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629 results on '"Galassi, Claudia"'

1. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu JM, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, and Kanneganti, Thirumala-Devi

Subjects
Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Generic health relevance, Good Health and Well Being, Animals, Humans, Apoptosis, Cell Death, Caspases, Carcinogenesis, Mammals, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

5. Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Author

Musella, Martina, Guarracino, Andrea, Manduca, Nicoletta, Galassi, Claudia, Ruggiero, Eliana, Potenza, Alessia, Maccafeo, Ester, Manic, Gwenola, Mattiello, Luca, Soliman Abdel Rehim, Sara, Signore, Michele, Pietrosanto, Marco, Helmer-Citterich, Manuela, Pallocca, Matteo, Fanciulli, Maurizio, Bruno, Tiziana, De Nicola, Francesca, Corleone, Giacomo, Di Benedetto, Anna, Ercolani, Cristiana, Pescarmona, Edoardo, Pizzuti, Laura, Guidi, Francesco, Sperati, Francesca, Vitale, Sara, Macchia, Daniele, Spada, Massimo, Schiavoni, Giovanna, Mattei, Fabrizio, De Ninno, Adele, Businaro, Luca, Lucarini, Valeria, Bracci, Laura, Aricò, Eleonora, Ziccheddu, Giovanna, Facchiano, Francesco, Rossi, Stefania, Sanchez, Massimo, Boe, Alessandra, Biffoni, Mauro, De Maria, Ruggero, Vitale, Ilio, and Sistigu, Antonella

Published
2022
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6. Quantitative assessment of mitophagy in irradiated cancer cells

Author

Guilbaud, Emma, primary, Spada, Sheila, additional, Bloy, Norma, additional, Galassi, Claudia, additional, Sato, Ai, additional, Jiménez-Cortegana, Carlos, additional, Aretz, Artur, additional, Buqué, Aitziber, additional, Yamazaki, Takahiro, additional, Demaria, Sandra, additional, and Galluzzi, Lorenzo, additional

Published
2023
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8. Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

Author

Manzini, Paola Maria, Ciccone, Giovannino, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Ghisetti, Valeria, D’Antico, Sergio, Galassi, Claudia, Saccona, Fabio, Castiglione, Anna, Birocco, Nadia, Francisci, Tiziana, Hu, Huijing, Pecoraro, Clara, Danielle, Franca, Labanca, Luciana, Bordiga, Anna Maria, Lorenzi, Marco, Camisasca, Giovanni, Giachino, Osvaldo, Pagliarino, Mauro, Ottone, Piero, Scuvera, Ilvana Tiziana Donatella, Guaschino, Roberto, Freilone, Roberto, Berti, Pierluigi, Pittaluga, Fabrizia, Avolio, Maria, Costa, Cristina, Raso, Samuele, Nucci, Aurora, Milan, Massimo, Baffa, Alessandra, Russo, Alessandra, Tornello, Antonella, Maddalena, Laura, Delios, Grazia, Marletto, Fabio Paolo, De Micheli, Anna Grazia, Mattei, Alessio, Baldassano, Stefano, Canta, Francesca, Russo, Maria Luisa, Bergamo, Daniele, Vitale, Francesco, Liccardi, Marco Maria, Chinaglia, Alessandra, Calcagno, Andrea, Converso, Marcella, Aldieri, Chiara, Libanore, Valentina, Blangetti, Ilaria, Benedetti, Valentina, Mitola, Barbara, and Scozzari, Gitana

Published
2022
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10. A microscale hybrid modelling system to assess the air quality over a large portion of a large European city

Author

Ancona, Carla, Angelini, Paola, Argentini, Stefania, Baldacci, Sandra, Bisceglia, Lucia, Bonafede, Michela, Bonomo, Sergio, Bonvicini, Laura, Broccoli, Serena, Brusasca, Giuseppe, Bucci, Simone, Calori, Giuseppe, Carlino, Giuseppe, Cernigliaro, Achille, Chieti, Antonio, Colacci, Annamaria, de’ Donato, Francesca, Demaria, Moreno, Fasola, Salvatore, Finardi, Sandro, Forastiere, Francesco, Galassi, Claudia, Gariazzo, Claudio, Rossi, Paolo Giorgi, La Grutta, Stefania, Licitra, Gaetano, Maio, Sara, Marinaccio, Alessandro, Michelozzi, Paola, Migliore, Enrica, Moro, Antonino, Nanni, Alessandro, Ottone, Marta, Parmagnani, Federica, Pepe, Nicola, Radice, Paola, Ranzi, Andrea, Renzi, Matteo, Scondotto, Salvatore, Scortichini, Matteo, Silibello, Camillo, Sozzi, Roberto, Stafoggia, Massimo, Tinarelli, Gianni, Uboldi, Francesco, Viegi, Giovanni, Zengarini, Nicolas, and Barbero, Daniela

Published
2021
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15. Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

Author

Manic, Gwenola, Musella, Martina, Corradi, Francesca, Sistigu, Antonella, Vitale, Sara, Soliman Abdel Rehim, Sara, Mattiello, Luca, Malacaria, Eva, Galassi, Claudia, Signore, Michele, Pallocca, Matteo, Scalera, Stefano, Goeman, Frauke, De Nicola, Francesca, Guarracino, Andrea, Pennisi, Rosa, Antonangeli, Fabrizio, Sperati, Francesca, Baiocchi, Marta, Biffoni, Mauro, Fanciulli, Maurizio, Maugeri-Saccà, Marcello, Franchitto, Annapaola, Pichierri, Pietro, De Maria, Ruggero, and Vitale, Ilio

Published
2021
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16. Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials

