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1. Features of Mild-to-Moderate COVID-19 Patients With Dysphonia

Author

Lechien, Jerome R., Chiesa-Estomba, Carlos M., Cabaraux, Pierre, Mat, Quentin, Huet, Kathy, Harmegnies, Bernard, Horoi, Mihaela, Le Bon, Serge Daniel, Rodriguez, Alexandra, Dequanter, Didier, Hans, Stéphane, Crevier-Buchman, Lise, Hochet, Baptiste, Distinguin, Lea, Chekkoury-Idrissi, Younes, Circiu, Marta, El Afia, Fahd, Barillari, Maria Rosaria, Cammaroto, Giovanni, Fakhry, Nicolas, Michel, Justin, Radulesco, Thomas, Martiny, Delphine, Lavigne, Philippe, Jouffe, Lionel, Descamps, Géraldine, Journe, Fabrice, Trecca, Eleonora M.C., Hsieh, Julien, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Vergez, Sebastien, Khalife, Mohamad, Molteni, Gabriele, Mannelli, Giuditta, Cantarella, Giovanna, Tucciarone, Manuel, Souchay, Christel, Leich, Pierre, Ayad, Tareck, and Saussez, Sven

Published
2022
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6. Validity and Reliability of the French Short Version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS).

Author

Leclercq, Céline, Chiesa-Estomba, Carlos M., Horoi, Mihaela, Le Bon, Serge D., Hans, Stephane, Distinguin, Lea, Chekkoury-Idrissi, Younes, Circiu, Marta P., Khalife, Mohamad, Saussez, Sven, and Lechien, Jérôme R.

Subjects
EXPERIMENTAL design, STATISTICS, RESEARCH evaluation, STATISTICAL reliability, RESEARCH methodology, RESEARCH methodology evaluation, VISUAL analog scale, MANN Whitney U Test, SEVERITY of illness index, CRONBACH'S alpha, QUESTIONNAIRES, QUALITY of life, SMELL disorders, DESCRIPTIVE statistics, DATA analysis software, DATA analysis, STATISTICAL correlation, FRENCH people
Abstract

Objective: To develop a French Short Version of the Questionnaire of Olfactory Disorders-Negative Statements (Fr-sQOD) to assess the quality of life impairments of patients with olfactory dysfunction (OD). Methods: Patients with OD and controls were enrolled from 2 academic centers. Individuals completed the Fr-sQOD, an OD visual analog scale severity, and the French version of the sinonasal outcome tool-22 (SNOT-22). Cronbach α was used to measure the internal consistency of Fr-sQOD. The reliability and the external validity of Fr-sQOD were assessed through a test–retest approach and by correlating Fr-sQOD with SNOT-22 scores, respectively. The external validity was assessed by correlation analysis between Fr-sQOD and the result of an assessment of the severity of OD on a visual analog scale. Results: Eighty patients completed the evaluations. The internal consistency was adequate (Cronbach α.96), and the test–retest reliability was high in the entire cohort (rs = 0.877, P <.001). The correlation between Fr-sQOD total scores and the severity of OD was moderate but significant (rs = −0.431; P =.001) supporting an acceptable external validity. Patients with OD had a significantly higher score of Fr-sQOD than healthy individuals (P <.001), indicating a high internal validity. Conclusion: The Fr-sQOD is a reliable and valid self-administered tool in the evaluation of the impact of OD on quality of life of French-speaking patients. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Parotitis-Like Symptoms Associated with COVID-19, France, March-April 2020

Author

Lechien, Jerome R., Chetrit, Annaelle, Chekkoury-Idrissi, Younes, Distinguin, Lea, Circiu, Marta, Saussez, Sven, Berradja, Najete, Edjlali, Myriam, Hans, Stephane, and Carlier, Robert

Subjects
Disease transmission, Coronaviruses, COVID-19, Medical schools, Health
Abstract

The worldwide spread of coronavirus disease (COVID-19) is associated with the emergence of many clinical pictures of the disease. Patients might have nose and throat symptoms, such as loss of [...]

Published
2020

10. Is Diet Sufficient as Laryngopharyngeal Reflux Treatment? A Cross‐Over Observational Study.

Author

Lechien, Jerome R., Crevier‐Buchman, Lise, Distinguin, Lea, Iannella, Giannicola, Maniaci, Antonino, De Marrez, Lisa G., Saussez, Sven, and Hans, Stéphane

