneke, de Boer, Ian H, Shea, Steven J, Meisinger, Christa, Thorand, Barbara, Koenig, Wolfgang, Döring, Angela, Verschuren, WM Monique, Blokstra, Anneke, Bueno-de-Mesquita, H Bas, Wilhelmsen, Lars, Rosengren, Annika, Lappas, Georgios, Fletcher, Astrid, Nitsch, Dorothea, Kuller, Lewis H, Grandits, Greg, Tverdal, Aage, Selmer, Randi, Nystad, Wenche, Mussolino, Michael, Gillum, Richard F, Hu, Frank B, Sun, Qi, Manson, JoAnn E, Rimm, Eric B, Hankinson, Susan E, Meade, Tom W, De Stavola, Bianca Lucia, Cooper, Jackie A, Bauer, Kenneth A, Davidson, Karina W, Kirkland, Susan, Shaffer, Jonathan A, Shimbo, Daichi, Kitamura, Akihiko, Iso, Hiroyasu, Sato, Shinichi, Holme, Ingar, Selmer, Randi, Tverdal, Aage, Nystad, Wenche, Nakagawa, Hidaeki, Miura, Katsuyuki, Sakurai, Masaru, Ducimetiere, Pierre, Jouven, Xavier, Bakker, Stephan JL, Gansevoort, Ron T, van der Harst, Pim, Hillege, Hans L, Crespo, Carlos J, Garcia-Palmieri, Mario R, Kee, Frank, Amouyel, Philippe, Arveiler, Dominique, Ferrières, Jean, Schulte, Helmut, Assmann, Gerd, Jukema, J Wouter, de Craen, Anton JM, Sattar, Naveed, Stott, David J, Cantin, Bernard, Lamarche, Benoît, Després, Jean-Pierre, Dagenais, Gilles R, Barrett-Connor, Elizabeth, Bergstrom, Jaclyn, Bettencourt, Richele R, Buisson, Catherine, Gudnason, Vilmundur, Aspelund, Thor, Sigurdsson, Gunnar, Thorsson, Bolli, Trevisan, Maurizio, Hofman, Albert, Ikram, M Arfan, Tiemeier, Henning, Witteman, Jacqueline CM, Tunstall-Pedoe, Hugh, Tavendale, Roger, Lowe, Gordon DO, Woodward, Mark, Devereux, Richard, Yeh, Jeun-Liang, Ali, Tauqeer, Calhoun, Darren, Ben-Shlomo, Yoav, Davey-Smith, George, Onat, Altan, Can, Günay, Nakagawa, Hidaeki, Sakurai, Masaru, Nakamura, Koshi, Morikawa, Yuko, Njølstad, Inger, Mathiesen, Ellisiv B, Løchen, Maja-Lisa, Wilsgaard, Tom, Sundström, Johan, Ingelsson, Erik, Michaëlsson, Karl, Cederholm, Tommy, Gaziano, J Michael, Buring, Julie, Ridker, Paul M, Gaziano, J Michael, Ridker, Paul M, Ulmer, Hanno, Diem, Günter, Concin, Hans, Rodeghiero, Francesco, Tosetto, Alberto, Wassertheil-Smoller, Sylvia, Manson, JoAnn E, Marmot, Michael, Clarke, Robert, Fletcher, Astrid, Brunner, Eric, Shipley, Martin, Kivimaki, Mika, Ridker, Paul M, Buring, Julie, Ford, Ian, Robertson, Michele, Ibañez, Alejandro Marín, Feskens, Edith, Geleijnse, Johanna M, Kromhout, Daan, Walker, Matthew, Watson, Sarah, Alexander, Myriam, Butterworth, Adam S, Angelantonio, Emanuele Di, Franco, Oscar H, Gao, Pei, Gobin, Reeta, Haycock, Philip, Kaptoge, Stephen, Seshasai, Sreenivasa R Kondapally, Lewington, Sarah, Pennells, Lisa, Rapsomaniki, Eleni, Sarwar, Nadeem, Thompson, Alexander, Thompson, Simon G, Walker, Matthew, Watson, Sarah, White, Ian R, Wood, Angela M, Wormser, David, Zhao, Xiaohui, and Danesh, John

