566 results on '"Hengstler, Jan G."'
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2. Acetaminophen overdose causes a breach of the blood–bile barrier in mice but not in rats
3. Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats
4. EDI3 knockdown in ER-HER2+ breast cancer cells reduces tumor burden and improves survival in two mouse models of experimental metastasis
5. Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
6. Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
7. Guidance for statistical design and analysis of toxicological dose–response experiments, based on a comprehensive literature review
8. The TGF-β1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects
9. Loss of Toll-like receptor 9 protects from hepatocellular carcinoma in murine models of chronic liver disease
10. Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells
11. Alterations in the hepatocyte epigenetic landscape in steatosis
12. Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth
13. Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences
14. PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat
15. The impact of physical fitness, social life, and cognitive functions on work ability in middle-aged and older adults
16. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis
17. Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease
18. Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation
19. Classification of hepatotoxicity of compounds based on cytotoxicity assays is improved by additional interpretable summaries of high-dimensional gene expression data
20. Risk assessment of parabens in a transcriptomics-based in vitro test
21. Sublethal necroptosis signaling promotes inflammation and liver cancer
22. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights
23. Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A
24. Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
25. Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity
26. Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes
27. Chronic stress is associated with specific path integration deficits
28. Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)
29. Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy
30. Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung
31. Identification of an FXR-modulated liver-intestine hybrid state in iPSC-derived hepatocyte-like cells
32. Long-term prognostic significance of HER2-low and HER2-zero in node-negative breast cancer
33. In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red assay
34. td2pLL: An intuitive time-dose-response model for cytotoxicity data with varying exposure durations
35. Automated Detection of Portal Fields and Central Veins in Whole-Slide Images of Liver Tissue
36. Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat
37. Identification of Ppar γ -modulated miRNA hubs that target the fibrotic tumor microenvironment
38. Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
39. Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
40. Intestinal Dysbiosis Amplifies Acetaminophen-Induced Acute Liver Injury
41. Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney
42. Comparing in vitro human liver models to in vivo human liver using RNA-Seq
43. Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.
44. The mediating role of KITLG DNA methylation in the association between childhood adversity and cortisol stress reactivity does not replicate in monocytes
45. Handling deviating control values in concentration-response curves
46. Long-term simulation of lead concentrations in agricultural soils in relation to human adverse health effects
47. The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods
48. Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study
49. Enhanced activation of human NK cells by drug-exposed hepatocytes
50. Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease
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