Abstract

Objectives/Hypothesis: To investigate the efficacy of low‐fat, low‐quick‐release sugar, high‐protein, alkaline, and plant‐based diet as single treatment for patients with laryngopharyngeal reflux (LPR). Study Design: Cross‐over observational study. Methods: Patients with LPR diagnosis at the hypopharyngeal‐esophageal multichannel intraluminal impedance‐pH‐monitoring were prospectively recruited from the reflux clinic of three University Hospitals. Patients were instructed to follow low‐fat, low‐quick‐release sugar, high‐protein, alkaline, and plant‐based diet for 6 to 12 weeks. Pre‐ to post‐treatment symptom and finding changes were evaluated with reflux symptom score (RSS) and reflux sign assessment. Findings were compared to those of a control period where patients did not receive any treatment or diet. Diet was evaluated with refluxogenic diet score (REDS). Results: Fifty patients completed the study (19 males). Otolaryngological, digestive, and total RSS scores significantly improved from baseline to 6‐week post‐diet, while there were no significant changes during the control period. At 6‐week post‐diet, 37 (74%) patients reported significant symptom improvement or relief. Among them, symptoms continued to improve from 6 to 12 weeks in 27 cases, corresponding to a diet success rate of 54%. The REDS was predictive of the baseline RSS (P =.031). Conclusion: Low‐fat, low‐quick‐release sugar, high‐protein, alkaline, and plant‐based diet is an alternative cost‐effective therapeutic approach for patients with LPR. Patients with higher REDS reported higher baseline symptom score. Level of Evidence: 3 Laryngoscope, 132:1916–1923, 2022 [ABSTRACT FROM AUTHOR]

Published
2022
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11. Validity and Reliability of the French Short Version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS)

Author

Leclercq, Céline, primary, Chiesa-Estomba, Carlos M., additional, Horoi, Mihaela, additional, Le Bon, Serge D., additional, Hans, Stephane, additional, Distinguin, Lea, additional, Chekkoury-Idrissi, Younes, additional, Circiu, Marta P., additional, Khalife, Mohamad, additional, Saussez, Sven, additional, and Lechien, Jérôme R., additional

Published
2021
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12. Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients

Author

UMONS - Research Institute for Health Sciences and Technology, Lechien, Jerome R., Chiesa-Estomba, Carlos M., Vaira, Luigi A., De Riu, Giacomo, Cammaroto, Giovanni, Chekkoury-Idrissi, Younes, Circiu, Marta, Distinguin, Lea, Journe, Fabrice, de Terwangne, Christophe, Machayekhi, Shahram, Barillari, Maria R., Calvo-Henriquez, Christian, Hans, Stéphane, Saussez, Sven, UMONS - Research Institute for Health Sciences and Technology, Lechien, Jerome R., Chiesa-Estomba, Carlos M., Vaira, Luigi A., De Riu, Giacomo, Cammaroto, Giovanni, Chekkoury-Idrissi, Younes, Circiu, Marta, Distinguin, Lea, Journe, Fabrice, de Terwangne, Christophe, Machayekhi, Shahram, Barillari, Maria R., Calvo-Henriquez, Christian, Hans, Stéphane, and Saussez, Sven

Abstract

Objective To investigate prevalence and epidemiological and clinical factors associated with olfactory dysfunction (OD) and gustatory dysfunction (GD) in COVID-19 patients according to the disease severity. Study design Cross-sectional study. Methods A total of 2579 patients with a positive diagnosis of COVID-19 were identified between March 22 and June 3, 2020 from 18 European hospitals. Epidemiological and clinical data were extracted. Otolaryngological symptoms, including OD and GD, were collected through patient-reported outcome questionnaire and Sniffin’Sticks tests were carried out in a subset of patients. Results A total of 2579 patients were included, including 2166 mild (84.0%), 144 moderate (5.6%) and 269 severe-to-critical (10.4%) patients. Mild patients presented an otolaryngological picture of the disease with OD, GD, nasal obstruction, rhinorrhea and sore throat as the most prevalent symptoms. The prevalence of subjective OD and GD was 73.7 and 46.8%, and decreases with the severity of the disease. Females had higher prevalence of subjective OD and GD compared with males. Diabetes was associated with a higher risk to develop GD. Among the subset of patients who benefited from psychophysical olfactory evaluations, there were 75 anosmic, 43 hyposmic and 113 normosmic patients. The prevalence of anosmia significantly decreased with the severity of the disease. Anosmia or hyposmia were not associated with any nasal disorder, according to SNOT-22. Conclusion OD and GD are more prevalent in patients with mild COVID-19 compared with individuals with moderate, severe or critical diseases. Females might have a higher risk of developing OD and GD compared with males.

Published
2021

13. Correction to: Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients (European Archives of Oto-Rhino-Laryngology, (2021), 278, 8, (2851-2859), 10.1007/s00405-020-06548-w)

Author

Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, Vaira, Luigi, De Riu, Giacomo, Cammaroto, Giovanni, Chekkoury-Idrissi, Younes, Circiu, Marta, Distinguin, Lea, Journé, Fabrice, de Terwangne, Christophe, Machayekhi, Shahram, Barillari, Maria Rosaria, Calvo-Henriquez, Christian, Hans, Stéphane, Saussez, Sven, Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, Vaira, Luigi, De Riu, Giacomo, Cammaroto, Giovanni, Chekkoury-Idrissi, Younes, Circiu, Marta, Distinguin, Lea, Journé, Fabrice, de Terwangne, Christophe, Machayekhi, Shahram, Barillari, Maria Rosaria, Calvo-Henriquez, Christian, Hans, Stéphane, and Saussez, Sven

Abstract

In the original publication of the article, one of the co-author’s name was published incorrectly as “Liugi A. Varia”. The correct name should read as “Luigi A. Vaira”. The original article has been updated., SCOPUS: er.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

14. Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients

Author

Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, Varia, Liugi L.A., De Riu, Giacomo, Cammaroto, Giovanni, Chekkoury-Idrissi, Younes, Circiu, Marta, Distinguin, Lea, Journé, Fabrice, de Terwangne, Christophe, Machayekhi, Shahram, Barillari, Maria Rosaria, Calvo-Henriquez, Christian, Hans, Stéphane, Saussez, Sven, Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, Varia, Liugi L.A., De Riu, Giacomo, Cammaroto, Giovanni, Chekkoury-Idrissi, Younes, Circiu, Marta, Distinguin, Lea, Journé, Fabrice, de Terwangne, Christophe, Machayekhi, Shahram, Barillari, Maria Rosaria, Calvo-Henriquez, Christian, Hans, Stéphane, and Saussez, Sven

Abstract

Objective: To investigate prevalence and epidemiological and clinical factors associated with olfactory dysfunction (OD) and gustatory dysfunction (GD) in COVID-19 patients according to the disease severity. Study design: Cross-sectional study. Methods: A total of 2579 patients with a positive diagnosis of COVID-19 were identified between March 22 and June 3, 2020 from 18 European hospitals. Epidemiological and clinical data were extracted. Otolaryngological symptoms, including OD and GD, were collected through patient-reported outcome questionnaire and Sniffin’Sticks tests were carried out in a subset of patients. Results: A total of 2579 patients were included, including 2166 mild (84.0%), 144 moderate (5.6%) and 269 severe-to-critical (10.4%) patients. Mild patients presented an otolaryngological picture of the disease with OD, GD, nasal obstruction, rhinorrhea and sore throat as the most prevalent symptoms. The prevalence of subjective OD and GD was 73.7 and 46.8%, and decreases with the severity of the disease. Females had higher prevalence of subjective OD and GD compared with males. Diabetes was associated with a higher risk to develop GD. Among the subset of patients who benefited from psychophysical olfactory evaluations, there were 75 anosmic, 43 hyposmic and 113 normosmic patients. The prevalence of anosmia significantly decreased with the severity of the disease. Anosmia or hyposmia were not associated with any nasal disorder, according to SNOT-22. Conclusion: OD and GD are more prevalent in patients with mild COVID-19 compared with individuals with moderate, severe or critical diseases. Females might have a higher risk of developing OD and GD compared with males., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

15. Is Diet Sufficient as Laryngopharyngeal Reflux Treatment? A Cross-Over Observational Study

Author

Lechien, Jérôme, Crevier-Buchman, Lise, Distinguin, Lea, Iannella, Giannicola, Maniaci, Antonino, De Marrez, Lisa L.G., Saussez, Sven, Hans, Stéphane, Lechien, Jérôme, Crevier-Buchman, Lise, Distinguin, Lea, Iannella, Giannicola, Maniaci, Antonino, De Marrez, Lisa L.G., Saussez, Sven, and Hans, Stéphane

Abstract

Objectives/Hypothesis: To investigate the efficacy of low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet as single treatment for patients with laryngopharyngeal reflux (LPR). Study Design: Cross-over observational study. Methods: Patients with LPR diagnosis at the hypopharyngeal-esophageal multichannel intraluminal impedance-pH-monitoring were prospectively recruited from the reflux clinic of three University Hospitals. Patients were instructed to follow low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet for 6 to 12 weeks. Pre- to post-treatment symptom and finding changes were evaluated with reflux symptom score (RSS) and reflux sign assessment. Findings were compared to those of a control period where patients did not receive any treatment or diet. Diet was evaluated with refluxogenic diet score (REDS). Results: Fifty patients completed the study (19 males). Otolaryngological, digestive, and total RSS scores significantly improved from baseline to 6-week post-diet, while there were no significant changes during the control period. At 6-week post-diet, 37 (74%) patients reported significant symptom improvement or relief. Among them, symptoms continued to improve from 6 to 12 weeks in 27 cases, corresponding to a diet success rate of 54%. The REDS was predictive of the baseline RSS (P =.031). Conclusion: Low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet is an alternative cost-effective therapeutic approach for patients with LPR. Patients with higher REDS reported higher baseline symptom score. Level of Evidence: 3 Laryngoscope, 2021., SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

16. Psychophysical evaluation of the olfactory function: European multicenter study on 774 covid-19 patients

Author

Vaira, Luigi, Lechien, Jérôme, Khalife, Mohamad, Petrocelli, Marzia, Hans, Stéphane, Distinguin, Lea, Salzano, Giovanni, Cucurullo, Marco, Doneddu, Piero, Salzano, Francesco Antonio, Biglioli, Federico, Journé, Fabrice, Piana, Andrea Fausto, De Riu, Giacomo, Saussez, Sven, Vaira, Luigi, Lechien, Jérôme, Khalife, Mohamad, Petrocelli, Marzia, Hans, Stéphane, Distinguin, Lea, Salzano, Giovanni, Cucurullo, Marco, Doneddu, Piero, Salzano, Francesco Antonio, Biglioli, Federico, Journé, Fabrice, Piana, Andrea Fausto, De Riu, Giacomo, and Saussez, Sven