Author

Axfors, Cathrine, Janiaud, Perrine, Schmitt, Andreas M., van’t Hooft, Janneke, Smith, Emily R., Haber, Noah A., Abayomi, Akin, Abduljalil, Manal, Abdulrahman, Abdulkarim, Acosta-Ampudia, Yeny, Aguilar-Guisado, Manuela, Al-Beidh, Farah, Alejandria, Marissa M., Alfonso, Rachelle N., Ali, Mohammad, AlQahtani, Manaf, AlZamrooni, Alaa, Anaya, Juan-Manuel, Ang, Mark Angelo C., Aomar, Ismael F., Argumanis, Luis E., Averyanov, Alexander, Baklaushev, Vladimir P., Balionis, Olga, Benfield, Thomas, Berry, Scott, Birocco, Nadia, Bonifacio, Lynn B., Bowen, Asha C., Bown, Abbie, Cabello-Gutierrez, Carlos, Camacho, Bernardo, Camacho-Ortiz, Adrian, Campbell-Lee, Sally, Cao, Damon H., Cardesa, Ana, Carnate, Jose M., Castillo, German Jr. J., Cavallo, Rossana, Chowdhury, Fazle R., Chowdhury, Forhad U. H., Ciccone, Giovannino, Cingolani, Antonella, Climacosa, Fresthel Monica M., Compernolle, Veerle, Cortez, Carlo Francisco N., Costa Neto, Abel, D’Antico, Sergio, Daly, James, Danielle, Franca, Davis, Joshua S., De Rosa, Francesco Giuseppe, Denholm, Justin T., Denkinger, Claudia M., Desmecht, Daniel, Díaz-Coronado, Juan C., Díaz Ponce-Medrano, Juan A., Donneau, Anne-Françoise, Dumagay, Teresita E., Dunachie, Susanna, Dungog, Cecile C., Erinoso, Olufemi, Escasa, Ivy Mae S., Estcourt, Lise J., Evans, Amy, Evasan, Agnes L. M., Fareli, Christian J., Fernandez-Sanchez, Veronica, Galassi, Claudia, Gallo, Juan E., Garcia, Patricia J., Garcia, Patricia L., Garcia, Jesus A., Garigliany, Mutien, Garza-Gonzalez, Elvira, Gauiran, Deonne Thaddeus V., Gaviria García, Paula A., Giron-Gonzalez, Jose-Antonio, Gómez-Almaguer, David, Gordon, Anthony C., Gothot, André, Grass Guaqueta, Jeser Santiago, Green, Cameron, Grimaldi, David, Hammond, Naomi E., Harvala, Heli, Heralde, Francisco M., Herrick, Jesica, Higgins, Alisa M., Hills, Thomas E., Hines, Jennifer, Holm, Karin, Hoque, Ashraful, Hoste, Eric, Ignacio, Jose M., Ivanov, Alexander V., Janssen, Maike, Jennings, Jeffrey H., Jha, Vivekanand, King, Ruby Anne N., Kjeldsen-Kragh, Jens, Klenerman, Paul, Kotecha, Aditya, Krapp, Fiorella, Labanca, Luciana, Laing, Emma, Landin-Olsson, Mona, Laterre, Pierre-François, Lim, Lyn-Li, Lim, Jodor, Ljungquist, Oskar, Llaca-Díaz, Jorge M., López-Robles, Concepción, López-Cárdenas, Salvador, Lopez-Plaza, Ileana, Lucero, Josephine Anne C., Lundgren, Maria, Macías, Juan, Maganito, Sandy C., Malundo, Anna Flor G., Manrique, Rubén D., Manzini, Paola M., Marcos, Miguel, Marquez, Ignacio, Martínez-Marcos, Francisco Javier, Mata, Ana M., McArthur, Colin J., McQuilten, Zoe K., McVerry, Bryan J., Menon, David K., Meyfroidt, Geert, Mirasol, Ma. Angelina L., Misset, Benoît, Molton, James S., Mondragon, Alric V., Monsalve, Diana M., Moradi Choghakabodi, Parastoo, Morpeth, Susan C., Mouncey, Paul R., Moutschen, Michel, Müller-Tidow, Carsten, Murphy, Erin, Najdovski, Tome, Nichol, Alistair D., Nielsen, Henrik, Novak, Richard M., O’Sullivan, Matthew V. N., Olalla, Julian, Osibogun, Akin, Osikomaiya, Bodunrin, Oyonarte, Salvador, Pardo-Oviedo, Juan M., Patel, Mahesh C., Paterson, David L., Peña-Perez, Carlos A., Perez-Calatayud, Angel A., Pérez-Alba, Eduardo, Perkina, Anastasia, Perry, Naomi, Pouladzadeh, Mandana, Poyato, Inmaculada, Price, David J., Quero, Anne Kristine H., Rahman, Md. M., Rahman, Md. S., Ramesh, Mayur, Ramírez-Santana, Carolina, Rasmussen, Magnus, Rees, Megan A., Rego, Eduardo, Roberts, Jason A., Roberts, David J., Rodríguez, Yhojan, Rodríguez-Baño, Jesús, Rogers, Benjamin A., Rojas, Manuel, Romero, Alberto, Rowan, Kathryn M., Saccona, Fabio, Safdarian, Mehdi, Santos, Maria Clariza M., Sasadeusz, Joe, Scozzari, Gitana, Shankar-Hari, Manu, Sharma, Gorav, Snelling, Thomas, Soto, Alonso, Tagayuna, Pedrito Y., Tang, Amy, Tatem, Geneva, Teofili, Luciana, Tong, Steven Y. C., Turgeon, Alexis F., Veloso, Januario D., Venkatesh, Balasubramanian, Ventura-Enriquez, Yanet, Webb, Steve A., Wiese, Lothar, Wikén, Christian, Wood, Erica M., Yusubalieva, Gaukhar M., Zacharowski, Kai, Zarychanski, Ryan, Khanna, Nina, Moher, David, Goodman, Steven N., Ioannidis, John P. A., and Hemkens, Lars G.

