8 results on '"Chu, Yan-Li"'
Search Results
2. Borrelia miyamotoi Infections in Humans and Ticks, Northeastern China
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Jiang, Bao-Gui, Jia, Na, Jiang, Jia-Fu, Zheng, Yuan-Chun, Chu, Yan-Li, Jiang, Rui-Ruo, Wang, Ya-Wei, Liu, Hong-Bo, Wei, Ran, Zhang, Wen-Hui, Li, Yan, Xu, Xiao-Wei, Ye, Jin-Ling, Yao, Nan-Nan, Liu, Xiao-Jing, Huo, Qiu-Bo, Sun, Yi, Song, Ju-Liang, Liu, Wei, and Cao, Wu-Chun
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Bites (Injuries) -- Analysis -- Health aspects ,Hospital patients -- Analysis -- Health aspects ,Anorexia nervosa -- Analysis -- Health aspects ,Infection -- Analysis -- Health aspects ,Phylogeny -- Analysis -- Health aspects ,RNA -- Analysis -- Health aspects ,Health - Abstract
Borrelia miyamotoi is an emerging pathogen first identified in Ixodes persulcatus ticks and rodents from Japan in 1994 (1,2). Since then, this bacterium has been discovered in various other Ixodes [...]
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- 2018
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3. Four plasma membrane-localized MGR transporters mediate xylem Mg2+ loading for root-to-shoot Mg2+ translocation in Arabidopsis.
- Author
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Meng, Su-Fang, Zhang, Bin, Tang, Ren-Jie, Zheng, Xiao-Jiang, Chen, Rui, Liu, Cong-Ge, Jing, Yan-Ping, Ge, Hai-Man, Zhang, Chi, Chu, Yan-Li, Fu, Ai-Gen, Zhao, Fu-Geng, Luan, Sheng, and Lan, Wen-Zhi
- Abstract
Magnesium (Mg
2+ ), an essential structural component of chlorophyll, is absorbed from the soil by roots and transported to shoots to support photosynthesis in plants. However, the molecular mechanisms underlying root-to-shoot Mg2+ translocation remain largely unknown. We describe here the identification of four plasma membrane (PM)-localized transporters, named Mg2+ release transporters (MGRs), that are critical for root-to-shoot Mg transport in Arabidopsis. Functional complementation assays in a Mg2+ -uptake-deficient bacterial strain confirmed that these MGRs conduct Mg2+ transport. PM-localized MGRs (MGR4, MGR5, MGR6, and MGR7) were expressed primarily in root stellar cells and participated in the xylem loading step of the long-distance Mg2+ transport process. In particular, MGR4 and MGR6 played a major role in shoot Mg homeostasis, as their loss-of-function mutants were hypersensitive to low Mg2+ but tolerant to high Mg2+ conditions. Reciprocal grafting analysis further demonstrated that MGR4 functions in the root to determine shoot Mg2+ accumulation and physiological phenotypes caused by both low- and high-Mg2+ stress. Taken together, our study has identified the long-sought transporters responsible for root-to-shoot Mg2+ translocation in plants. Plants deliver Mg2+ to shoots, which is crucial for chloroplast structure and photosynthesis. In this study, the authors have identified four plasma membrane-localized Mg2+ release transporters (MGRs) that can load Mg2+ into the xylem and thus determine shoot Mg2+ accumulation in Arabidopsis. [ABSTRACT FROM AUTHOR]- Published
- 2022
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4. Virome and Blood Meal-Associated Host Responses in Ixodes persulcatus Naturally Fed on Patients.