Abstract

Background: The objective evaluation of the olfactory function of coronavirus disease 2019 patients is difficult because of logistical and operator-safety problems. For this reason, in the literature, the data obtained from psychophysical tests are few and based on small case series. Methods: A multicenter, cohort study conducted in seven European hospitals between March 22 and August 20, 2020. The Sniffin-Sticks test and the Connecticut Chemosensory Clinical Research Center orthonasal olfaction test were used to objectively evaluate the olfactory function. Results: This study included 774 patients, of these 481 (62.1%) presented olfactory dysfunction (OD): 280 were hyposmic and 201 were anosmic. There was a significant difference between self-reported anosmia/hyposmia and psychophysical test results (p = 0.006). Patients with gastroesophageal disorders reported a significantly higher probability of presenting hyposmia (OR 1.86; p = 0.015) and anosmia (OR 2.425; p < 0.001). Fever, chest pain, and phlegm significantly increased the likelihood of having hyposmia but not anosmia or an olfactory disturbance. In contrast, patients with dyspnea, dysphonia, and severe-to-critical COVID-19 were significantly more likely to have no anosmia, while these symptoms had no effect on the risk of developing hyposmia or an OD. Conclusions: Psychophysical assessment represents a significantly more accurate assessment tool for olfactory function than patient self-reported clinical outcomes. Olfactory disturbances appear to be largely independent from the epidemiological and clinical characteristics of the patients. The non-association with rhinitis symptoms and the high prevalence as a presenting symptom make olfactory disturbances an important symptom in the differential diagnosis between COVID-19 and common flu., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

17. Clinical and epidemiological characteristics of 1420 European patients with mild‐to‐moderate coronavirus disease 2019

Author

Lechien, Jerome R., Chiesa‐Estomba, Carlos M., Place, Sammy, Van Laethem, Yves, Cabaraux, Pierre, Mat, Quentin, Huet, Kathy, Plzak, Jan, Horoi, Mihaela, Hans, Stéphane, Rosaria Barillari, Maria, Cammaroto, Giovanni, Fakhry, Nicolas, Martiny, Delphine, Ayad, Tareck, Jouffe, Lionel, Hopkins, Claire, Saussez, Sven, Blecic, Serge, De Siati, Daniele R., Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journe, Fabrice, Hsieh, Julien, Ris, Laurence, El Afia, Fahd, Harmegnies, Bernard, Distinguin, Lea, Chekkoury‐Idrissi, Younes, Circiu, Marta, Lavigne, Philippe, Lopez Delgado, Irene, Calvo‐Henriquez, Christian, Falanga, Chiara, Coppee, Frederique, Le Bon, Serge Daniel, Rodriguez, Alexandra, Dequanter, Didier, Cornelis, Jean‐Philippe, Vergez, Sebastien, Koenen, Lukas, Giuditta, Mannelli, Molteni, Gabriele, Tucciarone, Manuel, Radulesco, Thomas, Khalife, Mohamad, Fourneau, Anne‐Francoise, Cherifi, Soraya, Manto, Mario, Michel, Justin, Mannelli, Giuditta, Cantarella, Giovanna, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Assistance Publique - Hôpitaux de Marseille (APHM), Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), We would like to thank Bayesia (BayesiaLab?, Chang?, France) for the Network Analysis, Jean-Louis Vincent and Michel Van Haeverbeek for the review of the paper or their useful comments, the heads of the Hospitals, which have been involved in the study, for their help in the rapid conduction of the study and the agreement of ethics committees, the European Press/Media (i.e. Le Monde, La Libre, Le Soir, MediQuality, MedScape, and Le Specialiste) for their help in the spread of the information about the study, and FRMH & UMONS for the grant and the support., Lechien, J. R., Chiesa-Estomba, C. M., Place, S., Van Laethem, Y., Cabaraux, P., Mat, Q., Huet, K., Plzak, J., Horoi, M., Hans, S., Barillari, M. R., Cammaroto, G., Fakhry, N., Martiny, D., Ayad, T., Jouffe, L., Hopkins, C., Saussez, S., Blecic, S., De Siati, D. R., Leich, P., Souchay, C., Rossi, C., Journe, F., Hsieh, J., Ris, L., El Afia, F., Harmegnies, B., Distinguin, L., Chekkoury-Idrissi, Y., Circiu, M., Lavigne, P., Lopez Delgado, I., Calvo-Henriquez, C., Falanga, C., Coppee, F., Le Bon, S. D., Rodriguez, A., Dequanter, D., Cornelis, J. -P., Vergez, S., Koenen, L., Giuditta, M., Molteni, G., Tucciarone, M., Radulesco, T., Khalife, M., Fourneau, A. -F., Cherifi, S., Manto, M., Michel, J., Mannelli, G., and Cantarella, G.

