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1. Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk

Author: S. I. Dimitriadis, G. Perry, S. F. Foley, K. E. Tansey, D. K. Jones, P. Holmans, S. Zammit, J. Hall, M. C. O’Donovan, M. J. Owen, K. D. Singh, and D. E. Linden
Subjects: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Abstract Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric diseases. Magnetoencephalography (MEG) provides highly reliable visual-induced gamma oscillation estimates, both at sensor and source level. Recent studies have reported a deficit of visual gamma activity in schizophrenia patients, in medication naive subjects, and high-risk clinical participants, but the genetic contribution to such a deficit has remained unresolved. Here, for the first time, we use a genetic risk score approach to assess the relationship between genetic risk for schizophrenia and visual gamma activity in a population-based sample drawn from a birth cohort. We compared visual gamma activity in a group (N = 104) with a high genetic risk profile score for schizophrenia (SCZ-PRS) to a group with low SCZ-PRS (N = 99). Source-reconstructed V1 activity was extracted using beamformer analysis applied to MEG recordings using individual MRI scans. No group differences were found in the induced gamma peak amplitude or peak frequency. However, a non-parametric statistical contrast of the response spectrum revealed more robust group differences in the amplitude of high-beta/gamma power across the frequency range, suggesting that overall spectral shape carries important biological information beyond the individual frequency peak. Our findings show that changes in gamma band activity correlate with liability to schizophrenia and suggest that the index changes to synaptic function and neuronal firing patterns that are of pathophysiological relevance rather than consequences of the disorder.
Published: 2021
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2. Preclinical and clinical evidence for using perinatal tissue allografts in nerve sparing robot assisted radical prostatectomy to hasten recovery of functional outcomes: a literature review

Author: Alan G. Perry, Amanda Kahn, Jeremy Mercuri, Karma Rini, Jerry Chang, and Ram A. Pathak
Subjects: Prostate Cancer, Robotic Radical Prostatectomy, Nerve sparing, Erectile Dysfunction, Continence Recovery, Allograft, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Abstract Introduction Localized prostate cancer (PCa) is one of the most common malignancies in the United States. Despite continued refinement of robot assisted radical prostatectomy (RARP) surgical methods, post-surgical erectile dysfunction and urinary incontinence remain significant challenges due to iatrogenic injury of local nervous tissue. Thus, the development of therapeutic strategies, including the use of biologic adjuncts to protect and/or enhance recovery and function of nerves following RARP is of growing interest. Perinatal tissue allografts have been investigated as one such biologic adjunct to nerve sparing RARP. However, knowledge regarding their clinical efficacy in hastening return of potency and continence as well as the potential underpinning biological mechanisms involved remains understudied. Thus, the objective of this literature review was to summarize published basic science and clinical studies supporting and evaluating the use of perinatal allografts for nerve repair and their clinical efficacy as adjuncts to RARP, respectively. Methods The literature as of May 2024 was reviewed non-systematically using PubMed, EMBASE, Scopus, and Web of Science databases. The search terms utilized were “robotic prostatectomy”, “prostate cancer”, “nerve sparing”, “perinatal tissue”, “allograft”, “potency”, and “continence” alone or in combination. All articles were reviewed and judged for scientific merit by authors RP and JM, only peer-reviewed studies were considered. Results Eight studies of perinatal tissue allograph use in RARP were deemed worthy of inclusion in this nonsystematic review. Conclusions Incontinence and impotence remain significant comorbidities despite continued advancement in surgical technique. However, basic science research has demonstrated potential neurotrophic, anti-fibrotic, and anti-inflammatory properties of perinatal tissue allografts, and clinical studies have shown that patients who receive an intra-operative prostatic perinatal membrane wrap have faster return to potency and continence.
Published: 2024
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3. The effects of habitual resistance exercise training on cerebrovascular responses to lower body dynamic resistance exercise: A cross‐sectional study

Author: Stephanie Korad, Toby Mündel, and Blake G. Perry
Subjects: blood pressure, middle cerebral artery blood velocity, resistance exercise, Physiology, QP1-981
Abstract: Abstract Dynamic resistance exercise (RE) produces sinusoidal fluctuations in blood pressure with simultaneous fluctuations in middle cerebral artery blood velocity (MCAv). Some evidence indicates that RE may alter cerebrovascular function. This study aimed to examine the effects of habitual RE training on the within‐RE cerebrovascular responses. RE‐trained (n = 15, Female = 4) and healthy untrained individuals (n = 15, Female = 12) completed four sets of 10 paced repetitions (15 repetitions per minute) of unilateral leg extension exercise at 60% of predicted 1 repetition maximum. Beat‐to‐beat blood pressure, MCAv and end‐tidal carbon dioxide were measured throughout. Zenith, nadir and zenith‐to‐nadir difference in mean arterial blood pressure (MAP) and mean MCAv (MCAvmean) for each repetition were averaged across each set. Two‐way ANOVA was used to analyse dependent variables (training × sets), Bonferroni corrected t‐tests were used for post hoc pairwise comparisons. Group age (26 ± 7 trained vs. 25 ± 6 years untrained, P = 0.683) and weight (78 ± 15 vs. 71 ± 15 kg, P = 0.683) were not different. During exercise average MAP was greater for the RE‐trained group in sets 2, 3 and 4 (e.g., set 4: 101 ± 11 vs. 92 ± 7 mmHg for RE trained and untrained, respectively, post hoc tests all P =
Published: 2024
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4. Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis

Author: M. Schrag, C. Mueller, M. Zabel, A. Crofton, W.M. Kirsch, O. Ghribi, R. Squitti, and G. Perry
Subjects: Alzheimer's disease, Cognitive aging, Oxidative stress, Lipid peroxidation, Glutathione, Copper, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Abnormal oxidative stress is an established feature of Alzheimer's disease, but clinical trials aiming to reduce oxidative stress have not yet proven an effective therapy for dementia patients. The purpose of this review is to systematically analyze available data describing markers of oxidative stress and antioxidants in blood from subjects with Alzheimer's disease or those with mild cognitive impairment to highlight potential interactions between peripheral redox changes and central nervous system pathology and contribute to the design of future clinical study. PubMed, SCOPUS and Web of Science were systematically queried to collect studies which have evaluated markers of oxidative stress, levels of antioxidants, copper, transferrin and ceruloplasmin levels in blood from subjects with Alzheimer's disease and matched controls. After application of quality measures, results were aggregated in a random effects analysis. We found that markers of lipid peroxidation are elevated in blood in Alzheimer's disease and in mild cognitive impairment, copper metabolism is dysregulated and total antioxidant capacity is decreased. While surprisingly none of the major antioxidative enzymes are significantly decreased, non-enzymatic antioxidants in blood (particularly uric acid, vitamins A, E and C, α- and β-carotene) are significantly decreased. There is significant oxidative damage in peripheral blood early in the process of neurodegeneration. We propose that clinical studies assessing cognitive outcomes after antioxidant therapy tailor interventions to individual patients' deficiencies and confirm an improvement in an appropriate serological marker of oxidative stress. This strategy may be most effectively applied in a clinical trial of primary prevention.
Published: 2013
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5. The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia

Author: Siddharth Ramanan, Ajay D. Halai, Lorna Garcia-Penton, Alistair G. Perry, Nikil Patel, Katie A. Peterson, Ruth U. Ingram, Ian Storey, Stefano F. Cappa, Eleonora Catricala, Karalyn Patterson, James B. Rowe, Peter Garrard, and Matthew A. Lambon Ralph
Subjects: Alzheimer’s disease, Frontotemporal dementia, Language, Network-based statistics, Voxel-based morphometry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract Background Clinical variants of primary progressive aphasia (PPA) are diagnosed based on characteristic patterns of language deficits, supported by corresponding neural changes on brain imaging. However, there is (i) considerable phenotypic variability within and between each diagnostic category with partially overlapping profiles of language performance between variants and (ii) accompanying non-linguistic cognitive impairments that may be independent of aphasia magnitude and disease severity. The neurobiological basis of this cognitive-linguistic heterogeneity remains unclear. Understanding the relationship between these variables would improve PPA clinical/research characterisation and strengthen clinical trial and symptomatic treatment design. We address these knowledge gaps using a data-driven transdiagnostic approach to chart cognitive-linguistic differences and their associations with grey/white matter degeneration across multiple PPA variants. Methods Forty-seven patients (13 semantic, 15 non-fluent, and 19 logopenic variant PPA) underwent assessment of general cognition, errors on language performance, and structural and diffusion magnetic resonance imaging to index whole-brain grey and white matter changes. Behavioural data were entered into varimax-rotated principal component analyses to derive orthogonal dimensions explaining the majority of cognitive variance. To uncover neural correlates of cognitive heterogeneity, derived components were used as covariates in neuroimaging analyses of grey matter (voxel-based morphometry) and white matter (network-based statistics of structural connectomes). Results Four behavioural components emerged: general cognition, semantic memory, working memory, and motor speech/phonology. Performance patterns on the latter three principal components were in keeping with each variant’s characteristic profile, but with a spectrum rather than categorical distribution across the cohort. General cognitive changes were most marked in logopenic variant PPA. Regardless of clinical diagnosis, general cognitive impairment was associated with inferior/posterior parietal grey/white matter involvement, semantic memory deficits with bilateral anterior temporal grey/white matter changes, working memory impairment with temporoparietal and frontostriatal grey/white matter involvement, and motor speech/phonology deficits with inferior/middle frontal grey matter alterations. Conclusions Cognitive-linguistic heterogeneity in PPA closely relates to individual-level variations on multiple behavioural dimensions and grey/white matter degeneration of regions within and beyond the language network. We further show that employment of transdiagnostic approaches may help to understand clinical symptom boundaries and reveal clinical and neural profiles that are shared across categorically defined variants of PPA.
Published: 2023
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6. Algorithms for All: Can AI in the Mortgage Market Expand Access to Homeownership?

Author: Vanessa G. Perry, Kirsten Martin, and Ann Schnare
Subjects: mortgage market, BIPOC homeownership, ethics of AI, algorithmic bias, Electronic computers. Computer science, QA75.5-76.95
Abstract: Artificial intelligence (AI) is transforming the mortgage market at every stage of the value chain. In this paper, we examine the potential for the mortgage industry to leverage AI to overcome the historical and systemic barriers to homeownership for members of Black, Brown, and lower-income communities. We begin by proposing societal, ethical, legal, and practical criteria that should be considered in the development and implementation of AI models. Based on this framework, we discuss the applications of AI that are transforming the mortgage market, including digital marketing, the inclusion of non-traditional “big data” in credit scoring algorithms, AI property valuation, and loan underwriting models. We conclude that although the current AI models may reflect the same biases that have existed historically in the mortgage market, opportunities exist for proactive, responsible AI model development designed to remove the systemic barriers to mortgage credit access.
Published: 2023
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7. Vegetation responses to large dam removal on the Elwha River, Washington, USA

Author: Patrick B. Shafroth, Laura G. Perry, James M. Helfield, Joshua Chenoweth, and Rebecca L. Brown
Subjects: ecogeomorphology, sediment pulse, riparian vegetation, river restoration, drained reservoir, coastal vegetation, Evolution, QH359-425, Ecology, QH540-549.5
Abstract: Large dam removal can trigger changes to physical and biological processes that influence vegetation dynamics in former reservoirs, along river corridors downstream of former dams, and at a river’s terminus in deltas and estuaries. We present the first comprehensive review of vegetation response to major fluvial disturbance caused by the world’s largest dam removal. After being in place for nearly a century, two large dams were removed along the Elwha River, Washington, USA, between 2011 and 2014. The exposure, erosion, transport, and deposition of large volumes of sediment and large wood that were impounded behind the dams created new fluvial surfaces where plant colonization and growth have occurred. In the former reservoirs, dam removal exposed ~290 ha of unvegetated sediment distributed on three main landforms: valley walls, high terraces, and dynamic floodplains. In addition to natural revegetation in the former reservoirs, weed control and seeding and planting of desirable plants influenced vegetation trajectories. In early years following dam removal, ~20.5 Mt of trapped sediment were eroded from the former reservoirs and transported downstream. This sediment pulse, in combination with transport of large wood, led to channel widening, an increase in gravel bars, and floodplain deposition. The primary vegetation responses along the river corridor were a reduction in vegetated area associated with channel widening, plant establishment on new gravel bars, increased hydrochory, and altered plant community composition on gravel bars and floodplains. Plant species diversity increased in some river segments. In the delta, sediment deposition led to the creation of ~26.8 ha of new land surfaces and altered the distribution and dynamics of intertidal water bodies. Vegetation colonized ~16.4 ha of new surfaces: mixed pioneer vegetation colonized supratidal beach, river bars, and river mouth bars, and emergent marsh vegetation colonized intertidal aquatic habitats. In addition to the sediment-dominated processes that have created opportunities for plant colonization and growth, biological processes such as restored hydrochory and anadromous fish passage with associated delivery of marine-derived nutrients may influence vegetation dynamics over time. Rapid changes to landforms and vegetation growth were related to the large sediment pulse in the early years following dam removal, and the rate of change is expected to attenuate as the system adjusts to natural flow and sediment regimes.
Published: 2024
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8. Coastal vegetation responses to large dam removal on the Elwha River

Author: Laura G. Perry, Patrick B. Shafroth, Samuel J. Alfieri, and Ian M. Miller
Subjects: coastal wetland restoration, dam removal, ecological succession, pioneer geomorphic surfaces, riparian, river delta, Evolution, QH359-425, Ecology, QH540-549.5
Abstract: IntroductionLarge dam removals provide a restoration opportunity for shrinking coastal wetland habitats. Dam removal can increase sediment delivery to sediment-starved river deltas and estuaries by restoring natural sediment transport and mobilizing reservoir-impounded sediment. However, rapid mobilization of massive quantities of sediment stored behind large dams also constitutes a major ecological perturbation. Information is lacking on coastal habitat responses to sediment pulses of this magnitude.MethodsRemoval of two large dams along the Elwha River (Washington, USA) in 2011–2014 released ~20.5 Mt of impounded sediment, ~5.4 Mt of which were deposited in the delta and estuary (hereafter, delta). We used time series of aerial imagery, digital elevation models, and vegetation field sampling to examine plant community responses to this sediment pulse across seven years during and after dam removal.ResultsBetween 2011 and 2018, the Elwha River delta increased by ~26.8 ha. Vegetation colonized ~16.4 ha of new surfaces, with mixed pioneer vegetation on supratidal beach, river bars, and river mouth bars and emergent marsh vegetation in intertidal aquatic habitats. Colonization occurred on surfaces that were higher and more stable in elevation and farther from the shoreline. Compared to established delta plant communities, vegetation on new surfaces had lower cover of dominant species and functional groups, with very low woody cover, and lower graminoid cover than dunegrass and emergent marsh communities. Over time following surface stabilization, however, vegetation on new surfaces increased in species richness, cover, and similarity to established communities. By 2018, ~1.0 ha of vegetation on new surfaces had developed into dunegrass or willow–alder communities and ~5.9 ha had developed into emergent marsh. At the same time, dam removal had few discernible effects on established delta plant communities.DiscussionTogether, these results suggest that rapid sediment mobilization during large dam removal has potential to expand coastal wetland habitat without negatively affecting established plant communities. However, as sediment loads declined in 2016–2018, new delta surfaces decreased by ~4.5 ha, and ~1.6 ha of new vegetation reverted to no vegetation. Long-term persistence of the expanded coastal habitat will depend on ongoing erosional and depositional processes under the restored natural sediment regime.
Published: 2023
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9. Computational Modeling of the Feasibility of Substituted [1.1.1]Propellane Formation from Anionic Bridgehead Bromide Precursors

Author: Katherine E. Gates, Caitlin Herring, Andrew T. Lumpkin, Robert J. Maraski, Elizabeth G. Perry, Madelen G. Prado, Sarah L. Quigley, Jazmine V. Ridlehoover, Edith Salazar, Kynslei Sims, Kaitlin R. Stephenson, Emma A. Stewart, Mackenzie E. Sullivan, James R. Tucker, and Gary W. Breton
Subjects: General Medicine, propellanes, [1.1.1]propellane, optimization, strained bonds
Abstract: [1.1.1]Propellane, a compound whose structure includes two saturated carbons in which all four bonds are directed into a single hemisphere, is of theoretical interest, but has also seen recent practical applications. Mono-, di-, and trisubstituted derivatives of this propellane (by substitution of its CH2 bridges with O, S, NH, CF2, CO, SO, and SO2) remain unknown despite several computational studies that have suggested some may be stable. In this study, we show that, in several cases, substituted propellanes are spontaneously formed upon the attempted computational optimization of the geometries of anionic bridgehead bromide precursors using the ωB97X-D/aug-cc-pVDZ DFT method. Spontaneous formation suggests that these propellanes are at lower energy relative to the precursors and, therefore, are promising synthetic targets. The success or failure to spontaneously form the propellane is considered in relation to the length and strain energy of the central bridgehead-bridgehead bond, as well as the total strain energy of each propellane.
Published: 2023

10. Knowledge and perceptions of nutrition assistance programmes among young adult students

Author: Michelle G. Perry, Avery R. Ashley, Lanae B. Hood, and Rebecca L. Hagedorn‐Hatfield
Subjects: Nutrition and Dietetics, Medicine (miscellaneous)
Published: 2023

11. I’m Only Human? The Role of Racial Stereotypes, Humanness, and Satisfaction in Transactions with Anthropomorphic Sales Bots

Author: Nicole Davis, Nils Olsen, Vanessa G. Perry, Marcus M. Stewart, and Tiffany B. White
Subjects: Marketing, Economics and Econometrics, Applied Psychology
Published: 2023

12. Irresponsible contagions: Propagating harmful behavior through imitation

Author: Andrew Bryant, Jennifer J. Griffin, and Vanessa G. Perry
Subjects: Organizational Behavior and Human Resource Management, Economics and Econometrics, Philosophy, Management, Monitoring, Policy and Law, Business and International Management
Published: 2022

13. Relationship of Alcohol Misuse and Outcomes in Acute Respiratory Failure: Impact of COVID-19

Author: P.J. Offner, G. Perry, S.E. Jolley, R. Pomponio, R. Peterson, S. Slaughter, J. Gaydos, C. Higgins, J. McKeehan, and E.L. Burnham
Published: 2023

14. Alcohol, Cannabis and Combined Metabolites Differentially Affect Peripheral Blood Mononuclear Cell Gene Expression in a Dose-dependent Manner