Published
2021
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21. Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Author

Pedersen, Marie, Stafoggia, Massimo, Weinmayr, Gudrun, Andersen, Zorana J., Galassi, Claudia, Sommar, Johan, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Krog, Norun H., Aamodt, Geir, Pyko, Andrei, Pershagen, Göran, Korek, Michal, De Faire, Ulf, Pedersen, Nancy L., Östenson, Claes-Göran, Fratiglioni, Laura, Sørensen, Mette, Eriksen, Kirsten T., Tjønneland, Anne, Peeters, Petra H., Bueno-de-Mesquita, Bas, Vermeulen, Roel, Eeftens, Marloes, Plusquin, Michelle, Key, Timothy J., Jaensch, Andrea, Nagel, Gabriele, Concin, Hans, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Ranzi, Andrea, Cesaroni, Giulia, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Stayner, Leslie T., Kogevinas, Manolis, Nieuwenhuijsen, Mark J., Sokhi, Ranjeet, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018
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22. Nationwide epidemiological study for estimating the effect of extreme outdoor temperature on occupational injuries in Italy

Author

Alessandro Marinaccio, Matteo Scortichini, Claudio Gariazzo, Antonio Leva, Michela Bonafede, Francesca K. de' Donato, Massimo Stafoggia, Giovanni Viegi, Paola Michelozzi, Ancona Carla, Angelini Paola, Argentini Stefania, Baldacci Sandra, Bisceglia Lucia, Bonomo Sergio, Bonvicini Laura, Broccoli Serena, Brusasca Giuseppe, Bucci Simone, Calori Giuseppe, Carlino Giuseppe, Cernigliaro Achille, Chieti Antonio, Fasola Salvatore, Finardi Sandro, Forastiere Francesco, Galassi Claudia, Giorgi Rossi Paolo, La Grutta Stefania, Licitra Gaetano, Maio Sara, Migliore Enrica, Moro Antonino, Nanni Alessandro, Ottone Marta, Pepe Nicola, Radice Paola, Ranzi Andrea, Renzi Matteo, Scondotto Salvatore, Silibello Camillo, Sozzi Roberto, Tinarelli Gianni, and Uboldi Francesco

Subjects
Environmental sciences, GE1-350
Abstract

Background: Despite the relevance for occupational safety policies, the health effects of temperature on occupational injuries have been scarcely investigated. A nationwide epidemiological study was carried out to estimate the risk of injuries for workers exposed to extreme temperature and identify economic sectors and jobs most at risk. Materials and methods: The daily time series of work-related injuries in the industrial and services sector from the Italian national workers' compensation authority (INAIL) were collected for each of the 8090 Italian municipalities in the period 2006–2010. Daily air temperatures with a 1 × 1 km resolution derived from satellite land surface temperature data using mixed regression models were included. Distributed lag non-linear models (DLNM) were used to estimate the association between daily mean air temperature and injuries at municipal level. A meta-analysis was then carried out to retrieve national estimates. The relative risk (RR) and attributable cases of work-related injuries for an increase in mean temperature above the 75th percentile (heat) and for a decrease below the 25th percentile (cold) were estimated. Effect modification by gender, age, firm size, economic sector and job type were also assessed. Results: The study considered 2,277,432 occupational injuries occurred in Italy in the period 2006–2010. There were significant effects for both heat and cold temperatures. The overall relative risks (RR) of occupational injury for heat and cold were 1.17 (95% CI: 1.14–1.21) and 1.23 (95% CI: 1.17–1.30), respectively. The number of occupational injuries attributable to temperatures above and below the thresholds was estimated to be 5211 per year. A higher risk of injury on hot days was found among males and young (age 15–34) workers occupied in small-medium size firms, while the opposite was observed on cold days. Construction workers showed the highest risk of injuries on hot days while fishing, transport, electricity, gas and water distribution workers did it on cold days. Conclusions: Prevention of the occupational exposure to extreme temperatures is a concern for occupational health and safety policies, and will become a critical issue in future years considering climate change. Epidemiological studies may help identify vulnerable jobs, activities and workers in order to define prevention plans and training to reduce occupational exposure to extreme temperature and the risk of work-related injuries. Keywords: Climate change, Extreme outdoor air temperature, Occupational injuries, Heat impacts, Cold impacts, Case-crossover study

Published
2019
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24. Molecular determinants of immunogenic cell death elicited by radiation therapy.

Author

Galassi, Claudia, Klapp, Vanessa, Yamazaki, Takahiro, and Galluzzi, Lorenzo

Subjects
*CELL death, *RADIOTHERAPY, *IONIZING radiation, *CANCER cells, *IMMUNE response
Abstract

