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Your search keyword '"Dreyer, Rachel P."' showing total 409 results
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409 results on '"Dreyer, Rachel P."'

3. Whole Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized with Early-Onset Myocardial Infarction

Author

Khera, Amit V, Chaffin, Mark, Zekavat, Seyedeh M, Collins, Ryan L, Roselli, Carolina, Natarajan, Pradeep, Lichtman, Judith H, D'Onofrio, Gail, Mattera, Jennifer, Dreyer, Rachel, Spertus, John A, Taylor, Kent D, Psaty, Bruce M, Rich, Stephen S, Post, Wendy, Gupta, Namrata, Gabriel, Stacey, Lander, Eric, Ida Chen, Yii-Der, Talkowski, Michael E, Rotter, Jerome I, Krumholz, Harlan M, and Kathiresan, Sekar

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Health Sciences, Clinical Sciences, Sports Science and Exercise, Genetics, Clinical Research, Atherosclerosis, Human Genome, Prevention, Digestive Diseases, Heart Disease, Heart Disease - Coronary Heart Disease, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Aged, Cholesterol, LDL, Female, Genetic Predisposition to Disease, Genome, Human, Humans, Hyperlipoproteinemia Type II, Male, Middle Aged, Multifactorial Inheritance, Myocardial Infarction, Whole Genome Sequencing, genetics, humans, hypercholesterolemia, myocardial infarction, risk, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Abstract

BackgroundThe relative prevalence and clinical importance of monogenic mutations related to familial hypercholesterolemia and of high polygenic score (cumulative impact of many common variants) pathways for early-onset myocardial infarction remain uncertain. Whole-genome sequencing enables simultaneous ascertainment of both monogenic mutations and polygenic score for each individual.MethodsWe performed deep-coverage whole-genome sequencing of 2081 patients from 4 racial subgroups hospitalized in the United States with early-onset myocardial infarction (age ≤55 years) recruited with a 2:1 female-to-male enrollment design. We compared these genomes with those of 3761 population-based control subjects. We first identified individuals with a rare, monogenic mutation related to familial hypercholesterolemia. Second, we calculated a recently developed polygenic score of 6.6 million common DNA variants to quantify the cumulative susceptibility conferred by common variants. We defined high polygenic score as the top 5% of the control distribution because this cutoff has previously been shown to confer similar risk to that of familial hypercholesterolemia mutations.ResultsThe mean age of the 2081 patients presenting with early-onset myocardial infarction was 48 years, and 66% were female. A familial hypercholesterolemia mutation was present in 36 of these patients (1.7%) and was associated with a 3.8-fold (95% CI, 2.1-6.8; P3-fold increased odds of early-onset myocardial infarction. However, high polygenic score has a 10-fold higher prevalence among patients presents with early-onset myocardial infarction.Clinical trial registrationURL: https://www.clinicaltrials.gov . Unique identifier: NCT00597922.

Published
2019

9. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P., additional, Li, Fan, additional, Spatz, Erica S., additional, Caraballo, César, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C., additional, Lu, Yuan, additional, Krumholz, Harlan M., additional, Spertus, John A., additional, D’Onofrio, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H., additional

Published
2024
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12. Impact of Marital Stress on 1‐Year Health Outcomes Among Young Adults With Acute Myocardial Infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P., additional, Li, Fan, additional, Spatz, Erica S., additional, Caraballo‐Cordovez, César, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C., additional, Lu, Yuan, additional, Krumholz, Harlan M., additional, Spertus, John A., additional, D'Onofrio, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H., additional

Published
2023
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14. Comparison of Electrocardiographic Characteristics in Men Versus Women ≤ 55 Years With Acute Myocardial Infarction (a Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients Substudy)

Author

Barrabés, José A., Gupta, Aakriti, Porta-Sánchez, Andreu, Strait, Kelly M., Acosta-Vélez, J. Gabriel, D'Onofrio, Gail, Lidón, Rosa-Maria, Geda, Mary, Dreyer, Rachel P., Lorenze, Nancy P., Lichtman, Judith H., Spertus, John A., Bueno, Héctor, and Krumholz, Harlan M.

Published
2017
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17. Association of Marital/Partner Status with Hospital Readmission Among Young Adults With Acute Myocardial Infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P, additional, Li, Fan, additional, Spatz, Erica S, additional, Caraballo, César, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C, additional, Lu, Yuan, additional, Krumholz, Harlan M, additional, Spertus, John A, additional, D’Onofrio, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H, additional

Published
2023
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23. SEX DIFFERENCE IN CAUSES AND TIMING OF ONE-YEAR OUTCOMES AMONG YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS; RESULTS FROM THE VIRGO STUDY

