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391 results on '"De Silvestri, Annalisa"'

1. Antibiotics Removal during Continuous Renal Replacement Therapy in Septic Shock Patients: Mixed Modality Versus “Expanded Haemodialysis”

Author

Ferrari, Fiorenza, Milla, Paola, Sartori, Marco, Zanza, Christian, Tesauro, Manfredi, Longhitano, Yaroslava, De Silvestri, Annalisa, Abbruzzese, Chiara, De Rosa, Silvia, Lassola, Sergio, Samoni, Sara, Brendolan, Alessandra, Zanella, Monica, Scaravilli, Vittorio, Grasselli, Giacomo, Arpicco, Silvia, and Ronco, Claudio

Published
2024
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15. Impact of SARS-CoV-2 infection in patients with hereditary hemorrhagic telangiectasia: epidemiological and clinical data from the comprehensive Italian retrospective multicenter study

Author

Suppressa, Patrizia, Maiorano, Eugenia, Gaetani, Eleonora, Matti, Elina, Lenato, Gennaro Mariano, Serio, Ilaria, Masala, Maristella Salvatora, Passali, Giulio Cesare, Aguglia, Maria, Crocione, Claudia, Lopalco, Pietro Luigi, Caneschi, Francesca, Musella, Valeria, De Silvestri, Annalisa, Gambini, Giulia, Spinozzi, Giuseppe, Sabbà, Carlo, and Pagella, Fabio

Published
2023
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30. Does Meal or Water Intake Affect Ultrasound Attenuation Coefficient Estimate?

Author

Ferraioli, Giovanna, De Silvestri, Annalisa, and Barr, Richard G.

Subjects
ATTENUATION coefficients, DRINKING (Physiology), GENERALIZED estimating equations, ULTRASONIC imaging, DRINKING water
Abstract

Objectives: To assess whether meal or water intake may affect the measurement of the ultrasound (US) attenuation coefficient (AC) imaging, a parameter that is directly related to liver fat content. Methods: The study was performed in two centers (Italy and USA). AC was obtained using the ATI algorithm implemented in the Aplio i‐series US systems (Canon Medical Systems, Japan) by one operator at each center. Measurements were performed at baseline and 5, 15, 30, 45 minutes after drinking 500 mL of water (group 1), or 30, 45, 60, 90, 120 minutes after eating a meal of about 600 kcal (group 2). Multilevel generalized estimating equations for repeated measures were used for the statistical analysis to consider the clustered nature of the data. Results: Twenty‐six individuals were enrolled: 11 (10 females; age, 43.7 ± 12.5 years) in Italy and 15 (10 females; age, 60.7 ± 6.3 years) in USA. At B‐mode US, 10 (38.5%) had liver steatosis. The baseline AC values, in decibel/centimeter/megahertz, were 0.64 (0.12) in group 1 and 0.66 (0.13) in group 2. There was not any significant difference in AC values at every time‐point after water or meal intake either in group 1 or group 2. This result did not change including sex, age, and skin‐to‐liver capsule into the models. Conclusions: The measurement of the AC, which is a biomarker of liver steatosis, does not require a fasting state and drinking water does not affect the result. [ABSTRACT FROM AUTHOR]

Published
2024
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31. The Role of Neutrophil-Lymphocytes Ratio in the Prognosis of CIN2+ Recurrence after Excisional Treatment.

Author

Dominoni, Mattia, Barcellini, Amelia, Pasquali, Marianna Francesca, De Silvestri, Annalisa, Ferretti, Virginia Valeria, Cesari, Stefania, Fiandrino, Giacomo, Orlandi, Ester, and Gardella, Barbara

Subjects
BLOOD cell count, LEUKOCYTE count, CERVICAL intraepithelial neoplasia, NEUTROPHIL lymphocyte ratio, PAP test, GENITAL warts
Abstract