Subjects
0301 basic medicine, myalgia, Male, medicine, Original, [SDV]Life Sciences [q-bio], coronavirus, symptoms, Disease, epidemiological, 030204 cardiovascular system & hematology, patients, clinical, Olfaction Disorders, Taste Disorders, 0302 clinical medicine, Epidemiology, Sore throat, Prevalence, Nose, Age Factors, Headache, Middle Aged, 3. Good health, Europe, medicine.anatomical_structure, COVID-19, Female, patient, medicine.symptom, Symptom Assessment, Coronavirus Infections, Sex characteristics, Adult, medicine.medical_specialty, Pneumonia, Viral, 03 medical and health sciences, Betacoronavirus, Sex Factors, Throat, Internal medicine, Internal Medicine, Humans, Pandemics, covid‐19, rhinorrhea, business.industry, SARS-CoV-2, Bayes Theorem, Myalgia, coronaviru, 030104 developmental biology, business
Abstract

International audience; Background: The clinical presentation of European patients with mild-to-moderate COVID-19 infection is still unknown. Objective: To study the clinical presentation of COVID-19 in Europe. Methods: Patients with positive diagnosis of COVID-19 were recruited from 18 European hospitals. Epidemiological and clinical data were obtained through a standardized questionnaire. Bayesian analysis was used for analysing the relationship between outcomes. Results: A total of 1,420 patients completed the study (962 females, 30.7% of healthcare workers). The mean age of patients was 39.17 ± 12.09 years. The most common symptoms were headache (70.3%), loss of smell (70.2%), nasal obstruction (67.8%), cough (63.2%), asthenia (63.3%), myalgia (62.5%), rhinorrhea (60.1%), gustatory dysfunction (54.2%) and sore throat (52.9%). Fever was reported by 45.4%. The mean duration of COVID-19 symptoms of mild-to-moderate cured patients was 11.5 ± 5.7 days. The prevalence of symptoms significantly varied according to age and sex. Young patients more frequently had ear, nose and throat complaints, whereas elderly individuals often presented fever, fatigue and loss of appetite. Loss of smell, headache, nasal obstruction and fatigue were more prevalent in female patients. The loss of smell was a key symptom of mild-to-moderate COVID-19 patients and was not associated with nasal obstruction and rhinorrhea. Loss of smell persisted at least 7 days after the disease in 37.5% of cured patients. Conclusion: The clinical presentation of mild-to-moderate COVID-19 substantially varies according to the age and the sex characteristics of patients. Olfactory dysfunction seems to be an important underestimated symptom of mild-to-moderate COVID-19 that needs to be recognized as such by the WHO.

Published
2020
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18. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'oto-rhino-laryngologie, Lechien, Jerome R, Chiesa-Estomba, Carlos M, De Siati, Romolo Daniele, Horoi, Mihaela, Le Bon, Serge D, Rodriguez, Alexandra, Dequanter, Didier, Blecic, Serge, El Afia, Fahd, Distinguin, Lea, Chekkoury-Idrissi, Younes, Hans, Stéphane, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Lavigne, Philippe, Falanga, Chiara, Barillari, Maria Rosaria, Cammaroto, Giovanni, Khalife, Mohamad, Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journe, Fabrice, Hsieh, Julien, Edjlali, Myriam, Carlier, Robert, Ris, Laurence, Lovato, Andrea, De Filippis, Cosimo, Coppee, Frederique, Fakhry, Nicolas, Ayad, Tareck, Saussez, Sven, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'oto-rhino-laryngologie, Lechien, Jerome R, Chiesa-Estomba, Carlos M, De Siati, Romolo Daniele, Horoi, Mihaela, Le Bon, Serge D, Rodriguez, Alexandra, Dequanter, Didier, Blecic, Serge, El Afia, Fahd, Distinguin, Lea, Chekkoury-Idrissi, Younes, Hans, Stéphane, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Lavigne, Philippe, Falanga, Chiara, Barillari, Maria Rosaria, Cammaroto, Giovanni, Khalife, Mohamad, Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journe, Fabrice, Hsieh, Julien, Edjlali, Myriam, Carlier, Robert, Ris, Laurence, Lovato, Andrea, De Filippis, Cosimo, Coppee, Frederique, Fakhry, Nicolas, Ayad, Tareck, and Saussez, Sven

Abstract

OBJECTIVE: To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. METHODS: Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). RESULTS: A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001). CONCLUSION: Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.

Published
2020

19. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Author

Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, De Siati, Daniele D.R., Horoi, Mihaela, Le Bon, Serge-Daniel, Rodriguez, Alexandra, Dequanter, Didier, Blecic, Serge, El Afia, Fahd, Distinguin, Lea, Chekkoury-Idrissi, Younes, Hans, Stéphane, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Lavigne, Philippe, Falanga, Chiara, Barillari, Maria Rosaria, Cammaroto, Giovanni, Khalifé, Mohamad, Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journé, Fabrice, Hsieh, Julien J.W., Edjlali, Myriam, Carlier, Robert Yves, Ris, Laurence, Lovato, Andrea, De Filippis, Cosimo, Coppee, Frédérique, Fakhry, Nicolas, Ayad, Tareck, Saussez, Sven, Lechien, Jérôme, Chiesa-Estomba, Carlos Miguel, De Siati, Daniele D.R., Horoi, Mihaela, Le Bon, Serge-Daniel, Rodriguez, Alexandra, Dequanter, Didier, Blecic, Serge, El Afia, Fahd, Distinguin, Lea, Chekkoury-Idrissi, Younes, Hans, Stéphane, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Lavigne, Philippe, Falanga, Chiara, Barillari, Maria Rosaria, Cammaroto, Giovanni, Khalifé, Mohamad, Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journé, Fabrice, Hsieh, Julien J.W., Edjlali, Myriam, Carlier, Robert Yves, Ris, Laurence, Lovato, Andrea, De Filippis, Cosimo, Coppee, Frédérique, Fakhry, Nicolas, Ayad, Tareck, and Saussez, Sven

Abstract

Objective: To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. Methods: Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). Results: A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001). Conclusion: Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

20. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.

