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2. Surgeon experience influence lymphadenectomy during VATS lobectomy: National VATS database results

Author

Maurizio, Mancuso, Fausto, Pernazza, Majed, Refai, Franco, Stella, Desideria, Argnani, Giuseppe, Marulli, Angela, De Palma, Luigi, Bortolotti, Giovanna, Rizzardi, Piergiorgio, Solli, Giampiero, Dolci, Reinhold, Perkmann, Francesco, Zaraca, Roberto, Benvenuti Mauro, Diego, Gavezzoli, Roberto, Cherchi, Albino, Ferrari Paolo, Felice, Mucilli, Pierpaolo, Camplese, Giulio, Melloni, Federico, Mazza, Giorgio, Cavallesco, Pio, Maniscalco, Luca, Voltolini, Alessandro, Gonfiotti, Francesco, Sollitto, Pia, Ardò Nicoletta, Luca, Pariscenti Gian, Carlo, Risso, Corrado, Surrente, Camillo, Lopez, Andrea, Droghetti, Michele, Giovanardi, Cristiano, Breda, Fabio, Lo Giudice, Marco, Alloisio, Edoardo, Bottoni, Lorenzo, Spaggiari, Roberto, Gasparri, Massimo, Torre, Alessandro, Rinaldo, Mario, Nosotti, Davide, Tosi, Giampeiro, Negri, Alessandro, Bandiera, Alessandro, Baisi, Federico, Raveglia, Alessandro, Stefani, Pamela, Natali, Marco, Scarci, Emanuele, Pirondini, Carlo, Curcio, Dario, Amore, Ottavio, Rena, Samuele, Nicotra, Andrea, Dell' Amore, Alessandro, Bertani, Giorgia, Tancredi, Luca, Ampollini, Paolo, Carbognani, Francesco, Puma, Damiano, Vinci, Giuseppe, Cardillo, Francesco, Carleo, Nachira, Dania, Piero, Paladini, Marco, Ghisalberti, Roberto, Crisci, Duilio, Divisi, Diego, Fontana, Vittorio, Della Beffa, Angelo, Morelli, Francesco, Londero, Andrea, Imperatori, Nicola, Rotolo, Alberto, Andrea, Viti, Maurizio, Infante, Cristiano, Benato, Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, and Margaritora, Stefano

Published
2024
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3. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy

Author

Parini, Sara, Azzolina, Danila, Massera, Fabio, Mastromarino, Maria Giovanna, Papalia, Esther, Baietto, Guido, Curcio, Carlo, Crisci, Roberto, Rena, Ottavio, Alloisio, Marco, Amore, Dario, Ampollini, Luca, Ardò, Nicoletta, Argnani, Desideria, Baisi, Alessandro, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Cavallesco, Giorgio, Cherchi, Roberto, De Palma, Angela, Dell'Amore, Andrea, Della Beffa, Vittorio, Divisi, Duilio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo, Fontana, Diego, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Marulli, Giuseppe, Mazza, Federico, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Paladini, Piero, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Puma, Francesco, Raveglia, Federico, Refai, Majed, Rinaldo, Alessandro, Risso, Carlo, Rizzardi, Giovanna, Rotolo, Nicola, Scarci, Marco, Solli, Piergiorgio, Sollitto, Francesco, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Surrente, Corrado, Tancredi, Giorgia, Terzi, Alberto, Torre, Massimo, Tosi, Davide, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, and Zaraca, Francesco

Published
2023
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6. Robotic thymectomy in thymic tumors: a multicenter, nation-wide study

Author

Comacchio, Giovanni Maria, primary, Schiavon, Marco, additional, Zirafa, Carmelina Cristina, additional, De Palma, Angela, additional, Scaramuzzi, Roberto, additional, Meacci, Elisa, additional, Bongiolatti, Stefano, additional, Monaci, Nicola, additional, Lyberis, Paraskevas, additional, Novellis, Pierluigi, additional, Brandolini, Jury, additional, Parini, Sara, additional, Ricciardi, Sara, additional, D'Andrilli, Antonio, additional, Bottoni, Edoardo, additional, Gallina, Filippo Tommaso, additional, Marino, Maria Carlotta, additional, Lorenzoni, Giulia, additional, Francavilla, Andrea, additional, Rendina, Erino Angelo, additional, Cardillo, Giuseppe, additional, Rena, Ottavio, additional, Solli, Piergiorgio, additional, Alloisio, Marco, additional, Luzzi, Luca, additional, Facciolo, Francesco, additional, Voltolini, Luca, additional, Margaritora, Stefano, additional, Curcio, Carlo, additional, Marulli, Giuseppe, additional, Ruffini, Enrico, additional, Veronesi, Giulia, additional, Melfi, Franca, additional, and Rea, Federico, additional

Published
2024
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7. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Alloisio, Marco, Amore, Dario, Ampollini, Luca, Andreetti, Claudio, Argnani, Desideria, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benvenuti, Mauro Roberto, Bertani, Alessandro, Bertolaccini, Luca, Bortolotti, Luigi, Bottoni, Edoardo, Breda, Cristiano, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Casadio, Caterina, Cavallesco, Giorgio, Cherchi, Roberto, Crisci, Roberto, Curcio, Carlo, Dell’Amore, Andrea, Della Beffa, Vittorio, Dolci, Giampiero, Droghetti, Andrea, Ferrari, Paolo A., Fontana, Diego, Gargiulo, Gaetano, Gasparri, Roberto, Gavezzoli, Diego, Ghisalberti, Marco, Giovanardi, Michele, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Iurilli, Luciano, Lausi, Paolo, Lo Giudice, Fabio, Londero, Francesco, Luzzi, Luca, Lopez, Camillo, Mancuso, Maurizio, Maniscalco, Pio, Margaritora, Stefano, Meacci, Elisa, Melloni, Giulio, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Pariscenti, Gianluca, Perkmann, Reinhold, Pernazza, Fausto, Pirondini, Emanuele, Poggi, Camilla, Puma, Francesco, Refai, Majed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabbatini, Armando, Scarci, Marco, Spaggiari, Lorenzo, Stefani, Alessandro, Solli, Piergiorgio, Surrente, Corrado, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, Zaccagna, Gino, Zaraca, Francesco, Bongiolatti, Stefano, and Borgianni, Sara

Published
2021
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9. Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?