Author: E.L. Burnham, S. Slaughter, P.J. Offner, G. Perry, J. McClendon, W.J. Janssen, M. McGrath, and R.A. Peterson
Published: 2023

15. Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain

Author: Wensen Jiang, Juliane D Glaeser, Giselle Kaneda, Julia Sheyn, Jacob T Wechsler, Stephen Stephan, Khosrowdad Salehi, Julie L. Chan, Wafa Tawackoli, Pablo Avalos, Christopher Johnson, Chloe Castaneda, Linda EA Kanim, Teerachat Tanasansomboon, Joshua Burda, Oksana Shelest, Haneen Yameen, Tiffany G Perry, Michael Kropf, Jason M Cuellar, Dror Seliktar, Hyun W Bae, Laura S Stone, and Dmitriy Sheyn
Abstract: Low back pain (LBP) is often associated with the degeneration of human intervertebral discs (IVDs). However, the pain-inducing mechanism in degenerating discs remains to be elucidated. Here, we identified a subtype of locally residing nucleus pulposus cells (NPCs), generated by the environmental stress in degenerating discs, that triggered the onset of discogenic LBP. Single-cell transcriptomic analysis of human tissues showed a strong correlation between this specific pain-triggering subtype and the pain conditions in human degenerated discs. Next, we recreated this pain-triggering subtype by applying known exogenous stressors to healthy NPCsin vitro. The recreated pain phenotype activated functional sensory neurons responsein vitroand induced local inflammatory responses, hyperalgesia, and mechanical sensitivity in a healthy rat IVDin vivo. Our findings provide strong evidence of a previously unknown pain-inducing mechanism mediated by NPCs in degenerating IVDs. This newly defined pathway will aid in the development of NPC-targeted therapeutic strategies for clinically unmet need to attenuate discogenic LBP.One Sentence SummaryDiscogenic low back pain can be initiated by a stress-induced subtype of nucleus pulposus cells present in human degenerating intervertebral discs
Published: 2023

16. Postoperative Spinal Cerebrospinal Fluid-Venous Fistulas Associated With Dural Tears in Patients With Intracranial Hypotension or Superficial Siderosis—A Digital Subtraction Myelography Study

Author: Wouter I. Schievink, Marcel M. Maya, Ray M. Chu, Tiffany G. Perry, Franklin G. Moser, Rachelle B. Taché, Vikram S. Wadhwa, and Ravi S. Prasad
Subjects: Surgery, Neurology (clinical)
Published: 2023

17. Treatment of acid mine drainage and chromium (VI) removal using synthesised chitosan composites blended with kenaf fibre and γ-Fe2O3 nanoparticles

Author: C. N. Nkuna, E. R. Sadiku, G. Perry, B. Oboirien, M. K. Dludlu, and C. Thompson
Subjects: Environmental Engineering, Environmental Chemistry, General Agricultural and Biological Sciences
Published: 2022

18. Growth hormone deficiency during young adulthood and the benefits of growth hormone replacement

Author: M Ahmid, C G Perry, S F Ahmed, and M G Shaikh
Subjects: adolescence with childhood-onset growth hormone deficiency, transition, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Until quite recently, the management of children with growth hormone deficiency (GHD) had focussed on the use of recombinant human GH (rhGH) therapy to normalise final adult height. However, research over the past two decades that has demonstrated deficits in bone health and cardiac function, as well as impaired quality of life in adults with childhood-onset GHD (CO-GHD), has questioned this practice. Some of these studies suggested that there may be short-term benefits of rhGH in certain group of adolescents with GHD during transition, although the impact of GHD and replacement during the transition period has not been adequately investigated and its long-term benefits remain unclear. GH therapy remains expensive and well-designed long-term studies are needed to determine the cost effectiveness and clinical benefit of ongoing rhGH during transition and further into adulthood. In the absence of compelling data to justify widespread continuation of rhGH into adult life, there are several questions related to its use that remain unanswered. This paper reviews the effects of growth hormone deficiency on bone health, cardiovascular function, metabolic profile and quality of life during transition and young adulthood.
Published: 2016
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19. Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia

Author: Lea Tschaidse, Nicole Reisch, Wiebke Arlt, Aude Brac de la Perriere, Angelica Linden Hirschberg, Anders Juul, Ashwini Mallappa, Deborah P Merke, John D C Newell-Price, Colin G Perry, Alessandro Prete, D Aled Rees, Nike M M L Stikkelbroeck, Philippe A Touraine, Helen Coope, John Porter, Richard John M Ross, and Marcus Quinkler
Subjects: All institutes and research themes of the Radboud University Medical Center, Endocrinology, Endocrinology, Diabetes and Metabolism, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], General Medicine
Abstract: Objective Poorly controlled salt-wasting (SW) congenital adrenal hyperplasia (CAH) patients often require high 9α-fluorocortisol doses as they show high levels of 17-hydroxyprogesterone (17OHP), which is a mineralocorticoid (MC)-receptor antagonist. Design We investigated the renin–angiotensin–aldosterone system in patients with SW-CAH receiving twice daily modified-release hydrocortisone (MR-HC, Efmody) compared with standard glucocorticoid (GC) therapy. Methods Data were analyzed from the 6-month, phase 3 study of MR-HC (n = 42) versus standard GC therapy (n = 41). MC replacement therapy remained unchanged throughout the study. Blood pressure, serum potassium, serum sodium, plasma renin activity (PRA), and serum 17OHP and androstenedione concentrations were analyzed at baseline, 4, 12, and 24 weeks. Results The median serum 17OHP in the morning was significantly lower on MR-HC compared with standard GC at 24 weeks (2.5 nmol L–1 (IQR 8.3) versus 10.5 nmol L–1 (IQR 55.2), P = .001). PRA decreased significantly from baseline to 24 weeks in patients on MR-HC (0.83 ng L–1 s–1 (IQR 1.0) to 0.48 ng L–1 s–1 (IQR 0.61), P = .012) but not in patients on standard GC (0.53 ng L–1 s–1 (IQR 0.66) to 0.52 ng L–1 s–1 (IQR 0.78), P = .613). Serum sodium concentrations increased from baseline to 24 weeks in patients on MR-HC (138.8 ± 1.9 mmol L–1 to 139.3 ± 1.8 mmol L–1, P = .047), but remained unchanged on standard GC (139.8 ± 1.6 mmol L–1 to 139.3 ± 1.9 mmol L–1, P = .135). No significant changes were seen in systolic and diastolic blood pressure and serum potassium levels. Conclusion 6 months of MR-HC therapy decreased PRA and increased sodium levels indicating a greater agonist action of the 9α-fluorocortisol dose, which may be due to the decreased levels of the MC-receptor antagonist 17OHP.
Published: 2023

20. Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG

Author: Subodh Verma, Deepak L. Bhatt, Ph. Gabriel Steg, Michael Miller, Eliot A. Brinton, Terry A. Jacobson, Nitish K. Dhingra, Steven B. Ketchum, Rebecca A. Juliano, Lixia Jiao, Ralph T. Doyle, Craig Granowitz, C. Michael Gibson, Duane Pinto, Robert P. Giugliano, Matthew J. Budoff, R. Preston Mason, Jean-Claude Tardif, Christie M. Ballantyne, Fabrice M.A.C. Martens, Astrid Schut, Brian Olshansky, Mina Chung, Al Hallstrom, Lesly Pearce, Cyrus Mehta, Rajat Mukherjee, Anjan K. Chakrabarti, Eli V. Gelfand, Megan Carroll Leary, Duane S. Pinto, Yuri B. Pride, Steven Ketchum, Ramakrishna Bhavanthula, Gertrude Chester, Christina Copland, Katelyn Diffin, Ralph Doyle, Kurt Erz, Alex Giaquinto, Paula Glanton, Angela Granger, Richard H. Iroudayassamy, Rebecca Juliano, James Jin, Dimitry Klevak, Hardik Panchal, Robert Wang, Shin-Ru Wang, Gerard Abate, Peggy J. Berry, Rene Braeckman, Declan Doogan, Anne Elson, Amy HauptmannBaker, Isabel Lamela, Catherine Lubeck, Mehar Manku, Sabina Murphy, Monica Sanford, William Stirtan, Paresh Soni, Arnaud Bastien, Demetria Foster, Evangelito Gascon, Judith Johnson, Lasbert Latona, Gang Liu, Sandra Palleja, Nelly Sanjuan, Jimmy Shi, William Stager, Mukund Venkatakrishnan, Ahmed Youssef-Agha, Julie Zhu, Leela Aertker, Suresh Ankolekar, Lisa Goldberg, Natasa Rajicic, Jianfen Shu, Heng Zou, Magdy Mikhail, Gamil Dawood, N. Mathew Koshy, Sandip K. Mukherjee, Rafik Abadier, Andrea L. Lawless, William P. McGuinn, Howard Weintraub, Kathryn Rohr, Edmund Claxton, Robert J. Weiss, Terry D. Klein, Mani Nallasivan, Stephen Crowley, Marilyn King, Anthony D. Alfieri, David Fitz-Patrick, Irving Loh, Nolan J. Mayer, Rakesh Prashad, Samuel Lederman, Debra Weinstein, Harold E. Bays, Keith Chu, Alireza Maghsoudi, Paul D. Thompson, Jeff Carstens, Anna Chang, Kenneth R. Cohen, Julius Dean, Howard S. Ellison, Bernard Erickson, Enrique A. Flores, Daniel W. Gottlieb, Paul Grena, John R. Guyton, Peter H. Jones, John M. Joseph, Norman E. Lepor, Sam Lerman, Robert D. Matheney, Theodore R. Pacheco, Michael B. Russo, John Rubino, Edward S. Pereira, Albert A. Seals, Eduardo Viera, Alan D. Steljes, Jason Thompson, Shaival Kapadia, Michael McIvor, Jorge E. Salazar, Jose O. Santiago, Ralph Vicari, Martin R. Berk, William A. Kaye, Marcus McKenzie, David Podlecki, Brian D. Snyder, Stephen Nash, David M. Herrington, Wallace Johnson, Joseph R. Lee, Ronald Blonder, Alpa M. Patel, Ramon Castello, Susan Greco, Dean J. Kereiakes, Venkatesh K. Nadar, Mark Nathan, Ranganatha P. Potu, Robert Sangrigoli, Richard Smalling, Mitchell Davis, Robert Braastad, James McCriskin, Kunal Bodiwala, Joe L. Hargrove, Mark W. Graves, George Emlein, Raegan W. Durant, James W. Clower, Rohit Arora, Narendra Singh, Lisa Warsinger Martin, W Herbert Haught, Marc P. Litt, Michael D. Klein, Peter Hoagland, Michael Goldstein, Marco S. Mazzella, Daniel H. Dunker, Brian H. Kahn, Carlos S. Ince, Frank A. McGrew, Jay Lee, David Pan, Salman A. Khan, Uri Elkayam, Wasim Deeb, Anne C. Goldberg, Christopher S. Brown, Wayne N. Leimbach, Thomas S. Backer, David R. Sutton, Joel Gellman, Anu R. George, Alan S. Hoffman, Mark Kates, Kishlay Anand, Robert Bear, Brendan J. Cavanaugh, Ramon G. Reyes, Rodolfo Sotolongo, Kenneth Sabatino, Kevin Gallagher, Ehab Sorial, Chris Geohas, Kathleen E. Magness, Bernard P. Grunstra, Frederik A. Martin, William S. Knapp, Mel E. Lucas, John J. Champlin, Jason Demattia, Patrick H. Peters, Judith Kirstein, William J. Randall, Cezar S. Staniloae, Jennifer G. Robinson, Alexander Adler, Christopher Case, Andrew J. Kaplan, Gregory F. Lakin, Krishan K. Goyle, Michael J. DiGiovanna, Chester L. Fisher, Michael Lillestol, Michael Robinson, Robert G. Perry, Lawrence S. Levinson, Brian G. Everhart, Robert D. Madder, Earl F. Martin, Earl E. Martin, Imtiaz Alam, Jose Mari L. Elacion, Robina Poonawala, Taddese T. Desta, Jerome A. Robinson, Gilbert J. Martinez, Jakkidi S. Reddy, Jeffrey D. Wayne, Samuel Mujica Trenche, Westbrook I. Kaplan, Rubin H. Saavedra, Michael D. DiGregorio, Barry D. Bertolet, Neil J. Fraser, Terence T. Hart, Ronald J. Graf, David A. Jasper, Michael Dunn, Dan A. Streja, David J. Strobl, Nan Jiang, Vicki Kalen, Richard Mascolo, Mercedes B. Samson, Michael Stephens, Bret M. Bellard, Mario Juarez, Patrick J. McCarthy, John B. Checton, Michael Stillabower, Edward Goldenberg, Amin H. Karim, Naseem Jaffrani, Robert C. Touchon, Erich R. Fruehling, Clayton J. Friesen, Pradipta Chaudhuri, Frank H. Morris, Robert E. Broker, Rajesh J. Patel, Susan Hole, Randall P. Miller, Francisco G. Miranda, Sadia Dar, Shawn N. Gentry, Paul Hermany, Charles B. Treasure, Miguel E. Trevino, Raimundo Acosta, Anthony Japour, Samuel J. Durr, Thomas Wang, Om P. Ganda, Perry Krichmar, James L. Arter, Douglas Jacoby, Michael A. Schwartz, Amer Al-Karadsheh, Nelson E. Gencheff, John A. Pasquini, Richard Dunbar, Sarah Kohnstamm, Hector F. Lozano, Francine K. Welty, Thomas L. Pitts, Brian Zehnder, Salah El Hafi, Mark A. King, Arnold Ghitis, Marwan M. Bahu, Hooman Ranjbaran Jahromi, Ronald P. Caputo, Robert S. Busch, Michael D. Shapiro, Suhail Zavaro, Munib Daudjee, Shahram Jacobs, Vipul B. Shah, Frank Rubalcava, Mohsin T. Alhaddad, Henry Lui, Raj T. Rajan, Fadi E. Saba, Mahendra Pai N Gunapooti, Tshiswaka B. Kayembe, Timothy Jennings, Robert A. Strzinek, Michael H. Shanik, Pradeep K. Singh, Alastair C. Kennedy, Howard Rubenstein, Ramin Manshadi, Joanne Ladner, Lily Kakish, Ashley Kakish, Amy L. Little, Jaime Gerber, Nancy J. Hinchion, Janet Guarino, Denise Raychok, Susan Budzinski, Kathleen Kelley-Garvin, April Beckord, Jessica Schlinder, Arthur Schwartzbard, Stanley Cobos, Deborah Freeman, David Abisalih, Dervilla McCann, Kylie Guy, Jennifer Chase, Stacey Samuelson, Madeline Cassidy, Marissa Tardif, Jaime Smith, Brenna Sprout, Nanette Riedeman, Julie Goza, Lori Johnson, Chad Kraske, Sheila Hastings, Chris Dutka, Stephanie Smith, Toni McCabe, Kathleen Maloney, Paul Alfieri, Vinay Hosemane, Chanhsamone Syravanh, Cindy Pau, April Limcoiloc, Tabitha Carreira, Taryn S. Kurosawa, Razmig Krumian, Krista Preston, Ashraf Nashed, Daria Schneidman-Fernandez, Jack Patterson, John Tsakonas, Jennifer Esaki, Lynn Sprafka, Porous Patel, Brian Mitchell, Erin M. Ross, Donna Miller, Akash Prashad, Kristina M. Feyler, Natasha Juarbe, Sandra Herrera, Sarah M. Keiran, Becky Whitehead, Whitney Asher, Coury Hobbs, Abbey Elie, Jean Brooks, Amanda L. Zaleski, Brenda Foxen, Barb Lapke, Philippa Wright, Bristol Pavol, Gwen Carangi, Marla Turner, Katharine W. Sanders, Rikita S. Delamar, Virginia L. Wilson, Sarah M. Harvel, Alison M. Cartledge, Kaitlyn R. Bailey, Kathleen Mahon, Timothy Schuchard, Jen Humbert, Mark C. Hanson, Michael P. Cecil, James S. Abraham, Lorie Benedict, Claudia Slayton, Curtis S. Burnett, Rachel W. Ono-Lim, Sharon Budzinski, Shubi A. Khan, Sharon Goss, Terry Techmanski, Farida Valliani, Rimla Joseph, Edith Flores, Laurn Contreras, Ana Aguillon, Carrie-Ann Silvia, Maria Martin, Edmund K. Kerut, Leslie W. Levenson, Louis B. Glade, Brian J. Cospolich, Maureen W. Stein, Stephen P. LaGuardia, Thelma L. Sonza, Tracy M. Fife, Melissa Forschler, Jasmyne Watts, Judy Fritsch, Emese Futchko, Sarah Utech, Scott B. Baker, Miguel F. Roura, Scott A. Segel, James S. Magee, Cathy Jackson, Rebecca F. Goldfaden, Liudmila Quas, Elizabeth C. Ortiz, Michael Simpson, Robert Foster, Christopher Brian, James Trimm, Michael Bailey, Brian Snoddy, Van Reeder, Rachel Wilkinson, Harold Settle, Cynthia Massey, Angela Maiola, Michele Hall, Shelly Hall, Wanda Hall, Mark Xenakis, Janet Barrett, Giovanni Campanile, David Anthou, Susan F. Neill, Steven Karas, Enrique Polanco, Norberto Schechtman, Grace Tischner, Kay Warren, Cynthia St Cyr, Menna Kuczinski, Latrina Alexander, Maricruz Ibarra, Barry S. Horowitz, Jaime Steinsapir, Jeanette Mangual-Coughlin, Brittany Mooney, Precilia Vasquez, Kathleen Rodkey, Alexandria Biberstein, Christine Ignacio, Irina Robinson, Marcia Hibberd, Lisa B. Hoffman, Daniel J. Murak, Raghupathy Varavenkataraman, Theresa M. Ohlson Elliott, Linda A. Cunningham, Heather L. Palmerton, Sheri Poole, Jeannine Moore, Helene Wallace, Ted Chandler, Robert Riley, Farah Dawood, Amir Azeem, Michael Cammarata, Ashleigh Owen, Shivani Aggarwal, Waqas Qureshi, Mohamed Almahmoud, Abdullahi Oseni, Adam Leigh, Erin Barnes, Adam Pflum, Amer Aladin, Karen Blinson, Vickie Wayne, Lynda Doomy, Michele Wall, Valerie Bitterman, Cindi Young, Rachel Grice, Lioubov Poliakova, Jorge Davalos, David Rosenbaum, Mark Boulware, Heather Mazzola, J. Russell Strader, Russell Linsky, David Schwartz, Elizabeth Graf, Alicia Gneiting, Melissa Palmblad, Ashley Donlin, Emily Ensminger, Hillary Garcia, Dawn Robinson, Carolyn Tran, Jeffrey Jacqmein, Darlene Bartilucci, Michael Koren, Barbara Maluchnik, Melissa Parks, Jennifer Miller, Cynthia DeFosse, Albert B. Knouse, Amy Delancey, Stephanie Chin, Thomas Stephens, Mag Sohal, Juana Ingram, Swarooparani Kumar, Heather Foley, Nina Smith, Vera McKinney, Linda Schwarz, Judith Moore, Hildreth Vernon Anderson, Stefano Sdringola-Maranga, Ali Denktas, Elizabeth Turrentine, Rhonda Patterson, John Marshall, Terri Tolar, Donna Patrick, Pamela Schwartzkopf, Anthony M. Fletcher, Frances R. Harris, Sherry Clements, Tiffany Brown, William Smith, Stacey J. Baehl, Robin Fluty, Daniel VanHamersveld, Dennis Breen, Nancy Bender, Beverly Stafford, Tamika Washington, Margaret N. Pike, Mark A. Stich, Evyan Jawad, Amin Nadeem, Jill Nyland, Rhonda Hamer, Kendra Calhoun, Charlotte Mall, Samuel Cadogan, Kati Raynes, Richard Katz, Lorraine Marshall, Rashida Abbas, Jay L. Dinerman, John T. Hartley, Beth Lamb, Lisa Eskridge, Donna Raymond, Kristy Clemmer, Denise M. Fine, Paula Beardsley, Janet Werner, Bette Mahan, Courtney VanTol, Robert Herman, Christine Raiser-Vignola, Felicia McShan, Stefanie A. Neill, David R. Blick, Michael J. Liston, Denetta K. Nelson, Sandra K. Dorrell, Patricia Wyman, Ambereen Quraishi, Fernando Ferro, Frank Morris, Vicki J. Coombs, Autumn M. Mains, Austin A. Campbell, Jeanne Phelps, Cheryl A. Geary, Ellen G. Sheridan, Jean M. Downing, Arie Swatkowski, Tish Redden, Brian Dragutsky, Susan Thomas, Candace Mitchell, Diana Barker, Elanie Turcotte, Deborah Segerson, Jill Guy, Karena De La Mora, Jennifer Hong, Dennis Do, Rose Norris, Faisal Khan, Hector Montero, Stacy Kelly-White, Alan Cleland, Rosalyn Alcalde-Crawford, Melissa Morgan, Brijmohan Sarabu, Megan Minor, Shweta Kamat, Stephanie M. Estes, Nancee Harless, Alicia Disney, Jodi L. Pagano, Chad M. Alford, Noel W. Bedwell, Warren D. Hardy, Kevin DeAndrade, Jessica G. Elmore, Eric Auerbach, Anthony W. Haney, Miriam H. Brooks, Jose Torres, Lois Roper, Terry Backer, Katie Backer, John G. Evans, Ricardo A. Silva, Lorraine H. Dajani, Veronica Yousif, Tammy Ross, Sion K. Roy, Ronald Oudiz, Sajad Hamal, Ferdinand Flores, Amor Leahy, Debra Ayer, Swapna George, Chrisi Carine Stewart, Elvira Orellana, Cristina Boccalandro, Mary Rangel, Suzanne Hennings, Carl Vanselow, Teri Victor, Darlene Birdwell, Paul Haas, Anthony Sandoval, Gina Ciavarella, Caroline Saglam, Amy Bird, Keith Beck, Brian Poliquin, David Dominguez, Brittany Tenorio, Harvonya Perkins, Esther San Roman, Paris Bransford, Christy Lowrance, Marcy Broussard, Mary Ellis, Bobbi Skiles, Jessica Hamilton, Kathryn Hall, Diego Olvera, Julee A. Hartwell, Nevien Sorial, Mary Rickman, Kevin Berman, Nirav Mehta, Annie Laborin, Rodger Rothenberger, Sarah Beauvilliers, Kathy Morrell, Michael P. Schachter, Cindy L. Perkins, Elizabeth A. Gordon, Jennifer Lauer, Kim Bichsel, Kelly Oliver, Leslie J. Mellor, Candice Demattia, Jennifer Schomburg, Yenniffer Moreno, Eduardo Mansur-Garza, Lena Rippstein, Lorie Chacon, Andrea Pena, Michelle King, Susan Richardson, Annette Jessop, Nicole Tucker, Whitney Royer, Gilbert Templeton, Ann Moell, Christine Weller, Melissa J. Botts, Gretel Hollon, Elsa Homberg-Pinassi, Paula Forest, Aref Bin Abhulhak, Devona Chun-Furlong, Deborah Harrington, Emily Harlynn, Marjorie Schmitt, Constance Shelsky, Patricia Feldick, Mary Cherrico, Courtney Jagle, Nicholas Warnecke, Debra Myer, Deanna J. Ruder, Albina Underwood, Alan Rauba, George Carr, Barbara Oberhaus, Jessica Vanderfeltz, Mary Jo Stucky-Heil, Dale R. Gibson, Vonnie Fuentes, Kimberly L. Talbot, William C. Simon, Katlyn J. Grimes, Christina R. Wheeler, Cassaundra Shultz, Rhonda A. Metcalf, Jennifer L. Hill, Michelle R. Oliver, Basharat Ahmad, Fouzal Azeem, Abdul Rahim, George H. Freeman, Dawn Bloch, Heather Freeman, Jamie Brown, Sarah Rosbach, Pamela Melander, Nick Taralson, Alex Liu, Katlyn Harms, Mahfouz Michale, Jose Lopez, Maria Revoredo, Shari Edevane, Sarah Shawley, Timothy L. Jackson, Michael J. Oliver, Dina DeSalle, Patricia J. Matlock, Ionna M. Beraun, Heather Hendrix, Garrett Bromley, Ashley Niemerski, Gabby Teran, Sonia Guerrero, Murtaza Marvi, Zehra Palanpurwala, Andrea Torres, Patty Gloyd, Michelle Conger, Aziz Laurent, Olia Nayor, Catalina S. Villanueva, Munira Khambati, Tabetha J. Mumford, Melanie J. Castillo, Taddese Desta, Jerome Robinson, La Shawn Woods, Anita Bahri, Nancy Herrera, Cecilia Casaclang, Jeffrey R. Unger, Geraldine Martinez, Mia K. Moon, Stephen M. Mohaupt, Larry Sandoval, Louisito Valenzuela, Victora Ramirez, Nelly Mata, Veronica Avila, Marisol Patino, Cynthia Montano-Pereira, Omar Barnett, William M. Webster, Lorraine M. Christensen, Leighna Bofman, Melanie Livingston, Stacey Adams, Joseph Hobbs, Leesa Koskela, Mia Katz, Samuel Mujica-Trenche, Franklin Cala, Noreen T. Rana, Jennifer Scarlett, Milagros Cala Anaya, Marsha R. Jones, Kelly D. Hollis, Debbie Roth, Kristin Eads, Tina Watts, Judy Perkins, Alice Arnold, Daniel C. Ginsberg, Denise Quinn, Nicole Cureton, David B. Fittingoff, Mohammed I. Iqbal, Stephen R. White, Edith Sisneros, Michelle Ducca, David Streja, Danny Campos, Jennifer L. Boak, Farzeen Amir, Felice Anderson, James J. Kmetzo, Mary O. Bongarzone, Dawn Scott, Mary Grace De Leon, Cynthia Buda, William Graettinger, Michelle Alex, Erika Hess, James Govoni, Melissa Bartel, Travis L. Monchamp, Julie S. Roach, Sara Gibson, Amy M. Allfrey, Kristen Timpy, Kathy Bott, Karin A. Soucy, Jean Willis, Cecilia A. Valerio, Anusha Chunduri, Rebecca Coker, Nicole Vidrine, Ellen A. Thompson, Mark A. Studeny, Melissa K. Marcum, Tammy S. Monway, Douglas L. Kosmicki, Melissa J. Kelley, Corey M. Godfrey, Susan L. Krenk, Randy R. Holcomb, Deb K. Baehr, Mary K. Trauernicht, David Rowland Lowry, Betty Bondy Herts, Jeanne E Phelps, Jean-Marie Downing, Carol Gamer Dignon, Elisabeth S. Cockrill, Pravinchandra G. Chapla, Diane Fera, Margaret Chang, Patricia Fredette, Tamie Ashby, Renee Bergin, Zebediah A. Stearns, David B. Ware, Rachael M. Boudreaux, Joanna Rodriguez, Robert McKenzie, Amanda Huber, Rebecca Sommers, Heather Rowe, Stacy McLallen, Michale Haynes, Ashley Adamson, Janice Henderson, Lori McClure, Beverly A. Harris, Laura Ference, Sue Meissner-Dengler, Lisa Treasure, Doreen Nicely, Timothy L. Light, Tracey A. Osborn, Kimberly J. Mai, Pablo Vivas, Jose Rios, Dunia Rodriguez, Roger DeRaad, James Walder, Oscar Bailon, Denice Hockett, Debbie Anderson, Kelli McIntosh, Amber Odegard, Andrew Shepherd, Mary Seifert, Laurence Kelley, Rajendra Shetty, Michael Castine, David Brill, Gregory Fisher, Nicole Richmond, Kathleen Gray, Patricia Miller, Charlene Coneys, Yarixa Chanza, Monica Sumoza, Victoria M. Caudill, Kelly D. Harris, Courtney A. Manion, Melody J. Lineberger-Moore, Julie J. Wolfe, Barbara J. Rosen, Patricia DiVito, Janet L. Moffat, Christina Michaelis, Prashant Koshy, Diana Perea, Ghaith Al Yacoub, Stephanie Sadeghi, Thomas D. LeGalley, Rudolph F. Evonich, William J. Jean, Gary M. Friesen, John M. Pap, David A. Pesola, Mark D. Cowan, Kristofer M. Dosh, Dianna Larson, Adele M. Price, Jodi A. Nease, Jane E. Anderson, Lori A. Piggott, Robert Iwaoka, Kevin Sharkey, Edward McMillan, Laurie Lowder, Latisha Morgan, Kyle Davis, Tara Caldwell, Erica Breglio, Jasmine Summers, Rachel Poulimas, Muhammad Zahid, Hamid Syed, Maria Escobar, Jacob Levy, Rahma Warsi, Carol Ma, Puxiao Cen, Kimberly A. Cawthon, Delores B. Barnes, Deanna G. Allen, Margaret L. Warrington, Carol R. Stastny, Robin J. Michaels, Mohamad Saleh, John Sorin, Sunny Rathod, Urakay Juett, Steven Spencer, Aziza Keval, Jill McBride, Shane Young, Catherine Baxter, Carol Rasmussen, Shari L. Coxe, Luis Campos, Shahin Tavackoli, Diana Beckham, Darlynee Sanchez, Karanjit Basrai, Dorian Helms, Erica Clinton, Kasie Smith, Henry Cusnir, Mary Klaus Clark, Madhavagopal V. Cherukuri, Ameta Scarfaru, Stephen D. Nash, Loretta C. Grimm, Anna Grace, Kylie McElheran, Dino Subasic, Zedrick Buhay, Janet Litvinoff, Deepak Shah, Shannon Cervantes, Freda Usher, Farra Yasser, Theodore Trusevich, Ronnie L. Garcia, Jamison Wyatt, Rahul Bose, Holllilyn Miska, Traci Spivey, Amy B. Wren, Katie E. Vance, Lani L. Holman, Pam Gibbons, Elaine Eby, Sandra Shepard, Soratree Charoenthongtrakul, Brett Snodgrass, Mohammed Nazem, Shelly Keteenburg, Prathima Murthy, Frederic Prater, Ashley Rumfelt, Christina Eizensmits, Lisa Iannuzzi, Pourus R. Patel, Clellia Bergamino, Elizabeth McFeaters, Botros Rizk, Emiljia Pflaum, Danny Kalish, Rex Ambatali, Mona Ameli, Delaina Sanguinetti, Rakesh Vaidya, Martinus A.W. Broeders, Dorman Henrikus, Adrianus F.M. Kuijper, Nadea Al-Windy, Michael Magro, Karim Hamraoui, Ismail Aksoy, Guy L.J. Vermeiren, H.W.O. Roeters van Lennep, Gerard Hoedemaker, Johannes Jacobus Remmen, Kjell Bogaard, Dirk van der Heijden, Nicole MJ Knufman, Joost Frederiks, Johannes Willem Louwerenburg, Piet van Rossum, Johannes Milhous, Peter van der Meer, Arno van der Weerdt, Rob Breedveld, Mitran Keijzers, Walter Hermans, Ruud van de Wal, Peter A.G. Zwart, Marc M.J.M. van der Linden, Gerardus Zwiers, Dirk J. Boswijk, Jan Geert Tans, Jacob van Eck, Maarten V. Hessen, Barnabas J.B. Hamer, Stieneke Zoet-Nugteren, Lucien Theunissen, E.A. van Beek, Remco Nijmeijer, Pieter R. Nierop, Gerard Linssen, H.P. Swart, Timo Lenderink, Gerard L. Bartels, Frank den Hartog, Brian J. Berg van den, Wouter van Kempen, Susanne Kentgens, Gloria M. Rojas Lingan, Martinus M. Peeters, Hilligje Keterberg, Melchior Nierman, Annemieke K. den Hollander, Jacqueline Hoogendijk, Christine Voors-Pette, Vicdan Kose, Peter Viergever, Larysa Yena, Viktor Syvolap, Mykola P. Kopytsya, Olga Barna, Svitlana S. Panina, Mykhailo I. Lutai, Oxana V. Shershnyova, Iryna Luzkiv, Larysa S. Bula, Sergii Zotov, Ivan Vyjhovaniuk, Olena Lysunets, Volodymyr I. Koshlia, Nataliya Sydor, Myroslava F. Vayda, Olexiy Ushakov, Mykola Rishko, Viktor P. Shcherbak, Yevgeniya Svyshchenko, Vira Tseluyko, Andriy Yagensky, Viktoriia I. Zolotaikina, Olga Godlevska, Larysa Ivanova, Olena Koval, Olena I. Mitchenko, Galyna Y. Kardash, Yurii S. Rudyk, Mykola Stanislavchuk, Volodymyr