Summary: Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell‐associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) cell death occurs along with the emission of immunostimulatory cytokines and damage‐associated molecular patterns (DAMPs) that actively engage immune effector mechanisms (adjuvanticity), and (3) the microenvironment of dying cells is permissive for the initiation of adaptive immunity. Finally, ICD‐driven immune responses can only operate and exert cytotoxic effector functions if the microenvironment of target cancer cells enables immune cell infiltration and activity. Multiple forms of radiation, including non‐ionizing (ultraviolet) and ionizing radiation, elicit bona fide ICD as they increase both the antigenicity and adjuvanticity of dying cancer cells. Here, we review the molecular determinants of ICD as elicited by radiation as we critically discuss strategies to reinforce the immunogenicity of cancer cells succumbing to clinically available radiation strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Associazione Italiana per la Ricerca sul Cancro, Italian Institute for Genomic Medicine, Compagnia di San Paolo, Vitale, Ilio [0000-0002-5918-1841], Pietrocola, Federico [0000-0002-2930-234X], Guilbaud, Emma [0000-0001-5261-1944], Aaronson, Stuart A. [0000-0002-4643-0474], Dieter, Adam [0000-0002-5668-5032], Agostini, Massimiliano [0000-0003-3124-2072], Agostinis, Patrizia [0000-0003-1314-2115], Alnemri, Emad S. [0000-0002-7295-3383], Altucci, Lucia [0000-0002-7312-5387], Amelio, Ivano [0000-0002-9126-5391], Andrews, David W. [0000-0002-9266-7157], Aqeilan, Rami I. [0000-0002-6034-023X], Arama, Eli [0000-0001-5953-0629], Balachandran, Siddharth [0000-0003-2084-1803], Bano, Daniele [0000-0002-9617-5504], Bartek, Jiri [0000-0003-2013-7525], Bazan, Nicolas G. [0000-0002-9243-5444], Bernassola, Francesca [0000-0002-8883-8654], Bertrand, Mathieu J. M. [0000-0001-9000-0626], Bianchi, Marco Emilio [0000-0002-5329-6445], Blander, J. Magarian [0000-0001-9207-1700], Blandino, Giovanni [0000-0002-6970-2241], Blomgren, Klas [0000-0002-0476-7271], Bortner, Carl D. [0000-0002-5444-6628], Bove, Pierluigi [0000-0002-4788-2982], Boya, Patricia [0000-0003-3045-951X], Broz, Petr [0000-0002-2334-7790], Damgaard, Rune Busk [0000-0002-1709-6534], Calin, George A. [0000-0002-7427-0578], Campanella, Michelangelo [0000-0002-6948-4184], Candi, Eleonora [0000-0001-8332-4825], Carbone, Michele [0000-0001-8928-8474], Carmona-Gutierrez, Didac [0000-0001-7548-7771], Cecconi, Francesco [0000-0002-5614-4359], Chen, Guo‑Qiang [0000-0002-7226-1782], Cheng, Emily H. [0000-0002-3595-2648], Chipuk, Jerry E. [0000-0002-1337-842X], Cidlowski, John A. [0000-0003-1420-0516], Ciechanover, Aaron [0000-0001-9184-8944], Ciliberto, Gennaro [0000-0003-2851-8605], Conrad, Marcus [0000-0003-1140-5612], Czabotar, Peter E. [0000-0002-2594-496X], D’Angiolella, Vincenzo [0000-0001-8365-9094], Daugaard, Mads [0000-0001-8383-055X], Dawson, Valina L. [0000-0002-2915-3970], De Maria, Ruggero [0000-0003-2255-0583], Debatin, Klaus-Michael [0000-0002-8397-1886], Deberardinis, Ralph J. [0000-0002-2705-7432], Degterev, Alexei [0000-0002-8240-7132], Del Sal, Giannino [0000-0003-2185-6003], Deshmukh, Mohanish [0000-0002-2597-5862], Di Virgilio, Francesco [0000-0003-3566-1362], Diederich, Marc [0000-0003-0115-4725], Dixon, Scott J. [0000-0001-6230-8199], El-Deiry, Wafik S. [0000-0002-9577-8266], Elrod, John W. [0000-0003-3925-2224], Engeland, Kurt [0000-0003-3525-0440], Fimia, Gian María [0000-0003-4438-3325], Ganini, Carlo [0000-0002-5839-3965], García-Sáez, Ana J. [0000-0002-3894-5945], Garg, Abhishek D. [0000-0002-9976-9922], Garrido, Carmen [0000-0003-1368-1493], Gavathiotis, Evripidis [0000-0001-6319-8331], Ghosh, Sourav [0000-0001-5990-8708], Green, Douglas R. [0000-0002-7332-1417], Gronemeyer, Hinrich [0000-0001-9454-2449}, Häcker, Georg [0000-0003-1058-5746], Hajnóczky, György [0000-0003-3813-2570], Hardwick, J. Marie [0000-0002-4847-2045], Haupt, Ygal [0000-0001-5925-0096], He, Sudan [0000-0002-0846-1210], Heery, David M. [0000-0002-5035-2392], Hengartner, Michael O. [0000-0002-7584-596X], Hetz, Claudio [0000-0003-1120-7966], Hildeman, David A. [0000-0002-0421-8483], Ichijo, Hidenori [0000-0002-5005-6438], Jäättelä, Marja [0000-0001-5950-7111], Janic, Ana [0000-0002-4200-2560], Joseph, Bertrand [0000-0001-5655-9979], Jost, Philipp J. [0000-0003-2454-0362], Kanneganti, Thirumala-Devi [0000-0002-6395-6443], Karin, Michael [0000-0002-2758-6473], Kashkar, Hamid [0000-0003-2796-1429], Kaufmann, Thomas [0000-0001-9906-874X], Kelly, Gemma L. [0000-0002-6533-1201], Kepp, Oliver [0000-0002-6081-9558], Kimchi, Adi [0000-0002-8236-8989], Klionsky, Daniel J. [0000-0002-7828-8118], Kluck, Ruth [0000-0002-7101-1925], Krysko, Dmitri V. [0000-0002-9692-2047], Kulms, Dagmar [0000-0001-6874-0548], Kumar, Sharad [0000-0001-7126-9814], Lavandero, Sergio [0000-0003-4258-1483], Lavrik, Inna N. [0000-0002-9324-309X], Liccardi, Gianmaria [0000-0002-2662-1281], Linkermann, Andreas [0000-0001-6287-9725], Lipton, Stuart A. [0000-0002-3490-1259], Lockshin, Richard A. [0000-0002-4389-4898], López-Otín, Carlos [0000-0001-6964-1904], Luedde, Tom [0000-0002-6288-8821], MacFarlane, Marion [0000-0001-7886-1159], Madeo, Frank [0000-0002-5070-1329], Malorni, Walter [0000-0002-1223-7000], Manic, Gwenola [0000-0003-3759-8029], Marchi, Saverio [0000-0003-2708-1843], Marine, Jean-Christophe [0000-0003-2433-9837], Martin, Seamus J. [0000-0002-8539-3143], Martinou, Jean-Claude [0000-0002-9847-2051], Mastroberardino, Pier G. [0000-0003-2364-4258], Medema, Jan Paul [0000-0003-3045-2924], Mehlen, Patrick [0000-0003-1743-5417], Meier, Pascal [0000-0003-2760-6523], Melino, Gerry [0000-0001-9428-5972], Melino, Sonia [0000-0001-7694-5279], Miao, Edward A. [0000-0001-7295-3490], Moll, Ute M. [0000-0003-1908-7516], Muñoz-Pinedo, Cristina [0000-0002-9120-664X], Murphy, Daniel J. [0000-0002-5538-5468], Niklison-Chirou, Maria Victoria [0000-0002-2147-370X], Novelli, Flavia [0000-0002-3746-7478], Oberst, Andrew [0000-0002-9500-7912], Ofengeim, Dimitry [0000-0003-2348-3642], Opferman, Joseph T. [0000-0002-1147-5621], Oren, Moshe [0000-0003-4311-7172], Pagano, Michele [0000-0003-3210-2442], Panaretakis, Theocharis [0000-0001-5754-6950], Pasparakis, Manolis [0000-0002-9870-0966], Penninger, Josef M. [0000-0002-8194-3777], Pentimalli, Francesca [0000-0003-4740-6801], Pereira, David M. [0000-0003-0384-7592], Pervaiz, Shazib [0000-0002-4738-019X], Peter, Marcus E. [0000-0003-3216-036X], Pinton, Paolo [0000-0001-7108-6508], Porta, Giovanni [0000-0001-5260-2415], Puthalakath, Hamsa [0000-0001-5178-1175], Rabinovich, Gabriel A. [0000-0002-0947-8735], Rajalingam, Krishnaraj [0000-0002-4175-9633], Ravinchandran, Kodi S. 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M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravinchandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strappazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, G, Tait, Stephen W. 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[0000-0001-7872-0196], Walczak, Henning [0000-0002-6312-4591], Wallach, David [0000-0003-2724-9757], Wang, Ruoning [0000-0001-9798-8032], Weber, Achim [0000-0003-0073-3637], Yamazaki, Takahiro [0000-0002-7420-4394], Zakeri, Zahra [0000-0003-4386-8072], Zawacka-Pankau, Joanna E. [0000-0002-7415-2942], Zhivotovsky, Boris [0000-0002-2238-3482], Piacentini, Mauro [0000-0003-2919-1296], Kroemer, Guido [0000-0002-9334-4405], Galluzzi, Lorenzo [0000-0003-2257-8500 ], Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Dieter, Adam, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco Emilio, Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Bomer, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, T., Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K.-M., Chen, Guo‑Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, B., Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian María, Galassi, Claudia, Ganini, Carlo, García-Sáez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravinchandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strappazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, G, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, A., Villunger, Andreas, Von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Zahra, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibin, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Published
2023

