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101 results on '"Duan, Lingyan"'

34. COF‐based single Li+ solid electrolyte accelerates the ion diffusion and restrains dendrite growth in quasi‐solid‐state organic batteries.

Author

Zhao, Genfu, Mei, Zhiyuan, Duan, Lingyan, An, Qi, Yang, Yongxin, Zhang, Conghui, Tan, Xiaoping, and Guo, Hong

Abstract

A solid‐state electrolyte (SSE), which is a solid ionic conductor and electron‐insulating material, is known to play a crucial role in adapting a lithium metal anode to a high‐capacity cathode in a solid‐state battery. Among the various SSEs, the single Li‐ion conductor has advantages in terms of enhancing the ion conductivity, eliminating interfacial side reactions, and broadening the electrochemical window. Covalent organic frameworks (COFs) are optimal platforms for achieving single Li‐ion conduction behavior because of well‐ordered one‐dimensional channels and precise chemical modification features. Herein, we study in depth three types of Li‐carboxylate COFs (denoted LiOOC‐COFn, n = 1, 2, and 3) as single Li‐ion conducting SSEs. Benefiting from well‐ordered directional ion channels, the single Li‐ion conductor LiOOC‐COF3 shows an exceptional ion conductivity of 1.36 × 10−5 S cm−1 at room temperature and a high transference number of 0.91. Moreover, it shows excellent electrochemical performance with long‐term cycling, high‐capacity output, and no dendrites in the quasi‐solid‐state organic battery, with the organic small molecule cyclohexanehexone (C6O6) as the cathode and the Li metal as the anode, and enables effectively avoiding dissolution of the organic electrode by the liquid electrolyte. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Inhibition of p62-Keap1-Nrf2 Pathway Activation by Realgar Promotes the Inhibition of Esophageal Cancer Cell Proliferation, Migration, and Ferroptosis

Author

Zhang, Xiaolan, Yang, Ruyi, Wang, Hongbin, Cao, Changxia, Zhao, Wenling, Duan, Lingyan, and Chen, Fazhang

Abstract

Background: Realgar, a Chinese herbal decoction, has been used to treat various types of tumors with positive outcomes; however, there is a lack of convincing evidence on its use for the treatment of esophageal cancer (EC). In this study, the role of the p62-Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the regulation of EC cell proliferation, migration, and ferroptosis in response to realgar was assessed. Methods: Different concentrations of realgar (0, 10, 20, 40, 60, 80, and 100 μmol/L) were applied to the EC cell lines Eca109 and KYSE150. The inhibition rate and half-inhibitory concentration (IC50) were determined using the Cell Counting Kit-8 (CCK-8) method. Subsequently, the cells were treated with realgar (1/2IC50, IC50, 2IC50). Cell migration was measured using the scratch assay, and cell invasion was measured using the transwell assay. The mRNA expression of p62, Keap1, and Nrf2 was measured by quantitative real-time polymerase chain reaction (qRT-PCR), and the protein expression of p62, Keap1, Nrf2, matrix metalloproteinase (MMP)-2, MMP-9, E-cadherin, Slug, N-cadherin, and vimentin was measured by Western blot. The control, 2IC50, shRNA-NC, shRNA-p62, 2IC50 + shRNA-NC, 2IC50 + shRNA-p62, shRNA-Keap1, 2IC50 + shRNA-Keap1, and 2IC50 + shRNA-p62 + shRNA-Keap1 groups were defined. The CCK-8 method was used to measure the cell inhibition rate, and the clone formation assay was used to measure the clone formation ability. Moreover, the scratch assay was used to detect the cell migration ability, and the transwell assay was used to detect the cell invasion ability. Transmission electron microscopy was used to observe the mitochondrial morphology, Prussian blue staining was used to observe the intracellular iron particle distribution, and flow cytometry was used to detect changes in intracellular reactive oxygen species. In addition, qRT-PCR was performed to detect p62, Keap1, Nrf2, and glutathione peroxidase 4 (GPX4) mRNA expression, and Western blot was performed to detect p62, Keap1, Nrf2, E-cadherin, Slug, N-cadherin, and GPX4 protein expression. Results: Realgar inhibited Eca109 and KYSE150 cell proliferation in a time- and concentrationdependent manner. It also significantly inhibited the migration and invasion of Eca109 and KYSE150 cells and affected the mRNA and protein expression of p62, Keap1, and Nrf2. In response to realgar, low p62 expression inhibited the proliferation, migration, and invasion of Eca109 and KYSE150 cells, as well as ferroptosis induction. Conclusion: The findings demonstrate that inhibiting the p62-Keap1-Nrf2 signaling pathway promotes the inhibitory effects of realgar on EC cells.