Ivanovych Volkov, Olena G. Karlinskaya, Susanna A. Tykhonova, Nikolay Vatutin, Ganna Smirnova, Volodymyr M. Kovalenko, Viktor Lizogub, Denys Sebov, Oleksandr Dyadyk, Svetlana Andrievskaya, Mykola P. Krasko, Alexander N. Parkhomenko, Lidiya Horbach, Iryna G. Kupnovytska, Tetyana Pertseva, Oleksandr Karpenko, Dmytro Reshotko, Svitlana V. Zhurba, Leonid Rudenko, Viktoriia Yu Zharinova, Valerii B. Shatylo, Yuriy I. Karpenko, Mariya A. Orynchak, Tatiana R. Kameneva, Elena Zherlitsina, Diana N. Alpenidze, Grigoriy P. Arutyunov, Elena Baranova, Boris Bart, Dmitriy I. Belenkiy, Svetlana A. Boldueva, Elena A. Demchenko, Vera V. Eltishcheva, Alexander M. Gofman, Boris M. Goloshchekin, Ivan Gennadyevich Gordeev, Nikolay Gratsianskiy, Gadel Kamalov, Niyaz R. Khasanov, Irina M. Kholina, Zhanna D. Kobalava, Elena V. Kobeleva, Alexandra O. Konradi, Victor A. Kostenko, Andrey Dmitrievich Kuimov, Polina Y. Ermakova, Sofia K. Malyutina, Alexey V. Panov, Natalia V. Polezhaeva, Olga Reshetko, Nataliya P. Shilkina, Sergey B. Shustov, Elena A. Smolyarchuk, Raisa I. Stryuk, Elena Yurievnar Solovieva, Andrey V. Susekov, Natalia Vezikova, Svetlana N. Ivanova, Alexander A. Petrov, Vladimir O. Konstantinov, Alina S. Agafina, Victor Gurevich, Konstantin N. Zrazhevskiy, Tatiana V. Supryadkina, Nikita B. Perepech, Vadim L. Arkhipovskiy, Dmitry Yu Butko, Irina A. Zobenko, Olga V. Orlikova, Viktor Mordovin, Olga L. Barbarash, Anastasiya Lebedeva, Vladimir Nosov, Oleg V. Averkov, Elena P. Pavlikova, Yuri B. Karpov, Marina Lvovna Giorgadze, Oleg A. Khrustalev, Mikhail Arkhipov, Tatiana A. Raskina, Julia V. Shilko, Yulia Samoilova, Elena D. Kosmacheva, Sergey V. Nedogoda, Kathleen Coetzee, Lesley J. Burgess, F.C.R. Theron, Iftikhar O. Ebrahim, Gerbrand A. Haasbroek, Maria Pretorius, Julien S. Trokis, Dorothea V. Urbach, Mark J. Abelson, Adrian R. Horak, Aysha E. Badat, Ellen M. Makotoko, Hendrik Du Toit Theron, Padaruth Ramlachan, Clive H. Corbett, Ismail H. Mitha, Hendrik F.M. Nortje, Dirkie J. Jansen van Rensburg, Peter J. Sebastian, F.C.J. Bester, Louis J. van Zyl, Brian L. Rayner, Elżbieta Błach, Magda Dąbrowska, Grzegorz Kania, Agata E. Kelm-Warchol, Leszek P. Kinasz, Janusz Korecki, Mariusz Kruk, Ewa Laskowska-Derlaga, Andrzej Madej, Krzysztof Saminski, Katarzyna Wasilewska, Katarzyna Szymkowiak, Małgorzata Wojciechowska, Natalia Piorowska, Andrzej Dyczek, Rajpal K. Abhaichand, Ramesh B. Byrapaneni, Basavanagowdappa Hattur, Malipeddi Bhaskara Rao, Nitin Ghaisas, Sujit Shankar Kadam, Jugal B. Gupta, Santhosh M. Jayadev, V.A. Kothiwale, Atul Mathur, Vijay Bhaskar, Ravi K. Aluri, Udaya P. Ponangi, Mukesh K. Sarna, Sunil Sathe, Manish K. Sharma, Jilendra Pal Singh Sawhney, Chakrabhavi B. Keshavamurthy, Arun Srinivas, Hemant P. Thacker, A. Sharda, Johny Joseph, Sunil Dwivedi, Viswanathan Mohan, Rajendra K. Premchand, Jacques Bedard, Jean Bergeron, Ronald Collette, David Crowley, Richard Dumas, Sam Henein, Geoff Moran, William F. O’Mahony, Michael O’Mahony, Sammy Chan, Mark H. Sherman, Graham C. Wong, Brian D. Carlson, Milan K. Gupta, David Borts, Sean R. Peterson, Martyn Chilvers, Allan J. Kelly, Jean C. Gregoire, Simon Kouz, Josep Rodés Cabau, Minodora Andor, Mircea Cinteza, Radu Ciudin, Radu I. Cojan, Roxana O. Darabont, Dan-Lucian Dumitrascu, Carmen Fierbinteanu-Braticievici, Ana Gabriela Fruntelata, Constantin Militaru, Bogdon E. Minescu, Doina Luminita Serban, Florin Mitu, Dorel Nastase Melicovici, Ovidiu Petrascu, Octavian M. Pirvu, Cristian Podoleanu, Calin Pop, Rodica-Valentina V. Stanescu-Cioranu, Adrian Tase, Cristina Voiculet, Constantine N. Aroney, Anthony M. Dart, Timothy Davis, Karam Kostner, David N. O’Neal, Peter W. Purnell, Bhuwanendu B. Singh, David R. Sullivan, Peter Thompson, Gerald F. Watts, Adam F. Blenkhorn, John V. Amerena, Rafeeq Samie, Randall Hendriks, Joseph Proietto, Nikolai Petrovsky, Alan Whelan, David Colquhoun, Russell S. Scott, Simon C. Young, Tammy Pegg, Samuel JS Wilson, Andrew W. Hamer, Richard A. Luke, Hamish H. Hart, Gerard P. Devlin, Gerard T. Wilkins, Ian F. Ternouth, Samraj Nandra, Bruno S. Loeprich, Nicole McGrath, Stuart L. Tie, Rob J. Bos, Alexandra Wils, Tamara Jacobs, Erik A. Badings, Lillian A. Ebels-Tuinbeek, Mayke L. Scholten, Esther Bayraktar-Verver, Debby Zweers, Manoek Schiks, Carolien Kalkman, Tineke Tiemes, Jeanette Mulderij, Katarzyna Dabrowska, Wilma Wijnakker, Riny Van de Loo, Jeanne de Graauw, Giny Reijnierse, Mirjam van der Zeijst, Mariska Scholten, Henk R. Hofmeijer, Antoinette van Dijk-van der Zanden, Dineke J. van Belle, Jan Van Es, Gera Van Buchem, Wendy Zijda, Harald Verheij, Linnea Oldenhof-Janssen, Martina Bader, Marije Löwik, Sandra Stuij, Pascal Vantrimpont, Krista van Aken, Karen Hamilton, Han Blömer, Gabriela van Laerhoven, Raymond Tukkie, Maarten Janssen, Gerard Verdel, Jon Funke Küpper, Bob van Vlies, Caroline Kalkman, Joke Vooges, Marinella Vermaas, Rachel Langenberg, Niek Haenen, Frans Smeets, Arko Scheepmaker, Marcel Grosfeld, Ilvy Van Lieshout, Marleen van den Berg, Marian Wittekoek, Petra Mol, Antionette Stapel, Margaretha Sierevogel, Nancy van der Ven, Annemiek Berkelmans, Eric Viergever, Hanneke Kramer, Wilma Engelen, Karen V. Houwelingen, Thierry X. Wildbergh, Arend Mosterd, Coriet Hobé-Rap, Marjan van Doorn, Petra Bunschoten, Michel Freericks, Mireille Emans, Petra Den Boer-Penning, Els Verlek, Christine Freericks, Cornelis de Nooijer, Christina Welten, Ingrid Groenenberg, Claudia van der Horst, Esther Vonk, Geert Tjeerdsma, Gerard M. Jochemsen, Corinne van Daalen, Ingrid Y. Danse, Lucy Kuipers, Anke Pieterse, Antonius Oomen, Daan de Waard, Willem Jan Flu, Zusan Kromhout, Petra Van der Bij, Rob Feld, Brigitta Hessels-Linnemeijer, Rob Lardinois, Jan L. Posma, Zwanette R. Aukema-Wouda, Marjolijn Hendriks-van Woerden, Desiree van Wijk, Driek P. Beelen, Ingrid H. Hendriks, Jan J. Jonker, Stefanie Schipperen, Vicdan Köse, Gloria Rojas, Linda Goedhart, Hanneke van Meurs, Jacqueline Rijssemus, Lindy Swinkels-Diepenmaat, Marloes de Louw-Jansen, Dominique Bierens-Peters, Willem W. van Kempen, Marianne E. Wittekoek, Irmaina Agous, Geert Schenk, Janneke Wittekoek, Kevin Cox, Deborah F. Julia, Jan J.C. Jonker, Roel Janssen, Melchor Nierman, Hilligje Katerberg, Irene van der Haar, Willem W. Van Kempen, Taco van Mesdag, Leyda M. Alvarez Costa, Manon Schensema, Salomé Zweekhorst, Deborah Font Julia, Lauri Hanewinckel, Joyce Olsthoorn, Johan C. Berends, Arie C. van der Spek, Roy van der Berg, Rob J. Timmermann, Ingrid Boerema, Iryna Mudruk, Anna Khrystoforova, Serhii Kyselov, Yaroslava V. Hilova, Pavlo Logoida, Nataliia A. Sanina, Ilona P. Golikova, Olena O. Nemchyna, Ivan I. Isaichikov, Olga B. Potapova, Iurii V. Gura, Larysa Berestetska, Olena O. Kulianda, Oleksandr Tantsura, Oleksandr S. Kulbachuk, Volodymyr Petsentiy, Ihor Biskub, Tetyana Handych, Oleg Lagkuti, Alyna Gagarina, Taras Chendey, Oksana F. Bilonko, Olena Matova, Larysa Bezrodna, Olena Yarynkina, Tetiana Ovdiienko, Volodymyr Randchenko, Maryna Mospan, Olena Butko, Olga Romanenko, Mykhailo Pavelko, Iryna Sichkaruk, Svitlana O. Lazareva, Olena A. Kudryk, Inessa M. Koltsun, Tetiana Magdalits, Sergei Zadorozhniy, Kira Kompaniiets, Andrii Ivanov, Sergiy Romanenko, Pavlo Kaplan, Vadym Y. Romanov, Oksana P. Mykytyuk, Nataliia S. Zaitseva, Sergiy N. Pyvovar, Lyudmyla Burdeuna, Emerita Serdobinska, Tatiana I. Shevchenko, Igor I. Ivanytskyi, Olena V. Khyzhnyak, Nataliya Kalinkina, Olena Keting, Olena Sklyanna, Olga Kashanska, Anna Shevelok, Marina Khristichenko, Ievgenii Y. Titov, Danilenko O. Oleksander, Nataliia S. Polenova, Nataliia Altunina, Viktoriia Kororaieva, Stanislav Zborovskiy, Leonid Kholopov, Iurii Suliman, Lanna Lukashenko, Stanislav Shvaykin, Olexandr M. Glavatskiy, Roman O. Sychov, Roman L. Kulynych, Oleksandr A. Skarzhevskyi, Nataliia V. Dovgan, Marta Horbach, Olga Cherkasova, Iryna Tyshchenko, Liudmyla Todoriuk, Svitlana Kizim, Nataliia Brodi, Oleksandr Ivanko, Olga Garbarchuk, Liudmyla Alieksieieva, Tetiana L. Shandra, Olena Beregova, Larisa An Bodretska, Svitlana S. Naskalova, Ivanna A. Antoniuk-Shcheglova, Olena V. Bondarenko, Natalia G. Andreeva, Iryna I. Vakalyuk, Olha S. Chovganyuk, Nataliya R. Artemenko, Kiril A. Maltsev, Natalia Kalishevich, Natalia G. Kondratyeva, Svetlana A. Nikitina, Maria V. Martjanova, Anna V. Sokolova, Dmitrii O. Dragunov, Olga Kolesnik, Vera Larina, Oxana V. Tsygankova, Maria Ivanova, Illia A. Karpov, Elena M. Aronova, Ekaterina S. Vedernikova, Ekaterina I. Lubinskaya, Taras Y. Burak, Sergey I. Skichko, Farhad Rasulev, Ekaterina B. Soldatova, Alexander L. Fenin, Ilya I. Laptev, Elena E. Luchinkina, Alexandr Akatov, Natalia V. Polenova, Natalia N. Slavina, Irina N. Korovnika, Marina Yu Prochorova, Regina Shakirova, Elena N. Andreicheva, Olga A. Krasnova, Tinatin V. Lobzhanidze, Tatiana B. Dmitrova, Viktoriya V. Stakhiv, Maria I. Pechatnikova, Alexandra V. Panova, Maria Y. Tipikina, Oxana P. Rotar, Nikolay A. Bokovin, Saule K. Karabalieva, Farid Y. Tumarov, Elena V. Vasileva, Natalya Gennadevna Lozhkina, Ekaterina V. Filippova, Alisa I. Sharkaeva, Ekanerina V. Filippova Deilik, Natalia Yu Tolkacheva, Elena N. Domracheva, Andrey N. Ryabikov, Inga T. Abesadze, Marianna Z. Alugishvili, Elena P. Nikolaeva, Nadezda V. Smirnova, Valentina I. Rodionova, Polina V. Dolovstaya, Igor E. Yunonin, Sergey V. Kadin, Tatyana S. Sveklina, Anna V. Bushmanova, Elena L. Barkova, Irina S. Gomova, Yana V. Brytkova, Tatiana B. Ivanova, Marina Y. Zubareva, Inga Skopets, Lybov A. Galashevskaya, Emilia D. Butinskaya, Olga G. Gusarova, Natalia B. Kalishevich, Yana R. Pavlova, Marianna P Serebrenitskaya, Vitalina F. Grygorieva, Gulnara R. Kuchaeva, Inna A. Vasileva, Gulnara I. Ospanova, Yulia V. Vahrusheva, Irina A. Semenova, Irina E.E. Mikhailova, Olga O. Kvasova, Valeria D. Shurygina, Alexey E. Rivin, Alexey O. Savelyev, Alexey A. Savelyev, Olesya O. Milyaeva, Nadezhda N. Lapshina, Ninel A. Lantsova, Pavel V. Alexandrov, Evgeniy A. Orlikov, Alla Falkovskaya, Tatiana Ripp, Sergei Triss, Stanislav Pekarskiy, Sitkova Ekaterina, Evgeniya N. Zhuravleva, Olga Perova, Galina Kovaleva, Liubov Koroleva, Lydia Mishchenko, Boris P. Garshin, Svetlana A. Kutuzova, Lyudmila I. Provotorova, Igor P. Zadvorny, Olga V. Okhapkina, Anatoly O. Khrustalev, Tatiana Suvorova, Elena S. Shaf, Varvara A. Vershinina, Andrey A. Kozulin, Oxana A. Oleynik, Irina Y. Martynova, Natalia V. Kizhvatova, Alla S. Salasyuk, Vera V. Tsoma, Alla A. Ledyaeva, Elena V. Chumachek, S.C. Blignaut, Tersia Y. Alexander, Chano Du Plessis, Thirumani Govender, Samatha M. Du Toit, Leya Motala, Areesh Gassiep, Christina Naude (Smit), Marli Terblanche, Marlien Snoer (Kruger), Berenice Pillay, De Vries Basson, Marisa E. Theron, Bianca Fouche, Mareli E. Coetzee, Pieter Odendall, Frederik H. Van Wijk, Anna-Mari Conradie, Trudie Van der Westhuizen, Carine Tredoux, Mohamed S. Mookdam, Andie J. Van der Merwe, Karin Snyman, Gerda Smal, Yvonne De Jager, Thomas A. Mabin, Annusca King, Lindy L. Henley, Brenda M. Zwane, Jane Robinson, Marinda Karsten, Andonia M. Page, Valerie Nsabiyumva, Charmaine Krahenbuhl, Jaiprakash D. Patel, Yunus E. Motala, Ayesha Dawood, Nondumiso B. Koza, Lenore M.S. Peters, Shavashni Ramlachan, Wilhelm J. Bodenstein, Pierre Roux, Lizelle Fouche, Cecilia M. Boshoff, Haroon M. Mitha, Fathima Khan, Henry P. Cyster, Helen Cyster, E. C. Wessels, Florence J. Jacobs, Melanie A. Sebastian, Deborah A. Sebastian, Nadia Mahomed, Ignatius P. Immink, Celia Cotzee, Tanja Cronje, Madele Roscher, Maria Le Roux, Yvonne A. Trinder, Renata Wnętrzak-Michalska, Magdalena Piszczek, Andrzej Piela, Ewa Czernecka, Dorota Knychas, Alina Walczak, Izabella Gładysz, Katarzyna Filas, Ewelina Kiluk, Krzysztof Świgło, Iwona Jędrzejczyk, Kamila Łuczyńska, Katarzyna Tymendorf, Wojciech Piesiewicz, Wojciech L. Kinasz, Stefan Samborski, Ilona Bartuś, Gramzyna Latocha Korecka, Ewa Gulaj, Jolanta Sopa, Bogusław Derlaga, Marcin Baisiak, Allicia Kowalisko, Edyta Stainszewska-Marasazlek, Bartosz Szafran, Malgorzata Swiatkiewicz, Artur Racewicz, Sławomir Grycel, Jerzy Supronik, Sylwia Walendziuk, Magdalena Tarantowicz, Agata Stasiak, Anna Sidorowicz-Białynicka, Marek Dwojak, Ewa Jaźwińska-Tarnawska, Katarzyna Kupczyk, Kamila Martowska, Kamila Kulon, Katarzyna Gajda, Bivin Wilson, Krithika Velusamy, Swaidha S. Sadhiq, Bhavani Siddeshi, M. Bhanukumar, Abhishek Srivatsav, Madhan Ramesh, Sri Harsha Chalasani, Mini Johnson, Prashanth Gopu, Jeesa George, Sowmya Reddy, Swetha Tessy Thara Eleena, Damodara Rao Kodem, Haritha N. Nakkella, Padma Kumari Mandula, Anjan Kumar Vuriya, Syamala Rajana, Aruna Kale, Tiwari Rajeev, Raina Jain, Vipin Jain, Srilakshmi Mandayam Adhyapak, Lumin Sheeba, Uma C R, Ramya R, Aditya V. Kulkarni, M.S. Ganachari, Ruma Sambrekar, Mohammad Bilal, Kalyan Chakravarthy, Ravi Badhavath, Sravan Kumar, Meenakshi Simhadri, Farooque Salamuddin, Venkat Prasad, Vivek Dwivedi, Sudha Sarna, Tilak Arora, Deepak Chawla, Archana Sathe, Chaware Gayatree, Ajeet Nanda, Ram Avtar, Jyoti Sharma, Vaibhavi P S, Sasirekha D, Deepthi Kobbajji, Ramya Ningappa, Shwetha Shree, Chandrashekar K, Nandini M R, Sowjanya S, Devika I G, Yashaswini N, Sonika G, Rathna L, Priyanka R, Rupal J. Shrimanker, Lakshmi Vinutha Reddy, K. Sumathi, Babitha Devi, Bina N. Naik, Rohini Manjunath, Rajeshwari Ashok, Tony V. Kunjumon, Jesline Thomas, Shaik Samdhani, Kasthuri Selvam, Poongothai Subramani, Nandakumar Parthasarathy, Nirmal K. Bohra, Anvesh K. Gatla, Cheryl Horbatuk, Julie Sills, E B. Davey, Liz Paramonczyk, Olga Racanelli, Sandy Strybosch, Andre Belanger, Jean Palardy, Alicia Schiffrin, Sylvie Gauthier, Norman Kalyniuk, Shawn D. Whatley, Heather Lappala, Grishma Patel, Matthew Reeve, Catherine Moran, Jody Everitt, Teresa Ferrari, Christine Bouffard, Jirir Frohlich, Gordon Francis, John Mancini, Gregory Bondy, Debbie DeAngelis, Patricia Fulton, David W. Blank, Angela Lombardo, Mylène Roy, Jackie Chow, Hyman Fox, William J. Grootendorst, Angela Hutchinson, Sharon M. Chan, Christie Fitzgerald, Lynn Wilkins, Rebecca L. Raymond, Arlene Reyes, Lavoie Marc André, Denis Fortin, Hélène Ouimet, Thanh-Thao Tôn-Nu, Martine Dussureault, Marie-Hélène Blain, Madeleine Roy, Nathalie Kopajko, Chantal Fleury, Karine Maheux, Gabriela Valentina Ciobotaru, Maria C. Constantinescu, Carmen-Lucia Gherghinescu, Ana-Maria Avram, Ioan Manitiu, Aura Sinpetrean, Lucian Pop, Delia Lupu, Radu Usvat, Ana Petrisor, Nicoleta Dumitru, Camelia Moruju, Adelina Gheorghita, Magda V. Mitu, Cosmin Macarie, Ana Maria Pop, Maria-Catalina Diaconu, Iulia Grancea, Mihaela Cosma, Mihaela Crisan, Elizabeth Herron, Paul Nestel, Sally B. Kay, Kaye S. Carter, Imran Badshah, Ashley Makepeace, Jocelyn Drinkwater, Michelle England, Azette Rafei, Kylie Patterson, Alicia Jenkins, Sybil McAuley, Sue M. Kent, Joy E. Vibert, Leonie Perrett, Thomas David, Samantha L. Kaye, Monika O’Connor, Nimalie J. Perera, Nicole T. Lai, Kerry A. Kearins, Christinia Dicamillo, Heather Anderson, Louise Ferguson, Sharon D. Radtke, Charles T. Thamarappillil, Janice M. Boys, Anita K. Long, Toni Shanahan, Michael Nyguyen, Nicole Forrest, Gill Tulloch, Della Greenwell, Sarah L. Price, Aye N. Tint, Priya K. Sumithran, Tamara L. Debreceni, Lisa Walker, Mary Caruana, Kira Edwards, Maria Stathopoulos, Cilla Haywood, Dimitar Sajkov, Sharen Pringle, Anne Tabner, Kathrina Bartolay, Chamindi Abeyratne, Kylie Bragg, Patrick Mulhern, Peter Purnell, Lyn Williams, Jane Hamlyn, Aurelia Connelly, Jan Hoffman, Samantha Bailey, Jane Kerr, Zarnia Morrison, Sarah Maeder, Roberta McEwan, Prasanna Kunasekera, Patrice McGregor, Jo Young, Sharon Berry, Rick Cutfield, Michelle Choe, Catherine McNamara, Narrinder K. Shergill, Petra Crone, Miles G. Williams, Keith Dyson, Diana H. Schmid, Audrey C. Doak, Melissa Spooner, Colin Edwards, Anne Turner, Grainne M. McAnnalley, Raewyn A. Fisher, Fraser B. Hamilton, Denis H. Friedlander, Melissa R. Kirk, Jayne E. Scales, Marguerite A. McLelland, Neelam A. Dalman, Cathy E. Vickers, Carolyn Jackson, Wendy Coleman, Phillip I. Garden, and Wendy F. Arnold
Subjects: Male, medicine.medical_specialty, Rate ratio, Double-Blind Method, Ischemia, Risk Factors, Physiology (medical), Internal medicine, medicine, Clinical endpoint, Humans, Myocardial infarction, Coronary Artery Bypass, Stroke, Aged, business.industry, Unstable angina, Hazard ratio, Absolute risk reduction, Middle Aged, medicine.disease, Eicosapentaenoic Acid, Number needed to treat, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract: Background: Despite advances in surgery and pharmacotherapy, there remains significant residual ischemic risk after coronary artery bypass grafting surgery. Methods: In REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl–Intervention Trial), a multicenter, placebo-controlled, double-blind trial, statin-treated patients with controlled low-density lipoprotein cholesterol and mild to moderate hypertriglyceridemia were randomized to 4 g daily of icosapent ethyl or placebo. They experienced a 25% reduction in risk of a primary efficacy end point (composite of cardiovascular death, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina) and a 26% reduction in risk of a key secondary efficacy end point (composite of cardiovascular death, myocardial infarction, or stroke) when compared with placebo. The current analysis reports on the subgroup of patients from the trial with a history of coronary artery bypass grafting. Results: Of the 8179 patients randomized in REDUCE-IT, a total of 1837 (22.5%) had a history of coronary artery bypass grafting, with 897 patients randomized to icosapent ethyl and 940 to placebo. Baseline characteristics were similar between treatment groups. Randomization to icosapent ethyl was associated with a significant reduction in the primary end point (hazard ratio [HR], 0.76 [95% CI, 0.63–0.92]; P =0.004), in the key secondary end point (HR, 0.69 [95% CI, 0.56–0.87]; P =0.001), and in total (first plus subsequent or recurrent) ischemic events (rate ratio, 0.64 [95% CI, 0.50–0.81]; P =0.0002) compared with placebo. This yielded an absolute risk reduction of 6.2% (95% CI, 2.3%–10.2%) in first events, with a number needed to treat of 16 (95% CI, 10–44) during a median follow-up time of 4.8 years. Safety findings were similar to the overall study: beyond an increased rate of atrial fibrillation/flutter requiring hospitalization for at least 24 hours (5.0% vs 3.1%; P =0.03) and a nonsignificant increase in bleeding, occurrences of adverse events were comparable between groups. Conclusions: In REDUCE-IT patients with a history of coronary artery bypass grafting, treatment with icosapent ethyl was associated with significant reductions in first and recurrent ischemic events. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01492361.
Published: 2021