Author

Sawano, Mitsuaki, primary, Lu, Yuan, additional, Caraballo, Cesar, additional, Mahajan, Shiwani, additional, Dreyer, Rachel P., additional, Lichtman, Judith H., additional, D'Onofrio, Gail, additional, Spatz, Erica Sarah, additional, Khera, Rohan, additional, Onuma, Oyere, additional, Murugiah, Karthik, additional, Spertus, John A., additional, and Krumholz, Harlan M., additional

Published
2023
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25. Abstract P405: Low Social Support Mediates the Effect of Marital Stress on 12-month Cardiac-Specific Quality of Life in Young Adults With Acute Myocardial Infarction

Author

Zhu, Cenjing, primary, Dreyer, Rachel P, additional, Li, Fan, additional, Spatz, Erica S, additional, Caraballo, Cesar, additional, Mahajan, Shiwani, additional, Raparelli, Valeria, additional, Leifheit, Erica C, additional, Lu, Yuan, additional, Krumholz, Harlan M, additional, Spertus, John, additional, DONOFRIO, Gail, additional, Pilote, Louise, additional, and Lichtman, Judith H, additional

Published
2023
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26. Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction

Author

Okafor, Chinenye M., primary, Zhu, Cenjing, additional, Raparelli, Valeria, additional, Murphy, Terrence E., additional, Arakaki, Andrew, additional, D’Onofrio, Gail, additional, Tsang, Sui W., additional, Smith, Marcella Nunez, additional, Lichtman, Judith H., additional, Spertus, John A., additional, Pilote, Louise, additional, and Dreyer, Rachel P., additional

Published
2023
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37. PreScription DigitaL ThErapEutic for Patients with Insomnia (SLEEP-I): a protocol for a pragmatic randomised controlled trial

Author

Dreyer, Rachel P, primary, Berkowitz, Alyssa, additional, Yaggi, Henry Klar, additional, Schneeberg, Lynelle, additional, Shah, Nilay D, additional, Emanuel, Lindsay, additional, Kolla, Bhanuprakash, additional, Jeffery, Molly Moore, additional, Deeg, Mark, additional, Ervin, Keondae, additional, Thorndike, Frances, additional, and Ross, Joseph S, additional

Published
2022
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39. Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography

Author

Caraballo, César, primary, Mahajan, Shiwani, additional, Gu, Jianlei, additional, Lu, Yuan, additional, Spatz, Erica S., additional, Dreyer, Rachel P., additional, Zhang, MaoZhen, additional, Sun, NingLing, additional, Ren, Yihong, additional, Zheng, Xin, additional, Zhao, Hongyu, additional, Lu, Hui, additional, Ma, Zheng J., additional, and Krumholz, Harlan M., additional

Published
2022
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40. Depression and Perceived Stress After Spontaneous Coronary Artery Dissection and Comparison With Other Acute Myocardial Infarction (the VIRGO Experience)

Author

Murugiah, Karthik, primary, Chen, Lian, additional, Dreyer, Rachel P., additional, Bouras, Georgios, additional, Safdar, Basmah, additional, Lu, Yuan, additional, Spatz, Erica S., additional, Gupta, Aakriti, additional, Khera, Rohan, additional, Ng, Vivian G., additional, Bueno, Héctor, additional, Tweet, Marysia S., additional, Spertus, John A., additional, Hayes, Sharonne N., additional, Lansky, Alexandra, additional, and Krumholz, Harlan M., additional

Published
2022
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41. Sex Differences in PrEsentation, Risk Factors, Drug and Interventional Therapies, and OUtcomes of Elderly PatientS with Pulmonary Embolism: Rationale and design of the SERIOUS-PE study

Author

Bikdeli, Behnood, primary, Piazza, Gregory, additional, Jimenez, David, additional, Muriel, Alfonso, additional, Wang, Yun, additional, Khairani, Candrika D., additional, Rosovsky, Rachel P., additional, Mehdipoor, Ghazaleh, additional, O'Donoghue, Michelle L., additional, Spagnolo, Primavera, additional, Dreyer, Rachel P., additional, Bertoletti, Laurent, additional, López-Jiménez, Luciano, additional, Núñez, Manuel Jesús, additional, Blanco-Molina, Ángeles, additional, Bates, Shannon M., additional, Gerhard-Herman, Marie, additional, Goldhaber, Samuel Z., additional, Monreal, Manuel, additional, and Krumholz, Harlan M., additional

Published
2022
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42. Sex-Specific Risk Factors Associated With First Acute Myocardial Infarction in Young Adults

Author

Lu, Yuan, primary, Li, Shu-Xia, additional, Liu, Yuntian, additional, Rodriguez, Fatima, additional, Watson, Karol E., additional, Dreyer, Rachel P., additional, Khera, Rohan, additional, Murugiah, Karthik, additional, D’Onofrio, Gail, additional, Spatz, Erica S., additional, Nasir, Khurram, additional, Masoudi, Frederick A., additional, and Krumholz, Harlan M., additional

Published
2022
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