Objectives: The main risk factor involved in CIN2+ recurrence after treatment is the HPV persistent infection. The dysregulation of the immune system permits only HR-HPVs to become persistent infections, to promote cancer development, and to increase the risk of recurrence after treatment. Therefore, there is a shift to a Th2-type cytokine pattern during the carcinogenesis pathway; for this reason, the neutrophil-lymphocytes ratio (NLR) could be a marker of this immunological change. The study aimed to analyse the predictive role of NLR in the recurrence of high-grade CIN (CIN2+) after excisional treatment in a real-world life setting of patients treated for CIN2+. Design: This study wascross-sectional study. Participants/Materials, Setting, Methods: We examined a retrospective database of 444 patients, who attended the colposcopy service of our department from 2011 to 2020 due to an abnormal screening Pap smear, and we compared the clinical characteristics to NLR performed at the time of diagnosis. All analysed patients were treated according to an established protocol (colposcopy every 6 months for the first 2 years and every year for over 3 years) and HPV-DNA test and cervical biopsy were performed at entry and the end of follow-up. All patients underwent a blood sample examination, including complete white blood cell counts and collecting neutrophil and lymphocyte values expressed as 103/mL. Results: The sensitivity (SE) and specificity (SP) of the NLR cut-off point of 1.34 for the diagnosis of CIN2+ recurrence were 0.76 and 0.67, respectively. We found that CIN2+ recurrences were significantly higher in patients with NLR <1.34 (3.7% vs. 0.6%, p = 0.033) and the 5-year recurrence-free survival was higher in patients with NLR ≥1.34 (97% vs. 93%, p = 0.030). Limitations: Firstly, the retrospective analysis and low incidence of recurrence may limit the conclusions. Second, for the retrospective design of the study, we did not take into consideration the patient's comorbidities and habits (smoking) that may influence the NLR. On the other hand, the median duration of follow-up in our study was 26 months (IQR: 22–31), which fully reflects the incidence of recurrences. Conclusions: It is well known that CIN2+ lesions are sustained by deregulation of the immune system caused by persistent HPV infection, which may lead to cervical cancer. Among the actors underlying dysregulation of immunity, lymphocytes are involved in the permission of persistent infection and for this reason, NRL could be a reliable and cost-effective biomarker in predicting the risk of recurrence, especially for high-grade cervical lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Investigating the connection among thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents affected by type 1 diabetes.

Author

Calcaterra, Valeria, Mameli, Chiara, Macedoni, Maddalena, De Silvestri, Annalisa, Sgambetterra, Laura, Nosenzo, Federico, Redaelli, Francesca Chiara, Petitti, Agnese, Bosetti, Alessandra, and Zuccotti, Gianvincenzo

Abstract

A connection between thyroid hormones (THs) and diverse metabolic pathways has been reported. We evaluated thyroid function and tissue sensitivity to THs in children and adolescents with T1D in comparison to euthyroid controls. Additionally, we investigate whether a relationship exists between sensitivity indices and metabolic parameters. A retrospective analysis was conducted on 80 pediatric patients diagnosed with T1D. Clinical parameters, TSH, FT3, FT4, and the presence of MS were documented. Additionally, indices of peripheral sensitivity (FT3/FT4 ratio) and central sensitivity (TSH index, TSHI; TSH T4 resistance index, TT4RI; TSH T3 resistance index, TT3RI) were assessed. Thirty healthy subjects were considered as controls. The overall prevalence of MS was 7.27 %, with MS identified in 8 out of 80 (10 %) T1D subjects; none of the controls manifested MS (p<0.01). No significant differences were observed in indexes of tissue sensitivity to THs between subjects with or without MS (all p>0.05). Correlations between THs and indexes of THs tissue sensitivity and metabolic parameters in controls and T1D patients were noted. This study affirms a heightened prevalence of MS in children with T1D compared to controls and underscores the potential role of THs in maintaining metabolic equilibrium. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Percutaneous Coronary Intervention Techniques for Bifurcation Disease: Network Meta-analysis Reveals Superiority of Double-Kissing Crush

Author

Crimi, Gabriele, Mandurino-Mirizzi, Alessandro, Gritti, Valeria, Scotti, Valeria, Strozzi, Clara, de Silvestri, Annalisa, Montalto, Claudio, di Giacomo, Ciro, d’Ascenzo, Fabrizio, Repetto, Alessandra, Ferlini, Marco, Marinoni, Barbara, Ferrario, Maurizio, de Servi, Stefano, Visconti, Luigi Oltrona, and Klersy, Catherine

Published
2020
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42. A proposal for a semiquantitative scoring system for lymphedema using Non-contrast Magnetic Resonance Lymphography (NMRL): Reproducibility among readers and correlation with clinical grading

Author

Franconeri, Andrea, Ballati, Francesco, Panzuto, Fabio, Raciti, Maria Vittoria, Smedile, Antonella, Maggi, Alessia, Asteggiano, Carlo, Esposito, Marcello, Stoppa, Davide, Lungarotti, Luca, Bortolotto, Chandra, Giardini, Denisa, De Silvestri, Annalisa, and Calliada, Fabrizio

Published
2020
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45. Characterization of epidemiological distribution and outcome of COVID-19 in patients with hereditary hemorrhagic telangiectasia: a nationwide retrospective multi-centre study during first wave in Italy

Author

Suppressa, Patrizia, Pagella, Fabio, Lenato, Gennaro Mariano, Gaetani, Eleonora, Serio, Ilaria, Masala, Maristella Salvatora, Spinozzi, Giuseppe, Lizzio, Roberta, Matti, Elina, De Silvestri, Annalisa, Passali, Giulio Cesare, Aguglia, Maria, Crocione, Claudia, and Sabbà, Carlo

Published
2021
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48. Retrospective Investigation of Human Papillomavirus Cervical Infection and Lymphoma Incidence: A Clinical and Pathological Evaluation.