21. Mammals part 3

Author: S. E. Johnson, S. R. Tecot, F. B. Ralainasolo, J. H Ratsimbazafy, D. J Overdorff, G. Donati, C. L Tan, J. A. Norosoarinaivo, R. M. Randrianarison, T Mutschler, M. L. Sauther, F. P. Cuozzo, N. Vasey, A. L. Baden, J. H. Ratsimbazafy, G Donati, I. Norscia, M. Balestri, A. Zaramody, E. E. Louis, U. Thalmann, M Gamba, V. Torti, J. Powzyk, L. Miaretsoa, C. Giacoma, R. R. Lawler, A. F. Richard, E. J. Sterling, T. Sefczek, G. Perry, J. N. Rakotondrazandry, F. Ravelomandrato, D Gerber, C. E. Hawkins, K. Rivera, Z. J. Farris, F. J. Kerridge, S. M Goodman, A Murphy, V Andrianjakarivelo, M. D Carleton, and S. A. Jansa
Published: 2022

22. MR Defecating Proctography with Emphasis on Posterior Compartment Disorders

Author: Jonathan W. Revels, Bahar Mansoori, Shaimaa Fadl, Sherry S. Wang, Michael C. Olson, Shamus K. Moran, Martha F. Terrazas, Joel G. Fletcher, William R. G. Perry, Victoria Chernyak, and Achille Mileto
Subjects: Radiologists, Humans, Radiology, Nuclear Medicine and imaging, Pelvic Floor, Magnetic Resonance Imaging, Physical Examination, Defecography
Abstract: MR defecating proctography (MRDP) is a noninvasive examination that can be used for evaluating posterior compartment disorders. MRDP has several advantages over conventional fluoroscopic defecography. These benefits include high-contrast resolution evaluation of the deep pelvic organs, simultaneous multicompartmental assessment that is performed statically and dynamically during defecation, and lack of ionizing radiation. MRDP also provides a highly detailed anatomic evaluation of the pelvic floor supportive structures, including direct assessment of the pelvic floor musculature and indirect assessment of the endopelvic fascia. As the breadth of knowledge regarding anatomic and functional posterior compartment disorders expands, so too does the advancement of noninvasive and surgical treatment options for these conditions. High-quality MRDP examinations, with key anatomic and functional features reported, guide treatment planning. Reporting of MRDP examination findings with use of standardized terminology that emphasizes objective measurements rather than subjective grading aids consistent communication among radiologists, clinicians, and surgeons. Familiarity with commonly encountered posterior compartment pelvic floor pathologic entities that contribute to posterior compartment disorders and awareness of the essential information needed by surgeons are key to providing an optimal multidisciplinary discussion for planning pelvic floor dysfunction treatment. The authors provide an overview of the basic concepts of the MRDP acquisition technique, the anatomic abnormalities of posterior compartment pelvic floor pathologic entities associated with defecatory disorders, and recently developed interdisciplinary MRDP reporting templates and lexicons. In addition, the associated imaging findings that are key for surgical treatment guidance are highlighted.
Published: 2022

23. Models combining multiple scales of inference capture hydrologic and climatic drivers of riparian tree distributions

Author: Laura G. Perry, Catherine S. Jarnevich, and Patrick B. Shafroth
Subjects: Ecology, Ecology, Evolution, Behavior and Systematics
Published: 2022

24. Biting mechanics and niche separation in a specialized clade of primate seed predators.

Author: Justin A Ledogar, Theodora H Y Luk, Jonathan M G Perry, Dimitri Neaux, and Stephen Wroe
Subjects: Medicine, Science
Abstract: We analyzed feeding biomechanics in pitheciine monkeys (Pithecia, Chiropotes, Cacajao), a clade that specializes on hard-husked unripe fruit (sclerocarpy) and resistant seeds (seed predation). We tested the hypothesis that pitheciine crania are well-suited to generate and withstand forceful canine and molar biting, with the prediction that they generate bite forces more efficiently and better resist masticatory strains than the closely-related Callicebus, which does not specialize on unripe fruits and/or seeds. We also tested the hypothesis that Callicebus-Pithecia-Chiropotes-Cacajao represent a morphocline of increasing sclerocarpic specialization with respect to biting leverage and craniofacial strength, consistent with anterior dental morphology. We found that pitheciines have higher biting leverage than Callicebus and are generally more resistant to masticatory strain. However, Cacajao was found to experience high strain magnitudes in some facial regions. We therefore found limited support for the morphocline hypothesis, at least with respect to the mechanical performance metrics examined here. Biting leverage in Cacajao was nearly identical (or slightly less than) in Chiropotes and strain magnitudes during canine biting were more likely to follow a Cacajao-Chiropotes-Pithecia trend of increasing strength, in contrast to the proposed morphocline. These results could indicate that bite force efficiency and derived anterior teeth were selected for in pitheciines at the expense of increased strain magnitudes. However, our results for Cacajao potentially reflect reduced feeding competition offered by allopatry with other pitheciines, which allows Cacajao species to choose from a wider variety of fruits at various stages of ripeness, leading to reduction in the selection for robust facial features. We also found that feeding biomechanics in sympatric Pithecia and Chiropotes are consistent with data on food structural properties and observations of dietary niche separation, with the former being well-suited for the regular molar crushing of hard seeds and the latter better adapted for breaching hard fruits.
Published: 2018
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25. Primate body mass and dietary correlates of tooth root surface area

Author: Jonathan M. G. Perry, Adam Hartstone-Rose, Edwin Dickinson, Victoria A. Whichard, Ashley R. Deutsch, Kornelius Kupczik, and Giulia R. Lagomarsino
Subjects: Strepsirrhini, biology, biology.animal, Catarrhini, Primate, Platyrrhini, Allometry, Anatomy, biology.organism_classification, Tooth root surface
Published: 2021

26. DAUBENTONIIDAE

Author: E. J. Sterling, T. Sefczek, G. Perry, J. N. Rakotondrazandry, F. Ravelomandrato, and E. E. Louis
Published: 2022

27. GPU-Accelerated Background Generation Algorithm with Low Latency.

Author: Julius Fabian Ohmer, Peter G. Perry, and Nicholas J. Redding
Published: 2007
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28. Abstract 354: The progression of changes in cardiac structure and function in mice with epithelial ovarian cancer

Author: Bridget Coyle-Asbil, Leslie M. Ogilvie, Madison Pereira, Kathy Matuszewska, Luca J. Delfinis, Shivam Gandhi, Keith R. Brunt, Christopher G. Perry, Jim Petrik, and Jeremy A. Simpson
Subjects: Cancer Research, Oncology
Abstract: Introduction: Cancer cachexia, characterized by the progressive loss of muscle mass (i.e., atrophy), has a significant impact on patient prognosis and quality of life. While skeletal muscle atrophy and weakness are well characterized in cancer patients, the progression of cancer-induced cardiac atrophy has received little attention. Preliminary work from our lab has shown that cardiac dysfunction, measured by invasive hemodynamic assessment, precedes the development of metastatic disease in a mouse model of epithelial ovarian cancer (EOC). Yet, the time course of changes in cardiac structure and function throughout the progression of ovarian cancer remain unknown. Thus, we non-invasively assessed changes in cardiac structure and function through the progression of EOC. Methods: To investigate the impact of advanced ovarian cancer on cardiac structure and function, we used an orthotopic, syngeneic mouse model of EOC. This model was generated by injecting transformed murine ovarian surface epithelial cells (ID8; 1.0 × 106) or saline (surgical sham) directly under the ovarian bursa of syngeneic mice. Echocardiography was used to assess changes in cardiac structure and function throughout the progression of EOC at days 45, 60, 75, and 90 post-tumor induction (PTI). Morphometric assessments at each timepoint were used to determine the presence of cardiac atrophy. Results: Echocardiography showed that EOC mice had preserved left ventricular (LV) function (i.e., ejection fraction) with no change in structural dimensions at days 45, 60 and 75 PTI. By day 90 PTI, LV wall thickness and end-systolic dimension decreased, suggesting evidence of cardiac atrophy. Consistent with echocardiographic data, morphometric assessment showed profound atrophy at 90 days PTI, but preserved cardiac mass at all other timepoints compared to shams. Conclusion: Together, this work demonstrates that when non-invasive techniques are used to measure changes in cardiac structure, atrophy is not evident until advanced stage ovarian cancer (i.e., 90 days PTI). Despite this, preliminary work from our lab has shown that cardiac dysfunction is present in EOC mice by 45 days PTI when assessed by invasive hemodynamics. Although echocardiography is a widely used technique for measuring indices of cardiac structure and function, our work demonstrates it lacks sensitivity to detect cardiac deficits until the overt stages of disease that accompany cancer cachexia. Thus, it is important to consider that subclinical cardiac dysfunction may exist in the early stages of cancer progression, however, these changes may go undetected unless more sensitive hemodynamic assessments are employed. Citation Format: Bridget Coyle-Asbil, Leslie M. Ogilvie, Madison Pereira, Kathy Matuszewska, Luca J. Delfinis, Shivam Gandhi, Keith R. Brunt, Christopher G. Perry, Jim Petrik, Jeremy A. Simpson. The progression of changes in cardiac structure and function in mice with epithelial ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 354.
Published: 2023

29. Abstract 4248: Epithelial ovarian cancer causes cardiac dysfunction and myofilament dysregulation

Author: Leslie M. Ogilvie, Madison Pereira, Kathy Matuszewska, Bridget Coyle-Asbil, Luca J. Delfinis, Shivam Gandhi, Keith R. Brunt, Christopher G. Perry, W. Glen Pyle, Jim Petrik, and Jeremy A. Simpson
Subjects: Cancer Research, Oncology
Abstract: Introduction: The intersections between cancer and cardiovascular disease (CVD) have become increasingly relevant in the care of both patient populations. To date, the cardio-oncology field has largely focused on how cancer treatment influences long-term cardiac health. Indeed, many cancer therapeutics show various toxic effects to the cardiovascular system. However, studies have also shown cardiac deficits in therapy-naïve cancer patients. This suggests that these two disease states interact through similar signaling pathways, yet the mechanisms underlying cancer-induced cardiac dysfunction remain unknown. Thus, we investigated cardiac structure and function throughout the progression of epithelial ovarian cancer (EOC). Methods: We used an orthotopic, syngeneic mouse model of ovarian cancer. Briefly, transformed murine ovarian surface epithelial cells from C57BL/6 mice (ID8; 1.0 × 106), or saline for surgical controls, were injected under the ovarian bursa of syngeneic mice. In this model, 60 days after tumor induction, mice form large ovarian masses, numerous peritoneal lesions, and develop abdominal ascites - consistent with the clinical features of stage III (advanced) EOC. To determine whether cardiac abnormalities precede the presence of advanced disease, at 45 days post-tumor induction, mice were anesthetized, and left ventricular (LV) structure and function were assessed by echocardiography and invasive hemodynamics, respectively. Myofilament activity was measured with an actomyosin MgATPase assay and protein phosphorylation was determined by SDS-PAGE with Pro-Q Diamond phosphoprotein staining. Results: EOC mice showed systolic (i.e., reduced contraction rate) and diastolic dysfunction (i.e., reduced relaxation rate, elevated diastolic filling pressure), with no evidence of hypertrophy or atrophy (i.e., no change in LV wall thickness or dimension). While there were no observed differences in myofilament ATPase activity, phosphorylation of regulatory myosin light chain 2 (MYL2) and cardiac myosin binding protein C (cMyBP-C) decreased, and tropomyosin (Tpm) phosphorylation increased in EOC mice. Conclusion: Together, these data demonstrate that ovarian cancer impairs cardiac function and alters the regulation of myofilament proteins critical for contraction and relaxation. Interestingly, the observed dephosphorylation of MYL2 and cMyBP-C and hyperphosphorylation of Tpm are consistent with features of heart failure. The findings build upon our current understanding of the interactions between cancer and CVD and show that deficits in the heart precede the development of advanced malignancy. Future work further will investigate the tumor-heart axis to identify how tumor development disrupts normal cardiac physiology. Citation Format: Leslie M. Ogilvie, Madison Pereira, Kathy Matuszewska, Bridget Coyle-Asbil, Luca J. Delfinis, Shivam Gandhi, Keith R. Brunt, Christopher G. Perry, W. Glen Pyle, Jim Petrik, Jeremy A. Simpson. Epithelial ovarian cancer causes cardiac dysfunction and myofilament dysregulation. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4248.
Published: 2023

30. Functional Impairment Is Associated with Poor Outcomes after Arteriovenous Access Creation

Author: Scott R. Levin, Alik Farber, Elizabeth G. King, Alan G. Perry, Thomas W. Cheng, and Jeffrey J. Siracuse
Subjects: Surgery, Cardiology and Cardiovascular Medicine
Published: 2023

31. Market-Based Resource Allocation for Information-Collection Scenarios.

Author: Shih-Fen Cheng, Michael P. Wellman, and Dennis G. Perry
Published: 2003
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32. Fast Segmentation of Large Images.