Author

Lechien, Jerome R, Chiesa-Estomba, Carlos Miguel, De Siati, Daniele R, Horoi, Mihaela, Le Bon, Serge D, Rodriguez, Alexandra, Dequanter, Didier, Blecic, Serge, El Afia, Fahd, Distinguin, Lea, Chekkoury-Idrissi, Younes, Hans, Stéphane, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Lavigne, Philippe, Falanga, Chiara, Barillari, Maria Rosaria, Cammaroto, Giovanni, Khalife, Mohamad, Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journe, Fabrice, Hsieh, Julien, Edjlali, Myriam, Carlier, Robert Yves, Ris, Laurence, Lovato, Andrea, De Filippis, Cosimo, Coppee, Frédérique, Fakhry, Nicolas, Ayad, Tareck, Saussez, Sven, Lechien, Jerome R, Chiesa-Estomba, Carlos Miguel, De Siati, Daniele R, Horoi, Mihaela, Le Bon, Serge D, Rodriguez, Alexandra, Dequanter, Didier, Blecic, Serge, El Afia, Fahd, Distinguin, Lea, Chekkoury-Idrissi, Younes, Hans, Stéphane, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Lavigne, Philippe, Falanga, Chiara, Barillari, Maria Rosaria, Cammaroto, Giovanni, Khalife, Mohamad, Leich, Pierre, Souchay, Christel, Rossi, Camelia, Journe, Fabrice, Hsieh, Julien, Edjlali, Myriam, Carlier, Robert Yves, Ris, Laurence, Lovato, Andrea, De Filippis, Cosimo, Coppee, Frédérique, Fakhry, Nicolas, Ayad, Tareck, and Saussez, Sven

Abstract

To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection., info:eu-repo/semantics/published

Published
2020

21. MRI of Patients Infected With COVID-19 Revealed Cervical Lymphadenopathy

Author

Distinguin, Lea, Ammar, Amine, Lechien, Jérôme, Chetrit, Annaelle, Idrissi, Younes Chekkoury, Circiu, Marta, Saussez, Sven, Berradja, Najete, Edjlali, Myriam, Carlier, Robert Yves, Hans, Stéphane, Distinguin, Lea, Ammar, Amine, Lechien, Jérôme, Chetrit, Annaelle, Idrissi, Younes Chekkoury, Circiu, Marta, Saussez, Sven, Berradja, Najete, Edjlali, Myriam, Carlier, Robert Yves, and Hans, Stéphane

Abstract

SCOPUS: ed.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

22. Magnetic resonance imaging of COVID-19 anosmic patients reveals abnormalities of the olfactory bulb: Preliminary prospective study

Author

Chetrit, Annaelle, Lechien, Jérôme, Ammar, Amine, Chekkoury-Idrissi, Younes, Distinguin, Lea, Circiu, Marta, Saussez, Sven, Ballester, Marie Christine, Vasse, Marc, Berradja, Najete, Hans, Stéphane, Carlier, Robert Yves, Edjlali, Myriam, Chetrit, Annaelle, Lechien, Jérôme, Ammar, Amine, Chekkoury-Idrissi, Younes, Distinguin, Lea, Circiu, Marta, Saussez, Sven, Ballester, Marie Christine, Vasse, Marc, Berradja, Najete, Hans, Stéphane, Carlier, Robert Yves, and Edjlali, Myriam

Abstract

SCOPUS: le.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2020

23. Correction to: Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients

Author

Lechien, Jerome R., primary, Chiesa-Estomba, Carlos M., additional, Vaira, Luigi A., additional, De Riu, Giacomo, additional, Cammaroto, Giovanni, additional, Chekkoury-Idrissi, Younes, additional, Circiu, Marta, additional, Distinguin, Lea, additional, Journe, Fabrice, additional, de Terwangne, Christophe, additional, Machayekhi, Shahram, additional, Barillari, Maria R., additional, Calvo-Henriquez, Christian, additional, Hans, Stéphane, additional, and Saussez, Sven, additional

Published
2021
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24. Epidemiological, otolaryngological, olfactory and gustatory outcomes according to the severity of COVID-19: a study of 2579 patients

Author

Lechien, Jerome R., primary, Chiesa-Estomba, Carlos M., additional, Vaira, Luigi A., additional, De Riu, Giacomo, additional, Cammaroto, Giovanni, additional, Chekkoury-Idrissi, Younes, additional, Circiu, Marta, additional, Distinguin, Lea, additional, Journe, Fabrice, additional, de Terwangne, Christophe, additional, Machayekhi, Shahram, additional, Barillari, Maria R., additional, Calvo-Henriquez, Christian, additional, Hans, Stéphane, additional, and Saussez, Sven, additional

Published
2021
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25. Psychophysical Evaluation of the Olfactory Function: European Multicenter Study on 774 COVID-19 Patients