Author

Mancuso, M., Pernazza, F., Refai, M., Srella, F., Argnani, D., Marulli, G., De Palma, A., Bortolotti, L., Rizzardi, G., Solli, P.G., Dolci, G.P., Perkmann, R., Zaraca, F., Benvenuti, M., Gavezzoli, D., Cherchi, R., Ferrari, P., Mucilli, F., Camplese, P., Melloni, G., Mazza, F., Cavallesco, G., Maniscalco, P., Voltolini, L., Gonfiotti, A., Sollitto, F., Ardò, N., Pariscenti, G.L., Risso, C., Surrente, C., Lopez, C., Droghetti, A., Giovanardi, M., Breda, C., Giudice, Lo F., Alloisio, M., Bottoni, E., Spaggiari, L., Gasparri, R., Torre, M., Rinaldo, A., Nosotti, M., Tosi, D., Negri, G.P., Bandiera, A., Baisi, A., Raveglia, F., Stefani, A., Natali, P., Scarci, M., Pirondini, E., Curcio, C., Amore, D., Rena, O., Nicotra, S., Dell’ Amore, A., Bertani, A., Tancredi, G., Ampollini, L., Carbognani, P., Puma, F., Vinci, D., Cardillo, G., Carleo, F., Margaritora, S., Meacci, E., Luzzi, L., Ghisalberti, M., Crisci, R., Divisi, D., Lausi, P., Guerrera, F., Fontana, D., Beffa, V. Della, Morelli, A., Londero, F., Imperatori, A., Rotolo, N., Terzi, A., Viti, A., Infante, M., Benato, C., Zaraca, Francesco, Pipitone, Marco, Feil, Birgit, Perkmann, Reinhold, Bertolaccini, Luca, Curcio, Carlo, and Crisci, Roberto

Published
2021
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10. Surgeon experience influence lymphadenectomy during VATS lobectomy: National VATS database results

Author

Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Meacci, Elisa (ORCID:0000-0001-8424-3816), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Meacci, Elisa (ORCID:0000-0001-8424-3816), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)

Abstract

Objectives: Aim of this study is to identify the factors that may influence the lymphadenectomy during VATS anatomical lung resection with particular interest on operator experience. Materials and methods: Clinical and pathological data from the prospective VATS Italian nationwide registry were reviewed and analysed. Patients with incomplete data regarding tumor and surgical characteristics, GGO, or with distant metastases were excluded. Patients clinical data, tumor characteristics, operation information and surgeon experience were collected and compared to resected lymph nodes number (#RN), resected N2 nodes number (#N2RN) and resected N2 stations number. A multivariable model was built using logistic regression analysis. Surgeon experience was categorized considering the number of VATS major anatomical resection and years after residency. Results: The final analysis was conducted on 3727 patients. The median #RN and #N2RN were 11 (1-51) and 5 (0-41). Regarding the analysed outcomes, #N2RN > 6 resulted in 1812 (48.8%)cases, #RN > 10 in 2124 (57.0%)cases and more than 3 N2 stations were harvested in 1447 (38.8%)patients. First operator experience with number of VATS lobectomies>50 (p < 0.001), operator seniority after residency5-10years (p < 0.001), cTNM II/III(p = 0.017), lobectomy/bilobectomy vs segmentectomy (p < 0.001), and upper/middle lobe tumor location (p < 0.005)resulted significantly associated to #N2RN > 6 at the multivariable analysis. First operator experience with number of VATS lobectomies>50 (p < 0.001), operator seniority after residency5-10years (p < 0.001) and lobectomy/bilobectomy (p < 0.001) resulted significantly associated to #RN > 10 at the multivariable analysis. Conclusions: Our study showed that lymphadenectomy during VATS lobectomy is influenced by tumor factors such as c

Published
2024

11. Conversion due to vascular injury during video-assisted thoracic surgery lobectomy: A multicentre retrospective analysis from the Italian video-assisted thoracic surgery group registry

Author

Bertolaccini, Luca, Davoli, Fabio, Pardolesi, Alessandro, Brandolini, Jury, Argnani, Desideria, Bertani, Alessandro, Droghetti, Andrea, Gonfiotti, Alessandro, Divisi, Duilio, Crisci, Roberto, Solli, Piergiorgio, Nosotti, Mario, Curcio, Carlo, Amore, Dario, Marulli, Giuseppe, Nicotra, Samuele, De Negri, Andrea, Maineri, Paola, di Rienzo, Gaetano, Lopez, Camillo, Morelli, Angelo, Londero, Francesco, Spaggiari, Lorenzo, Gasparri, Roberto, Baietto, Guido, Casadio, Caterina, Infante, Maurizio, Benato, Cristiano, Alloisio, Marco, Bottoni, Edoardo, Cardillo, Giuseppe, Carleo, Francesco, Stella, Franco, Dolci, Giampiero, Puma, Francesco, Vinci, Damiano, Cavallesco, Giorgio, Maniscalco, Pio, Ampollini, Luca, Carbognani, Paolo, Terzi, Alberto, Viti, Andrea, Negri, Giampiero, Bandiera, Alessandro, Perkmann, Reinhold, Zaraca, Francesco, Andretti, Claudio, Poggi, Camilla, Mucilli, Felice, Camplese, Pierpaolo, Luzzi, Luca, Ghisalberti, Marco, Imperatori, Andrea, Rotolo, Nicola, Bortolotti, Luigi, Rizzardi, Giovanna, Torre, Massimo, Rinaldo, Alessandro, Sabbatini, Armando, Refai, Majed, Benvenuti, Mauro Roberto, Benetti, Diego, Stefani, Alessandro, Natali, Pamela, Lausi, Paolo, and Guerrera, Francesco

Published
2019
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15. Persistent alveolar air leak following pulmonary lobectomy: an old problem in a modern era.