Author: David J. Crisp, Peter G. Perry, and Nicholas J. Redding
Published: 2003

33. Dispersion at the edges of near road noise barriers

Author: L.H. Brouwer, Akula Venkatram, David Heist, and Steven G. Perry
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Geometry, 010501 environmental sciences, Atmospheric dispersion modeling, Edge (geometry), 01 natural sciences, Pollution, Line source, Article, Plume, Environmental science, Dispersion (water waves), Waste Management and Disposal, Noise barrier, 0105 earth and related environmental sciences, Crosswind, Wind tunnel
Abstract: This paper presents an analysis of data from a wind tunnel study conducted to examine the dispersion of emissions at the edges of near-road noise barriers. The study is motivated by the concern that a barrier positioned downwind of a roadway may guide highly polluted plumes along the barrier leading to heightened concentrations as the plume spills around and downwind of the barrier end. The wind tunnel database consists of measurements of dispersion around a simulated roadway segment with various noise barrier configurations. Each roadway segment simulated in the wind tunnel had full-scale equivalent dimensions of 135 m long. Barrier segments, 135 m long with a height (H) of 6 m, were located on the downwind side of the source at a distance of 18 m from it (measured perpendicularly from the line source). Examination of the concentration patterns associated with the cases indicates that 1) vertical mixing induced by barriers persists at crosswind distances up to the edge (lateral end) of the barrier and downwind distances of x/H = 10, 2) concentration levels at all heights below z/H = 1 increase towards the edge of the barrier at downwind distances less than x/H = 7, and 3) concentration is well mixed in the vertical at the edge of the barrier, and the levels can be higher than in the middle of the barrier even when the source ends at the edge of the barrier. We have formulated a parameterization that captures the major features of these observations and can be incorporated in models such as RLINE.
Published: 2021

34. RF09 | PSAT70 Comparison of Prednisolone Versus Modified-release Hydrocortisone (Efmody) in the Treatment of Congenital Adrenal Hyperplasia (CAH)

Author: Deborah P Merke, Ashwini Mallappa, Wiebke Arlt, Aude Brac De La Perriere, Angelica Linden Hirschberg, Anders Juul, John D C Newell-Price, Colin G Perry, Alessandro Prete, Aled Rees, Nicole Reisch, Monica Stikkelbroeck, Philippe A Touraine, Helen J Coope, John Porter, and Richard J Ross
Subjects: Endocrinology, Diabetes and Metabolism
Abstract: Background Prednisolone and prednisone have a longer plasma elimination half-life after oral administration than hydrocortisone: 2.1 to 3.5 vs ∼1.5hrs1,2. For this reason, prednis(ol)one has been used in Congenital Adrenal Hyperplasia (CAH) by giving a dose in the evening to try to prevent the overnight rise in adrenal androgens. Modified-release hydrocortisone (MRHC) capsules, (Efmody, Diurnal Ltd, Cardiff UK), replicate the cortisol diurnal rhythm and improve the control of CAH compared to standard glucocorticoid therapy3. This post-hoc sub-analysis examines CAH control in MRHC treated patients switched from prednis(ol)one. Methods We reviewed the data of all patients taking prednis(ol)one in the randomised study of standard treatment versus MRHC3: 39 classic CAH patients on prednis(ol)one (alone or combined with hydrocortisone) (36 prednisolone; 3 prednisone) were randomised either to continue prednis(ol)one or switched to MRHC at the same hydrocortisone dose equivalent (HDE=prednisolone dose x5). Patients were assessed after 4 weeks following which blinded dose titration according to 17OHP and A4 control was performed to bring 17OHP into the optimal range ( Results Median baseline dose (HDE) was 30mg (n=39), androgen control was 56%. In patients randomised to MRHC (n=18), 39% were controlled at baseline and 94% at 4 weeks without dose adjustment. At 24 weeks, after androgen-control guided titration, the HDE dose in the prednis(ol)one group was 34mg, and in the MRHC group 27.5mg, with control being 71% and 94%, respectively. Percentage inhibition of 9am 17OHP from the levels at baseline to that at 24 weeks in the prednis(ol)one group was 32% and in the MRHC group 91%. In this study period there were no adrenal crises in the MRHC group and one in the prednis(ol)one group. MRHC-treated patients in the extension study were further titrated according to clinician assessment, at interim analysis the median MRHC dose was 20mg (median reduction 10mg) and 82% of patients were controlled at 18 months (n=28). In the ongoing extension study of all patients on MRHC (221 patient years), there were 12 adrenal crises in 5 patients (5.4/100 patient years). Conclusions Control of CAH is better on MRHC than prednisolone: 94% vs 39%; and the dose of MRHC can be down titrated to an adrenal replacement dose whilst maintaining control in the majority (82%) of patients. References 1. Pickup ME. Clin Pharmacokinet 1979 4 111-128; 2. Toothaker RD. J Pharm Sci 1982 71 573-576; 3. Merke DP. JCEM 2021 106 e2063-e2077. Presentation: Saturday, June 11, 2022 1:00 p.m. - 1:05 p.m., Saturday, June 11, 2022 1:00 p.m. - 3:00 p.m.
Published: 2022

35. Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: Evidence from population sample stratified for polygenic risk

Author: S I Dimitriadis, G Perry, T M Lancaster, K E Tansey, K D Singh, P Holmans, A Pocklington, G Davey Smith, S Zammit, J Hall, M C O’Donovan, M J Owen, D K Jones, D E Linden, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: MHeNs - R2 - Mental Health, School for Mental Health & Neuroscience, and RS: MHeNs - R3 - Neuroscience
Subjects: semi-metric percentage, ABNORMALITIES, CEREBRAL ASYMMETRY, DISORDERS, LANGUAGE LATERALIZATION, ORIGIN, SCORES, Cognitive Neuroscience, CINGULUM, tractography, DIFFUSION, structural brain networks, schizophrenia, Cellular and Molecular Neuroscience, Avon Longitudinal Study of Parents and Children (ALSPAC), AGE, genetic risk for schizophrenia, brain connectomics, diffusion magnetic resonance imaging (dMRI), Bristol Population Health Science Institute
Abstract: Research studies based on tractography have revealed a prominent reduction of asymmetry in some key white-matter tracts in schizophrenia (SCZ). However, we know little about the influence of common genetic risk factors for SCZ on the efficiency of routing on structural brain networks (SBNs). Here, we use a novel recall-by-genotype approach, where we sample young adults from a population-based cohort (ALSPAC:N genotyped = 8,365) based on their burden of common SCZ risk alleles as defined by polygenic risk score (PRS). We compared 181 individuals at extremes of low (N = 91) or high (N = 90) SCZ-PRS under a robust diffusion MRI-based graph theoretical SBN framework. We applied a semi-metric analysis revealing higher SMR values for the high SCZ-PRS group compared with the low SCZ-PRS group in the left hemisphere. Furthermore, a hemispheric asymmetry index showed a higher leftward preponderance of indirect connections for the high SCZ-PRS group compared with the low SCZ-PRS group (PFDR
Published: 2022

36. Cerebral autoregulation across the menstrual cycle in eumenorrheic women

Author: Stephanie Korad, Toby Mündel, Jui‐Lin Fan, and Blake G. Perry
Subjects: Adult, Male, Middle Cerebral Artery, Young Adult, Estradiol, Physiology, Cerebrovascular Circulation, Physiology (medical), Homeostasis, Humans, Female, Menstrual Cycle
Abstract: There is emerging evidence that ovarian hormones play a significant role in the lower stroke incidence observed in pre-menopausal women compared with men. However, the role of ovarian hormones in cerebrovascular regulation remains to be elucidated. We examined the blood pressure-cerebral blood flow relationship (cerebral autoregulation) across the menstrual cycle in eumenorrheic women (n = 12; mean ± SD: age, 31 ± 7 years). Participants completed sit-to-stand and Valsalva maneuvers (VM, mouth pressure of 40 mmHg for 15 s) during the early follicular (EF), late follicular (LF), and mid-luteal (ML) menstrual cycle phases, confirmed by serum measurement of progesterone and 17β-estradiol. Middle cerebral artery blood velocity (MCAv), arterial blood pressure and partial pressure of end-tidal carbon dioxide were measured. Cerebral autoregulation was assessed by transfer function analysis during spontaneous blood pressure oscillations, rate of regulation (RoR) during sit-to-stand maneuvers, and Tieck's autoregulatory index during VM phases II and IV (AI-II and AI-IV, respectively). Resting mean MCAv (MCAv
Published: 2022

37. Alcohol Consumption and Misuse Among Patients with Respiratory Failure Before and During the COVID-19 Pandemic

Author: G. Perry, C. Higgins, J. McKeehan, J. Gaydos, S.E. Jolley, and E.L. Burnham
Published: 2022

38. The

Author: Andrew J, Zhao, Julia, Montes-Laing, Wick M G, Perry, Mari, Shiratori, Emily, Merfeld, Stephen L, Rogers, and Derek A, Applewhite
Subjects: Mammals, Cytoskeletal Proteins, Focal Adhesions, Cell Movement, Microfilament Proteins, Animals, Drosophila Proteins, Drosophila, Microtubules, Actins, Zebrafish
Abstract: The spectraplakin family of proteins includes ACF7/MACF1 and BPAG1/dystonin in mammals, VAB-10 in
Published: 2022

39. NF-κB inhibitor, NEMO-binding domain peptide attenuates intervertebral disc degeneration

Author: Linda E.A. Kanim, Michael A. Kropf, Juliane D. Glaeser, Tiffany G. Perry, Jason M. Cuellar, Dmitriy Sheyn, Zachary NaPier, Khosrowdad Salehi, and Hyun W. Bae
Subjects: medicine.medical_treatment, Inflammation, Context (language use), Intervertebral Disc Degeneration, Article, Fibrin, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, In vivo, medicine, Animals, Humans, Orthopedics and Sports Medicine, Viability assay, Intervertebral Disc, 030222 orthopedics, biology, business.industry, NF-kappa B, Intervertebral disc, Rats, Cell biology, medicine.anatomical_structure, Cytokine, biology.protein, Surgery, Neurology (clinical), medicine.symptom, Peptides, business, 030217 neurology & neurosurgery
Abstract: BACKGROUND CONTEXT Nonphysiological mechanical loading and inflammation are both critically involved in intervertebral disc (IVD) degeneration, which is characterized by an increase in cytokines and matrix metalloproteases (MMPs) in the nucleus pulposus (NP). This process is known to be mediated by the NF-κB pathway. CLINICAL SIGNIFICANCE Current clinical treatments for IVD degeneration focus on the alleviation of symptoms rather than targeting the underlying mechanism. Injection of an NF-κB inhibitor may attenuate the progression of IVD degeneration. PURPOSE To investigate the ability of the NF-κB inhibitor, NEMO binding domain peptide (NBD), to alter IVD degeneration processes by reducing IL-1β- and mechanically-induced cytokine and MMP levels in human nucleus pulposus cells in vitro, and by attenuating IVD degeneration in an in vivo rat model for disc degeneration. STUDY DESIGN Experimental in vitro and animal model. PATIENT SAMPLE Discarded specimens of lumbar disc from 21 patients, and 12 Sprague Dawley rats. OUTCOME MEASURES Gene and protein expression, cell viability, µMRI and histology. METHODS IL-1β-prestimulated human nucleus pulposus cells embedded into fibrin constructs were loaded in the Flexcell FX-5000 compression system at 5 kPa and 1 Hz for 48 hours in the presence and absence of NBD. Unloaded hNPC/fibrin constructs served as controls. Cell viability in loaded and unloaded constructs was quantified, and gene and protein expression levels determined. For in vivo testing, a rat needle disc puncture model was employed. Experimental groups included injured discs with and without NBD injection and uninjured controls. Levels of disc degeneration were determined via µMRI, qPCR and histology. Funding sources include $48,874 NASS Young Investigator Research Grant and $119,174 NIH 5K01AR071512-02. There were no applicable financial relationships or conflicts of interest. RESULTS Mechanical compression of hNPC/fibrin constructs resulted in upregulation of MMP-3 and IL-8. Supplementation of media with 10 μM NBD during loading increased cell viability, and decreased MMP-3 gene and protein levels. IVD injury in rat resulted in an increase in MMP-3, IL-1β and IL-6 gene expression. Injections of 250 µg of NBD during disc injury resulted in decreased IL-6 gene expression. µMRI analysis demonstrated a reduction of disc hydration in response to disc needle injury, which was attenuated in NBD-treated IVDs. Histological evaluation showed NP and AF lesion in injured discs, which was attenuated by NBD injection. CONCLUSIONS The results of this study show NBD peptide's capacity to reduce IL-1β- and loading-induced MMP-3 levels in hNPC/fibrin constructs while increasing the cells’ viability, and to attenuate IVD degeneration in rat, involving downregulation of IL-6. Therefore, NBD may be a potential therapeutic agent to treat IVD degeneration.
Published: 2020

40. A Household Survey to Evaluate Access to Surgical Care in Vanuatu

Author: N. Bunkley, Anna J Dare, Ian P. Bissett, M. Buka, J. Bong, B Leodoro, and W R G Perry
Subjects: Adult, Male, Rural Population, Demographics, Psychological intervention, Health Services Accessibility, 03 medical and health sciences, Household survey, 0302 clinical medicine, Vanuatu, Surveys and Questionnaires, Environmental health, Humans, Medicine, Family Characteristics, business.industry, Surgical care, Census, Access port, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Surgery, business, Delivery of Health Care, Inclusion (education), Healthcare system
Abstract: Surgical care is an integral part of any healthcare system, yet there is a paucity of data on the burden of surgical disease, surgical capacity and access to surgical services in the Pacific region. This study aimed to evaluate access to surgical care through a pilot household survey in the Vanuatu island of Efate and five of its surrounding islands. The 2009 Vanuatu census’ GPS coordinates were used to randomly select 150 rural and 150 urban households from Efate and its surrounding islands. A total of 143 urban households and 142 rural households were available for inclusion in this study. A household questionnaire was developed to evaluate access to surgical care and included information regarding household demographics, socio-economic indicators and perceived and realised barriers to accessing care. The questionnaire was administered by local health workers, and data were collected electronically. Questionnaires were completed by 285 households. Two hundred and forty-one out of 254 (94.8%) households reported being able to access Port Vila Hospital, if required. The most commonly cited potential barriers to accessing surgical care were financial constraints (42.4%) and transport (26.4%). Our results provide important insights into the geographic, sociocultural and economic barriers to seeking, reaching and receiving surgical care in this region of Vanuatu. Identifying specific areas and communities with poor access to care, alongside the determinants of access, will help in designing both clinical and policy interventions to improve access to surgical care.
Published: 2020

41. Axion Dark Matter Experiment: Detailed design and operations

Author: R. Khatiwada, D. Bowring, A. S. Chou, A. Sonnenschein, W. Wester, D. V. Mitchell, T. Braine, C. Bartram, R. Cervantes, N. Crisosto, N. Du, L. J. Rosenberg, G. Rybka, J. Yang, D. Will, S. Kimes, G. Carosi, N. Woollett, S. Durham, L. D. Duffy, R. Bradley, C. Boutan, M. Jones, B. H. LaRoque, N. S. Oblath, M. S. Taubman, J. Tedeschi, John Clarke, A. Dove, A. Hashim, I. Siddiqi, N. Stevenson, A. Eddins, S. R. O’Kelley, S. Nawaz, A. Agrawal, A. V. Dixit, J. R. Gleason, S. Jois, P. Sikivie, N. S. Sullivan, D. B. Tanner, J. A. Solomon, E. Lentz, E. J. Daw, M. G. Perry, J. H. Buckley, P. M. Harrington, E. A. Henriksen, K. W. Murch, and G. C. Hilton
Subjects: Quantum Physics, High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Astrophysics - Instrumentation and Methods for Astrophysics, Quantum Physics (quant-ph), Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), High Energy Physics - Experiment
Abstract: Axion Dark Matter eXperiment (ADMX) ultra low noise haloscope technology has enabled the successful completion of two science runs (1A and 1B) that looked for dark matter axions in the $2.66$ to $3.1$ $\mu$eV mass range with Dine-Fischler-Srednicki-Zhitnisky (DFSZ) sensitivity Ref. [1,2]. Therefore, it is the most sensitive axion search experiment to date in this mass range. We discuss the technological advances made in the last several years to achieve this sensitivity, which includes the implementation of components, such as state-of-the-art quantum limited amplifiers and a dilution refrigerator. Furthermore, we demonstrate the use of a frequency tunable Microstrip Superconducting Quantum Interference Device (SQUID) Amplifier (MSA), in Run 1A, and a Josephson Parametric Amplifier (JPA), in Run 1B, along with novel analysis tools that characterize the system noise temperature., Comment: 23 pages, 28 figures
Published: 2022

