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28 results on '"Gaffney, Jessica"'

6. DLK1: A Novel Biomarker of Placental Insufficiency in Stillbirth and Live Birth.

Author

Page, Jessica M., Allshouse, Amanda A., Gaffney, Jessica E., Roberts, Victoria H. J., Thorsten, Vanessa, Gibbins, Karen J., Dudley, Donald J., Saade, George, Goldenberg, Robert L., Stoll, Barbara J., Hogue, Carol J., Bukowski, Radek, Parker, Corette, Conway, Deborah, Reddy, Uma M., Varner, Michael W., Frias, Antonio E., and Silver, Robert M.

Subjects
FETAL malnutrition, CROSS-sectional method, PLACENTA, SMALL for gestational age, CALCIUM-binding proteins, FETAL growth retardation, LOGISTIC regression analysis, ENZYME-linked immunosorbent assay, PREGNANCY outcomes, PERINATAL death, DESCRIPTIVE statistics, ODDS ratio, GESTATIONAL age, RESEARCH, GROWTH factors, COMPARATIVE studies, BIOMARKERS, MEMBRANE proteins, REGRESSION analysis
Abstract

Objective Delta-like homolog 1 (DLK1) is a growth factor that is reduced in maternal sera in pregnancies with small for gestational age neonates. We sought to determine if DLK1 is associated with stillbirth (SB), with and without placental insufficiency. Study Design A nested case-control study was performed using maternal sera from a multicenter case-control study of SB and live birth (LB). SB and LB were stratified as placental insufficiency cases (small for gestational age <5% or circulatory lesions on placental histopathology) or normal placenta controls (appropriate for gestational age and no circulatory lesions). Enzyme-linked immunosorbent assay (ELISA) was used to measure DLK1. The mean difference in DLK1 was compared on the log scale in an adjusted linear regression model with pairwise differences, stratified by term/preterm deliveries among DLK1 results in the quantifiable range. In exploratory analysis, geometric means were compared among all data and the proportion of "low DLK1" (less than the median value for gestational age) was compared between groups and modeled using linear and logistic regression, respectively. Results Overall, 234 SB and 234 LB were analyzed; 246 DLK1 values were quantifiable within the standard curve. Pairwise comparisons of case and control DLK1 geometric means showed no significant differences between groups. In exploratory analysis of all data, adjusted analysis revealed a significant difference for the LB comparison only (SB: 71.9 vs. 99.1 pg/mL, p = 0.097; LB: 37.6 vs. 98.1 pg/mL, p = 0.005). In exploratory analysis of "low DLK1," there was a significant difference between the odds ratio of having "low DLK1" between preterm cases and controls for both SB and LB. There were no significant differences in geometric means nor "low DLK1" between SB and LB. Conclusion In exploratory analysis, more placental insufficiency cases in preterm SB and LB had "low DLK1." However, low DLK1 levels were not associated with SB. Key Points Maternally circulating DLK1 is correlated with placental insufficiency. Maternally circulating DLK1 is not correlated with SB. DLK1 is a promising marker for placental insufficiency. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Quantitative longitudinal T2* mapping for assessing placental function and association with adverse pregnancy outcomes across gestation

Author

Schabel, Matthias C., primary, Roberts, Victoria H. J., additional, Gibbins, Karen J., additional, Rincon, Monica, additional, Gaffney, Jessica E., additional, Streblow, Aaron D., additional, Wright, Adam M., additional, Lo, Jamie O., additional, Park, Byung, additional, Kroenke, Christopher D., additional, Szczotka, Kathryn, additional, Blue, Nathan R., additional, Page, Jessica M., additional, Harvey, Kathy, additional, Varner, Michael W., additional, Silver, Robert M., additional, and Frias, Antonio E., additional

Published
2022
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10. DLK1: A Novel Biomarker of Placental Insufficiency in Stillbirth and Live Birth

Author

Page, Jessica M., additional, Allshouse, Amanda A., additional, Gaffney, Jessica E., additional, Roberts, Victoria H. J., additional, Thorsten, Vanessa, additional, Gibbins, Karen J., additional, Dudley, Donald J., additional, Saade, George, additional, Goldenberg, Robert L., additional, Stoll, Barbara J., additional, Hogue, Carol J., additional, Bukowski, Radek, additional, Parker, Corette, additional, Conway, Deborah, additional, Reddy, Uma M., additional, Varner, Michael W., additional, Frias, Antonio E., additional, and Silver, Robert M., additional

Published
2022
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12. Assessing placental function across gestation: a multi-institutional study of BOLD-MRI for the prediction of adverse pregnancy outcomes