Author

Amore, Dario, Caterino, Umberto, Casazza, Dino, Ievoli, Riccardo, Imitazione, Pasquale, Saglia, Alessandro, Izzo, Alessandro, Rispoli, Marco, and Curcio, Carlo

Subjects
VIDEO-assisted thoracic surgery, PREOPERATIVE risk factors, LOBECTOMY (Lung surgery), LUNG surgery, TRANSIENT ischemic attack, TEMPORAL lobectomy
Abstract

Persistent alveolar air leak (PAAL) after major lung resection remains a common complication in thoracic surgery. The aim of this study was to identify a subset of patients with high risk of developing PAAL after pulmonary lobectomy. Another objective was to evaluate the influence of PAAL on postoperative complications and length of hospital stay. A retrospective analysis on 895 patients undergoing pulmonary lobectomy from January 2014 to December 2019 was performed. PAAL was defined as air leak lasting more than 5 days after lung surgery. Univariate analyses and logistic regressions were performed to identify the predictors of PAAL. A backward selection algorithm was used to identify the optimal set of predictors. The incidence of PAAL was 8.2% (74/895). Male gender (p=0.017), BMI (p<0.001), transient ischemic attack (p=0.031), FEV1 (p=0.018), lobectomy combined with adjacent subsegmentectomy (p=0.018), partial and extended pleural adhesions (p=0.033 and p=0.038, respectively) were identified as independent risk factors for PAAL through logistic regression. A weak positive correlation was found between video-assisted thoracic surgery (VATS) and PAAL following pulmonary lobectomy (p=0.100). PAAL was found to be associated with higher risk of postoperative morbidity (p=0.002) and with longer hospital stay (p<0.001). Both preoperative and intraoperative risk factors may be responsible for PAAL after pulmonary lobectomy. VATS does not appear to prevent this postoperative complication. An alveolar air leak lasting beyond 5 days after pulmonary lobectomy is associated with worse postoperative outcomes. [ABSTRACT FROM AUTHOR]

Published
2023

16. Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC

Author

Salvi Rosario, Meoli Ilernando, Cennamo Antonio, Perrotta Fabio, Saverio Cerqua Francesco, Montesano Raffaele, Curcio Carlo, Lassandro Francesco, Stefanelli Francesco, Grella Edoardo, Tafuri Domenico, Mazzarella Gennaro, and Bianco Andrea

Subjects
respiratory function tests, non-small cell lung cancer, thoracic surgery, pulmonary rehabilitation program, frail patients, aging, Medicine
Abstract

Thoracic surgery remains the better therapeutic option for non-small cell lung cancer patients that are diagnosed in early stage disease. Preoperative lung function assessment includes respiratory function tests (RFT) and cardio-pulmonary exercise testing (CPET). Vo2 peak, FEV1 and DLCO as well as recognition of performance status, presence of co-morbidities, frailty indexes, and age predict the potential impact of surgical resection on patient health status and survival risk. In this study we have retrospectively assessed the benefit of a high-intensity preoperative pulmonary rehabilitation program (PRP) in 14 patients with underlying lung function impairment prior to surgery. Amongst these, three patients candidate to surgical resection exhibited severe functional impairment associated with high score of frailty according CHS and SOF index, resulting in a substantial mortality risk.

Published
2016
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17. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature

Author

Perrotta Fabio, Cerqua Francesco Saverio, Cammarata Antonino, Izzo Alessandro, Bergaminelli Carlo, Curcio Carlo, Guarino Carmine, Grella Edoardo, Forzano Imma, Cennamo Antonio, Tafuri Domenico, Rocca Aldo, Bianco Andrea, and Mazzarella Gennaro

Subjects
solitary fibrous tumor of the pleura (sftp), surgical treatment, embolization, giant tumors, Medicine
Abstract

The fibrous tumors of the pleura are rare primary tumors, accounting for 5% of malignant pleural neoplasms, which generally originate from sub-mesothelial mesenchymal tissue of the visceral pleura. These tumours generally exhibit clinical benign behavior although 12% of solitary fibrous tumors can be malignant and have worse outcomes. These tumors are considered “giant” when the lesion > 15 cm. Surgical treatment is the best choice for both benign and malignant neoplasms. We retrospectively analyzed the main case series of giant fibrous tumors of the pleura. In addition we report our experience of a 76-year-old woman treated by pre-surgical embolization involving implantation of vascular plugs. Surgery was successfully carried out without complications; imaging and functional assessment 6 months post intervention demonstrated both the absence of recurrence and improvement of lung function parameters.

Published
2016
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18. Prolonged air leak after video-assisted thoracic anatomical pulmonary resections: a clinical predicting model based on data from the Italian VATS group registry, a machine learning approach

Author

Divisi, Duilio, Pipitone, Marco, Perkmann, Reinhold, Bertolaccini, Luca, Curcio, Carlo, Baldinelli, Francesco, Crisci, Roberto, and Zaraca, Francesco

Subjects
Prolonged air leak (PAL), risk factors, risk predictive model, video-assisted thoracoscopic surgery lobectomy (VATS lobectomy)
Published
2023

19. Moving Immune Checkpoint Inhibitors to Early Non-Small Cell Lung Cancer: A Narrative Review

Author

Viscardi, Giuseppe, primary, Vitiello, Fabiana, additional, Servetto, Alberto, additional, Gristina, Valerio, additional, Pizzutilo, Elio Gregory, additional, Canciello, Maria Anna, additional, Medusa, Paola Maria, additional, Salomone, Fabio, additional, Di Guida, Gaetano, additional, Mollica, Mariano, additional, Aronne, Luigi, additional, Scaramuzzi, Roberto, additional, Napolitano, Filomena, additional, Battiloro, Ciro, additional, Caputo, Francesca, additional, Gilli, Marina, additional, Totaro, Giuseppe, additional, Curcio, Carlo, additional, Rocco, Danilo, additional, and Montesarchio, Vincenzo, additional

Published
2022
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20. Air leak and intraoperative bleeding in thoracic surgery: a Delphi consensus among the members of Italian society of thoracic surgery

Author

Cardillo, Giuseppe, primary, Nosotti, Mario, additional, Scarci, Marco, additional, Torre, Massimo, additional, Alloisio, Marco, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Cagini, Lucio, additional, Casablanca, Giuseppe, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, Crucitti, Pierfilippo, additional, Curcio, Carlo, additional, Denegri, Andrea, additional, Droghetti, Andrea, additional, Guggino, Gianluca, additional, Imperatori, Andrea, additional, Infante, Maurizio Valentino, additional, Lucchi, Marco, additional, Macrì, Paolo, additional, Marulli, Giuseppe, additional, Melloni, Giulio, additional, Paci, Massimiliano, additional, Paladini, Piero, additional, Pariscenti, Gian Luca, additional, Potenza, Enrico, additional, Rea, Federico, additional, Refai, Majed, additional, Rena, Ottavio, additional, Ricciardi, Sara, additional, Rusca, Michele, additional, Sollitto, Francesco, additional, Taurchini, Marco, additional, Terzi, Alberto, additional, Voltolini, Luca, additional, and Crisci, Roberto, additional

Published
2022
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21. Circumferential esophageal leiomyoma: Management by combined robotic surgery and intraoperative endoscopy.