42. Design, construction and operation of the ProtoDUNE-SP Liquid Argon TPC

Author: Abud, A. Abed Abi, B. Acciarri, R. Acero, M. A. Adames, M. R. Adamov, G. Adams, D. Adinolfi, M. Aduszkiewicz, A. and Aguilar, J. Ahmad, Z. Ahmed, J. Ali-Mohammadzadeh, B. and Alion, T. Allison, K. Monsalve, S. Alonso Alrashed, M. and Alt, C. Alton, A. Amedo, P. Anderson, J. and Andreopoulos, C. Andreotti, M. Andrews, M. P. Andrianala, F. and Andringa, S. Anfimov, N. Ankowski, A. Antoniassi, M. and Antonova, M. Antoshkin, A. Antusch, S. Aranda-Fernandez, A. and Ariga, A. Arnold, L. O. Arroyave, M. A. Asaadi, J. and Asquith, L. Aurisano, A. Aushev, V Autiero, D. and Ayala-Torres, M. Azfar, F. Back, A. Back, H. Back, J. J. and Backhouse, C. Baesso, P. Bagaturia, I Bagby, L. and Balashov, N. Balasubramanian, S. Baldi, P. Baller, B. and Bambah, B. Barao, F. Barenboim, G. Barker, G. J. and Barkhouse, W. Barnes, C. Barr, G. Barranco Monarca, J. and Barros, A. Barros, N. Barrow, J. L. Basharina-Freshville, A. and Bashyal, A. Basque, V Belchior, E. Battat, J. B. R. and Battisti, F. Bay, F. Alba, J. L. Bazo Beacom, J. F. and Bechetoille, E. Behera, B. Bellantoni, L. Bellettini, G. and Bellini, V Beltramello, O. Belver, D. Benekos, N. and Montiel, C. Benitez Neves, F. Bento Berger, J. Berkman, S. and Bernardini, P. Berner, R. M. Berns, H. Bertolucci, S. and Betancourt, M. Betancur Rodriguez, A. Bevan, A. Bezerra, T. J. C. Bhattacharjee, M. Bhuller, S. Bhuyan, B. Biagi, S. Bian, J. Biassoni, M. Biery, K. Bilki, B. Bishai, M. Bitadze, A. Blake, A. Blaszczyk, F. D. M. Blazey, G. C. Blucher, E. Boissevain, J. Bolognesi, S. Bolton, T. and Bomben, L. Bonesini, M. Bongrand, M. Bonini, F. and Booth, A. Booth, C. Boran, F. Bordoni, S. Borkum, A. and Boschi, T. Bostan, N. Bour, P. Bourgeois, C. Boyd, S. B. and Boyden, D. Bracinik, J. Braga, D. Brailsford, D. and Branca, A. Brandt, A. Bremer, J. Brew, C. Brianne, E. and Brice, S. J. Brizzolari, C. Bromberg, C. Brooijmans, G. and Brooke, J. Bross, A. Brunetti, G. Brunetti, M. and Buchanan, N. Budd, H. Butorov, I Cagnoli, I Caiulo, D. and Calabrese, R. Calafiura, P. Calcutt, J. Calin, M. and Calvez, S. Calvo, E. Caminata, A. Campanelli, M. and Cankocak, K. Caratelli, D. Carini, G. Carlus, B. and Carneiro, M. F. Carniti, P. Terrazas, I. Caro Carranza, H. and Carroll, T. Casta, J. F. Castillo, A. Castromonte, C. and Catano-Mur, E. Cattadori, C. Cavalier, F. Cavanna, F. and Centro, S. Cerati, G. Cervelli, A. Cervera Villanueva, A. Chalifour, M. Chappell, A. Chardonnet, E. and Charitonidis, N. Chatterjee, A. Chattopadhyay, S. Chen, H. and Chen, K. Chen, M. Chen, Y. Chen, Z. Cheon, Y. and Cherdack, D. Chi, C. Childress, S. Chiriacescu, A. and Chisnall, G. Cho, K. Choate, S. Chokheli, D. Chong, P. S. Choubey, S. Christensen, A. Christian, D. and Christodoulou, G. Chukanov, A. Chung, M. Church, E. and Cicero, V Clarke, P. Coan, T. E. Cocco, A. G. Coelho, J. A. B. Conley, E. Conley, R. Conrad, J. M. Convery, M. and Copello, S. Corwin, L. Valentim, R. Cremaldi, L. and Cremonesi, L. Crespo-Anadon, I, J. Crisler, M. Cristaldo, E. and Cross, R. Cudd, A. Cuesta, C. Cui, Y. Cussans, D. and Dabrowski, M. Dalager, O. da Motta, H. Peres, L. Da Silva David, C. David, Q. Davies, G. S. Davini, S. and Dawson, J. De, K. De Almeida, R. M. Debbins, P. De Bonis, I Decowski, M. P. de Gouvea, A. De Holanda, P. C. and Astiz, I. L. De Icaza Deisting, A. De Jong, P. Delbart, A. and Delepine, D. Delgado, M. Dell'Acqua, A. De Lurgio, P. and de Mello Neto, J. R. T. DeMuth, D. M. Dennis, S. and Densham, C. Deptuch, G. W. De Roeck, A. De Romeri, V De Souza, G. Devi, R. Dharmapalan, R. Dias, M. Diaz, F. and Diaz, J. S. Di Domizio, S. Di Giulio, L. Ding, P. Di Noto, L. Distefano, C. Diurba, R. Diwan, M. Djurcic, Z. and Doering, D. Dolan, S. Dolek, F. Dolinski, M. J. and Domine, L. Douglas, D. Douillet, D. Drake, G. Drielsma, F. Duarte, L. Duchesneau, D. Duffy, K. Dunne, P. and Durkin, T. Duyang, H. Dvornikov, O. Dwyer, D. A. and Dyshkant, A. S. Eads, M. Earle, A. Edmunds, D. Eisch, J. and Emberger, L. Emery, S. Ereditato, A. Erjavec, T. and Escobar, C. O. Eurin, G. Evans, J. J. Ewart, E. Ezeribe, A. C. Fahey, K. Falcone, A. Fani, M. Farnese, C. and Farzan, Y. Fedoseev, D. Felix, J. Feng, Y. and Fernandez-Martinez, E. Fernandez Menendez, P. Fernandez Morales, M. Ferraro, F. Fields, L. Filip, P. Filthaut, F. and Fiorentini, A. Fiorini, M. Fitzpatrick, R. S. Flanagan, W. and Fleming, B. Flight, R. Forero, V, D. Fowler, J. Fox, W. Franc, J. Francis, K. Franco, D. Freeman, J. and Freestone, J. Fried, J. Friedland, A. Robayo, F. Fuentes and Fuess, S. Furic, I Furmanski, A. P. Gabrielli, A. Gago, A. Gallagher, H. Gallas, A. Gallego-Ros, A. Gallice, N. and Galymov, V Gamberini, E. Gamble, T. Ganacim, F. and Gandhi, R. Gandrajula, R. Gao, F. Gao, S. Garcia, A. C. B. Garcia-Gamez, D. Garcia-Peris, M. A. Gardiner, S. and Gastler, D. Gauvreau, J. Ge, G. Gelli, B. Gendotti, A. and Gent, S. Ghorbani-Moghaddam, Z. Giammaria, P. Giammaria, T. Gibin, D. Gil-Botella, I Gilligan, S. Girerd, C. and Giri, A. K. Gnani, D. Gogota, O. Gold, M. Gollapinni, S. and Gollwitzer, K. Gomes, R. A. Gomez Bermeo, V, L. Gomez Fajardo, L. S. Gonnella, F. Gonzalez-Cuevas, J. A. Gonzalez Diaz, D. Gonzalez-Lopez, M. Goodman, M. C. Goodwin, O. and Goswami, S. Gotti, C. Goudzovski, E. Grace, C. Graham, M. Gran, R. Granados, E. Granger, P. Grant, A. and Grant, C. Gratieri, D. Green, P. Greenler, L. Greer, J. and Grenard, J. Griffith, W. C. Groh, M. Grudzinski, J. and Grzelak, K. Gu, W. Guardincerri, E. Guarino, V Guarise, M. Guenette, R. Guerard, E. Guerzoni, M. Guglielmi, A. and Guo, B. Guthikonda, K. K. Gutierrez, R. Guzowski, P. and Guzzo, M. M. Gwon, S. Ha, C. Habig, A. Hadavand, H. and Haenni, R. Hahn, A. Haiston, J. Hamacher-Baumann, P. and Hamernik, T. Hamilton, P. Han, J. Harris, D. A. and Hartnell, J. Harton, J. Hasegawa, T. Hasnip, C. Hatcher, R. Hatfield, K. W. Hatzikoutelis, A. Hayes, C. and Hayrapetyan, K. Hays, J. Hazen, E. He, M. Heavey, A. and Heeger, K. M. Heise, J. Hennessy, K. Henry, S. and Morquecho, M. A. Hernandez Herner, K. Hertel, L. Hewes, J. and Higuera, A. Hill, T. Hillier, S. J. Himmel, A. and Hirsch, L. R. Ho, J. Hoff, J. Holin, A. Hoppe, E. and Horton-Smith, G. A. Hostert, M. Hourlier, A. Howard, B. and Howell, R. Hristova, I Hronek, M. S. Huang, J. Huang, J. and Hugon, J. Iles, G. Ilic, N. Iliescu, A. M. and Illingworth, R. Ingratta, G. Ioannisian, A. Isenhower, L. and Itay, R. Izmaylov, A. Jackson, C. M. Jain, V James, E. Jang, W. Jargowsky, B. Jediny, F. Jena, D. Jeong, Y. S. Jesus-Valls, C. Ji, X. Jiang, L. Jimenez, S. and Jipa, A. Johnson, R. Johnston, N. Jones, B. Jones, S. B. and Judah, M. Jung, C. K. Junk, T. Jwa, Y. Kabirnezhad, M. Kaboth, A. Kadenko, I Kalra, D. Kakorin, I and Kalitkina, A. Kamiya, F. Kaneshige, N. Karagiorgi, G. and Karaman, G. Karcher, A. Karolak, M. Karyotakis, Y. and Kasai, S. Kasetti, S. P. Kashur, L. Kazaryan, N. Kearns, E. Keener, P. Kelly, K. J. Kemp, E. Kemularia, O. and Ketchum, W. Kettell, S. H. Khabibullin, M. Khotjantsev, A. and Khvedelidze, A. Kim, D. King, B. Kirby, B. Kirby, M. and Klein, J. Koehler, K. Koerner, L. W. Kohn, S. and Koller, P. P. Kolupaeva, L. Korablev, D. Kordosky, M. and Kosc, T. Kose, U. Kostelecky, V. A. Kothekar, K. and Krennrich, F. Kreslo, I Kropp, W. Kudenko, Y. and Kudryavtsev, V. A. Kulagin, S. Kumar, J. Kumar, P. and Kunze, P. Kuruppu, C. Kus, V Kutter, T. Kvasnicka, J. and Kwak, D. Lambert, A. Land, B. J. Lande, K. Lane, C. E. Lang, K. Langford, T. Langstaff, M. Larkin, J. and Lasorak, P. Last, D. Lastoria, C. Laundrie, A. Laurenti, G. Lawrence, A. Lazanu, I LaZur, R. Lazzaroni, M. and Le, T. Leardini, S. Learned, J. LeBrun, P. LeCompte, T. and Lee, C. Lee, S. Y. Miotto, G. Lehmann Lehnert, R. de Oliveira, M. A. Leigui Leitner, M. Lepin, L. M. Li, L. and Li, S. W. Li, T. Li, Y. Liao, H. Lin, C. S. Lin, Q. and Lin, S. Ling, J. Lister, A. Littlejohn, B. R. Liu, J. Lockwitz, S. Loew, T. Lokajicek, M. 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Weber, M. Wei, H. Weinstein, A. Wenman, D. Wetstein, M. White, A. and Whitehead, L. H. Whittington, D. Wilking, M. J. Wilkinson, C. Williams, Z. Wilson, F. Wilson, R. J. Wisniewski, W. and Wolcott, J. Wongjirad, T. Wood, A. Wood, K. and Worcester, E. Worcester, M. Wret, C. Wu, W. Wu, W. and Xiao, Y. Xie, F. Yandel, E. Yang, G. Yang, K. Yang, S. Yang, T. Yankelevich, A. Yershov, N. Yonehara, K. and Young, T. Yu, B. Yu, H. Yu, H. Yu, J. Yuan, W. and Zaki, R. Zalesak, J. Zambelli, L. Zamorano, B. Zani, A. and Zazueta, L. Zeller, G. P. Zennamo, J. Zeug, K. and Zhang, C. Zhao, M. Zhivun, E. Zhu, G. Zilberman, P. and Zimmerman, E. D. Zito, M. Zucchelli, S. Zuklin, J. and Zutshi, V Zwaska, R. DUNE Collaboration
Abstract: The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 x 6 x 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful operation between 2018 and 2020 demonstrates the effectiveness of the single-phase far detector design. This paper describes the design, construction, assembly and operation of the detector components.
Published: 2022

43. Invasion of Siberian Elm (Ulmus pumila) Along the South Platte River: the Roles of Seed Source, Human Influence, and River Geomorphology

Author: Lindsay V. Reynolds, Laura G. Perry, Patrick B. Shafroth, Gabrielle Katz, and Andrew Norton
Subjects: Ecology, Environmental Chemistry, General Environmental Science
Published: 2022

44. Erratum to: Measurement of exclusive Υ photoproduction from protons in pPb collisions at s NN = 5.02 TeV (The European Physical Journal C, (2019), 79, 3, (277), 10.1140/epjc/s10052-019-6774-8)

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Woods, N. CMS Collaboration
Abstract: In this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected. © CERN for the benefit of the CMS collaboration 2022.
Published: 2022

45. Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at root s(NN)=5.02 TeV

Author: Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Dragicevic, M. Ero, J. Del Valle, A. Escalante and Flechl, M. Fruhwirth, R. Jeitler, M. Krammer, N. and Kratschmer, I Liko, D. Madlener, T. Mikulec, I Rad, N. and Schieck, J. Schofbeck, R. Spanring, M. Waltenberger, W. and Wulz, C-E Zarucki, M. Drugakov, V Mossolov, V and Gonzalez, J. Suarez Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. Kello, T. Lelek, A. Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. Van Mechelen, P. Van Putte, S. and Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. and D'Hondt, J. De Clercq, J. Lontkovskyi, D. Lowette, S. and Marchesini, I Moortgat, S. Python, Q. Tavernier, S. and Van Doninck, W. Van Mulders, P. Beghin, D. Bilin, B. and Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. and Favart, L. Grebenyuk, A. Kalsi, A. K. Moureaux, L. and Popov, A. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. Cornelis, T. Dobur, D. Khvastunov, I Niedziela, M. Roskas, C. Skovpen, K. and Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. and Giammanco, A. Lemaitre, V Prisciandaro, J. Saggio, A. and Vischia, P. Zobec, J. Alves, G. A. Silva, G. Correia and Hensel, C. Moraes, A. Batista Das Chagas, E. Belchior and Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. and Da Silveira, G. G. Damiao, D. De Jesus Martins, C. De Oliveira and De Souza, S. Fonseca Malbouisson, H. Martins, J. and Figueiredo, D. Matos Jaime, M. Medina De Almeida, M. Melo and Herrera, C. Mora Mundim, L. Nogima, H. Prado Da Silva, W. L. and Teles, P. Rebello Rosas, L. J. Sanchez Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Da Silva De Araujo, F. Torres Pereira, A. Vilela Bernardes, C. A. and Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. and Lemos, D. S. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. Iaydjiev, P. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. and Bonchev, M. Dimitrov, A. Ivanov, T. Litov, L. Pavlov, B. and Petkov, P. Petrov, A. Fang, W. Gao, X. Yuan, L. and Ahmad, M. Hu, Z. Wang, Y. Chen, G. M. Chen, H. S. and Chen, M. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. and Spiezia, A. Tao, J. Yazgan, E. Zhang, H. Zhang, S. and Zhao, J. Agapitos, A. Ban, Y. Chen, G. Levin, A. Li, J. Li, L. Li, Q. Mao, Y. Qian, S. J. Wang, D. and Wang, Q. Xiao, M. Avila, C. Cabrera, A. Florez, C. and Gonzalez Hernandez, C. F. Segura Delgado, M. A. Mejia Guisao, J. and Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Vanegas Arbelaez, N. Godinovic, N. Lelas, D. Puljak, I Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V Ferencek, D. and Kadija, K. Mesic, B. Roguljic, M. Starodumov, A. and Susa, T. Ather, M. W. Attikis, A. Erodotou, E. Ioannou, A. Kolosova, M. Konstantinou, S. Mavromanolakis, G. and Mousa, J. Nicolaou, C. Ptochos, F. Razis, P. A. and Rykaczewski, H. Saka, H. Tsiakkouri, D. 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Ghiasi Hanson, G. Karapostoli, G. Long, O. R. Manganelli, N. Negrete, M. Olmedo Paneva, I, M. Si, W. Wimpenny, S. Yates, B. R. Zhang, Y. and Branson, J. G. Chang, P. Cittolin, S. Cooperstein, S. and Deelen, N. Derdzinski, M. Duarte, J. Gerosa, R. Gilbert, D. Hashemi, B. Klein, D. Krutelyov, V Letts, J. and Masciovecchio, M. May, S. Padhi, S. Pieri, M. Sharma, V and Tadel, M. Wurthwein, F. Yagil, A. Della Porta, G. Zevi and Amin, N. Bhandari, R. Campagnari, C. Citron, M. and Dutta, V Incandela, J. Marsh, B. Mei, H. Ovcharova, A. and Qu, H. Richman, J. Sarica, U. Stuart, D. Wang, S. and Anderson, D. Bornheim, A. Cerri, O. Dutta, I and Lawhorn, J. M. Lu, N. Mao, J. Newman, H. B. Nguyen, T. Q. Pata, J. Spiropulu, M. Vlimant, J. R. Xie, S. and Zhang, Z. Zhu, R. Y. Alison, J. Andrews, M. B. Ferguson, T. Mudholkar, T. Paulini, M. Sun, M. Vorobiev, I and Weinberg, M. Cumalat, J. P. Ford, W. T. MacDonald, E. and Mulholland, T. Patel, R. Perloff, A. Stenson, K. Ulmer, K. A. Wagner, S. R. Alexander, J. Cheng, Y. Chu, J. and Datta, A. Frankenthal, A. Mcdermott, K. Patterson, J. R. and Quach, D. Ryd, A. Tan, S. M. Tao, Z. Thom, J. and Wittich, P. Zientek, M. Abdullin, S. Albrow, M. Alyari, M. Apollinari, G. Apresyan, A. Apyan, A. Banerjee, S. and Bauerdick, L. A. T. Beretvas, A. Berry, D. Berryhill, J. and Bhat, P. C. Burkett, K. Butler, J. N. Canepa, A. and Cerati, G. B. Cheung, H. W. K. Chlebana, F. Cremonesi, M. and Elvira, V. D. Freeman, J. Gecse, Z. Gottschalk, E. and Gray, L. Green, D. Grunendahl, S. Gutsche, O. Hanlon, J. and Harris, R. M. Hasegawa, S. Heller, R. Hirschauer, J. and Jayatilaka, B. Jindariani, S. Johnson, M. Joshi, U. and Klijnsma, T. Klima, B. Kortelainen, M. J. Kreis, B. and Lammel, S. Lewis, J. Lincoln, D. Lipton, R. Liu, M. and Liu, T. Lykken, J. Maeshima, K. Marraffino, J. M. Mason, D. McBride, P. Merkel, P. Mrenna, S. Nahn, S. and O'Dell, V Papadimitriou, V Pedro, K. Pena, C. Ravera, F. and Hall, A. Reinsvold Ristori, L. Schneider, B. and Sexton-Kennedy, E. Smith, N. Soha, A. Spalding, W. J. and Spiegel, L. Stoynev, S. Strait, J. Taylor, L. Tkaczyk, S. Tran, V, N. Uplegger, L. Vaandering, E. W. Vidal, R. and Wang, M. Weber, H. A. Woodard, A. Acosta, D. Avery, P. Bourilkov, D. Cadamuro, L. Cherepanov, V Errico, F. and Field, R. D. Guerrero, D. Joshi, B. M. Kim, M. and Konigsberg, J. Korytov, A. Lo, K. H. Matchev, K. and Menendez, N. Mitselmakher, G. Rosenzweig, D. Shi, K. and Wang, J. Wang, S. Zuo, X. Joshi, Y. R. Adams, T. and Askew, A. Hagopian, S. Hagopian, V Johnson, K. F. and Khurana, R. Kolberg, T. Martinez, G. Perry, T. Prosper, H. Schiber, C. Yohay, R. Zhang, J. Baarmand, M. M. and Hohlmann, M. Noonan, D. Rahmani, M. Saunders, M. and Yumiceva, F. Adams, M. R. Apanasevich, L. Betts, R. R. and Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, O. Gerber, C. E. Hangal, D. A. Hofman, D. J. Kumar, V Mills, C. and Oh, G. Roy, T. Tonjes, M. B. Varelas, N. Viinikainen, J. and Wang, H. Wang, X. Wu, Z. Alhusseini, M. Bilki, B. and Dilsiz, K. Durgut, S. Gandrajula, R. P. Haytmyradov, M. and Khristenko, V Koseyan, O. K. Merlo, J-P Mestvirishvili, A. Moeller, A. Nachtman, J. Ogul, H. Onel, Y. Ozok, F. Penzo, A. Snyder, C. Tiras, E. Wetzel, J. Yi, K. and Blumenfeld, B. Cocoros, A. Eminizer, N. Gritsan, V, A. and Hung, W. T. Kyriacou, S. Maksimovic, P. Mantilla, C. and Roskes, J. Swartz, M. Vami, T. A. Barrera, C. Baldenegro and Baringer, P. Bean, A. Boren, S. Bylinkin, A. Isidori, T. and Khalil, S. King, J. Krintiras, G. Kropivnitskaya, A. and Lindsey, C. Majumder, D. Mcbrayer, W. Minafra, N. and Murray, M. Rogan, C. Royon, C. Sanders, S. Schmitz, E. and Takaki, J. D. Tapia Wang, Q. Williams, J. Wilson, G. and Duric, S. Ivanov, A. Kaadze, K. Kim, D. Maravin, Y. and Mendis, D. R. Mitchell, T. Modak, A. Mohammadi, A. and Rebassoo, F. Wright, D. Baden, A. Baron, O. Belloni, A. and Eno, S. C. Feng, Y. Hadley, N. J. Jabeen, S. Jeng, G. Y. Kellogg, R. G. Mignerey, A. C. Nabili, S. Seidel, M. Skuja, A. Tonwar, S. C. Wang, L. Wong, K. and Abercrombie, D. Allen, B. Bi, R. Brandt, S. Busza, W. and Cali, I. A. D'Alfonso, M. Ceballos, G. Gomez Goncharov, M. Harris, P. Hsu, D. Hu, M. Klute, M. Kovalskyi, D. and Lee, Y-J Luckey, P. D. Maier, B. Marini, A. C. and Mcginn, C. Mironov, C. Narayanan, S. Niu, X. Paus, C. and Rankin, D. Roland, C. Roland, G. Shi, Z. Stephans, G. S. F. Sumorok, K. Tatar, K. Velicanu, D. Wang, J. and Wang, T. W. Wyslouch, B. Chatterjee, R. M. Evans, A. and Guts, S. Hansen, P. Hiltbrand, J. Jain, Sh Kubota, Y. and Lesko, Z. Mans, J. Revering, M. Rusack, R. Saradhy, R. Schroeder, N. Strobbe, N. Wadud, M. A. Acosta, J. G. and Oliveros, S. Bloom, K. Chauhan, S. Claes, D. R. and Fangmeier, C. Finco, L. Golf, F. Kamalieddin, R. and Kravchenko, I Siado, J. E. Snow, G. R. Stieger, B. Tabb, W. Agarwal, G. Harrington, C. Iashvili, I. Kharchilava, A. McLean, C. Nguyen, D. Parker, A. Pekkanen, J. and Rappoccio, S. Roozbahani, B. Alverson, G. Barberis, E. and Freer, C. Haddad, Y. Hortiangtham, A. Madigan, G. and Marzocchi, B. Morse, D. M. Nguyen, V Orimoto, T. and Skinnari, L. Tishelman-Charny, A. Wamorkar, T. Wang, B. and Wisecarver, A. Wood, D. Bhattacharya, S. Bueghly, J. and Fedi, G. Gilbert, A. Gunter, T. Hahn, K. A. Odell, N. and Schmitt, M. H. Sung, K. Velasco, M. Bucci, R. Dev, N. Goldouzian, R. Hildreth, M. Anampa, K. Hurtado and Jessop, C. Karmgard, D. J. Lannon, K. Li, W. Loukas, N. and Marinelli, N. Mcalister, I Meng, F. Musienko, Y. and Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. Wayne, M. and Wightman, A. Wolf, M. Alimena, J. Bylsma, B. and Cardwell, B. Durkin, L. S. Francis, B. Hill, C. Ji, W. and Lefeld, A. Ling, T. Y. Winer, B. L. Dezoort, G. and Elmer, P. Hardenbrook, J. Haubrich, N. Higginbotham, S. and Kalogeropoulos, A. Kwan, S. Lange, D. Lucchini, M. T. and Luo, J. Marlow, D. Mei, K. Ojalvo, I Olsen, J. and Palmer, C. Piroue, P. Stickland, D. Tully, C. Malik, S. and Norberg, S. Barker, A. Barnes, V. E. Chawla, R. Das, S. Gutay, L. Jones, M. Jung, A. W. Mahakud, B. and Miller, D. H. Negro, G. Neumeister, N. Peng, C. C. and Piperov, S. Qiu, H. Schulte, J. F. Trevisani, N. Wang, F. Xiao, R. Xie, W. Cheng, T. Dolen, J. Parashar, N. and Baty, A. Behrens, U. Dildick, S. Ecklund, K. M. and Freed, S. Geurts, F. J. M. Kilpatrick, M. Kumar, Arun and Li, W. Padley, B. P. Redjimi, R. Roberts, J. Rorie, J. and Shi, W. Leiton, A. G. Stahl Tu, Z. Zhang, A. Bodek, A. de Barbaro, P. Demina, R. Dulemba, J. L. Fallon, C. and Ferbel, T. Galanti, M. Garcia-Bellido, A. Hindrichs, O. and Khukhunaishvili, A. Ranken, E. Taus, R. Chiarito, B. and Chou, J. P. Gandrakota, A. Gershtein, Y. Halkiadakis, E. and Hart, A. Heindl, M. Hughes, E. Kaplan, S. Laflotte, I and Lath, A. Montalvo, R. Nash, K. Osherson, M. Salur, S. Schnetzer, S. Somalwar, S. Stone, R. Thomas, S. and Acharya, H. Delannoy, A. G. Spanier, S. Bouhali, O. and Dalchenko, M. De Mattia, M. Delgado, A. Eusebi, R. and Gilmore, J. Huang, T. Kamon, T. Kim, H. Luo, S. and Malhotra, S. Marley, D. Mueller, R. Overton, D. Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. and De Guio, F. Hegde, V Kunori, S. Lamichhane, K. Lee, S. W. Mengke, T. Muthumuni, S. Peltola, T. Undleeb, S. and Volobouev, I Wang, Z. Whitbeck, A. Greene, S. Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. Ni, H. and Padeken, K. Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. and Cummings, G. Hakala, J. Hirosky, R. Joyce, M. Ledovskoy, A. Neu, C. Tannenwald, B. Wang, Y. Wolfe, E. Xia, F. and Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. and Thapa, P. Black, K. Bose, T. Buchanan, J. Caillol, C. and Carlsmith, D. Dasu, S. De Bruyn, I Dodd, L. Galloni, C. He, H. Herndon, M. Herve, A. Hussain, U. Lanaro, A. Loeliger, A. Loveless, R. Sreekala, J. Madhusudanan and Mallampalli, A. Pinna, D. Ruggles, T. Savin, A. Sharma, V Smith, W. H. Teague, D. Trembath-reichert, S. CMS Collaboration
Subjects: High Energy Physics::Experiment
Abstract: The first evidence for X(3872) production in relativistic heavy ion collisions is reported. The X(3872) production is studied in lead-lead (Pb-Pb) collisions at a center-of-mass energy of root s(NN) = 5.02 TeV per nucleon pair, using the decay chain X(3872) -> J/psi pi(+)pi(-) -> mu(+) mu(-) pi(+)pi(-). The data were recorded with the CMS detector in 2018 and correspond to an integrated luminosity of 1.7 nb(-1). The measurement is performed in the rapidity and transverse momentum ranges vertical bar y vertical bar < 1.6 and 15 < p(T) < 50 GeV/c. The significance of the inclusive X(3872) signal is 4.2 standard deviations. The prompt X(3872) to psi 2S yield ratio is found to be rho(Pb-Pb) = 1.08 +/- 0.49(stat) +/- 0.52(syst), to be compared with typical values of 0.1 for pp collisions. This result provides a unique experimental input to theoretical models of the X(3872) production mechanism, and of the nature of this exotic state.
Published: 2022

