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19. Histological changes in the rat brain and spinal cord following prolonged intracerebroventricular infusion of cerebrospinal fluid from amyotrophic lateral sclerosis patients are similar to those caused by the disease

Author

Gómez-Pinedo, U., Galán, L., Yañez, M., Matias-Guiu, J., Valencia, C., Guerrero-Sola, A., Lopez-Sosa, F., Brin, J.R., Benito-Martin, M.S., Leon-Espinosa, G., Vela-Souto, A., Lendinez, C., Guillamón-Vivancos, T., Matias-Guiu, J.A., Arranz-Tagarro, J.A., Barcia, J.A., and Garcia, A.G.

Published
2018
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20. La infusión intracerebroventricular prolongada de líquido cefalorraquídeo procedente de pacientes con esclerosis lateral amiotrófica provoca cambios histológicos en el cerebro y la médula espinal de la rata similares a los hallados en la enfermedad

Author

Gómez-Pinedo, U., Galán, L., Yañez, M., Matias-Guiu, J., Valencia, C., Guerrero-Sola, A., Lopez-Sosa, F., Brin, J.R., Benito-Martin, M.S., Leon-Espinosa, G., Vela-Souto, A., Lendinez, C., Guillamon-Vivancos, T., Matias-Guiu, J.A., Arranz-Tagarro, J.A., Barcia, J.A., and Garcia, A.G.

Published
2018
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23. Murine experimental models of amyotrophic lateral sclerosis: An update

Author

Moreno-Jiménez, L., primary, Benito-Martín, M.S., additional, Sanclemente-Alamán, I., additional, Matías-Guiu, J.A., additional, Sancho-Bielsa, F., additional, Canales-Aguirre, A., additional, Mateos-Díaz, J.C., additional, Matías-Guiu, J., additional, Aguilar, J., additional, and Gómez-Pinedo, U., additional

Published
2023
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43. Will neurological care change over the next 5 years due to the COVID-19 pandemic?

Author

Universidad de Sevilla. Departamento de Cirugía, Matías-Guiu, J., Matias-Guiu, J. A., Alvarez-Sabin, J., Ramon Ara, J., Arenillas, J., Casado-Naranjo, I., Jiménez Hernández, María Dolores, Diez-Tejedor, E., Universidad de Sevilla. Departamento de Cirugía, Matías-Guiu, J., Matias-Guiu, J. A., Alvarez-Sabin, J., Ramon Ara, J., Arenillas, J., Casado-Naranjo, I., Jiménez Hernández, María Dolores, and Diez-Tejedor, E.

Abstract

Introduction The COVID-19 pandemic will give rise to long-term changes in neurological care, which are not easily predictable. Material and methods A key informant survey was used to enquire about the changes expected in the specialty over the next 5 years. The survey was completed by heads of neurology departments with broad knowledge of the situation, having been active during the pandemic. Results Despite a low level of consensus between participants, there was strong (85%) and moderate consensus (70%) about certain subjects, mainly the increase in precautions to be taken, the use of telemedicine and teleconsultations, the reduction of care provided in in-person consultations to avoid the presence of large numbers of people in waiting rooms, the development of remote training solutions, and the changes in monitoring visits during clinical trials. There was consensus that there would be no changes to the indication of complementary testing or neurological examination. Conclusion The key informant survey identified the foreseeable changes in neurological care after the pandemic., Introducción La pandemia de COVID-19 va a conllevar cambios en la asistencia neurológica, que no se pueden prever fácilmente a largo plazo. Material y métodos A través de un modelo de informadores clave se busca el consenso de cómo va a ser la especialidad en un plazo de 5 años, siendo los encuestados jefes de servicio de neurología con conocimiento amplio de la situación al haber actuado durante la pandemia. Resultados Aunque se obtiene un grado de acuerdo bajo entre los encuestados, sí se describen acuerdos por consenso a nivel mayor (85%) y menor (70%). Los principales acuerdos se refieren al incremento de precauciones, al uso de la telemedicina, al mantenimiento de las consultas telefónicas, a la reducción de asistencia a las consultas evitando que hayan salas de espera con un número alto de personas, al desarrollo de técnicas docentes no presenciales y a la adaptación en el desarrollo de ensayos clínicos en relación con la visita de los monitores. Sin embargo, no se acuerda que haya cambios en la indicación de exploraciones complementarias, ni en la propia exploración neurológica. Conclusión El método de informadores clave ha permitido conocer qué cambios se pueden prever tras la pandemia.

Published
2020

48. Variant rs4149584 (R92Q) of the TNFRSF1A gene in patients with familial multiple sclerosis

Author

Gomez Pinedo, U., Matías Guiu, J. A., Torre Fuentes, Laura, Montero Escribano, P., Hernández Lorenzo, Laura, Pytel, V., Maietta, P., Álvarez de Andrés, Sara, Sanclemente Alamán, I., Moreno Jimenez, D. Ojeda-Hernandez, N. Villar-Gómez, M.S. Benito-Martin, B. Selma-Calvo, L. Vidorreta-Ballesteros, R. Madrid, J. Matías-Guiu, Madrid González, Ricardo, Matías-Guiu Guía, Jorge, Gomez Pinedo, U., Matías Guiu, J. A., Torre Fuentes, Laura, Montero Escribano, P., Hernández Lorenzo, Laura, Pytel, V., Maietta, P., Álvarez de Andrés, Sara, Sanclemente Alamán, I., Moreno Jimenez, D. Ojeda-Hernandez, N. Villar-Gómez, M.S. Benito-Martin, B. Selma-Calvo, L. Vidorreta-Ballesteros, R. Madrid, J. Matías-Guiu, Madrid González, Ricardo, and Matías-Guiu Guía, Jorge

Abstract

Genomic studies have identified numerous genetic variants associated with sus-ceptibility to multiple sclerosis (MS); however, each one explains only a small percentage of therisk of developing the disease. These variants are located in genes involved in specific path-ways, which supports the hypothesis that the risk of developing MS may be linked to alterationsin these pathways, rather than in specific genes. We analyzed the role of the TNFRSF1A gene,which encodes one of the TNF- receptors involved in a signaling pathway previously linked toautoimmune disease.Methods: We included 138 individuals from 23 families including at least 2 members with MS,and analyzed the presence of exonic variants of TNFRSF1A through whole-exome sequencing.We also conducted a functional study to analyze the pathogenic mechanism of variant rs4149584(-g.6442643C > G, NM 001065.4:c.362 G > A, R92Q) by plasmid transfection into human oligo-dendroglioma (HOG) cells, which behave like oligodendrocyte lineage cells; protein labelingwas used to locate the protein within cells. We also analyzed the ability of transfected HOGcells to proliferate and differentiate into oligodendrocytes., Depto. de Genética, Fisiología y Microbiología, Fac. de Ciencias Biológicas, TRUE, pub

Published
2022

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