Author

Amore, Dario, Casazza, Dino, Caterino, Umberto, Massa, Simona, Muto, Emanuele, and Curcio, Carlo

Abstract

Leiomyoma is the most common benign tumor of the esophagus. Open thoracotomy, the traditional approach adopted for the enucleation of the esophageal leiomyoma, over the years, has been gradually replaced by video-assisted thoracoscopic surgery. However, this minimally invasive approach has limitations, such as two-dimensional vision and reduced range of motion, which have recently been overcome by technical advantages of robot-assisted surgery. In the surgical management of circumferential esophageal leiomyoma, a combined use of robotic surgery and intraoperative endoscopy may be helpful to facilitate tumor enucleation and to prevent esophageal mucosal injury during the surgical procedure. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Rate and Predictors of Unforeseen PN1/PN2-Disease in Surgically Treated cN0 NSCLC-Patients with Primary Tumor > 3 cm: Nationwide Results from Italian VATS-Group Database

Author

Lococo, Filippo, Nachira, Dania, Chiappetta, Marco, Sperduti, Isabella, Congedo, Maria Teresa, Meacci, Elisa, Leoncini, Fausto, Trisolini, Rocco, Crisci, Roberto, Curcio, Carlo, Casiraghi, Monica, Margaritora, Stefano, and On The Behalf Of The Italian Vats Group, Null

Subjects
surgery, VATS-Group, NSCLC, VATS, nodal upstaging, staging, General Medicine
Abstract

Background. Since no robust data are available on the real rate of unforeseen N1-N2 disease (uN) and the relative predictive factors in clinical-N0 NSCLC with peripheral tumours > 3 cm, the usefulness of performing a (mini)invasive mediastinal staging in this setting is debated. Herein, we investigated these issues in a nationwide database. Methods. From 01/2014 to 06/2020, 15,784 thoracoscopic major lung resections were prospectively recorded in the “Italian VATS-Group” database. Among them, 1982 clinical-N0 peripheral solid-type NSCLC > 3 cm were identified, and information was retrospectively reviewed. A mean comparison of more than two groups was made by ANOVA (Bonferroni correction for multiple comparisons), while associations between the categorical variables were estimated with a Chi-square test. The multivariate logistic regression model and Kaplan–Meyer method were used to identify the independent predictors of nodal upstaging and survival results, respectively. Results. At pathological staging, 229 patients had N1-involvement (11.6%), and 169 had uN2 disease (8.5%). Independent predictors of uN1 were SUVmax (OR: 1.98; CI 95: 1.44–2.73, p = 0.0001) and tumour-size (OR: 1.52; CI: 1.11–2.10, p = 0.01), while independent predictors of uN2 were age (OR: 0.98; CI 95: 0.96–0.99, p = 0.039), histology (OR: 0.48; CI 95: 0.30–0.78, p = 0.003), SUVmax (OR: 2.07; CI 95: 1.15–3.72, p = 0.015), and the number of resected lymph nodes (OR: 1.03; CI 95: 1.01–1.05, p = 0.002). Conclusions. The unforeseen N1-N2 disease in cN0/NSCLCs > 3 cm undergoing VATS resection is observable in between 12 and 8% of all cases. We have identified predictors that could guide physicians in selecting the best candidate for (mini)invasive mediastinal staging.

Published
2023

26. The Overweight Paradox: Impact of Body Mass Index on Patients Undergoing VATS Lobectomy or Segmentectomy

Author

Parini, Sara, primary, Azzolina, Danila, additional, Massera, Fabio, additional, Mastromarino, Maria Giovanna, additional, Papalia, Esther, additional, Baietto, Guido, additional, Curcio, Carlo, additional, Crisci, Roberto, additional, Rena, Ottavio, additional, Alloisio, Marco, additional, Amore, Dario, additional, Ampollini, Luca, additional, Ardò, Nicoletta, additional, Argnani, Desideria, additional, Baisi, Alessandro, additional, Bandiera, Alessandro, additional, Benato, Cristiano, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Bortolotti, Luigi, additional, Bottoni, Edoardo, additional, Breda, Cristiano, additional, Camplese, Pierpaolo, additional, Carbognani, Paolo, additional, Cardillo, Giuseppe, additional, Carleo, Francesco, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, De Palma, Angela, additional, Dell'Amore, Andrea, additional, Della Beffa, Vittorio, additional, Divisi, Duilio, additional, Dolci, Giampiero, additional, Droghetti, Andrea, additional, Ferrari, Paolo, additional, Fontana, Diego, additional, Gasparri, Roberto, additional, Gavezzoli, Diego, additional, Ghisalberti, Marco, additional, Giovanardi, Michele, additional, Gonfiotti, Alessandro, additional, Guerrera, Francesco, additional, Imperatori, Andrea, additional, Infante, Maurizio, additional, Lausi, Paolo, additional, Lo Giudice, Fabio, additional, Londero, Francesco, additional, Lopez, Camillo, additional, Mancuso, Maurizio, additional, Maniscalco, Pio, additional, Margaritora, Stefano, additional, Marulli, Giuseppe, additional, Mazza, Federico, additional, Meacci, Elisa, additional, Melloni, Giulio, additional, Morelli, Angelo, additional, Mucilli, Felice, additional, Natali, Pamela, additional, Negri, Giampiero, additional, Nicotra, Samuele, additional, Nosotti, Mario, additional, Paladini, Piero, additional, Pariscenti, Gianluca, additional, Perkmann, Reinhold, additional, Pernazza, Fausto, additional, Pirondini, Emanuele, additional, Puma, Francesco, additional, Raveglia, Federico, additional, Refai, Majed, additional, Rinaldo, Alessandro, additional, Risso, Carlo, additional, Rizzardi, Giovanna, additional, Rotolo, Nicola, additional, Scarci, Marco, additional, Solli, Piergiorgio, additional, Sollitto, Francesco, additional, Spaggiari, Lorenzo, additional, Stefani, Alessandro, additional, Stella, Franco, additional, Surrente, Corrado, additional, Tancredi, Giorgia, additional, Terzi, Alberto, additional, Torre, Massimo, additional, Tosi, Davide, additional, Vinci, Damiano, additional, Viti, Andrea, additional, Voltolini, Luca, additional, and Zaraca, Francesco, additional