46. Perioperative Complications Following Spine Surgery in Adult Patients with Achondroplasia

Author: Julie L. Chan, Miguel D. Quintero-Consuegra, Linda E.A. Kanim, Michael A. Kropf, Robert Bernstein, Tiffany G. Perry, Corey T. Walker, Moise Danielpour, and Alexander Tuchman
Subjects: Orthopedics and Sports Medicine, Surgery, Neurology (clinical)
Abstract: Study Design Retrospective cohort study Objectives To describe the common types of complications and their risk factors during spine surgery in patients with achondroplasia. Methods A retrospective review was performed of medical records of adult achondroplasia patients who underwent spine surgery at our institution between 2007 and 2021. Inclusion criteria were achondroplasia and age >16 years. Surgical encounters were evaluated for durotomy, postoperative neurologic deficit, wound compromise, medical complications, and return to the operating room. Statistical analysis included evaluation of relationships across complications and fisher exact test applied to bivariate/categorical variables and t-test/ANOVA for continuous variables. Multivariable analysis using logistic regression was performed to account for patient characteristics Results Fifty-five patients with achondroplasia underwent 95 surgeries. Forty-nine percent of the surgeries involved a complication. These included durotomy (33.7%), neurologic deficit (11.6%), wound compromise (6.3%), and other medical complications (6.3%). Thirteen percent of surgeries required return to the operating room. The greatest number of complications occurred in thoracolumbar region (60.0%) compared to cervicothoracic (18.2%) and craniocervical junction (33.3%). Chronologically later surgical encounters had decreased complications and durotomies only occurred in thoracolumbar surgeries (45.7%). Conclusions Adult patients with achondroplasia undergoing surgery chronologically later in this set of consecutive patients were at a decreased risk for complications. Thoracolumbar surgeries were at the greatest risk for durotomies. Male sex was a risk factor for durotomy, while age was a risk factor for neurologic deficit. The potential for adverse surgical events should be considered when evaluating patients with achondroplasia for spine surgery.
Published: 2023

47. CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding

Author: Benjamin G. Perry, Rommie E. Amaro, Claudia R. Gordijo, Cora Scholten, Andrew R. Leach, Alexander Hillisch, Kristina Edfeldt, Johanna M. Jansen, Uta Lessel, Gerhard F. Ecker, Rima Al-awar, Matthieu Schapira, Daniel Kuhn, Masoud Vedadi, John D. Chodera, Suzanne Ackloo, Ian Dunham, Robert A. Batey, Wendy D. Cornell, Ingo Muegge, Ulrich A. K. Betz, Hatylas Azevedo, Cristian Bologa, Yoshua Bengio, Kumar Singh Saikatendu, Timothy M. Willson, Aled M. Edwards, Vijayaratnam Santhakumar, John Moult, Alpha A. Lee, Patrick Riley, Michael K. Gilson, Matthew H. Todd, Gerhard Hessler, Cheryl H. Arrowsmith, Andrea Volkamer, Tudor I. Oprea, Anders Hogner, and John J. Irwin
Subjects: Public–private partnership, Open science, Development (topology), Computer science, Drug discovery, Critical assessment, Relevance (information retrieval), Benchmarking, Cache, Data science
Abstract: Computational approaches in drug discovery and development hold great promise, with artificial intelligence methods undergoing widespread contemporary use, but the experimental validation of these new approaches is frequently inadequate. We are initiating Critical Assessment of Computational Hit-finding Experiments (CACHE) as a public benchmarking project that aims to accelerate the development of small molecule hit-finding algorithms by competitive assessment. Compounds will be identified by participants using a wide range of computational methods for dozens of protein targets selected for different types of prediction scenarios, as well as for their potential biological or pharmaceutical relevance. Community-generated predictions will be tested centrally and rigorously in an experimental hub(s), and all data, including the chemical structures of experimentally tested compounds, will be made publicly available without restrictions. The ability of a range of computational approaches to find novel compounds will be evaluated, compared, and published. The overarching goal of CACHE is to accelerate the development of computational chemistry methods by providing rapid and unbiased feedback to those developing methods, with an ancillary and valuable benefit of identifying new compound-protein binding pairs for biologically interesting targets. The initiative builds on the power of crowd sourcing and expands the open science paradigm for drug discovery.
Published: 2021

48. CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding

Author: Suzanne Ackloo, Rima Al-awar, Rommie E. Amaro, Cheryl H. Arrowsmith, Hatylas Azevedo, Robert A. Batey, Yoshua Bengio, Ulrich A.K. Betz, Cristian G. Bologa, John D. Chodera, Wendy D. Cornell, Ian Dunham, Gerhard F. Ecker, Kristina Edfeldt, Aled M. Edwards, Michael K. Gilson, Claudia R. Gordijo, Gerhard Hessler, Alexander Hillisch, Anders Hogner, John J. Irwin, Johanna M. Jansen, Daniel Kuhn, Andrew R. Leach, Alpha A. Lee, Uta Lessel, John Moult, Ingo Muegge, Tudor I. Oprea, Benjamin G. Perry, Patrick Riley, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Matthieu Schapira, Cora Scholten, Matthew H. Todd, Masoud Vedadi, Andrea Volkamer, and Timothy M. Willson
Subjects: public-private partnership, machine learning, in silico design, CACHE, open science, small molecule drug discovery, artificial intelligence, computational chemistry, hit-finding challenges
Abstract: Computational approaches in drug discovery and development hold great promise, with artificial intelligence methods undergoing widespread contemporary use, but the experimental validation of these new approaches is frequently inadequate. We are initiating Critical Assessment of Computational Hit-finding Experiments (CACHE) as a public benchmarking project that aims to accelerate the development of small molecule hit-finding algorithms by competitive assessment. Compounds will be identified by participants using a wide range of computational methods for dozens of protein targets selected for different types of prediction scenarios, as well as for their potential biological or pharmaceutical relevance. Community-generated predictions will be tested centrally and rigorously in an experimental hub(s), and all data, including the chemical structures of experimentally tested compounds, will be made publicly available without restrictions. The ability of a range of computational approaches to find novel compounds will be evaluated, compared, and published. The overarching goal of CACHE is to accelerate the development of computational chemistry methods by providing rapid and unbiased feedback to those developing methods, with an ancillary and valuable benefit of identifying new compound-protein binding pairs for biologically interesting targets. The initiative builds on the power of crowd sourcing and expands the open science paradigm for drug discovery., ACKNOWLEDGEMENTS The Structural Genomics Consortium is a registered charity (no: 1097737) that receives funds from Bayer AG, Boehringer Ingelheim, Bristol Myers Squibb, Genentech, Genome Canada through Ontario Genomics Institute [OGI-196], Janssen, Merck KGaA (aka EMD in Canada and US), Pfizer, Takeda and the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875510. The JU receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and Ontario Institute for Cancer Research, Royal Institution for the Advancement of Learning McGill University, Kungliga Tekniska Hoegskolan, Diamond Light Source Limited. This communication reflects the views of the authors and the JU is not liable for any use that may be made of the information contained herein. M. K. Gilson acknowledges funding from National Institute of General Medical Sciences (GM061300). J. J. Irwin acknowledges funding from National Institute of General Medical Sciences (GM133836). These findings are solely of the authors and do not necessarily represent the views of the NIH. The Lee laboratory at the University of Cambridge receives funding from multiple sources, including Pfizer, AstraZeneca, the Engineering and Physical Sciences Research Council and the Winton Programme for the Physics of Sustainability. T.I. Oprea and C. G. Bologa acknowledge funding from the National Institutes of Health Common Fund program, Illuminating the Druggable Genome (CA224370 and TR002278). COMPETING INTERESTS M. K. Gilson has an equity interest in and is a cofounder and scientific advisor of VeraChem LLC. J. J. Irwin is a co-founder of Blue Dolphin LLC, which undertakes fee-for-service ligand discovery. A.A. Lee is the chief scientific officer and a shareholder of PostEra Inc. T. I. Oprea has received honoraria from or consulted for Abbott, AstraZeneca, Chiron, Genentech, Infinity Pharmaceuticals, Merz Pharmaceuticals, Merck Darmstadt, Mitsubishi Tanabe, Novartis, Ono Pharmaceuticals, Pfizer, Roche, Sanofi and Wyeth, and is on the Scientific Advisory Board of ChemDiv and InSilico Medicine.
Published: 2021

49. Directional sensitivity of the cerebral pressure-flow relationship in young healthy individuals trained in endurance and resistance exercise

Author: Marc‐Antoine Roy, Lawrence Labrecque, Blake G. Perry, Stephanie Korad, Jonathan D. Smirl, and Patrice Brassard
Subjects: Middle Cerebral Artery, Nutrition and Dietetics, Physiology, Physiology (medical), Cerebrovascular Circulation, Humans, Blood Pressure, Resistance Training, General Medicine, Exercise, Blood Flow Velocity
Abstract: What is the central question of this study? Does habitual exercise modality affect the directionality of the cerebral pressure-flow relationship? What is the main finding and its importance? These data suggest the hysteresis-like pattern of dynamic cerebral autoregulation appears present in long-term sedentary and endurance-trained individuals, but absent in resistance-trained individuals. This is the first study to expand knowledge on the directional sensitivity of the cerebral pressure-flow relationship to trained populations.Evidence suggests the cerebrovasculature may be more efficient at dampening cerebral blood flow (CBF) variations when mean arterial pressure (MAP) transiently increases, compared to when it decreases. Despite divergent MAP and CBF responses to acute endurance and resistance training, the long-term impact of habitual exercise modality on the directionality of dynamic cerebral autoregulation (dCA) is currently unknown. Thirty-six young healthy participants (sedentary (n = 12), endurance-trained (n = 12), and resistance-trained (n = 12)) undertook a 5-min repeated squat-stand protocol at two forced MAP oscillation frequencies (0.05 and 0.10 Hz). Middle cerebral artery mean blood velocity (MCAv) and MAP were continuously monitored. We calculated absolute (ΔMCAv
Published: 2021

50. Dark Matter Axion Search Using a Josephson Traveling Wave Parametric Amplifier

Author: C. Bartram, T. Braine, R. Cervantes, N. Crisosto, N. Du, G. Leum, P. Mohapatra, T. Nitta, L. J. Rosenberg, G. Rybka, J. Yang, John Clarke, I. Siddiqi, A. Agrawal, A. V. Dixit, M. H. Awida, A. S. Chou, M. Hollister, S. Knirck, A. Sonnenschein, W. Wester, J. R. Gleason, A. T. Hipp, S. Jois, P. Sikivie, N. S. Sullivan, D. B. Tanner, E. Lentz, R. Khatiwada, G. Carosi, C. Cisneros, N. Robertson, N. Woollett, L. D. Duffy, C. Boutan, M. Jones, B. H. LaRoque, N. S. Oblath, M. S. Taubman, E. J. Daw, M. G. Perry, J. H. Buckley, C. Gaikwad, J. Hoffman, K. Murch, M. Goryachev, B. T. McAllister, A. Quiskamp, C. Thomson, M. E. Tobar, V. Bolkhovsky, G. Calusine, W. Oliver, and K. Serniak
Subjects: High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), High Energy Physics - Experiment
Abstract: We describe the first implementation of a Josephson Traveling Wave Parametric Amplifier (JTWPA) in an axion dark matter search. The operation of the JTWPA for a period of about two weeks achieved sensitivity to axion-like particle dark matter with axion–photon couplings above 10−13 Ge V−1 over a narrow range of axion masses centered around 19.84 µeV by tuning the resonant frequency of the cavity over the frequency range of 4796.7–4799.5 MHz. The JTWPA was operated in the insert of the axion dark matter experiment as part of an independent receiver chain that was attached to a 0.56-l cavity. The ability of the JTWPA to deliver high gain over a wide (3 GHz) bandwidth has engendered interest from those aiming to perform broadband axion searches, a longstanding goal in this field.
Published: 2021

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