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304 results on '"Bonavita, Simona"'

2. ChatGPT vs. neurologists: a cross-sectional study investigating preference, satisfaction ratings and perceived empathy in responses among people living with multiple sclerosis

Author

Maida, Elisabetta, Moccia, Marcello, Palladino, Raffaele, Borriello, Giovanna, Affinito, Giuseppina, Clerico, Marinella, Repice, Anna Maria, Di Sapio, Alessia, Iodice, Rosa, Spiezia, Antonio Luca, Sparaco, Maddalena, Miele, Giuseppina, Bile, Floriana, Scandurra, Cristiano, Ferraro, Diana, Stromillo, Maria Laura, Docimo, Renato, De Martino, Antonio, Mancinelli, Luca, Abbadessa, Gianmarco, Smolik, Krzysztof, Lorusso, Lorenzo, Leone, Maurizio, Leveraro, Elisa, Lauro, Francesca, Trojsi, Francesca, Streito, Lidia Mislin, Gabriele, Francesca, Marinelli, Fabiana, Ianniello, Antonio, De Santis, Federica, Foschi, Matteo, De Stefano, Nicola, Morra, Vincenzo Brescia, Bisecco, Alvino, Coghe, Giancarlo, Cocco, Eleonora, Romoli, Michele, Corea, Francesco, Leocani, Letizia, Frau, Jessica, Sacco, Simona, Inglese, Matilde, Carotenuto, Antonio, Lanzillo, Roberta, Padovani, Alessandro, Triassi, Maria, Bonavita, Simona, and Lavorgna, Luigi

Published
2024
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5. Long-term effectiveness of natalizumab in secondary progressive multiple sclerosis: A propensity-matched study

Author

Avolio, Carlo, Balgera, Roberto, Banfi, Paola, Bellantonio, Paolo, Bramanti, Placido, Capone, Lorenzo, Cavalletti, Guido, Chiveri, Luca, Clerici, Raffaella, Clerico, Marinella, Corea, Francesco, Dattola, Vincenzo, De Robertis, Francesca, Di Battista, Giancarlo, Galgani, Simonetta, Gatto, Maurizia, Grasso, Maria Grazia, Inglese, Matilde, Lo Russo, Lorenzo, Logullo, Francesco Ottavio, Mantegazza, Renato, Protti, Alessandra, Rezzonico, Monica, Rottoli, Mariarosa, Salvetti, Marco, Scarpini, Elio, Sinisi, Leonardo, Sparaco, Maddalena, Spitaleri, Daniele, Tassinari, Tiziana, Tonietti, Simone, Valentino, Paola, Valzania, Franco, Venturi, Simonetta, Chisari, Clara G., Aguglia, Umberto, Amato, Maria Pia, Bergamaschi, Roberto, Bertolotto, Antonio, Bonavita, Simona, Morra, Vincenzo Brescia, Cavalla, Paola, Cocco, Eleonora, Conte, Antonella, Cottone, Salvatore, De Luca, Giovanna, Di Sapio, Alessia, Filippi, Massimo, Gallo, Antonio, Gasperini, Claudio, Granella, Franco, Lus, Giacomo, Maimone, Davide, Maniscalco, Giorgia Teresa, Marfia, Girolama, Moiola, Lucia, Paolicelli, Damiano, Pesci, Ilaria, Ragonese, Paolo, Rovaris, Marco, Salemi, Giuseppe, Solaro, Claudio, Totaro, Rocco, Trojano, Maria, Vianello, Marika, Zaffaroni, Mauro, Lepore, Vito, and Patti, Francesco

Published
2024
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6. NEDA-3 achievement in early highly active relapsing remitting multiple sclerosis patients treated with Ocrelizumab or Natalizumab

Author

Signoriello, Elisabetta, Signori, Alessio, Lus, Giacomo, Romano, Giuseppe, Marfia, Girolama Alessandra, Landi, Doriana, Napoli, Francesca, D' Amico, Emanuele, Zanghí, Aurora, Di Filippo, Paola Sofia, Caliendo, Daniele, Carotenuto, Antonio, Spiezia, Antonio Luca, Fantozzi, Roberta, Centonze, Diego, Lucchini, Matteo, Mirabella, Massimiliano, Cocco, Eleonora, Frau, Jessica, Maniscalco, Giorgia Teresa, Di Battista, Maria Elena, Foschi, Matteo, Surcinelli, Andrea, Bonavita, Simona, Abbadessa, Gianmarco, Pasquali, Livia, Di Gregorio, Maria, Ferrò, Maria Teresa, Sormani, Maria Pia, and Schiavetti, Irene