Published
2022
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29. Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer

Author

Terlizzi, Michela, Colarusso, Chiara, De Rosa, Ilaria, De Rosa, Nicolina, Somma, Pasquale, Curcio, Carlo, Sanduzzi, Alessandro Zamparelli, Micheli, Pietro, Molino, Antonio, Saccomanno, Antonello, SALVI, ROSARIO, Aquino, Rita P., Pinto, Aldo, Sorrentino, Rosalinda, SANDUZZI ZAMPARELLI, ALESSANDRO, Terlizzi, Michela, Colarusso, Chiara, De Rosa, Ilaria, De Rosa, Nicolina, Somma, Pasquale, Curcio, Carlo, Sanduzzi, Alessandro Zamparelli, Micheli, Pietro, Molino, Antonio, Saccomanno, Antonello, Salvi, Rosario, Aquino, Rita P., Pinto, Aldo, Sorrentino, Rosalinda, and SANDUZZI ZAMPARELLI, Alessandro

Subjects
0301 basic medicine, medicine.medical_specialty, Tuberculosis, Prognosi, diagnosis, Survival rate", "Lung cancer, Caspase 4, NSCLC, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, Lung cancer, Survival rate, non-small cell lung cancer, COPD, Lung, biology, business.industry, Correction, medicine.disease, respiratory tract diseases, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Biomarker, Diagnosis, biology.protein, Biomarker (medicine), biomarker, Non small cell, prognosis, business, Diagnosi, Research Paper
Abstract

Late diagnosis limits therapeutic options and survival rate of non-small cell lung cancer (NSCLC) patients. Therefore the identification of biomarkers represents an emerging medical need. A highly sensitive and specific test was developed to identify/quantify a novel/selective diagnostic biomarker for NSCLC patients, caspase-4. This test was validated by using i) plasma from 125 NSCLC patients and 79 healthy (non-pathological) subjects, ii) plasma from 139 smokers and iii) from 70 chronic-obstructive pulmonary disease (COPD) patients. Caspase-4 quantification was also assessed in the lung tumor mass of 98 paired NSCLC patients compared to 10 non-tumor lung tissues (i.e. tuberculosis). Circulating caspase-4 was detected in both healthy and NSCLC patients; however at different range values: 2.603-3.372 ng/ml for NSCLC patients (95% CI) compared to 0.3994-0.6219 ng/ml for healthy subjects (95% CI). The sensitivity of the test ranged from 97.07% to 100%; the specificity was 88.1% with a positive predictive value of 92.54%, accuracy of 95.19% and AUC of 0.971. Smokers (95% CI, 0.3947-0.6197 ng/ml) and COPD patients (95% CI, 1.703-2.995 ng/ml) showed intermediate values of circulating caspase-4. Tissue levels of caspase-4 in the tumor mass showed that 72 (72.7%) out of 99 patients were positive. More importantly, higher levels (cut-off value = 0.307 ng/ml) of caspase-4 in the tumor mass were associated to reduced overall survival (median 0.92 years) compared to NSCLC patients with lower levels (median 3.02 years). We report for the first time caspase-4 as a novel diagnostic and prognostic biomarker, opening new therapeutic perspectives for NSCLC patients.

Published
2018

31. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Bongiolatti, Stefano, primary, Gonfiotti, Alessandro, additional, Borgianni, Sara, additional, Crisci, Roberto, additional, Curcio, Carlo, additional, Voltolini, Luca, additional, Alloisio, Marco, additional, Amore, Dario, additional, Ampollini, Luca, additional, Andreetti, Claudio, additional, Argnani, Desideria, additional, Baietto, Guido, additional, Bandiera, Alessandro, additional, Benato, Cristiano, additional, Benvenuti, Mauro Roberto, additional, Bertani, Alessandro, additional, Bertolaccini, Luca, additional, Bortolotti, Luigi, additional, Bottoni, Edoardo, additional, Breda, Cristiano, additional, Camplese, Pierpaolo, additional, Carbognani, Paolo, additional, Cardillo, Giuseppe, additional, Casadio, Caterina, additional, Cavallesco, Giorgio, additional, Cherchi, Roberto, additional, Dell’Amore, Andrea, additional, Della Beffa, Vittorio, additional, Dolci, Giampiero, additional, Droghetti, Andrea, additional, Ferrari, Paolo A., additional, Fontana, Diego, additional, Gargiulo, Gaetano, additional, Gasparri, Roberto, additional, Gavezzoli, Diego, additional, Ghisalberti, Marco, additional, Giovanardi, Michele, additional, Guerrera, Francesco, additional, Imperatori, Andrea, additional, Infante, Maurizio, additional, Iurilli, Luciano, additional, Lausi, Paolo, additional, Lo Giudice, Fabio, additional, Londero, Francesco, additional, Luzzi, Luca, additional, Lopez, Camillo, additional, Mancuso, Maurizio, additional, Maniscalco, Pio, additional, Margaritora, Stefano, additional, Meacci, Elisa, additional, Melloni, Giulio, additional, Morelli, Angelo, additional, Mucilli, Felice, additional, Natali, Pamela, additional, Negri, Giampiero, additional, Nicotra, Samuele, additional, Nosotti, Mario, additional, Pariscenti, Gianluca, additional, Perkmann, Reinhold, additional, Pernazza, Fausto, additional, Pirondini, Emanuele, additional, Poggi, Camilla, additional, Puma, Francesco, additional, Refai, Majed, additional, Rinaldo, Alessandro, additional, Rizzardi, Giovanna, additional, Rosso, Lorenzo, additional, Rotolo, Nicola, additional, Russo, Emanuele, additional, Sabbatini, Armando, additional, Scarci, Marco, additional, Spaggiari, Lorenzo, additional, Stefani, Alessandro, additional, Solli, Piergiorgio, additional, Surrente, Corrado, additional, Terzi, Alberto, additional, Torre, Massimo, additional, Vinci, Damiano, additional, Viti, Andrea, additional, Zaccagna, Gino, additional, and Zaraca, Francesco, additional