Published
2012
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24. Serum Immunoglobulin G Is Associated With Decreased Risk of Pancreatic Cancer in the Swedish AMORIS Study

Author

Sollie, Sam, primary, Santaolalla, Aida, additional, Michaud, Dominique S., additional, Sarker, Debashis, additional, Karagiannis, Sophia N., additional, Josephs, Debra H., additional, Hammar, Niklas, additional, Walldius, Goran, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2020
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26. Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

Author

Yiu, Andrew, Van Hemelrijck, Mieke, Garmo, Hans, Holmberg, Lars, Malmström, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, and Wulaningsih, Wahyu

Subjects
Male, Sweden, Cancer och onkologi, Incidence, Uric Acid, Social Class, Cancer and Oncology, Neoplasms, Population Surveillance, cancer, Humans, Female, Prospective study, Uric acid, Cancer, Research Paper, prospective study, Follow-Up Studies, Proportional Hazards Models
Abstract

Objectives: Serum uric acid has been suggested to be associated with cancer risk. We aimed to study the association between serum uric acid and cancer incidence in a large Swedish cohort. Results: A positive association was found between uric acid levels and overall cancer risk, and results were similar with adjustment for glucose, triglycerides and BMI. Hazard ratio (HR) for overall cancer for the 4th quartile of uric acid compared to the 1st was 1.08 (95% CI: 1.05-1.11) in men and 1.12 (1.09 - 1.16) in women. Site-specific analysis showed a positive association between uric acid and risk of colorectal, hepatobiliary, kidney, nonmelanoma skin, and other cancers in men and of head and neck and other cancers in women. An inverse association was observed for pulmonary and central nervous system (CNS) cancers in men and breast, lymphatic and haematological, and CNS malignancies in women. Materials and Methods: We included 493,281 persons aged 20 years and older who had a measurement of serum uric acid and were cancer-free at baseline in the AMORIS study. Multivariable Cox proportional hazards regression was used to investigate sex-specific quartiles of serum uric acid in relation to cancer risk in men and women. Analysis was further adjusted for serum glucose, triglycerides and, where available, BMI. Site-specific analysis was performed for major cancers. Conclusions: Altered uric acid levels were associated with risk of overall and some specific cancers, further indicating the potential role of uric acid metabolism in carcinogenesis.

Published
2017

27. Additional file 1: of Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis

Author

Santaolalla, Aida, Garmo, Hans, Grigoriadis, Anita, Sundeep Ghuman, Hammar, Niklas, Jungner, Ingmar, Gรถran Walldius, Lambe, Mats, Holmberg, Lars, and Hemelrijck, Mieke

Abstract

Table S1. Laboratory fully automated methods with automatic calibration were performed at one accredited laboratory (CALAB to measure the serum biomarkers examine in the study. Table S2. Panel of serum markers describing standard medical cut-offs information. Table S3. Characteristics of the study population by LCA-derived metabolic classes. (DOCX 28 kb)

Published
2019
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31. Thyroid cancer risk in the Swedish AMORIS study : the role of inflammatory biomarkers in serum.

Author

Ghoshal, Arunangshu, Garmo, Hans, Arthur, Rhonda, Carroll, Paul, Holmberg, Lars, Hammar, Niklas, Jungner, Ingmar, Malmström, Håkan, Lambe, Mats, Walldius, Göran, Van Hemelrijck, Mieke, Ghoshal, Arunangshu, Garmo, Hans, Arthur, Rhonda, Carroll, Paul, Holmberg, Lars, Hammar, Niklas, Jungner, Ingmar, Malmström, Håkan, Lambe, Mats, Walldius, Göran, and Van Hemelrijck, Mieke

