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130 results on '"He, Qiheng"'

8. High glutamine increases stroke risk by inducing the endothelial‐to‐mesenchymal transition in moyamoya disease

Author

He, Qiheng, primary, Li, Junsheng, additional, Tao, Chuming, additional, Zeng, Chaofan, additional, Liu, Chenglong, additional, Zheng, Zhiyao, additional, Mou, Siqi, additional, Liu, Wei, additional, Zhang, Bojian, additional, Yu, Xiaofan, additional, Zhai, Yuanren, additional, Wang, Jia, additional, Zhang, Qian, additional, Zhang, Yan, additional, Zhang, Dong, additional, Zhao, Jizong, additional, and Ge, Peicong, additional

Published
2024
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9. Circulating immune cell landscape and T‐cell abnormalities in patients with moyamoya disease

Author

Ge, Peicong, primary, Tao, Chuming, additional, Wang, Wenjing, additional, He, Qiheng, additional, Liu, Chenglong, additional, Zheng, Zhiyao, additional, Mou, Siqi, additional, Zhang, Bojian, additional, Liu, Xingju, additional, Zhang, Qian, additional, Wang, Rong, additional, Li, Hao, additional, Zhang, Dong, additional, and Zhao, Jizong, additional

Published
2024
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11. Genotype-phenotype correlations in multiple lesions of familial cerebral cavernous malformations concerning phosphatidylinositol 3-kinase catalytic subunit alpha mutations

Author

Wang, Jie, Tang, Jihong, Yang, Yingxi, Jiao, Yuming, Huo, Ran, Xu, Hongyuan, Zhao, Shaozhi, Sun, Yingfan, He, Qiheng, Yu, Qifeng, Wang, Shuo, Zhao, Jizong, Wang, Jiguang, Cao, Yong, Wang, Jie, Tang, Jihong, Yang, Yingxi, Jiao, Yuming, Huo, Ran, Xu, Hongyuan, Zhao, Shaozhi, Sun, Yingfan, He, Qiheng, Yu, Qifeng, Wang, Shuo, Zhao, Jizong, Wang, Jiguang, and Cao, Yong

Published
2024

12. Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review.

Author

Cao, Tianqing, He, Shenghong, Wang, Luchen, Chai, Xiaoke, He, Qiheng, Liu, Dongsheng, Wang, Dong, Wang, Nan, He, Jianghong, Wang, Shouyang, Yang, Yi, Zhao, Jizong, and Tan, Huiling

Subjects
DEEP brain stimulation, CONSCIOUSNESS disorders, MOVEMENT disorders, LITERATURE reviews, SUBTHALAMIC nucleus, PATIENT selection, BRAIN injuries
Abstract

Background: The management of patients with disorders of consciousness (DOC) presents substantial challenges in clinical practice. Deep brain stimulation (DBS) has emerged as a potential therapeutic approach, but the lack of standardized regulatory parameters for DBS in DOC hinders definitive conclusions. Objective: This comprehensive review aims to provide a detailed summary of the current issues concerning patient selection, target setting, and modulation parameters in clinical studies investigating the application of DBS for DOC patients. Methods: A meticulous systematic analysis of the literatures was conducted, encompassing articles published from 1968 to April 2023, retrieved from reputable databases (PubMed, Embase, Medline, and Web of Science). Results: The systematic analysis of 21 eligible articles, involving 146 patients with DOC resulting from acquired brain injury or other disorders, revealed significant insights. The most frequently targeted regions were the Centromedian‐parafascicular complex (CM‐pf) nuclei and central thalamus (CT), both recognized for their role in regulating consciousness. However, other targets have also been explored in different studies. The stimulation frequency was predominantly set at 25 or 100 Hz, with pulse width of 120 μs, and voltages ranged from 0 to 4 V. These parameters were customized based on individual patient responses and evaluations. The overall clinical efficacy rate in all included studies was 39.7%, indicating a positive effect of DBS in a subset of DOC patients. Nonetheless, the assessment methods, follow‐up durations, and outcome measures varied across studies, potentially contributing to the variability in reported efficacy rates. Conclusion: Despite the challenges arising from the lack of standardized parameters, DBS shows promising potential as a therapeutic option for patients with DOC. However, there still remains the need for standardized protocols and assessment methods, which are crucial to deepen the understanding and optimizing the therapeutic potential of DBS in this specific patient population. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

