9 results on '"Cavalcante, Bruno Raphael Ribeiro"'
Search Results
2. Long-term consequences of COVID-19 on mental health and the impact of a physically active lifestyle: a narrative review.
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Roever, Leonardo, Cavalcante, Bruno Raphael Ribeiro, and Improta-Caria, Alex Cleber
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EXERCISE & psychology , *MENTAL illness risk factors , *ONLINE information services , *COGNITION disorders , *VACCINATION , *LIFESTYLES , *COVID-19 , *ATTITUDE (Psychology) , *RISK assessment , *SLEEP disorders , *MENTAL depression , *VACCINE hesitancy , *RESEARCH funding , *MEDLINE , *THEMATIC analysis , *ANXIETY , *COVID-19 pandemic - Abstract
Background: Coronavirus-19 disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Respiratory viruses damage not only the upper respiratory tract in humans, but also several different organs such as the brain. Some of the neurological consequences of COVID-19 reported are anosmia, headache, stroke, declined cognitive function, and impaired mental health, among others. People who had COVID-19 have a higher risk of sequelae in the central nervous system (CNS). However, it is not known which are all possible sequelae and how long will last the long-term effects of the COVID-19 pandemic on behavioral patterns and quality of life. Aim: We intend to address the long-term impacts of COVID-19 on mental health and the relevance of physical exercise during the pandemic. Methods: We conducted a literature search using PubMed to find the articles that were related to these themes. Results: We found 23,489 papers initially, and then we applied the inclusion/exclusion criteria to narrow down our search to 3617 articles and selected 1380 eligible articles after a thorough reading of titles and abstracts. The findings indicated that COVID-19 impacted general mental health and led many not only hospitalized patients to develop cognitive decline, memory impairment, anxiety, sleep alterations, and depressive-like behavior. Furthermore, the fear of vaccines and their effects had negatively affected mental health and directly impacted mortality rates in unvaccinated COVID-19 patients. Conclusions: Preventive measures must be undertaken, such as the vaccination of the entire population, vaccination hesitancy discouragement by creating awareness among individuals, and people's engagement in a physically active lifestyle, since being physically active is a low-cost and effective measure to restore or inhibit the negative outcomes from COVID-19 on mental health. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Arsenic Trioxide Triggers Apoptosis of Metastatic Oral Squamous Cells Carcinoma with Concomitant Downregulation of GLI1 in Hedgehog Signaling.
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Nogueira, Raphael Luís Rocha, de Araújo, Taís Bacelar Sacramento, Valverde, Ludmila Faro, Silva, Viviane Aline Oliveira, Cavalcante, Bruno Raphael Ribeiro, Rossi, Erik Aranha, Allahdadi, Kyan James, dos Reis, Mitermayer Galvão, Pereira, Thiago Almeida, Coletta, Ricardo D., Bezerra, Daniel Pereira, de Freitas Souza, Bruno Solano, Dias, Rosane Borges, and Rocha, Clarissa A. Gurgel
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ARSENIC trioxide ,HEDGEHOG signaling proteins ,SQUAMOUS cell carcinoma ,CELL morphology ,NUCLEAR fragmentation ,APOPTOSIS - Abstract
Given the lack of advances in Oral Squamous Cell Carcinoma (OSCC) therapy in recent years, pharmacological strategies to block OSCC-related signaling pathways have gained prominence. The present study aimed to evaluate the therapeutic potential of Arsenic Trioxide (ATO) concerning its antitumoral effects and the inhibition of the Hedgehog (HH) pathway in OSCC. Initially, ATO cytotoxicity was assessed in a panel of cell lines. Cell viability, cell cycle, death patterns, and cell morphology were analyzed, as well as the effect of ATO on the expression of HH pathway components. After the cytotoxic assay, HSC3 cells were chosen for all in vitro assays. ATO increased apoptotic cell death and nuclear fragmentation in the sub-G1 cell cycle phase and promoted changes in cell morphology. In addition, the reduced expression of GLI1 indicated that ATO inhibits HH activity. The present study provides evidence of ATO as an effective cytotoxic drug for oral cancer treatment in vitro. [ABSTRACT FROM AUTHOR]
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- 2022
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4. In silico approaches for drug repurposing in oncology: Protocol for a scoping review of existing evidence.