Published
2021
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32. Post-operative outcomes and quality of life assessment after thoracoscopic lobectomy for Non-small-cell lung cancer in octogenarians: Analysis from a national database

Author

Bongiolatti, Stefano, Gonfiotti, Alessandro, Borgianni, Sara, Crisci, Roberto, Curcio, Carlo, Voltolini, Luca, Margaritora, Stefano, Italian VATS, Group, Margaritora, Stefano (ORCID:0000-0002-9796-760X), Bongiolatti, Stefano, Gonfiotti, Alessandro, Borgianni, Sara, Crisci, Roberto, Curcio, Carlo, Voltolini, Luca, Margaritora, Stefano, Italian VATS, Group, and Margaritora, Stefano (ORCID:0000-0002-9796-760X)

Abstract

Background: Thoracoscopic lobectomy (VATS-L) for non-small-cell lung cancer (NSCLC) is a well-established option for early stage NSCLC, but the evidences are limited for octogenarians. Objective: The objectives of this multi-institutional study were to evaluate the post-operative outcomes of VATS-L in octogenarians and to estimate the post-operative quality of life (QoL) using a validated questionnaire (EuroQoL5D). Methods: Data from patients underwent VATS-L between 2014 and 2019 were analysed and divided into two groups: Group A (younger patients) and Group B (octogenarians). To define predictors for complications, univariate and multivariable logistic regression analysis were performed. Results: 7023 patients underwent VATS-L and 329 (4.6%) were octogenarians. 30-day and 90-day post-operative mortality were similar (0.95% vs 0.91%, p = 0.84 and 1.3% vs 1.2%, p = 0.58), whereas the percentage of patients who suffered from any complication (25.5% vs 31.9%, p = 0.012) and the complication rate (31.6% vs 45.2%, p= 0.01) were higher for octogenarians. At discharge, the values of EuroQoL5D were worse in group B, but after one month these levels became similar. Age 80 years had a significant influence on morbidity on both univariate and multivariable analyses (p = 0.025). Conclusions: VATS-L for NSCLC can be performed in selected octogenarians without increased risk of postoperative death, acceptable not-life-threatening complications and a moderate impact on QoL.

Published
2021

33. Standardized uptake value and radiological density attenuation as predictive and prognostic factors in patients with solitary pulmonary nodules: our experience on 1,592 patients

Author

Divisi, Duilio, Barone, Mirko, Bertolaccini, Luca, Rocco, Gaetano, Solli, Piergiorgio, Crisci, Roberto, Italian Vats Group, Ampollini, Luca, Alloisio, Marco, Andreetti, Claudio, Amore, Dario, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benetti, Diego, Benvenuti, Mauro, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Casadio, Caterina, Cavallesco, Giorgio, Curcio, Carlo, Denegri, Andrea, Di Rienzo, Gaetano, Dolci, Giampiero, Droghetti, Andrea, Gasparri, Roberto, Ghisalberti, Marco, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Londero, Francesco, Lopez, Camillo, Luzzi, Luca, Maineri, Paola, Maniscalco, Pio, Marulli, Giuseppe, Monteverde, Marco, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Perkmann, Reinhold, Poggi, Camilla, Puma, Francesco, Refai, Mayed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabatini, Armando, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, Zaraca, Francesco, Divisi, Duilio, Barone, Mirko, Bertolaccini, Luca, Rocco, Gaetano, Solli, Piergiorgio, Crisci, Roberto, Italian VATS, Group, Negri, G, Ampollini, Luca, Alloisio, Marco, Andreetti, Claudio, Amore, Dario, Baietto, Guido, Bandiera, Alessandro, Benato, Cristiano, Benetti, Diego, Benvenuti, Mauro, Bertani, Alessandro, Bortolotti, Luigi, Bottoni, Edoardo, Camplese, Pierpaolo, Carbognani, Paolo, Cardillo, Giuseppe, Carleo, Francesco, Casadio, Caterina, Cavallesco, Giorgio, Curcio, Carlo, Denegri, Andrea, Di Rienzo, Gaetano, Dolci, Giampiero, Droghetti, Andrea, Gasparri, Roberto, Ghisalberti, Marco, Gonfiotti, Alessandro, Guerrera, Francesco, Imperatori, Andrea, Infante, Maurizio, Lausi, Paolo, Londero, Francesco, Lopez, Camillo, Luzzi, Luca, Maineri, Paola, Maniscalco, Pio, Marulli, Giuseppe, Monteverde, Marco, Morelli, Angelo, Mucilli, Felice, Natali, Pamela, Negri, Giampiero, Nicotra, Samuele, Nosotti, Mario, Perkmann, Reinhold, Poggi, Camilla, Puma, Francesco, Refai, Mayed, Rinaldo, Alessandro, Rizzardi, Giovanna, Rosso, Lorenzo, Rotolo, Nicola, Russo, Emanuele, Sabatini, Armando, Spaggiari, Lorenzo, Stefani, Alessandro, Stella, Franco, Terzi, Alberto, Torre, Massimo, Vinci, Damiano, Viti, Andrea, Voltolini, Luca, and Zaraca, Francesco

Subjects
Lung adenocarcinoma, Pulmonary and Respiratory Medicine, medicine.medical_specialty, VATS lobectomy, Standardized uptake value, Malignancy, Ground-glass opacity, NO, 030218 nuclear medicine & medical imaging, Maximum standardized uptake value, 03 medical and health sciences, 0302 clinical medicine, ground glass opacities, Solitary pulmonary nodule (SPN), maximum standardized uptake value, lymph node metastases, lung adenocarcinoma, Lymph node metastase, medicine, Ground glass opacities, Lymph node metastases, Lung cancer, Lymph node, business.industry, Ground glass opacitie, Nodule (medicine), medicine.disease, Primary tumor, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Original Article, Radiology, medicine.symptom, business
Abstract

