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431 results on '"Campbell, Lesley V."'

5. A Mobile Phone and Web-Based Intervention for Improving Mental Well-Being in Young People With Type 1 Diabetes: Design of a Randomized Controlled Trial

Author

Clarke, Janine, Vatiliotis, Veronica, Verge, Charles F, Holmes-Walker, Jane, Campbell, Lesley V, Wilhelm, Kay, and Proudfoot, Judy

Subjects
Medicine, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

BackgroundYoung people with type 1 diabetes experience elevated levels of emotional distress that impact negatively on their diabetes self-care, quality of life, and disease-related morbidity and mortality. While the need is great and clinically significant, a range of structural (eg, service availability), psychological (eg, perceived stigma), and practical (eg, time and lifestyle) barriers mean that a majority of young people do not access the support they need to manage the emotional and behavioral challenges of type 1 diabetes. ObjectiveThe aim of this study is to examine the effectiveness of a fully-automated cognitive behavior therapy-based mobile phone and Web-based psychotherapeutic intervention (myCompass) for reducing mental health symptoms and diabetes-related distress, and improving positive well-being in this vulnerable patient group. MethodsA two-arm randomized controlled trial will be conducted. Young people with type 1 diabetes and at least mild psychological distress will be recruited via outpatient diabetes centers at three tertiary hospitals in Sydney, Australia, and referred for screening to a study-specific website. Data will be collected entirely online. Participants randomized to the intervention group will use the myCompass intervention for 7 weeks, while at the same time a control group will use an active placebo program matched to the intervention on duration, mode of delivery, and interactivity. ResultsThe primary outcome will be mental well-being (ie, depression, anxiety, diabetes-related distress, and positive well-being), for which data will be collected at baseline, post-intervention, and after 3 months follow-up. Secondary outcomes will be functional (work and social functioning and diabetes self-care), biochemical measures (HbA1c), and mental health self-efficacy. We aim to recruit 280 people into the study that will be conducted entirely online. Group differences will be analyzed on an intention-to-treat basis using mixed models repeated measures. ConclusionsWe hypothesize that scores on the outcome measures will improve significantly for young people who use the mobile phone and Web-based intervention compared to the control group. myCompass is a public health intervention that is broadly available and free to use. If effective, the program has the capacity to provide convenient and accessible evidenced-based care to the large group of young people with type 1 diabetes who do not currently access the psychosocial support they need. Trial registrationAustralian New Zealand Clinical Trials Registry: ACTRN12614000974606; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=366607 (Archived by WebCite at http://www.webcitation.org/6YGdeT0Dk).

Published
2015
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37. A Web-Based Cognitive Behavior Therapy Intervention to Improve Social and Occupational Functioning in Adults With Type 2 Diabetes (The SpringboarD Trial): Randomized Controlled Trial

Author

Clarke, Janine, Sanatkar, Samineh, Baldwin, Peter A, Fletcher, Susan, Gunn, Jane, Wilhelm, Kay, Campbell, Lesley V, Zwar, Nicholas Arnold, Harris, Mark Fort, Lapsley, Helen, Hadzi-Pavlovic, Dusan, Christensen, Helen, Proudfoot, Judy G, Clarke, Janine, Sanatkar, Samineh, Baldwin, Peter A, Fletcher, Susan, Gunn, Jane, Wilhelm, Kay, Campbell, Lesley V, Zwar, Nicholas Arnold, Harris, Mark Fort, Lapsley, Helen, Hadzi-Pavlovic, Dusan, Christensen, Helen, and Proudfoot, Judy G

Abstract

BACKGROUND: Depressive symptoms are common in people with type 2 diabetes mellitus (T2DM). Effective depression treatments exist; however, access to psychological support is characteristically low. Web-based cognitive behavioral therapy (CBT) is accessible, nonstigmatizing, and may help address substantial personal and public health impact of comorbid T2DM and depression. OBJECTIVE: The aim of this study was to evaluate the Web-based CBT program, myCompass, for improving social and occupational functioning in adults with T2DM and mild-to-moderate depressive symptoms. myCompass is a fully automated, self-guided public health treatment program for common mental health problems. The impact of treatment on depressive symptoms, diabetes-related distress, anxiety symptoms, and self-care behavior was also examined. METHODS: Participants with T2DM and mild-to-moderate depressive symptoms (N=780) were recruited online via Google and Facebook advertisements targeting adults with T2DM and via community and general practice settings. Screening, consent, and self-report scales were all self-administered online. Participants were randomized using double-blind computerized block randomization to either myCompass (n=391) for 8 weeks plus a 4-week tailing-off period or an active placebo intervention (n=379). At baseline and postintervention (3 months), participants completed the Work and Social Adjustment Scale, the primary outcome measure. Secondary outcome measures included the Patient Health Questionnaire-9 item, Diabetes Distress Scale, Generalized Anxiety Disorder Questionnaire-7 item, and items from the Self-Management Profile for Type 2 Diabetes. RESULTS: myCompass users logged in an average of 6 times and completed an average of .29 modules. Healthy Lifestyles users logged in an average of 4 times and completed an average of 1.37 modules. At baseline, mean scores on several outcome measures, including the primary outcome of work and social functioning, were near to the norma

Published
2019

46. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids

Author

Borkman, Mark, Storlien, Leonard H., Pan, David A., Jenkins, Arthur B., Chisholm, Donald J., and Campbell, Lesley V.

Subjects
Insulin resistance -- Physiological aspects, Bilayer lipid membranes -- Physiological aspects, Unsaturated fatty acids -- Measurement
Abstract

Insulin sensitivity may be related to the concentration of polyunsaturated fatty acids in the phospholipids of skeletal-muscle cell membranes. Skeletal muscle is the primary site of insulin action and is the most insulin-sensitive tissue. Fatty acid composition within the phospholipids greatly influences the cell membranes' properties and may determine their hormonal sensitivity. Muscle samples were taken from 27 patients undergoing heart surgery and the relationship between the phospholipid fatty acid composition and the level of serum insulin, which reflects insulin resistance, was determined. Reduced levels of polyunsaturated fatty acid levels were associated with reduced insulin sensitivity. Muscle sample analysis and insulin levels measured in 13 healthy men also indicated that concentration of polyunsaturated fatty acids and insulin sensitivity are directly correlated.

Published
1993

49. The lower limb in people with diabetes: position statement of the Australian Diabetes Society

Author

Campbell, Lesley V., Graham, Antony R., Kidd, Rosalind M., Molloy, Hugh F., O'Rourke, Sharon, and Colagiuri, Stephen

Subjects
Amputation -- Causes of, Diabetes -- Complications, Health
Abstract

Diabetic lower-limb problems are common for people with diabetes, with amputations 15% times more likely than in those without the condition. Recommendations from the Australian Diabetes Society for reducing diabetic lower limb disease are presented.

Published
2000

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