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Li, Liang-Jing, Ning, Nian-Zhi, Zheng, Yuan-Chun, Chu, Yan-Li, Cui, Xiao-Ming, Zhang, Ming-Zhu, Guo, Wen-Bin, Wei, Ran, Liu, Hong-Bo, Sun, Yi, Ye, Jin-Ling, Jiang, Bao-Gui, Yuan, Ting-Ting, Li, Jie, Bian, Cai, Bell-Sakyi, Lesley, Wang, Hui, Jiang, Jia-Fu, Song, Ju-Liang, and Cao, Wu-Chun
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IXODES ,REACTIVE oxygen species ,WATCHFUL waiting - Abstract
The long-lasting co-evolution of ticks with pathogens results in mutual adaptation. Blood-feeding is one of the critical physiological behaviors that have been associated with the tick microbiome; however, most knowledge was gained through the study of laboratory-reared ticks. Here we detached Ixodes persulcatus ticks at different stages of blood-feeding from human patients and performed high-throughput transcriptomic analysis on them to identify their virome and genes differentially expressed between flat and fully fed ticks. We also traced bloodmeal sources of those ticks and identified bats and three other potential mammalian hosts, highlighting the public health significance. We found Jingmen tick virus and 13 putative new viruses belonging to 11 viral families, three of which even exhibited high genetic divergence from viruses previously reported in the same tick species from the same geographic region. Furthermore, differential expression analysis suggested a downregulation of antioxidant genes in the fully fed I. persulcatus ticks, which might be related to bloodmeal-related redox homeostasis. Our work highlights the significance of active surveillance of tick viromes and suggests a role of reactive oxygen species (ROS) in modulating changes in the microbiome during blood-feeding. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Human infections with Rickettsia raoultii, China
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Jia, Na, Zheng, Yuan-Chun, Ma, Lan, Huo, Qiu-Bo, Ni, Xue-Bing, Jiang, Bao-Gui, Chu, Yan-Li, Jiang, Rui-Ruo, Jiang, Jia- Fu, and Cao, Wu-Chun
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Rickettsia -- Diagnosis -- Genetic aspects ,Rickettsial diseases -- Causes of -- Care and treatment -- Demographic aspects ,Health - Abstract
Rickettsia raoultii was first detected in Rhipicephalus pumilio and Dermacentor nuttalli ticks from the former Soviet Union in 1999 and initially named RpA4, DnS14, and DnS28 (1). In 2008, it [...]
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- 2014
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6. CFTR is essential for sperm fertilizing capacity and is correlated with sperm quality in humans.
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Chu-Yan Li, Ling-Ying Jiang, Wen-Ying Chen, Kun Li, Hui-Qiang Sheng, Ya Ni, Jian-Xin Lu, Wan-Xiang Xu, Song-Ying Zhang, and Qi-Xian Shi
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CYSTIC fibrosis , *SPERMATOZOA , *HUMAN fertility , *MALE infertility , *MALE reproductive organ diseases - Abstract
BACKGROUND: Our previous studies have demonstrated the cystic fibrosis transmembrane conductance regulator (CFTR) is important for capacitation and male fertility in mouse and guinea pig spermatozoa. However, the exact function of CFTR on human sperm fertilizing capacity, and correlation with sperm quality has not been established. The present study may shed light on some unexplained male infertility, and on a possible new method for diagnosis of male infertility and strategy for male contraception. [ABSTRACT FROM PUBLISHER]
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- 2010
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7. Human infection with a novel tick-borne Anaplasma species in China: a surveillance study.