Published
2023
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38. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis

Author

Yu, Yingying, primary, Jiang, Li, additional, Wang, Hao, additional, Shen, Zhe, additional, Cheng, Qi, additional, Zhang, Pan, additional, Wang, Jiaming, additional, Wu, Qian, additional, Fang, Xuexian, additional, Duan, Lingyan, additional, Wang, Shufen, additional, Wang, Kai, additional, An, Peng, additional, Shao, Tuo, additional, Chung, Raymond T., additional, Zheng, Shusen, additional, Min, Junxia, additional, and Wang, Fudi, additional

Published
2020
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40. Extrusion-based manufacturing and structural engineering for highly sensitive piezoresistive strain sensors : a fundamental study

Author

Duan, Lingyan, Cardon, Ludwig, and D'hooge, Dagmar

Subjects
Technology and Engineering
Abstract

Flexibele en rekbare sensoren worden bestudeerd voor potentiele toepassingen zoals draagbare elektronica. Een eenvoudige synthese van dit type sensoren met hoge gevoeligheid, zonder hysterese en lange tijdsstabiliteit die bovendien gemakkelijk schaalbaar is, is stil uitdagend. Dit doctoraatsonderzoek focust zich daarom op het ontwikkelen van een eenvoudige en effectieve methode om hoge-prestatie pi?zoresistieve reksensoren te vervaardigen met schaalbare en kost-effici?nte verwerkingstechnieken. Conventionele extrusie en laser direct writing technieken gecombineerd met transferprocessen werden in het onderzoek ingezet. Rekening houdend met verwerkingsmethodes en materialen werden verschillende hi?rarchische structuren voor het aanpassen van elektromechanische eigenschappen ontwikkeld; met name hoofdzakelijk gevoeligheid (gekwantificeerd door vervormingsfactor), werkingsgebied en dynamisch hysteresis gedrag. Het extruderen van een polymeerblend bestaande uit meerdere fasen (TPU/OCB) resulteerde in een unieke co-continue structuur met een selectieve distributie van CB. Een lagere concentratie CB was vereist voor percolatievorming en een verhoogde gevoeligheid werd aangetoond. Laser induced graphene (LIG) is een recent ontwikkelde methode om grafeen te vormen op een koolstofrijke precursor. In dit werk werd gebruik gemaakt van CO2 laser graveren om een 3D poreuze grafeenlaag op het oppervlak van een PI-film te vormen, dit onder omgevingscondities. De laserparameters werden aangepast om de kwaliteit van het grafeen te verbereren (oppervlaktestructuur en elektrische eigenschappen).

Published
2019

47. Constructing nano spinel phase and Li+ conductive network to enhance the electrochemical stability of ultrahigh-Ni cathode.

Author

Huang, Wenjin, Sun, Yongjiang, Zhao, Guiquan, Liu, Qing, Zhao, Genfu, Duan, Lingyan, An, Qi, Ren, Futong, Sun, Mengjiao, Xia, Shubiao, and Guo, Hong

Subjects
*PHASE transitions, *UNIT cell, *STRUCTURAL stability, *OXIDATION states, *TITANIUM dioxide, *TUNGSTEN
Abstract

A novel integrated strategy is proposed to construct the LiNi 0.9 Co 0.09 W 0.01 O 2 with simultaneous spinel phase and Li 2 TiO 3 conductive network, which can enhance the lithium-ion migration kinetics and structural stability of ultrahigh-Ni cathode materials. [Display omitted] The tungsten with high oxidation states (W6+) had been proved to effectively improve the electrochemical performance of ultrahigh-nickel (Ni ≥ 90 %) cathode materials due to the unique microstructures. However, the exat location and underlying action mechanism of tungsten are still not well-understood, and there have been no reports on in-situ modification from bulk to surface simultaneously for these novel cathode materials. Here, a novel integrated strategy is proposed for in-situ modification of LiNi 0.9 Co 0.09 W 0.01 O 2 (NCW). Innovatively, the introduction of nano spinel phase and titanium pinned into the lattice further suppresses the anisotropic variation of unit cell and promotes the lithium-ion migration kinetics within the bulk. Additionally, the Li 2 TiO 3 conductive network enhances migration kinetics across interface and protects the active material against electrolyte erosion. Furthermore, the combination of in-situ analysis and DFT calculation reveals the ordered distribution of tungsten and the suppression effects of titanium on phase transition and cobalt redox. Consequently, the titanium-modified NCW exhibits significantly improved electrochemical performance, such as capacity retention of 93.0 % at 1C after 500 cycles in pouch-type full-cell, along with stable lattice oxygen during operation. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Efficient design of piezoresistive sensors based on carbon black conductive composites

Author

Duan, Lingyan, Spoerk, Martin, Cornillie, P., Xiang, Hao, Zhang, J., Ludwig Cardon, and Dagmar R. D'hooge

Subjects
Technology and Engineering
Abstract

Flexible and stretchable sensors are widely investigated taking into account their potential for wearable electronics, such as electronic skin, healthcare monitoring, human-machine interfaces, and soft robotics. In this contribution, highly sensitive conductive polymer composites (CPCs) for piezoresistive sensing are summarized, considering a straightforward manufacturing process based on extrusion of thermoplastic polyurethane (TPU) and/or olefin block copolymer (OBC), carbon black (CB), and additionally polyethylene-octene elastomer (POE) grafted with maleic anhydride (POE-g-MA). The design of the formulation variables is successfully performed to enable both low and high strain sensing, as highlighted by both static and dynamic testing.

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