Author

Vaira, Luigi Angelo, primary, Lechien, Jerome R., additional, Khalife, Mohamad, additional, Petrocelli, Marzia, additional, Hans, Stephane, additional, Distinguin, Lea, additional, Salzano, Giovanni, additional, Cucurullo, Marco, additional, Doneddu, Piero, additional, Salzano, Francesco Antonio, additional, Biglioli, Federico, additional, Journe, Fabrice, additional, Piana, Andrea Fausto, additional, De Riu, Giacomo, additional, and Saussez, Sven, additional

Published
2021
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26. Magnetic resonance imaging of COVID-19 anosmic patients reveals abnormalities of the olfactory bulb: Preliminary prospective study

Author

Chetrit, Annaelle, primary, Lechien, Jerome R., additional, Ammar, Amine, additional, Chekkoury-Idrissi, Younes, additional, Distinguin, Lea, additional, Circiu, Marta, additional, Saussez, Sven, additional, Ballester, Marie-Christine, additional, Vasse, Marc, additional, Berradja, Najete, additional, Hans, Stephane, additional, Carlier, Robert, additional, and Edjlali, Myriam, additional

Published
2020
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27. Epidemiological, Otolaryngological, Olfactory and Gustatory Outcomes According to the Severity of COVID-19: A study of 2,579 Patients.

Author

Lechien, Jerome, primary, Chiesa-Estomba, Carlos, additional, Vaira, Luigi, additional, Riu, Giacomo De, additional, Cammaroto, Giovanni, additional, Idrissi, Younes Chekkoury, additional, Circiu, Marta, additional, Distinguin, Lea, additional, journe, fabrice, additional, Terwangne, Christophe de, additional, machayekhi, shahram, additional, Barillari, Maria, additional, Calvo-Henriquez, Christian, additional, Hans, Stephane, additional, and Saussez, Sven, additional

Published
2020
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28. MRI of Patients Infected With COVID-19 Revealed Cervical Lymphadenopathy

Author

Distinguin, Lea, primary, Ammar, Amine, additional, Lechien, Jerome R., additional, Chetrit, Annaelle, additional, Idrissi, Younes Chekkoury, additional, Circiu, Marta, additional, Saussez, Sven, additional, Berradja, Najete, additional, Edjlali, Myriam, additional, Carlier, Robert, additional, and Hans, Stephane, additional

Published
2020
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29. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Author

Lechien, Jerome R., primary, Chiesa-Estomba, Carlos M., additional, De Siati, Daniele R., additional, Horoi, Mihaela, additional, Le Bon, Serge D., additional, Rodriguez, Alexandra, additional, Dequanter, Didier, additional, Blecic, Serge, additional, El Afia, Fahd, additional, Distinguin, Lea, additional, Chekkoury-Idrissi, Younes, additional, Hans, Stéphane, additional, Delgado, Irene Lopez, additional, Calvo-Henriquez, Christian, additional, Lavigne, Philippe, additional, Falanga, Chiara, additional, Barillari, Maria Rosaria, additional, Cammaroto, Giovanni, additional, Khalife, Mohamad, additional, Leich, Pierre, additional, Souchay, Christel, additional, Rossi, Camelia, additional, Journe, Fabrice, additional, Hsieh, Julien, additional, Edjlali, Myriam, additional, Carlier, Robert, additional, Ris, Laurence, additional, Lovato, Andrea, additional, De Filippis, Cosimo, additional, Coppee, Frederique, additional, Fakhry, Nicolas, additional, Ayad, Tareck, additional, and Saussez, Sven, additional

Published
2020
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30. MRI of Patients Infected With COVID-19 Revealed Cervical Lymphadenopathy.

Author

Distinguin, Lea, Ammar, Amine, Lechien, Jerome R., Chetrit, Annaelle, Idrissi, Younes Chekkoury, Circiu, Marta, Saussez, Sven, Berradja, Najete, Edjlali, Myriam, Carlier, Robert, and Hans, Stephane

Subjects
*LYMPHATIC disease diagnosis, *MAGNETIC resonance imaging, *NECK, *COVID-19
Abstract

The article presents several patients who were diagnosed with coronavirus disease 2019 (COVID-19) and cervical lymphadenopathy (CLA). They presented symptoms like asthenia, nasal obstruction, rhinorrhea, and fever. Also cited are the diseases where CLA could develop like cat scratch disease, toxoplasmosis, and Epstein-Barr virus-related mononucleosis.

Published
2021
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32. Features of Mild-to-Moderate COVID-19 Patients With Dysphonia