28. The humoral and cellular response to mRNA SARS‐CoV‐2 vaccine is influenced by HLA polymorphisms.

Author

Bertinetto, Francesca Eleonora, Magistroni, Paola, Mazzola, Gina Adriana, Costa, Cristina, Elena, Garino, Alizzi, Silvia, Scozzari, Gitana, Migliore, Enrica, Galassi, Claudia, Ciccone, Giovannino, Ricciardelli, Guido, Scarmozzino, Antonio, Angelone, Lorenzo, Cassoni, Paola, Cavallo, Rossana, Vaisitti, Tiziana, Deaglio, Silvia, and Amoroso, Antonio

Subjects
HUMORAL immunity, COVID-19 vaccines, VACCINE effectiveness, ALLELES, MEDICAL personnel, GENETIC variation
Abstract

Host genetic variability contributes to susceptibility to SARS‐CoV‐2 infection and COVID‐19 evolution and the role of HLA system has not clearly emerged, suggesting the involvement of other factors. Studying response to vaccination with Spyke protein mRNA represents an ideal model to highlight whether the humoral or cellular responses are influenced by HLA. Four hundred and sixteen workers, vaccinated with Comirnaty beginning 2021, were selected within the Azienda Ospedaliera Universitaria "Città della Salute e della Scienza di Torino." The humoral response was determined with the LIAISON® kit, while the analysis of the cellular response was performed with the Quantiferon SARS‐CoV‐2 assay, for the S1 (receptor‐binding domain; Ag1) and S1 and S2 (Ag2) subunits of the Spyke protein. Six HLA loci were typed by next‐generation sequencing. Associations between HLA and vaccine response were performed with univariate and multivariate analyses. An association was found between A*03:01, B*40:02 and DPB1*06:01 and high antibody concentration and between A*24:02, B*08:01 and C*07:01 and low humoral responses. The haplotype HLA‐A*01:01 ~ B1*08:01 ~ C*07:01 ~ DRB1*03:01 ~ DQB1*02:01 conferred an increased risk of low humoral response. Considering cellular responses, 50% of the vaccinated subjects responded against Ag1 and 59% against Ag2. Carriers of DRB1*15:01 displayed a higher cellular response both to Ag1 and Ag2 compared to the rest of the cohort. Similarly, DRB1*13:02 predisposed to a robust cellular response to Ag1 and Ag2, while DRB1*11:04 showed an opposite trend. Cellular and humoral responses to Comirnaty are influenced by HLA. Humoral response is mainly associated to class I alleles, with A*03:01, previously associated to protection against severe COVID‐19, and response to vaccination, standing out. Cellular response predominantly involves class II alleles, with DRB1*15:01 and DPB1*13:01 prevailing. Affinity analysis for Spyke peptides is generally in line with the association results. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts

Author

Wolf, Kathrin, Stafoggia, Massimo, Cesaroni, Giulia, Andersen, Zorana Jovanovic, Beelen, Rob, Galassi, Claudia, Hennig, Frauke, Migliore, Enrica, Penell, Johanna, Ricceri, Fulvio, Sørensen, Mette, Turunen, Anu W., Hampel, Regina, Hoffmann, Barbara, Kälsch, Hagen, Laatikainen, Tiina, Pershagen, Göran, Raaschou-Nielsen, Ole, Sacerdote, Carlotta, Vineis, Paolo, Badaloni, Chiara, Cyrys, Josef, de Hoogh, Kees, Eriksen, Kirsten T., Jedynsk, Aleksandra, Keuken, Menno, Kooter, Ingeborg, Lanki, Timo, Ranzi, Andrea, Sugiri, Dorothea, Tsai, Ming-Yi, Wang, Meng, Hoek, Gerard, Brunekreef, Bert, Peters, Annette, and Forastiere, Francesco

Published
2015

31. 1144 IL17-producing γδ T cells promote resistance to CDK4/6 inhibitors in HR+HER2-breast cancer