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Cavalcante, Bruno Raphael Ribeiro, Freitas, Raíza Dias, Siquara da Rocha, Leonardo de Oliveira, Rocha, Gisele Vieira, de Carvalho Pachêco, Túlio Cosme, Pereira Ramos, Pablo Ivan, and Gurgel Rocha, Clarissa Araújo
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DRUG repositioning , *ANTINEOPLASTIC agents , *SCIENCE databases , *WEB databases , *GREY literature - Abstract
Drug repurposing has been applied in the biomedical field to optimize the use of existing drugs, leading to a more efficient allocation of research resources. In oncology, this approach is particularly interesting, considering the high cost related to the discovery of new drugs with therapeutic potential. Computational methods have been applied to predict associations between drugs and their targets. However, drug repurposing has not always been promising and its efficiency has yet to be proven. Therefore, the present scoping review protocol was developed to screen the literature on how in silico strategies can be implemented in drug repurposing in oncology. The scoping review will be conducted according to the Arksey and O'Malley framework (2005) and the Joanna Briggs Institute recommendations. We will search the PubMed/MEDLINE, Embase, Scopus, and Web of Science databases, as well as the grey literature. We will include peer-reviewed research articles involving in silico strategies applied to drug repurposing in oncology, published between January 1, 2003, and December 31, 2021. Data will be charted and findings described according to review questions. We will report the scoping review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review guidelines (PRISMA-ScR). [ABSTRACT FROM AUTHOR]
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- 2022
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5. Physical exercise consequences on memory in obesity: A systematic review.
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De Sousa, Ricardo Augusto Leoni, Santos, Letícia Gomes, Lopes, Paulo Maurício, Cavalcante, Bruno Raphael Ribeiro, Improta‐Caria, Alex Cleber, and Cassilhas, Ricardo Cardoso
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OBESITY ,RESISTANCE training ,COGNITION disorders ,MEMORY loss ,EXERCISE intensity ,ANIMAL-assisted therapy - Abstract
Summary: Obesity is associated with changes in memory. Thus, the aim of this systematic review was to investigate the physical exercise consequences on memory in obesity. A search was carried out in the PubMed, Lilacs, and Scielo databases with the following descriptors: "physical exercise," "memory," and "obesity." A total of 16 studies were analyzed in this review. Low, moderate, and high intensity exercise training showed positive effects on memory in patients with obesity (100%). The animal models of obesity used in their physical exercise protocols: treadmill (72.7%) or wheel running (27.3%). Most of the animal studies (81.8%) revealed positive effects of the physical exercise protocol on memory in obesity. Mouse was the most commonly used animal (54.5%), and a 60% high‐fat diet (HFD) was the most commonly method used to induce obesity (82%). We did not identify any knockout model of obesity that was used to evaluate memory and used physical exercise as the main intervention. Thus, exercise training, independently if it is resistance or endurance training, seems to be an excellent intervention to prevent and inhibit cognitive impairment and memory loss on obese patients and animal models of obesity. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19?
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da Silva, Kátia Nunes, Gobatto, André Luiz Nunes, Costa-Ferro, Zaquer Suzana Munhoz, Cavalcante, Bruno Raphael Ribeiro, Caria, Alex Cleber Improta, de Aragão França, Luciana Souza, Nonaka, Carolina Kymie Vasques, de Macêdo Lima, Fernanda, Lopes-Pacheco, Miquéias, Rocco, Patricia Rieken Macêdo, and de Freitas Souza, Bruno Solano
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COVID-19 ,COVID-19 pandemic ,SARS-CoV-2 ,STROMAL cells ,ADULT respiratory distress syndrome - Abstract
The COVID-19 pandemic, caused by the rapid global spread of the novel coronavirus (SARS-CoV-2), has caused healthcare systems to collapse and led to hundreds of thousands of deaths. The clinical spectrum of COVID-19 is not only limited to local pneumonia but also represents multiple organ involvement, with potential for systemic complications. One year after the pandemic, pathophysiological knowledge has evolved, and many therapeutic advances have occurred, but mortality rates are still elevated in severe/critical COVID-19 cases. Mesenchymal stromal cells (MSCs) can exert immunomodulatory, antiviral, and pro-regenerative paracrine/endocrine actions and are therefore promising candidates for MSC-based therapies. In this review, we discuss the rationale for MSC-based therapies based on currently available preclinical and clinical evidence of safety, potential efficacy, and mechanisms of action. Finally, we present a critical analysis of the risks, limitations, challenges, and opportunities that place MSC-based products as a therapeutic strategy that may complement the current arsenal against COVID-19 and reduce the pandemic's unmet medical needs. [ABSTRACT FROM AUTHOR]
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- 2021
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7. Generation of integration-free iPS cell lines from three sickle cell disease patients from the state of Bahia, Brazil.