Author

Schabel, Matthias, primary, Roberts, Victoria, additional, Gibbins, Karen, additional, Rincon, Monica, additional, Gaffney, Jessica, additional, Streblow, Aaron, additional, Wright, Adam, additional, Lo, Jaime, additional, Park, Byung, additional, Kroenke, Christopher, additional, Szczotka, Kathryn, additional, Blue, Nathan, additional, Page, Jessica, additional, Harvey, Kathy, additional, Varner, Michael W., additional, Silver, Robert, additional, and Frias, Antonio, additional

Published
2021
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19. 936: Novel biomarker of placental insufficiency in a stillbirth cohort

Author

Page, Jessica M., primary, Allshouse, Amanda A., additional, Gaffney, Jessica E., additional, Roberts, Victoria H., additional, Gibbins, Karen J., additional, Frias, Antonio E., additional, Dudley, Donald J., additional, Goldenberg, Robert L., additional, Reddy, Uma M., additional, Saade, George R., additional, Bukowski, Radek, additional, and Silver, Robert M., additional

Published
2020
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20. Placental adaptations in a nonhuman primate model of gestational protein restriction.

Author

Roberts, Victoria H.J., Gaffney, Jessica E., Morgan, Terry K., and Frias, Antonio E.

Subjects
PRIMATES, AMNIOTIC liquid, TAURINE, FETAL development, SOMATOMEDIN C
Abstract

We previously demonstrated decreased placental perfusion, reduced amniotic fluid protein content, and increased pregnancy loss in a nonhuman primate model of gestational protein restriction. Here, our objective was to link these detrimental findings with a functional placental assessment. As blood flow is critical to maternal-fetal exchange, we hypothesized that a protein-restricted diet would impair placental taurine uptake. Pregnant rhesus macaques were maintained on either control chow (CON, n = 5), a 33% protein-restricted diet (PR33, n = 5), or a 50% PR diet (PR50, n = 5) prior to and throughout pregnancy. Animals were delivered on gestational day 135 (G135; term is G168). Taurine activity was determined in fresh placental villous explants. Taurine transporter (TauT) protein expression, placental growth factor (PLGF), and insulin-like growth factor (IGF)-1 and IGF-2 protein concentrations were measured, and histological assessment was performed. Fetal body weights and placental weights were comparable between all three groups at G135. Placental taurine uptake was decreased in PR33- and PR50-fed animals compared to CON, yet TauT expression was unchanged across groups. PLGF was significantly increased in PR50 vs. CON, with no change in IGF-1 or IGF-2 expression in placental homogenate from PR-fed animals. Accelerated villous maturation was observed in all PR50 cases, three of five PR33, and was absent in CON. We demonstrate conserved fetal growth, despite a decrease in placental taurine uptake. Increased expression of PLGF and expansion of the syncytiotrophoblast surface area in the severely protein-restricted animals suggest a compensatory mechanism by the placenta to maintain fetal growth. [ABSTRACT FROM AUTHOR]

Published
2021
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27. Abstract B192: Identification and characterization of highly potent and selective RET kinase inhibitors for the treatment of RET-driven cancers

Author

Brandhuber, Barbara J., primary, Nanda, Nisha, additional, Haas, Julia, additional, Bouhana, Karyn, additional, Williams, Lance, additional, Winski, Shannon, additional, Burkard, Michael, additional, Tuch, Brian, additional, Ebata, Kevin, additional, Low, Jennifer, additional, Sullivan, Francis, additional, Hanson, Lauren, additional, Morales, Tony, additional, Vigers, Guy, additional, Gaffney, Jessica, additional, Wallace, Ross D., additional, Blake, James, additional, Jiang, Yutong, additional, Rothenberg, S. Michael, additional, and Andrews, Steven, additional

Published
2015
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28. Evolving Gender Hybridity in the Crime Solving Partnerships of 'Bones' and 'Castle': A Study of the Move Away from Gender Binaries in Media and Society

Author

Gaffney, Jessica E.

Subjects
Communication, Hybridity, Gender, Hegemonic, Crime Drama, Partner
Abstract

The crime solving genre provides a perfect venue for study of the changing expectations of gender shifts in society. The two programs which provide the best examples are Castle and Bones. In each of these television shows, there is a male-female crime-solving dyad which reflect social and economic trends in the larger culture. In both, different gendered behaviors are blended to create a new type of character — more interesting than the stereotypical crime-solver of the past. This gender ambiguity can be viewed as the basis for hybridity. Although it is important to identify trends of change, neither society as a whole nor television programming are ready to abandon traditional male-female pairings. Males and females still respond to each other in sexual ways, regardless of their changing gender hybridity. The expression of these changes enables us to view the new characters and their roles as more interesting than they once were.

Published
2011

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