Search

Your search keyword '"Brückner, U B"' showing total 46 results
Start Over Author "Brückner, U B" Search Limiters Academic (Peer-Reviewed) Journals
46 results on '"Brückner, U B"'

15. Animal Models of Sepsis.

Author

Freise, H., Brückner, U. B., and Spiegel, H. U.

Subjects
*ANIMAL models in research, *SEPSIS
Abstract

Knowledge of sepsis is growing rapidly and new pathogenetic concepts and therapeutic strategies evolve. The animal models of sepsis catalyze this development. Any model of this complex disease is inevitably a compromise between clinical realism and experimental simplification. Against the background of current pathogenetic concepts this review tries to analyze the validity and clinical relevance of each model. Endotoxemia and bacteremia represent models without an infectious focus. They reproduce many characteristics of sepsis and are highly controlled and standardized. However, they reflect a primarily systemic challenge and create neither an infectious focus nor the protracted immune reaction that characterizes sepsis. In this respect, any model with an infectious focus is decisively closer to clinical reality. In these models the peritoneal cavity is contaminated either by bacteria or inoculated feces or perforation of the bowel wall. Both the bolus injection and the implantation of carriers loaded with bacteria or feces are used. In fecal spesis and perforation models the complete spectrum of enteric pathogens is present in the septic focus and infective selection is undisturbed. Here the pathophysiologic and immunologic features of clinical sepsis are successfully reproduced. However, presumably due to inadequate control of the bacterial challenge, only poor interlaboratory standardization is possible. As to optimize models for the clinical reality the choice of an appropriate class of models is crucial. Moreover the incorporation of clinical therapy such as volume resuscitation, antibiotic therapy and surgical treatment of the septic focus is indispensable. Finally, the importance of simulation of comorbidities cannot be overemphasized. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

16. Early inflammatory mediator response following isolated traumatic brain injury and other major trauma in humans.

Author

Arand, M., Melzner, H., Kinzl, L., Brückner, U. B., and Gebhard, F.

Subjects
BRAIN injuries, INFLAMMATORY mediators, CYTOKINES, IMMUNOREGULATION, ARACHIDONIC acid, CHEMICAL ecology, INTERLEUKINS
Abstract

The inflammatory response following isolated traumatic brain injury (TBI) is characterised by the release of pro- and anti-inflammatory mediators. In order to determine the important mediators regarding survival and outcome of patients with severe traumatic isolated head injuries, we performed this prospective preclinical and clinical study starting upon arrival at the site of the accident. After approval by the local ethics board committee, 94 multiple-injury patients were enrolled. Of these, 72 patients suffered from major injuries; the other 22 patients had a severe isolated brain injury and were allotted to subsets of survival or nonsurvival. Of the pro- and anti-inflammatory mediators (cytokines, arachidonic acid metabolites and soluble adhesion molecules), interleukin-6 (IL-6), IL-12 and malone dialdehyde (MDA) appeared to be of specific importance; maximum IL-6 plasma levels were eightfold higher in cases of nonsurvival than in those of survival. Patients that did not survive TBI were the only ones to express an IL-12 increase, whereas survivors and patients with other major trauma did not show any increase within the first 24 h. An early distinct decrease of MDA showed in patients who did not survive TBI, in contrast to survivor patients who exposed almost constant levels during the first 24 h. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

38. 7

Author

Gebhard, F, Riepl, C, Pfetsch, H, Kinzl, L, and Brückner, U B

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results