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Martins, Gabriele Louise Soares, Paredes, Bruno Diaz, Azevedo, Carine Machado, Sampaio, Gabriela Louise De Almeida, Nonaka, Carolina Kymie Vasques, Cavalcante, Bruno Raphael Ribeiro, Da Silva, Katia Nunes, Pereira, Ciro Silveira E., Soares, Milena Botelho Pereira, Dos Santos, Ricardo Ribeiro, and Souza, Bruno Solano De Freitas
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Copyright of Stem Cell Research is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2018
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8. Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease.
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Improta-Caria, Alex Cleber, Nonaka, Carolina Kymie Vasques, Cavalcante, Bruno Raphael Ribeiro, De Sousa, Ricardo Augusto Leoni, Aras Júnior, Roque, and Souza, Bruno Solano de Freitas
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MICRORNA ,EXERCISE ,ALZHEIMER'S disease ,GENETIC regulation ,NON-coding RNA ,NEUROFIBRILLARY tangles ,MIDDLE-aged persons - Abstract
Alzheimer disease (AD) is one of the most common neurodegenerative diseases, affecting middle-aged and elderly individuals worldwide. AD pathophysiology involves the accumulation of beta-amyloid plaques and neurofibrillary tangles in the brain, along with chronic neuroinflammation and neurodegeneration. Physical exercise (PE) is a beneficial non-pharmacological strategy and has been described as an ally to combat cognitive decline in individuals with AD. However, the molecular mechanisms that govern the beneficial adaptations induced by PE in AD are not fully elucidated. MicroRNAs are small non-coding RNAs involved in the post-transcriptional regulation of gene expression, inhibiting or degrading their target mRNAs. MicroRNAs are involved in physiological processes that govern normal brain function and deregulated microRNA profiles are associated with the development and progression of AD. It is also known that PE changes microRNA expression profile in the circulation and in target tissues and organs. Thus, this review aimed to identify the role of deregulated microRNAs in the pathophysiology of AD and explore the possible role of the modulation of microRNAs as a molecular mechanism involved in the beneficial actions of PE in AD. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy.
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Nonaka, Carolina Kymie Vasques, Macêdo, Carolina Thé, Cavalcante, Bruno Raphael Ribeiro, Alcântara, Adriano Costa de, Silva, Daniela Nascimento, Bezerra, Milena da Rocha, Caria, Alex Cleber Improta, Tavora, Fábio Rocha Fernandes, Neto, João David de Souza, Noya-Rabelo, Márcia Maria, Rogatto, Silvia Regina, Ribeiro dos Santos, Ricardo, Souza, Bruno Solano de Freitas, and Soares, Milena Botelho Pereira
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CHAGAS' disease ,HEART fibrosis ,CARDIOMYOPATHIES ,MICRORNA ,CARDIAC hypertrophy ,BIOMARKERS - Abstract
Chagas disease (CD) affects approximately 6–7 million people worldwide, from which 30% develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years. Currently available diagnostic methods are capable of adequately identifying infected patients, but do not provide information regarding the individual risk of developing the most severe form of the disease. The identification of biomarkers that predict the progression from asymptomatic or indeterminate form to CCC, may guide early implementation of pharmacological therapy. Here, six circulating microRNAs (miR-19a-3p, miR-21-5p, miR-29b-3p, miR-30a-5p, miR-199b-5p and miR-208a-3p) were evaluated and compared among patients with CCC (n = 28), CD indeterminate form (n = 10) and healthy controls (n = 10). MiR-19a-3p, miR-21-5p, and miR-29b-3p were differentially expressed in CCC patients when compared to indeterminate form, showing a positive correlation with cardiac dysfunction, functional class, and fibrosis, and a negative correlation with ejection fraction and left ventricular strain. Cardiac tissue analysis confirmed increased expression of microRNAs in CCC patients. In vitro studies using human cells indicated the involvement of these microRNAs in the processes of cardiac hypertrophy and fibrosis. Our study suggests that miRNAs are involved in the process of cardiac fibrosis and remodeling presented in CD and indicate a group of miRNAs as potential biomarkers of disease progression in CCC. [ABSTRACT FROM AUTHOR]
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- 2019
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