Abstract

Chronic inflammation is one of the underlying risks associated with thyroid cancer. We ascertained the association between commonly measured serum biomarkers of inflammation and the risk of thyroid cancer in Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. 226,212 subjects had baseline measurements of C-reactive protein, albumin and haptoglobin. Leukocytes were measured in a subgroup of 63,845 subjects. Associations between quartiles and dichotomized values of inflammatory markers and risk of thyroid cancer were analysed using multivariate Cox proportional hazard models. 202 individuals were diagnosed with thyroid cancer during a mean follow-up of 19.6 years. There was a positive association between lower albumin levels and risk of developing thyroid cancer [Hazard Ratio for albumin ≤ 40 g/L: 1.50 (95% Confidence Interval = 1.04-2.16)]. When stratified by a metabolic score, we observed similar association for albumin with higher HR among those with metabolic score ≥ 1, as compared to those with metabolic score of 0 [HR 1.98 (95% CI = 1.11-3.54) vs 1.17 (95% CI = 0.72-1.89)] (P = 0.19). Apart from albumin, none of the serum markers of inflammation studied showed a link with the risk of developing thyroid cancer-suggesting that the role of inflammation may be more complicated and requires assessment of more specialised measurements of inflammation.

Published
2018
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32. Cardiovascular events in patients under age fifty with early findings of elevated lipid and glucose levels - The AMORIS study

Author

Ivert, Torbjörn, Malmström, Håkan, Hammar, Niklas, Carlsson, Axel C, Wändell, Per E., Holzmann, Martin J., Jungner, Ingmar, Ärnlov, Johan, Walldius, Göran, Ivert, Torbjörn, Malmström, Håkan, Hammar, Niklas, Carlsson, Axel C, Wändell, Per E., Holzmann, Martin J., Jungner, Ingmar, Ärnlov, Johan, and Walldius, Göran

Abstract

Background: The long-term trajectories of lipid and glucose levels in subjects who experience a major cardiovascular (CV) event at a young age has not been well studied. Our objective was to investigate lipid, lipoprotein, apolipoprotein (apo), and glucose levels in individuals experiencing a CV event before 50 years of age. Methods and findings: A first CV event [non-fatal myocardial infarction (MI), coronary revascularisation, or CV related death] before age 50 was recorded in 2,939 (cumulative incidence 1.2% in males and 0.3% in females) of 361,353 individuals included in the prospective Swedish AMORIS (Apolipoprotein-related MOrtality RISk) study with health examinations 1985-1996 and follow-up through 2011. In a nested case-control analysis, cases with a CV event were matched to randomly selected controls. Population risk factor trajectories were calculated up to 20 years prior to an event. Total cholesterol (TC), triglyceride (TG), and glucose levels were higher in cases than in controls as early as 20 years prior to the event with differences increasing over time. Low density lipoprotein, apoB, and the apoB/apoA-1 ratio were higher and increased over time, while HDL and apoA-1 were lower in cases compared to controls. The odds ratio was 2.5 (95% confidence interval 1.6-3.7) for TC >= 5 mmol/L and TG >= 1.7 mmol/L in cases versus controls. The adjusted population-attributable fractions including lipids, glucose, diabetes, smoking, hypertension, and obesity indicated that about 50% of CV events before age 50 may be associated with elevated lipid and glucose levels. Conclusions: Elevated TC, TG, LDL, apoB, and glucose levels and high apoB/apo A-1 ratio documented two decades before a CV event in subjects younger than 50 years may account for about half of CV events before age 50, which calls for early recognition and possibly treatment of modifiable CV risk factors in young individuals.

Published
2018
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33. Circulating gamma-glutamyl transferase and development of specific breast cancer subtypes: findings from the Apolipoprotein Mortality Risk (AMORIS) cohort

Author

Shackshaft, Lydia, Van Hemelrijck, Mieke, Garmo, Hans, Malmström, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, and Wulaningsih, Wahyu

Subjects
Medicine(all), Adult, Sweden, Receptor, ErbB-2, Short Report, Breast Neoplasms, gamma-Glutamyltransferase, Middle Aged, GGT, Cohort Studies, Breast cancer, Glucose, Apolipoproteins, Receptors, Estrogen, Case-Control Studies, Population Surveillance, Odds Ratio, Humans, Female, Prospective study, skin and connective tissue diseases, Receptors, Progesterone, Triglycerides, Biomarkers, Aged
Abstract