Author

Ge, Peicong, primary, Yin, Zihan, additional, Tao, Chuming, additional, Zeng, Chaofan, additional, Yu, Xiaofan, additional, Lei, Shixiong, additional, Li, Junsheng, additional, Zhai, Yuanren, additional, Ma, Long, additional, He, Qiheng, additional, Liu, Chenglong, additional, Liu, Wei, additional, Zhang, Bojian, additional, Zheng, Zhiyao, additional, Mou, Siqi, additional, Zhao, Zhikang, additional, Wang, Shuang, additional, Sun, Wei, additional, Guo, Min, additional, Zheng, Shuai, additional, Zhang, Jia, additional, Deng, Xiaofeng, additional, Liu, Xingju, additional, Ye, Xun, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhang, Shaosen, additional, Wang, Chengjun, additional, Yang, Ziwen, additional, Zhang, Nijia, additional, Wu, Mingxing, additional, Sun, Jian, additional, Zhou, Yujia, additional, Shi, Zhiyong, additional, Ma, Yonggang, additional, Zhou, Jianpo, additional, Yu, Shaochen, additional, Li, Jiaxi, additional, Lu, Junli, additional, Gao, Faliang, additional, Wang, Wenjing, additional, Chen, Yanming, additional, Zhu, Xingen, additional, Zhang, Dong, additional, and Zhao, Jizong, additional

Published
2024
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19. Correlation of Serum N-Acetylneuraminic Acid with the Risk of Moyamoya Disease

Author

Liu, Chenglong, primary, Ge, Peicong, additional, Zeng, Chaofan, additional, Yu, Xiaofan, additional, Zhai, Yuanren, additional, Liu, Wei, additional, He, Qiheng, additional, Li, Junsheng, additional, Liu, Xingju, additional, Wang, Jia, additional, Ye, Xun, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhao, Jizong, additional, and Zhang, Dong, additional

Published
2023
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23. SomaticGJA4mutation in intracranial extra-axial cavernous hemangiomas

Author

Huo, Ran, primary, Yang, Yingxi, additional, Xu, Hongyuan, additional, Zhao, Shaozhi, additional, Song, Dong, additional, Weng, Jiancong, additional, Ma, Ruochen, additional, Sun, Yingfan, additional, Wang, Jie, additional, Jiao, Yuming, additional, Zhang, Junze, additional, He, Qiheng, additional, Wu, Ruolei, additional, Wang, Shuo, additional, Zhao, Ji-Zong, additional, Zhang, Junting, additional, Wang, Jiguang, additional, and Cao, Yong, additional

Published
2023
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24. Association between methionine sulfoxide and risk of moyamoya disease

Author

Li, Junsheng, primary, Ge, Peicong, additional, He, Qiheng, additional, Liu, Chenglong, additional, Zeng, Chaofan, additional, Tao, Chuming, additional, Zhai, Yuanren, additional, Wang, Jia, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhang, Dong, additional, and Zhao, Jizong, additional

Published
2023
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26. Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas

Author

Huo, Ran, Yang, Yingxi, Xu, Hongyuan, Zhao, Shaozhi, Song, Dong, Weng, Jiancong, Ma, Ruochen, Sun, Yingfan, Wang, Jie, Jiao, Yuming, Zhang, Junze, He, Qiheng, Wu, Ruolei, Wang, Shuo, Zhao, Jizong, Zhang, Junting, Wang, Jiguang, Cao, Yong, Huo, Ran, Yang, Yingxi, Xu, Hongyuan, Zhao, Shaozhi, Song, Dong, Weng, Jiancong, Ma, Ruochen, Sun, Yingfan, Wang, Jie, Jiao, Yuming, Zhang, Junze, He, Qiheng, Wu, Ruolei, Wang, Shuo, Zhao, Jizong, Zhang, Junting, Wang, Jiguang, and Cao, Yong

Abstract

Objective: Extra-axial cavernous hemangiomas (ECHs) are sporadic and rare intracranial occupational lesions that usually occur within the cavernous sinus. The aetiology of ECHs remains unknown. Methods: Whole-exome sequencing was performed on ECH lesions from 12 patients (discovery cohort) and droplet digital polymerase-chain-reaction (ddPCR) was used to confirm the identified mutation in 46 additional cases (validation cohort). Laser capture microdissection (LCM) was carried out to capture and characterise subgroups of tissue cells. Mechanistic and functional investigations were carried out in human umbilical vein endothelial cells and a newly established mouse model. Results: We detected somatic GJA4 mutation (c.121G>T, p.G41C) in 5/12 patients with ECH in the discovery cohort and confirmed the finding in the validation cohort (16/46). LCM followed by ddPCR revealed that the mutation was enriched in lesional endothelium. In vitro experiments in endothelial cells demonstrated that the GJA4 mutation activated SGK-1 signalling that in turn upregulated key genes involved in cell hyperproliferation and the loss of arterial specification. Compared with wild-type littermates, mice overexpressing the GJA4 mutation developed ECH-like pathological morphological characteristics (dilated venous lumen and elevated vascular density) in the retinal superficial vascular plexus at the postnatal 3 weeks, which were reversed by an SGK1 inhibitor, EMD638683. Conclusions: We identified a somatic GJA4 mutation that presents in over one-third of ECH lesions and proposed that ECHs are vascular malformations due to GJA4-induced activation of the SGK1 signalling pathway in brain endothelial cells.