Author

Petroni, Giulia, primary, Gouin, Kenneth, additional, Galassi, Claudia, additional, Buqué, Aitziber, additional, Bloy, Norma, additional, Yamazaki, Takahiro, additional, Sato, Ai, additional, Jiménez-Cortegana, Carlos, additional, Kirchmair, Alexander, additional, Massa, Chiara, additional, Andrea, Carlos Eduardo De, additional, Navarro, Belén, additional, Serrano, Irantzu, additional, Manzano, Esther Navarro, additional, Finotello, Francesca, additional, Zhou, Xi, additional, García-Martínez, Elena, additional, Rodríguez-Ruiz, María, additional, Seliger, Barbara, additional, Sánchez-Margalet, Víctor, additional, Cruz-Merino, Luis de la, additional, McArthur, Heather, additional, Formenti, Silvia, additional, Knott, Simon, additional, and Galluzzi, Lorenzo, additional

Published
2022
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32. Risk of Intensive Care Unit admission or mortality in patients hospitalised for COVID-19 during the first two waves: An Italian cohort study

Author

Sacerdote, Carlotta, primary, Milani, Lorenzo, additional, Castiglione, Anna, additional, Pagano, Eva, additional, Migliore, Enrica, additional, Albera, Carlo, additional, Bo, Mario, additional, Brazzi, Luca, additional, De Rosa, Francesco Giuseppe, additional, Durazzo, Marilena, additional, Lupia, Enrico, additional, Montrucchio, Giuseppe, additional, Pivetta, Emanuele, additional, Porta, Massimo, additional, Scaglione, Luca, additional, Veglio, Franco, additional, Zanierato, Marinella, additional, Ricceri, Fulvio, additional, Caramello, Valeria, additional, Scozzari, Gitana, additional, Scarmozzino, Antonio, additional, Auzzas, Grazia Maria, additional, Balestro, Cristina, additional, Brentisci, Carol, additional, Brunetti, Francesco, additional, Fiandra, Umberto, additional, Galassi, Claudia, additional, Gangemi, Manuela, additional, Giacometti, Lisa, additional, Gilardetti, Marco, additional, Lazzarato, Fulvio, additional, Martins, Vitor Hugo, additional, Papurello, Matteo, additional, di Sant’Angelo, Francesca Ponti, additional, Roggero, Stefano, additional, Saccona, Fabio, additional, Silvestre, Carlo, additional, Stura, Antonella, additional, Turco, Danila, additional, Vischia, Federico, additional, and Zozzoli, Susanna, additional

Published
2022
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33. Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project

Author

Beelen, Rob, Raaschou-Nielsen, Ole, Stafoggia, Massimo, Andersen, Zorana Jovanovic, Weinmayr, Gudrun, Hoffmann, Barbara, Wolf, Kathrin, Samoli, Evangelia, Fischer, Paul, Nieuwenhuijsen, Mark, Vineis, Paolo, Xun, Wei W, Katsouyanni, Klea, Dimakopoulou, Konstantina, Oudin, Anna, Forsberg, Bertil, Modig, Lars, Havulinna, Aki S, Lanki, Timo, Turunen, Anu, Oftedal, Bente, Nystad, Wenche, Nafstad, Per, De Faire, Ulf, Pedersen, Nancy L, Östenson, Claes-Göran, Fratiglioni, Laura, Penell, Johanna, Korek, Michal, Pershagen, Göran, Eriksen, Kirsten Thorup, Overvad, Kim, Ellermann, Thomas, Eeftens, Marloes, Peeters, Petra H, Meliefste, Kees, Wang, Meng, Bueno-de-Mesquita, Bas, Sugiri, Dorothea, Krämer, Ursula, Heinrich, Joachim, de Hoogh, Kees, Key, Timothy, Peters, Annette, Hampel, Regina, Concin, Hans, Nagel, Gabriele, Ineichen, Alex, Schaffner, Emmanuel, Probst-Hensch, Nicole, Künzli, Nino, Schindler, Christian, Schikowski, Tamara, Adam, Martin, Phuleria, Harish, Vilier, Alice, Clavel-Chapelon, Françoise, Declercq, Christophe, Grioni, Sara, Krogh, Vittorio, Tsai, Ming-Yi, Ricceri, Fulvio, Sacerdote, Carlotta, Galassi, Claudia, Migliore, Enrica, Ranzi, Andrea, Cesaroni, Giulia, Badaloni, Chiara, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Katsoulis, Michail, Trichopoulou, Antonia, Brunekreef, Bert, and Hoek, Gerard

Published
2014
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34. Oxidative stress and inflammation mediate the effect of air pollution on cardio‐ and cerebrovascular disease: A prospective study in nonsmokers

Author

Fiorito, Giovanni, Vlaanderen, Jelle, Polidoro, Silvia, Gulliver, John, Galassi, Claudia, Ranzi, Andrea, Krogh, Vittorio, Grioni, Sara, Agnoli, Claudia, Sacerdote, Carlotta, Panico, Salvatore, Tsai, Ming‐Yi, Probst‐Hensch, Nicole, Hoek, Gerard, Herceg, Zdenko, Vermeulen, Roel, Ghantous, Akram, Vineis, Paolo, Naccarati, Alessio, and Vogel, U.

Published
2018
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35. Land use regression models for the oxidative potential of fine particles (PM2.5) in five European areas

Author

Gulliver, John, Morley, David, Dunster, Chrissi, McCrea, Adrienne, van Nunen, Erik, Tsai, Ming-Yi, Probst-Hensch, Nicoltae, Eeftens, Marloes, Imboden, Medea, Ducret-Stich, Regina, Naccarati, Alessio, Galassi, Claudia, Ranzi, Andrea, Nieuwenhuijsen, Mark, Curto, Ariadna, Donaire-Gonzalez, David, Cirach, Marta, Vermeulen, Roel, Vineis, Paolo, Hoek, Gerard, and Kelly, Frank J.