Background Different etiological pathways may precede development of specific breast cancer subtypes and impact prevention or treatment strategies. We investigated the association between gamma-glutamyl transferase (GGT) and development of specific breast cancer subtypes based on oestrogen receptor (ER), progesterone receptor (PR) and HER2 status. Methods We included 231,283 cancer-free women in a Swedish cohort. Associations between GGT and breast cancer subtypes were investigated with nested case–control and case–case analyses. We used logistic regression models to assess serum GGT in relation to breast cancer subtype, based on individual and combined receptor status. Results Positive associations were found between serum GGT and development of ER+, ER− and PR+ breast cancers compared to controls (odds ratio (OR) 1.14 (95% confidence interval (CI) 1.08–1.19), 1.11 (1.01–1.23) and 1.18 (1.12–1.24), respectively) and of ER+/PR+ tumours. We found inverse associations between GGT levels and PR− breast cancers compared to PR+ (OR 0.87 (0.80–0.95)), between ER+/PR− tumours compared to ER+/PR+ tumours and between ER−/PR−/HER+ compared to ER+/HER2 or PR+/HER2 tumours (OR 0.55 (95% CI 0.34–0.90). Conclusion The observed associations between pre-diagnostic serum GGT and different breast cancer subtypes may indicate distinct underlying pathways and require further investigations to tease out their clinical implications. Electronic supplementary material The online version of this article (doi:10.1186/s13058-017-0816-7) contains supplementary material, which is available to authorized users.

Published
2017

37. Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort

Author

Melvin, Jennifer C, Garmo, Hans, Holmberg, Lars, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Lambe, Mats, and Van Hemelrijck, Mieke

Subjects
Adult, Blood Glucose, LDL cholesterol, Breast cancer (BC), Lipoproteins, Prognosis, Breast Neoplasms, Triglycerides, lcsh:RC254-282, Severity, HDL cholesterol, Risk Factors, Biomarkers, Tumor, Humans, Obesity, Apolipoprotein A-I, Aged, Total cholesterol, Sweden, Cancer och onkologi, Apolipoprotein B, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cholesterol, Cancer and Oncology, Apolipoprotein B-100, Female, lipids (amino acids, peptides, and proteins), Glucose, Research Article
Abstract

Background The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in the Swedish Apolipoprotein MORtality RISk (AMORIS) cohort. We conducted a follow-up analysis including information on tumour characteristics. Methods One thousand eight hundred twenty-four women diagnosed with BC, with serum biomarker levels of glucose, triglycerides, cholesterol (total, HDL, and LDL), and apolipoproteins A-1 and B recorded in a routine health check at baseline were included. BC severity was split into categories (good, moderate, and poor prognosis) based on ER status, TNM stage, and age at diagnosis. Proportional odds models were used to obtain odds ratios (ORs) and 95% confidence intervals (CI), with the interval time between baseline measurement and BC diagnosis accounted for. Results Serum glucose and the ApoB/ApoA-1 ratio showed a non-statistically significant positive association with BC severity (proportional OR: 1.25 (95%CI: 0.92–1.70) for glucose (

Published
2017

38. Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study

Author

Arthur, Rhonda, primary, Møller, Henrik, additional, Garmo, Hans, additional, Häggström, Christel, additional, Holmberg, Lars, additional, Stattin, Pär, additional, Malmström, Håkan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Robinson, David, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2018
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41. Serum inflammatory markers in relation to prostate cancer severity and death

Author

Crawley, Danielle, primary, Williams, Robert, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Stattin, Par, additional, Malmstrom, Hakan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Robinson, David, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2018
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43. Serum biomarkers to predict risk of testicular and penile cancer in AMORIS

Author

Ghoshal, Arunangshu, Garmo, Hans, Arthur, Rhonda, Hammar, Niklas, Jungner, Ingmar, Malmström, Håkan, Lambe, Mats, Walldius, Göran, Van Hemelrijck, Mieke, Ghoshal, Arunangshu, Garmo, Hans, Arthur, Rhonda, Hammar, Niklas, Jungner, Ingmar, Malmström, Håkan, Lambe, Mats, Walldius, Göran, and Van Hemelrijck, Mieke