Author

Maria Rosaria Barillari, Lionel Jouffe, Mihaela Horoi, Sébastien Vergez, Carlos M. Chiesa-Estomba, Fabrice Journe, Giovanna Cantarella, Serge-Daniel Le Bon, Justin Michel, Delphine Martiny, Kathy Huet, Marta P. Circiu, Géraldine Descamps, Didier Dequanter, Pierre Cabaraux, Christian Calvo-Henriquez, Lea Distinguin, Julien Hsieh, Tareck Ayad, Mohamad Khalife, Bernard Harmegnies, Jerome R. Lechien, Irene Lopez Delgado, Younes Chekkoury-Idrissi, Alexandra Rodriguez, Pierre Leich, Baptiste Hochet, Manuel Tucciarone, Nicolas Fakhry, Philippe Lavigne, Gabriele Molteni, Giuditta Mannelli, Thomas Radulesco, Christel Souchay, Giovanni Cammaroto, Eleonora M C Trecca, Stéphane Hans, Quentin Mat, Sven Saussez, Lise Crevier-Buchman, Fahd El Afia, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lechien, Jerome R., Chiesa-Estomba, Carlos M., Cabaraux, Pierre, Mat, Quentin, Huet, Kathy, Harmegnies, Bernard, Horoi, Mihaela, Bon, Serge D. Le, Rodriguez, Alexandra, Dequanter, Didier, Hans, Stéphane, Crevier-Buchman, Lise, Hochet, Baptiste, Distinguin, Lea, Chekkoury-Idrissi, Youne, Circiu, Marta, Afia, Fahd El, Barillari, Maria Rosaria, Cammaroto, Giovanni, Fakhry, Nicola, Michel, Justin, Radulesco, Thoma, Martiny, Delphine, Lavigne, Philippe, Jouffe, Lionel, Descamps, Géraldine, Journe, Fabrice, Trecca, Eleonora M. C., Hsieh, Julien, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Vergez, Sebastien, Khalife, Mohamad, Molteni, Gabriele, Mannelli, Giuditta, Cantarella, Giovanna, Tucciarone, Manuel, Souchay, Christel, Leich, Pierre, Ayad, Tareck, and Saussez, Sven

Subjects
Male, medicine.medical_specialty, Nausea, [SDV]Life Sciences [q-bio], ENT, Dysphonia, Covid-19, Coronavirus, Voice, Symptoms, Clinical, Findings, ENT, Chest pain, Article, 030507 speech-language pathology & audiology, 03 medical and health sciences, Speech and Hearing, Clinical, 0302 clinical medicine, Throat, Internal medicine, Epidemiology, medicine, Prevalence, otorhinolaryngologic diseases, Humans, Dysphonia−Covid-19−Coronavirus−Voice−Symptoms−Clinical−Findings−ENT, 030223 otorhinolaryngology, Hoarseness, business.industry, COVID-19, Bayes Theorem, Findings, LPN and LVN, Dysphonia, Dysphagia, 3. Good health, Coronavirus, Diarrhea, medicine.anatomical_structure, Otorhinolaryngology, Symptoms, Vomiting, Voice, Sputum, Female, medicine.symptom, 0305 other medical science, business, Covid-19
Abstract

International audience; Introduction: To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients.Methods: The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general, and otolaryngological symptoms. Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. The outcomes were compared between dysphonic and nondysphonic patients. The association between dysphonia severity and outcomes was studied through Bayesian analysis.Results: A total of 188 patients were dysphonic, accounting for 26.8% of cases. Females developed more frequently dysphonia than males (P = 0.022). The proportion of smokers was significantly higher in the dysphonic group (P = 0.042). The prevalence of the following symptoms was higher in dysphonic patients compared with nondysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea, and vomiting. The severity of dyspnea, dysphagia, ear pain, face pain, throat pain, and nasal obstruction was higher in dysphonic group compared with nondysphonic group. There were significant associations between the severity of dysphonia, dysphagia, and cough.Conclusion: Dysphonia may be encountered in a quarter of patients with mild-to-moderate COVID-19 and should be considered as a symptom list of the infection. Dysphonic COVID-19 patients are more symptomatic than nondysphonic individuals. Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation.

Published
2022

33. Validity and Reliability of the French Short Version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS).

Author

Leclercq C, Chiesa-Estomba CM, Horoi M, Le Bon SD, Hans S, Distinguin L, Chekkoury-Idrissi Y, Circiu MP, Khalife M, Saussez S, and Lechien JR

Subjects
Humans, Reproducibility of Results, Surveys and Questionnaires, Smell, Quality of Life, Olfaction Disorders diagnosis
Abstract

Objective: To develop a French Short Version of the Questionnaire of Olfactory Disorders-Negative Statements (Fr-sQOD) to assess the quality of life impairments of patients with olfactory dysfunction (OD)., Methods: Patients with OD and controls were enrolled from 2 academic centers. Individuals completed the Fr-sQOD, an OD visual analog scale severity, and the French version of the sinonasal outcome tool-22 (SNOT-22). Cronbach α was used to measure the internal consistency of Fr-sQOD. The reliability and the external validity of Fr-sQOD were assessed through a test-retest approach and by correlating Fr-sQOD with SNOT-22 scores, respectively. The external validity was assessed by correlation analysis between Fr-sQOD and the result of an assessment of the severity of OD on a visual analog scale., Results: Eighty patients completed the evaluations. The internal consistency was adequate (Cronbach α .96), and the test-retest reliability was high in the entire cohort (r s = 0.877, P < .001). The correlation between Fr-sQOD total scores and the severity of OD was moderate but significant (r s = -0.431; P = .001) supporting an acceptable external validity. Patients with OD had a significantly higher score of Fr-sQOD than healthy individuals ( P < .001), indicating a high internal validity., Conclusion: The Fr-sQOD is a reliable and valid self-administered tool in the evaluation of the impact of OD on quality of life of French-speaking patients., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
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