Author

Gardella, Barbara, Dominoni, Mattia, Pasquali, Marianna Francesca, Gotti, Manuel, Fraticelli, Sara, Lucioni, Marco, Cesari, Stefania, Fiandrino, Giacomo, De Silvestri, Annalisa, Zerbi, Caterina, Lazic, Tanja, Arcaini, Luca, Paulli, Marco, and Spinillo, Arsenio

Subjects
HUMAN papillomavirus, PAPILLOMAVIRUS diseases, REGULATORY T cells, PAP test, AUTOIMMUNE diseases, LYMPHOMAS
Abstract

Objective: Human papillomavirus (HPV) persistence is considered the main risk factor for neoplastic progression, and evidence suggests that regulatory T cells play an important role in the failure of viral elimination. Regulatory T cells may be involved in maintaining a microenvironment favourable for viral persistence and neoplasticity, through a deregulation of the local immune response. The association between altered immune function and the development of chronic infections, cancer (solid and haematological), and autoimmune diseases is documented in the literature. The purpose of this retrospective analysis was to evaluate the possible correlation between HPV cervical infection and lymphoma incidence in women attending colposcopy due to an abnormal Pap smear during a period of 15 years. Design: This is a cross-sectional study. Participants: We investigated retrospectively the incidence of haematological diseases in women aged 21–84 with an abnormal Pap smear who referred to our centre between 2004 and 2019. Setting: This study was conducted at the university hospital. Methods: In our analysis, we included women with diagnoses of HL and NHL after the detection of abnormal Pap smears and HPV infections. We excluded patients with a diagnosis of lymphoma preceding the date of the abnormal Pap smear and HPV test. Results: We divided the patients into two groups in order to analyse the standard incidence ratio (SIR): HL patients (19/7,064, 0.26%) and NHL patients (22/7,064, 0.31%). In our sample, we reported a significant risk of developing lymphoma compared to the general population, both for HL and NHL disease, at age <45 years. Regarding HL, the SIR of disease in women 45 years was 4.886 (95% CI 2.775–9.6029) and in women between 45 and 59 years was 2.612 (95% CI 0.96–7.108804). On the other hand, for NHL in women 45 years, we reported an SIR of about 3.007 (95%, CI 1.273–7.101575), in women aged 45–59 years, the SIR was 4.291 (95% CI 2.444–7.534399), and in women aged 60–74 years, the SIR was 3.283 (95% CI 1.054–10.22303). Limitations: This retrospective analysis was conducted in a single centre in Northern Italy and did not consider all interregional differences existing in the country in terms of HPV genotypes, ethnicity, and population characteristics. Regarding the analysis of SIR for HL and NHL, we did not divide the disease into subtypes because of the small sample of cases. Finally, we considered in our analysis only women with an abnormal Pap smear and not the general population. Conclusions: Women with chronic and persistent HPV infections may have a higher relative risk of developing lymphoma. This possible association may be caused by the deregulation of the immune system response against HPV and the failure of viral clearance, especially in younger women. [ABSTRACT FROM AUTHOR]

Published
2024
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49. IL‐17, GAL‐10, and TGF‐β are promising noninvasive biomarkers of pediatric eosinophilic esophagitis.

Author

Votto, Martina, Naso, Matteo, De Amici, Mara, Castagnoli, Riccardo, De Silvestri, Annalisa, De Filippo, Maria, Testa, Giorgia, Marseglia, Gian Luigi, and Licari, Amelia

Subjects
EOSINOPHILIC esophagitis, INTERLEUKIN-17, BIOMARKERS, EXTRACELLULAR matrix proteins, TRANSFORMING growth factors
Abstract

This article presents a study that explores the use of noninvasive biomarkers for diagnosing and monitoring pediatric eosinophilic esophagitis (EoE), a chronic allergic disorder affecting the esophagus. The study identifies interleukin (IL)-17, galectin (GAL)-10, and transforming growth factor (TGF)-β as potential biomarkers for EoE. However, more research is required to validate these biomarkers and incorporate them into clinical practice. The study was conducted ethically on children and adolescents. Overall, this research suggests that these biomarkers could enhance the diagnosis and management of EoE, but further investigation is necessary. [Extracted from the article]

Published
2024
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