Abstract

Purpose: To evaluate the association between commonly measured serum biomarkers of inflammation and penile and testicular cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. Materials and methods: A total of 205,717 subjects had baseline measurements of C-reactive protein, albumin, and haptoglobin. The association between quartiles and dichotomised values of inflammatory markers and penile and testicular cancer risk were analysed by using multivariate Cox proportional hazard models. Results: A total of 125 men were diagnosed with testicular cancer and 50 with penile cancer during a mean follow-up of 20.3 years. No statistically significant trends were seen between serum inflammatory markers and risk of penile cancer, but higher albumin levels increased the risk of testicular cancer [HR for albumin (g/L): 1.10 (95% CI: 1.03-1.18)]. However, this trend was not observed when using medical cut-offs of albumin. Conclusions: In the present study, we did not find support for an association between commonly used markers of inflammation and risk of testicular or penile cancer. The role of inflammation may be more complicated and require assessment of more specialised measurements of inflammation in future studies.

Published
2017
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44. Serum inflammatory markers and colorectal cancer risk and survival

Author

Ghuan, Sundeep, Van Hemelrijck, Mieke, Garmo, Hans, Holmberg, Lars, Malmström, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Wulaningsih, Wahyu, Ghuan, Sundeep, Van Hemelrijck, Mieke, Garmo, Hans, Holmberg, Lars, Malmström, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, and Wulaningsih, Wahyu

Abstract

Background: Inflammation has been linked with development of some cancers. We investigated systemic inflammation in relation to colorectal cancer incidence and subsequent survival using common serum inflammatory markers Design: A cohort of men and women aged 20 years and older in greater Stockholm area with serum C-reactive protein (CRP) and albumin measured between 1986 and 1999 were included (n-325 599). A subset of these had baseline measurements of haptoglobin and leukocytes. Multivariable Cox regression was performed to assess risk of colorectal cancer by levels of inflammatory markers, adjusting for potential confounders. Analyses were stratified by circulating glucose, total cholesterol and triglycerides. Overall and CRC-specific death following diagnosis were assessed as secondary outcomes. Results: A total of 4764 individuals were diagnosed with colorectal cancer. A positive association between haptoglobin and colorectal cancer incidence was found (hazard ratio (HR): 1.17; 95% CI: 1.06-1.28). A positive association was also observed with leukocytes (HR: 1.21; 95% CI: 1.03-1.42). No evidence of association was noted between CRP and colorectal cancer risk. Higher risks of all-cause death were seen with haptoglobin and leukocytes levels. Higher haptoglobin levels were linked with an increased risk of colorectal cancer death (HR: 1.19; 95% CI: 1.01-1.41). Conclusions: Prediagnostic systemic inflammation may impact colorectal cancer incidence and survival; therefore, prompting investigations linking inflammatory pathways preceding colorectal cancer with disease severity and progression.

Published
2017
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45. Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival

Author

Wulaningsih, Wahyu, Holmberg, Lars, Garmo, Hans, Karagiannis, Sophia N., Ahlstedt, Staffan, Malmstrom, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Ng, Tony, and Van Hemelrijck, Mieke

Subjects
Cancer och onkologi, Allergy, Cancer and Oncology, atopy, cancer, cohort, Original Research, immunoglobulin E
Abstract

Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE ≥35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan–Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70–0.99. A similar trend was seen with specific IgE scores overall (Ptrend = 0.007) and in women (Ptrend = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (TH2)-biased response in development of some cancers.

Published
2016

46. Serum inflammatory markers in relation to prostate cancer severity and death

Author

Crawley, Danielle, primary, Williams, Robert, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Stattin, Par, additional, Malmstrom, Hakan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Goran, additional, Robinson, David, additional, Jungner, Ingmar, additional, and Van Hemelrijck, Mieke, additional

Published
2017
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50. Serum inflammatory markers and colorectal cancer risk and survival

Author

Ghuman, Sundeep, primary, Van Hemelrijck, Mieke, additional, Garmo, Hans, additional, Holmberg, Lars, additional, Malmström, Håkan, additional, Lambe, Mats, additional, Hammar, Niklas, additional, Walldius, Göran, additional, Jungner, Ingmar, additional, and Wulaningsih, Wahyu, additional

Published
2017
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