Background: Multislice computed tomography (MSCT) increased detection of solitary pulmonary nodules (SPNs), changing the management based on radiological and clinical factors. When 18-fluorine fluorodeoxyglucose positron emission tomography combined with computed tomography ( 18 F-FDG-PET/CT) was considered for the evaluation of nodules, the maximum standardized uptake value (SUVmax) more than 2.5 is used frequently as a cut off for malignancy. The purpose of this study is to evaluate SUVmax PET/CT and pulmonary attenuation patterns at MSCT in patients with SPN according to morphological and pathological characteristics of the lesion. Methods: A retrospective study on 1,592 SPN patients was carried out following approval by the Italian Registry of VATS Lobectomies. Results: All patients underwent VATS lobectomy. On histologic examination, 98.1% had primary or second metachronous primary lung cancers. In addition, 10.7% presented occult lymph node metastases (pN1 or pN2) on histological examination. Nodule attenuation on CT was associated with the histology of the lesion (p= 0.030); in particular, pure ground glass opacities (pGGOs) and partially solid nodules were related to adenocarcinomatous histotypes. Conversely, a significant relationship between SUVmax and age, nodule size, pathological node status (pN) was found (P=0.007, P=0.000 and P=0.002 respectively). Conclusions: Nodule attenuation can predict the histology of the lesion whereas SUVmax may relate to the propensity to lymph node metastases.

Published
2017

35. Additional file 1 of Recommendations from the Italian intersociety consensus on Perioperative Anesthesia Care in Thoracic surgery (PACTS) part 1: preadmission and preoperative care

Author

Piccioni, Federico, Droghetti, Andrea, Bertani, Alessandro, Coccia, Cecilia, Corcione, Antonio, Corsico, Angelo Guido, Crisci, Roberto, Curcio, Carlo, Naja, Carlo Del, Feltracco, Paolo, Fontana, Diego, Gonfiotti, Alessandro, Lopez, Camillo, Massullo, Domenico, Nosotti, Mario, Ragazzi, Riccardo, Rispoli, Marco, Romagnoli, Stefano, Scala, Raffaele, Scudeller, Luigia, Taurchini, Marco, Tognella, Silvia, Umari, Marzia, Valenza, Franco, and Petrini, Flavia

Subjects
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, Data_FILES
Abstract

Additional file 1. Search strategy and keywords.

Published
2020
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37. Predicting a Prolonged Air Leak After Video-Assisted Thoracic Surgery, Is It Really Possible?

Author

Zaraca, Francesco, primary, Pipitone, Marco, additional, Feil, Birgit, additional, Perkmann, Reinhold, additional, Bertolaccini, Luca, additional, Curcio, Carlo, additional, Crisci, Roberto, additional, Mancuso, M., additional, Pernazza, F., additional, Refai, M., additional, Srella, F., additional, Argnani, D., additional, Marulli, G., additional, De Palma, A., additional, Bortolotti, L., additional, Rizzardi, G., additional, Solli, P.G., additional, Dolci, G.P., additional, Perkmann, R., additional, Zaraca, F., additional, Benvenuti, M., additional, Gavezzoli, D., additional, Cherchi, R., additional, Ferrari, P., additional, Mucilli, F., additional, Camplese, P., additional, Melloni, G., additional, Mazza, F., additional, Cavallesco, G., additional, Maniscalco, P., additional, Voltolini, L., additional, Gonfiotti, A., additional, Sollitto, F., additional, Ardò, N., additional, Pariscenti, G.L., additional, Risso, C., additional, Surrente, C., additional, Lopez, C., additional, Droghetti, A., additional, Giovanardi, M., additional, Breda, C., additional, Giudice, Lo F., additional, Alloisio, M., additional, Bottoni, E., additional, Spaggiari, L., additional, Gasparri, R., additional, Torre, M., additional, Rinaldo, A., additional, Nosotti, M., additional, Tosi, D., additional, Negri, G.P., additional, Bandiera, A., additional, Baisi, A., additional, Raveglia, F., additional, Stefani, A., additional, Natali, P., additional, Scarci, M., additional, Pirondini, E., additional, Curcio, C., additional, Amore, D., additional, Rena, O., additional, Nicotra, S., additional, Dell’ Amore, A., additional, Bertani, A., additional, Tancredi, G., additional, Ampollini, L., additional, Carbognani, P., additional, Puma, F., additional, Vinci, D., additional, Cardillo, G., additional, Carleo, F., additional, Margaritora, S., additional, Meacci, E., additional, Luzzi, L., additional, Ghisalberti, M., additional, Crisci, R., additional, Divisi, D., additional, Lausi, P., additional, Guerrera, F., additional, Fontana, D., additional, Beffa, V. Della, additional, Morelli, A., additional, Londero, F., additional, Imperatori, A., additional, Rotolo, N., additional, Terzi, A., additional, Viti, A., additional, Infante, M., additional, and Benato, C., additional

Published
2021
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39. Is It Possible to Establish a Reliable Correlation between Maximum Standardized Uptake Value of 18-Fluorine Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and Histological Types of Non-Small Cell Lung Cancer? Analysis of the Italian VATS Group Database

Author

Divisi, Duilio, Rinaldi, Marta, Necozione, Stefano, Curcio, Carlo, Rea, Federico, Zaraca, Francesco, De Vico, Andrea, Zaccagna, Gino, Di Leonardo, Gabriella, Crisci, Roberto, and On Behalf Of The Italian Vats Group, Null

Subjects
Medicine (General), medicine.medical_specialty, 18F-FDG-PET/CT, Clinical Biochemistry, VATS lobectomy, Standardized uptake value, NSCLC, Article, R5-920, biological framework, SUVmax, VATS group, data quality, Post-hoc analysis, medicine, Lung cancer, medicine.diagnostic_test, business.industry, Histology, medicine.disease, Positron emission tomography, Adenocarcinoma, Histopathology, Nuclear medicine, business
Abstract