Published
2018
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36. Long-term Exposure to Air Pollution and Cardiovascular Mortality: An Analysis of 22 European Cohorts

Author

Beelen, Rob, Stafoggia, Massimo, Raaschou-Nielsen, Ole, Andersen, Zorana Jovanovic, Xun, Wei W., Katsouyanni, Klea, Dimakopoulou, Konstantina, Brunekreef, Bert, Weinmayr, Gudrun, Hoffmann, Barbara, Wolf, Kathrin, Samoli, Evangelia, Houthuijs, Danny, Nieuwenhuijsen, Mark, Oudin, Anna, Forsberg, Bertil, Olsson, David, Salomaa, Veikko, Lanki, Timo, Yli-Tuomi, Tarja, Oftedal, Bente, Aamodt, Geir, Nafstad, Per, De Faire, Ulf, Pedersen, Nancy L., Östenson, Claes-Göran, Fratiglioni, Laura, Penell, Johanna, Korek, Michal, Pyko, Andrei, Eriksen, Kirsten Thorup, Tjønneland, Anne, Becker, Thomas, Eeftens, Marloes, Bots, Michiel, Meliefste, Kees, Wang, Meng, Bueno-de-Mesquita, Bas, Sugiri, Dorothea, Krämer, Ursula, Heinrich, Joachim, de Hoogh, Kees, Key, Timothy, Peters, Annette, Cyrys, Josef, Concin, Hans, Nagel, Gabriele, Ineichen, Alex, Schaffner, Emmanuel, Probst-Hensch, Nicole, Dratva, Julia, Ducret-Stich, Regina, Vilier, Alice, Clavel-Chapelon, Françoise, Stempfelet, Morgane, Grioni, Sara, Krogh, Vittorio, Tsai, Ming-Yi, Marcon, Alessandro, Ricceri, Fulvio, Sacerdote, Carlotta, Galassi, Claudia, Migliore, Enrica, Ranzi, Andrea, Cesaroni, Giulia, Badaloni, Chiara, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Katsoulis, Michail, Trichopoulou, Antonia, Vineis, Paolo, and Hoek, Gerard

Published
2014

37. Long term exposure to ambient air pollution and incidence of acute coronary events : prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project

Author

Cesaroni, Giulia, Forastiere, Francesco, Stafoggia, Massimo, Andersen, Zorana J, Badaloni, Chiara, Beelen, Rob, Caracciolo, Barbara, de Faire, Ulf, Erbel, Raimund, Eriksen, Kirsten T, Fratiglioni, Laura, Galassi, Claudia, Hampel, Regina, Heier, Margit, Hennig, Frauke, Hilding, Agneta, Hoffmann, Barbara, Houthuijs, Danny, Jöckel, Karl-Heinz, Korek, Michal, Lanki, Timo, Leander, Karin, Magnusson, Patrik K E, Migliore, Enrica, Ostenson, Caes-Göran, Overvad, Kim, Pedersen, Nancy L, Juha, Pekkanen J, Penell, Johanna, Pershagen, Göran, Pyko, Andrei, Raaschou-Nielsen, Ole, Ranzi, Andrea, Ricceri, Fulvio, Sacerdote, Carlotta, Salomaa, Veikko, Swart, Wim, Turunen, Anu W, Vineis, Paolo, Weinmayr, Gudrun, Wolf, Kathrin, de Hoogh, Kees, Hoek, Gerard, Brunekreef, Bert, and Peters, Annette

Published
2014

39. Risk of Intensive Care Unit admission or mortality in patients hospitalised for COVID-19 during the first two waves: An Italian cohort study

Author

Auzzas, Grazia Maria, Balestro, Cristina, Brentisci, Carol, Brunetti, Francesco, Fiandra, Umberto, Galassi, Claudia, Gangemi, Manuela, Giacometti, Lisa, Gilardetti, Marco, Lazzarato, Fulvio, Martins, Vitor Hugo, Papurello, Matteo, di Sant’Angelo, Francesca Ponti, Roggero, Stefano, Saccona, Fabio, Silvestre, Carlo, Stura, Antonella, Turco, Danila, Vischia, Federico, Zozzoli, Susanna, Sacerdote, Carlotta, Milani, Lorenzo, Castiglione, Anna, Pagano, Eva, Migliore, Enrica, Albera, Carlo, Bo, Mario, Brazzi, Luca, De Rosa, Francesco Giuseppe, Durazzo, Marilena, Lupia, Enrico, Montrucchio, Giuseppe, Pivetta, Emanuele, Porta, Massimo, Scaglione, Luca, Veglio, Franco, Zanierato, Marinella, Ricceri, Fulvio, Caramello, Valeria, Scozzari, Gitana, and Scarmozzino, Antonio

Published
2022
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40. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Raaschou-Nielsen, Ole, Andersen, Zorana J, Beelen, Rob, Samoli, Evangelia, Stafoggia, Massimo, Weinmayr, Gudrun, Hoffmann, Barbara, Fischer, Paul, Nieuwenhuijsen, Mark J, Brunekreef, Bert, Xun, Wei W, Katsouyanni, Klea, Dimakopoulou, Konstantina, Sommar, Johan, Forsberg, Bertil, Modig, Lars, Oudin, Anna, Oftedal, Bente, Schwarze, Per E, Nafstad, Per, De Faire, Ulf, Pedersen, Nancy L, Östenson, Claes-Göran, Fratiglioni, Laura, Penell, Johanna, Korek, Michal, Pershagen, Göran, Eriksen, Kirsten T, Sørensen, Mette, Tjønneland, Anne, Ellermann, Thomas, Eeftens, Marloes, Peeters, Petra H, Meliefste, Kees, Wang, Meng, Bueno-de-Mesquita, Bas, Key, Timothy J, de Hoogh, Kees, Concin, Hans, Nagel, Gabriele, Vilier, Alice, Grioni, Sara, Krogh, Vittorio, Tsai, Ming-Yi, Ricceri, Fulvio, Sacerdote, Carlotta, Galassi, Claudia, Migliore, Enrica, Ranzi, Andrea, Cesaroni, Giulia, Badaloni, Chiara, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Trichopoulou, Antonia, Bamia, Christina, Vineis, Paolo, and Hoek, Gerard