Published
2023

30. Somatic GJA4 Mutation in Intracranial Extra-axial Cavernous Hemangiomas

Author

Huo, Ran, primary, Yang, Yingxi, additional, Xu, Hongyuan, additional, Zhao, Shaozhi, additional, Song, Dong, additional, Weng, Jiancong, additional, Ma, Ruochen, additional, Sun, Yingfan, additional, Wang, Jie, additional, Jiao, Yuming, additional, Zhang, Junze, additional, He, Qiheng, additional, Wu, Ruolei, additional, Wang, Shuo, additional, Zhao, Jizong, additional, Zhang, Junting, additional, Wang, Jiguang, additional, and Cao, Yong, additional

Published
2022
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33. Association of circulating branched-chain amino acids with risk of moyamoya disease

Author

Zeng, Chaofan, primary, Ge, Peicong, additional, Liu, Chenglong, additional, Yu, Xiaofan, additional, Zhai, Yuanren, additional, Liu, Wei, additional, He, Qiheng, additional, Li, Junsheng, additional, Liu, Xingju, additional, Wang, Jia, additional, Ye, Xun, additional, Zhang, Qian, additional, Wang, Rong, additional, Zhang, Yan, additional, Zhao, Jizong, additional, and Zhang, Dong, additional

Published
2022
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39. Chinese Cerebrovascular Neurosurgery Society and Chinese Interventional & Hybrid Operation Society, of Chinese Stroke Association Clinical Practice Guidelines for Management of Brain Arteriovenous Malformations in Eloquent Areas

Author

Wang, Mingze, primary, Jiao, Yuming, additional, Zeng, Chaofan, additional, Zhang, Chaoqi, additional, He, Qiheng, additional, Yang, Yi, additional, Tu, Wenjun, additional, Qiu, Hancheng, additional, Shi, Huaizhang, additional, Zhang, Dong, additional, Kang, Dezhi, additional, Wang, Shuo, additional, Liu, A-li, additional, Jiang, Weijian, additional, Cao, Yong, additional, and Zhao, Jizong, additional

Published
2021
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47. Polarization-modulated random fiber laser

Author

Wu, Han, primary, Wang, Zinan, additional, He, Qiheng, additional, Fan, Mengqiu, additional, Li, Yunqi, additional, Sun, Wei, additional, Zhang, Li, additional, Li, Yi, additional, and Rao, Yunjiang, additional

Published
2016
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50. T Cells Immune Imbalance Present in Patients With Multiple Intracranial Aneurysms.

Author

Tao C, Liu C, Ge P, Chan L, Pang Y, Li J, He Q, Liu W, Mou S, Zheng Z, Zhang B, Zhao Z, Sun W, Zhang Q, Wang R, Zhang Y, Wang W, Zhang D, and Zhao J

Abstract

Growing evidence suggests that systemic immune and inflammatory responses may play a critical role in the formation and development of aneurysms. Exploring the differences between single intracranial aneurysm (SIA) and multiple IAs (MIAs) could provide insights for targeted therapies. However, there is a lack of comprehensive and detailed characterization of changes in circulating immune cells in MIAs. Peripheral blood mononuclear cell (PBMC) samples from patients with SIA (n = 16) or MIAs (n = 6) were analyzed using high-dimensional mass cytometry to evaluate the frequency and phenotype of immune cell subtypes. A total of 25 cell clusters were identified, revealing that the immune signature of MIAs included cluster changes. Compared to patients with SIA, patients with MIAs exhibited immune dysfunction and regulatory imbalance in T-cell clusters. They also had reduced numbers of CD8+ T cells and their subgroups CD8+ Te and CD8+ Tem cells, as well as reduced numbers of the CD4+ T-cell subgroup CD27-CD4+ Tem cells. Furthermore, compared to SIA, MIAs were associated with enhanced T-cell immune activation, with elevated expression levels of CD3, CD25, CD27, CCR7, GP130, and interleukin 10. This study provides insights into the circulating immune cell profiles in patients with MIAs, highlighting the similarities and differences between patients with SIA and those with MIAs. Furthermore, the study suggests that circulating immune dysfunction may contribute to development of MIAs., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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