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Li, Hao, Zheng, Yuan-Chun, Ma, Lan, Jia, Na, Jiang, Bao-Gui, Jiang, Rui-Ruo, Huo, Qiu-Bo, Wang, Ya-Wei, Liu, Hong-Bo, Chu, Yan-Li, Song, Yu-Dong, Yao, Nan-Nan, Sun, Tie, Zeng, Fan-Yi, Dumler, J Stephen, Jiang, Jia-Fu, and Cao, Wu-Chun
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TICK-borne diseases , *ANAPLASMA phagocytophilum , *POLYMERASE chain reaction , *IMMUNOFLUORESCENCE , *SEROCONVERSION , *ANTIBODY titer - Abstract
Summary Background Anaplasma phagocytophilum and Anaplasma ovis cause human infections. We investigated the potential for human pathogenicity of a newly discovered Anaplasma species infecting goats in China. Methods We collected blood samples from patients with a history of tick bite in the preceding 2 months at Mudanjiang Forestry Central Hospital of Heilongjiang Province from May 1, to June 10, 2014, to detect the novel Anaplasma species by PCR. We inoculated positive samples into cell cultures. We characterised the isolated pathogen by morphological and phylogenetic analyses. We tested serum antibodies by indirect immunofluorescence assay. Findings 28 (6%) of 477 patients assessed were infected with the novel Anaplasma species according to PCR and sequencing. We isolated the pathogen in vitro from three patients. Phylogenetic analyses of rrs, gltA, groEL, msp2 , and msp4 showed that the pathogen was distinct from all known Anaplasma species. We provisionally nominate it “ Anaplasma capra ”. 22 (92%) of 24 patients with data available had seroconversion or a four-fold increase in antibody titres. All 28 patients developed non-specific febrile manifestations, including fever in 23 (82%), headache in 14 (50%), malaise in 13 (46%), dizziness in nine (32%), myalgia in four (14%), and chills in four (14%). Additionally, ten (36%) of 28 patients had rash or eschar, eight (29%) had lymphadenopathy, eight (29%) had gastrointestinal symptoms, and three (11%) had stiff neck. Five patients were admitted to hospital because of severe disease. Six (35%) of 17 patients with data available had high hepatic aminotransferase concentrations. Interpretation The emergence of “ A capra ” as a cause of human disease suggests that individuals living in or travelling to endemic regions in northern China should take precautions to reduce their risk of exposure to this novel tick-borne pathogen. Funding Natural Science Foundation of China and the US National Institutes of Health. [ABSTRACT FROM AUTHOR]
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- 2015
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8. Epidemiological, clinical, and laboratory characteristics of 48 cases of "Babesia venatorum" infection in China: a descriptive study.
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Jiang, Jia-Fu, Zheng, Yuan-Chun, Jiang, Rui-Ruo, Li, Hao, Huo, Qiu-Bo, Jiang, Bao-Gui, Sun, Yi, Jia, Na, Wang, Ya-Wei, Ma, Lan, Liu, Hong-Bo, Chu, Yan-Li, Ni, Xue-Bing, Liu, Kun, Song, Yu-Dong, Yao, Nan-Nan, Wang, Hong, Sun, Tie, and Cao, Wu-Chun
- Abstract
Background: Human babesiosis is an emerging zoonosis. "Babesia venatorum" has been identified in only four asplenic men and a child so far. We aimed to describe the epidemiological, clinical, and laboratory characteristics of a series of cases with "B venatorum" infection identified in a sentinel hospital in China.Methods: We recruited participants with a recent tick bite at Mudanjiang Forestry Central Hospital, Heilongjiang province, China. Cases were diagnosed through PCR followed by sequencing, microscopic identification, or isolation by animal inoculation, or both.Findings: 48 individuals (30 women or girls; median age 45 years, range 7 months to 75 years) with "B venatorum" infection were identified. 32 of these individuals were confirmed cases and 16 were probable cases. None of the 48 cases had received a blood transfusion or had a splenectomy. Geographically, cases were distributed diffusely throughout the hospital catchment area. Of the 32 confirmed cases, 21 (66%) presented with a fever, 13 (41%) with a headache, 12 (38%) with myalgia or arthralgia, and three (9%) with chills. 14 (44%) patients had fatigue, eight (25%) had dizziness, and eight (25%) had hypersomnia. Six (19%) patients had an erythematous non-pruritic rash around the tick-bite site and two (6%) had lymphadenopathy. Seven (22%) and four (13%) patients had anaemia and thrombocytopenia, respectively, and seven (50%) of 14 patients with confirmed infection had increased hepatic transaminase concentrations. In the confirmed cases, concentrations of intercellular adhesion molecule 3 (p<0·001), P-selectin (p<0·05), and platelet endothelial cell adhesion molecule 1 (p<0·001) were significantly reduced, whereas tumour necrosis factor α (p<0·01) and vascular cell adhesion molecule 1 (p<0·001) were significantly increased.Interpretation: "B venatorum" infection should be included in the differential diagnosis of patients with a tick-exposure history in areas where this pathogen has previously been identified in ticks or people.Funding: Natural Science Foundation of China and Mega-Project for Infectious Diseases. [ABSTRACT FROM AUTHOR]- Published
- 2015
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