Background. Although positron emission tomography/computed tomography, often integrated with 2-deoxy-2-[fluorine-18] fluorine-D-glucose (18F-FDG-PET/CT), is fundamental in the assessment of lung cancer, the relationship between metabolic avidity of different histotypes and maximum standardized uptake value (SUVmax) has not yet been thoroughly investigated. The aim of the study is to establish a reliable correlation between Suvmax and histology in non-small cell lung cancer (NSCLC), in order to facilitate patient management. Methods. We retrospectively assessed the data about lung cancer patients entered in the Italian Registry of VATS Group from January 2014 to October 2019, after establishing the eligibility criteria of the study. In total, 8139 patients undergoing VATS lobectomy were enrolled: 3260 females and 4879 males. The relationship between SUVmax and tumor size was also analyzed. Results. The mean values of SUVmax in the most frequent types of lung cancer were as follows: (a) 4.88 ± 3.82 for preinvasive adenocarcinoma; (b) 5.49 ± 4.10 for minimally invasive adenocarcinoma; (c) 5.87 ± 4.18 for invasive adenocarcinoma; and (d) 8.85 ± 6.70 for squamous cell carcinoma. Processing these data, we displayed a statistically difference (p < 0.000001) of FDG avidity between adenocarcinoma and squamous cell carcinoma. Moreover, by classifying patients into five groups based on tumor diameter and after evaluating the SUVmax value for each group, we noted a statistical correlation (p < 0.000001) between size and FDG uptake, also confirmed by the post hoc analysis. Conclusions. There is a correlation between SUVmax, histopathology outcomes and tumor size in NSCLC. Further clinical trials should be performed in order to confirm our data.

Published
2021

40. Comparison of operative and postoperative characteristics and outcomes between thoracoscopic segmentectomy and lobectomy for non-small-cell lung cancer: a propensity score matching study from the Italian VATS Group Registry.

Author

Dell'Amore, Andrea, Lomangino, Ivan, Cannone, Giorgio, Terzi, Stefano, Pangoni, Alessandro, Lorenzoni, Giulia, Nicotra, Samuele, Schiavon, Marco, Zuin, Andrea, Gregori, Dario, Crisci, Roberto, Curcio, Carlo, Rea, Federico, and Group, the Italian VATS

Subjects
LOBECTOMY (Lung surgery), NON-small-cell lung carcinoma, PROPENSITY score matching, TREATMENT effectiveness, VIDEO-assisted thoracic surgery, LENGTH of stay in hospitals
Abstract

OBJECTIVES Only few studies compared the surgical morbidity and mortality of thoracoscopic segmentectomy versus lobectomy for non-small-cell lung cancer, in particular, by relating the segmental resections with the corresponding anatomical lobes. METHODS We enrolled a total of 7487 patients who underwent VATS lobectomy (7269) or segmentectomy (218) from January 2014 to July 2019. A propensity score matching approach was used to account for potential confounding factors between the 2 groups. After matching, 349 lobectomies and 208 segmentectomies were included in the analysis. We analysed the operative and postoperative outcomes of video-assisted anatomical segmentectomy compared with video-assisted lobectomy and, in details, the results of segmentectomy with its corresponding lobectomy in a large cohort of patients from the Italian VATS Group Registry. RESULTS The overall conversion rate to thoracotomy was not statistically different between the groups (27 patients 8% vs 7 patients 3%, P  = 0.1). The lobectomy group had a greater number of resected lymph nodes (median 11 vs 8, P  = 0.006). No significant differences were detected in 30-day mortality (1.4%, 5 patients vs 0.9%, 2 patients), overall complications (18%, 62 patients vs 14%, 29 patients) and prolonged air leakage (31 patients, 9% vs 12 patients, 6%) between lobectomy and segmentectomy, respectively. No statistical differences were found regarding the median duration of drainage (3.2 days, P  = 1) and the overall median length of hospital stay (6.4 days, P  = 0.1) between the 2 groups. In the context of segmentectomy versus corresponding lobectomy, the right upper lobectomy compared with right upper segmentectomy showed a higher number of resected lymph nodes (P  = 0.027). No statistical differences were reported in terms of conversion rate and postoperative complication and mortality. CONCLUSIONS Segmentectomy could be considered a safe procedure without significant differences compared to thoracoscopic lobectomy in terms of postoperative morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Identification of a novel subpopulation of Caspase-4 positive Non-Small Cell Lung Cancer patients.

Author

Terlizzi, Michela, primary, Colarusso, Chiara, additional, De Rosa, Ilaria, additional, Somma, Pasquale, additional, Curcio, Carlo, additional, Aquino, Rita, additional, Panico, Luigi, additional, Salvi, Rosario, additional, Marino, Federica Zito, additional, Botti, Gerardo, additional, Pinto, Aldo, additional, and Sorrentino, Rosalinda, additional

Published
2020
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45. Low-dose oral etoposide is an active option for patients with heavily pre-treated thymic epithelial tumors.

Author

Ottaviano, Margaret, primary, Tortora, Marianna, additional, Giuliano, Mario, additional, Terracciano, Daniela, additional, Di Lauro, Vincenzo, additional, Picozzi, Fernanda, additional, Parola, Sara, additional, Riccio, Vittorio, additional, De Placido, Pietro, additional, Pietroluongo, Erica, additional, Liotti, Antonietta, additional, La Civita, Evelina, additional, Guggino, Gianluca, additional, Cicalese, Marcellino, additional, Curcio, Carlo, additional, Longo, Michele, additional, Botti, Gerardo, additional, Daniele, Bruno, additional, De Placido, Sabino, additional, and Palmieri, Giovannella, additional

Published
2020
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47. Video-assisted thoracoscopic surgery lobectomy in lung cancer after neoadjuvant chemotherapy: feasibility and security analysis through video-assisted thoracoscopic surgery national registry data evaluation

Author

Zaccagna, Gino, primary, Zaraca, Carlo, additional, Di Leonardo, Gabriella, additional, Bertolaccini, Luca, additional, Zaraca, Francesco, additional, De Vico, Andrea, additional, Curcio, Carlo, additional, Crisci, Roberto, additional, Divisi, Duilio, additional, and VATS Group, Italian, additional

Published
2020
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50. Effectiveness of home-based preoperative pulmonary rehabilitation in COPD patients undergoing lung cancer resection

Author

Rispoli, Marco, primary, Salvi, Rosario, additional, Cennamo, Antonio, additional, Di Natale, Davide, additional, Natale, Giovanni, additional, Meoli, Ilernando, additional, Gioia, Maria Rosaria, additional, Esposito, Marianna, additional, Nespoli, Moana Rossella, additional, De Finis, Mario, additional, Buono, Salvatore, additional, Corcione, Antonio, additional, Lavoretano, Sabrina, additional, Bianco, Andrea, additional, Fiorelli, Alfonso, additional, Curcio, Carlo, additional, and Perrotta, Fabio, additional

Published
2020
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