Published
2013
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41. Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts

Author

Rusconi, Franca, Zugna, Daniela, Annesi-Maesano, Isabella, Baïz, Nour, Barros, Henrique, Correia, Sofia, Duijts, Liesbeth, Forastiere, Francesco, Inskip, Hazel, Kelleher, Cecily C., Larsen, Pernille S., Mommers, Monique, Andersen, Anne-Marie Nybo, Penders, John, Pike, Katharine, Porta, Daniela, Sonnenschein-van der Voort, Agnes, Sunyer, Jordi, Torrent, Maties, Viljoen, Karien, Vrijheid, Martine, Richiardi, Lorenzo, and Galassi, Claudia

Published
2017
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45. Factors Influencing Level and Persistence of Anti SARS-CoV-2 IgG after BNT162b2 Vaccine: Evidence from a Large Cohort of Healthcare Workers

Author

Costa, Cristina, Migliore, Enrica, Galassi, Claudia, Scozzari, Gitana, Ciccone, Giovannino, Coggiola, Maurizio, Pira, Enrico, Scarmozzino, Antonio, La Valle, Giovanni, Cassoni, Paola, Cavallo, Rossana, and on behalf of the Collaborative Group, Null

Subjects
Pharmacology, Infectious Diseases, Drug Discovery, Immunology, Pharmacology (medical), SARS-CoV-2, serology, mRNA vaccination, health care workers
Abstract

We aimed at evaluating quantitative IgG response to BNT162b2 COVID-19 vaccine among health care workers (HCW), and exploring the role of demographic, clinical, and occupational factors as predictors of IgG levels. On May 2021, among 6687 HCW at the largest tertiary care University-Hospital of Northwestern Italy, at a median of 15 weeks (Interquartile range-IQR 13.6–16.0) after second-dose, serological response was present in 99.8%. Seropositivity was >97% in all the subgroups, except those self-reporting immunodeficiency (94.9%). Overall, the median serological IgG value was 990 BAU/mL (IQR 551–1870), with most of subjects with previous SARS-CoV-2 infection or with shorter time lapse (2–8 weeks) between vaccination and serology with values in the highest quintile (>2080). At multivariable analysis, significant predictors of lower values were increasing age, male, current smoking, immunodeficiency, recent occupational contacts, and increasing time lapse from vaccination; conversely, previous infection and recent household contacts were significantly associated with higher IgG levels. Subjects with previous infection kept a very high level (around 2000 BAU/mL) up to 120 days. These results, besides supporting a high serological response up to 4–5 months, suggest predictive factors of faster decay of IgG levels that could be useful in tailoring vaccination strategies.

Published
2022

46. Additional file 1 of Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

Author

Manzini, Paola Maria, Ciccone, Giovannino, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Ghisetti, Valeria, D’Antico, Sergio, Galassi, Claudia, Saccona, Fabio, Castiglione, Anna, Birocco, Nadia, Francisci, Tiziana, Hu, Huijing, Pecoraro, Clara, Danielle, Franca, Labanca, Luciana, Bordiga, Anna Maria, Lorenzi, Marco, Camisasca, Giovanni, Giachino, Osvaldo, Pagliarino, Mauro, Ottone, Piero, Scuvera, Ilvana Tiziana Donatella, Guaschino, Roberto, Freilone, Roberto, Berti, Pierluigi, Pittaluga, Fabrizia, Avolio, Maria, Costa, Cristina, Raso, Samuele, Nucci, Aurora, Milan, Massimo, Baffa, Alessandra, Russo, Alessandra, Tornello, Antonella, Maddalena, Laura, Delios, Grazia, Marletto, Fabio Paolo, De Micheli, Anna Grazia, Mattei, Alessio, Baldassano, Stefano, Canta, Francesca, Russo, Maria Luisa, Bergamo, Daniele, Vitale, Francesco, Liccardi, Marco Maria, Chinaglia, Alessandra, Calcagno, Andrea, Converso, Marcella, Aldieri, Chiara, Libanore, Valentina, Blangetti, Ilaria, Benedetti, Valentina, Mitola, Barbara, and Scozzari, Gitana

Abstract

Additional file 1. Supplementary appendix.

Published
2022
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48. A nationwide study of air pollution from particulate matter and daily hospitalizations for respiratory diseases in Italy

Author

Renzi, Matteo, primary, Scortichini, Matteo, additional, Forastiere, Francesco, additional, de' Donato, Francesca, additional, Michelozzi, Paola, additional, Davoli, Marina, additional, Gariazzo, Claudio, additional, Viegi, Giovanni, additional, Stafoggia, Massimo, additional, Ancona, Carla, additional, Bucci, Simone, additional, Renzi, Matteo, additional, Bonafede, Michela, additional, Marinaccio, Alessandro, additional, Argentini, Stefania, additional, Sozzi, Roberto, additional, Bonomo, Sergio, additional, Fasola, Salvatore, additional, La Grutta, Stefania, additional, Cernigliaro, Achille, additional, Scondotto, Salvatore, additional, Baldacci, Sandra, additional, Maio, Sara, additional, Licitra, Gaetano, additional, Moro, Antonino, additional, Angelini, Paola, additional, Bonvicini, Laura, additional, Broccoli, Serena, additional, Ottone, Marta, additional, Rossi, Paolo Giorgi, additional, Colacci, Annamaria, additional, Parmagnani, Federica, additional, Ranzi, Andrea, additional, Galassi, Claudia, additional, Migliore, Enrica, additional, Bisceglia, Lucia, additional, Chieti, Antonio, additional, Brusasca, Giuseppe, additional, Calori, Giuseppe, additional, Finardi, Sandro, additional, Nanni, Alessandro, additional, Pepe, Nicola, additional, Radice, Paola, additional, Silibello, Camillo, additional, Tinarelli, Gianni, additional, Uboldi, Francesco, additional, and Carlino, Giuseppe, additional

Published
2022
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