Published
2024
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8. Health related quality of life in the domain of physical activity predicts confirmed disability progression in people with relapsing remitting multiple sclerosis

Author

Abbadessa, Gianmarco, Ponzano, Marta, Bile, Floriana, Miele, Giuseppina, Signori, Alessio, Cepparulo, Simone, Sparaco, Maddalena, Signoriello, Elisabetta, Maniscalco, Giorgia Teresa, Lanzillo, Roberta, Morra, Vincenzo Brescia, Lus, Giacomo, Sormani, Maria Pia, Lavorgna, Luigi, and Bonavita, Simona

Published
2023
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11. Is It Time for Ocrelizumab Extended Interval Dosing in Relapsing Remitting MS? Evidence from An Italian Multicenter Experience During the COVID-19 Pandemic

Author

Zanghì, Aurora, Avolio, Carlo, Signoriello, Elisabetta, Abbadessa, Gianmarco, Cellerino, Maria, Ferraro, Diana, Messina, Christian, Barone, Stefania, Callari, Graziella, Tsantes, Elena, Sola, Patrizia, Valentino, Paola, Granella, Franco, Patti, Francesco, Lus, Giacomo, Bonavita, Simona, Inglese, Matilde, and D’Amico, Emanuele

Published
2022
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12. Predictors of Cladribine Effectiveness and Safety in Multiple Sclerosis: A Real-World, Multicenter, 2-Year Follow-Up Study

Author

Petracca, Maria, Ruggieri, Serena, Barbuti, Elena, Ianniello, Antonio, Fantozzi, Roberta, Maniscalco, Giorgia Teresa, Andreone, Vincenzo, Landi, Doriana, Marfia, Girolama Alessandra, Di Gregorio, Maria, Iodice, Rosa, Sinisi, Leonardo, Maida, Elisabetta, Missione, Rosanna, Coppola, Cinzia, Bonavita, Simona, Borriello, Giovanna, Centonze, Diego, Lus, Giacomo, Pozzilli, Carlo, and Signoriello, Elisabetta

Published
2022
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15. Telemedicine application to headache: a critical review

Author

Spina, Emanuele, Tedeschi, Gioacchino, Russo, Antonio, Trojsi, Francesca, Iodice, Rosa, Tozza, Stefano, Iovino, Aniello, Iodice, Francesco, Abbadessa, Gianmarco, di Lorenzo, Francesco, Miele, Giuseppina, Maida, Elisabetta, Cerullo, Giovanni, Sparaco, Maddalena, Silvestro, Marcello, Leocani, Letizia, Bonavita, Simona, Manganelli, Fiore, and Lavorgna, Luigi

Published
2022
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21. PML risk is the main factor driving the choice of discontinuing natalizumab in a large multiple sclerosis population: results from an Italian multicenter retrospective study

Author

Chisari, Clara G., Comi, Giancarlo, Filippi, Massimo, Paolicelli, Damiano, Iaffaldano, Pietro, Zaffaroni, Mauro, Brescia Morra, Vincenzo, Cocco, Eleonora, Marfia, Girolama Alessandra, Grimaldi, Luigi Maria, Inglese, Matilde, Bonavita, Simona, Lugaresi, Alessandra, Salemi, Giuseppe, De Luca, Giovanna, Cottone, Salvatore, Conte, Antonella, Sola, Patrizia, Aguglia, Umberto, Maniscalco, Giorgia Teresa, Gasperini, Claudio, Ferrò, Maria Teresa, Pesci, Ilaria, Amato, Maria Pia, Rovaris, Marco, Solaro, Claudio, Lus, Giacomo, Maimone, Davide, Bergamaschi, Roberto, Granella, Franco, Di Sapio, Alessia, Bertolotto, Antonio, Totaro, Rocco, Vianello, Marika, Cavalla, Paola, Bellantonio, Paolo, Lepore, Vito, and Patti, Francesco

Published
2022
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22. Disability assessment using Google Maps

Author

Lavorgna, Luigi, Iaffaldano, Pietro, Abbadessa, Gianmarco, Lanzillo, Roberta, Esposito, Sabrina, Ippolito, Domenico, Sparaco, Maddalena, Cepparulo, Simone, Lus, Giacomo, Viterbo, Rosa, Clerico, Marinella, Trojsi, Francesca, Ragonese, Paolo, Borriello, Giovanna, Signoriello, Elisabetta, Palladino, Raffaele, Moccia, Marcello, Brigo, Francesco, Troiano, Maria, Tedeschi, Gioacchino, and Bonavita, Simona

Published
2022
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28. MRI activity and extended interval of Natalizumab dosing regimen: a multicentre Italian study

Author

De Mercanti, Stefania Federica, Signori, Alessio, Cordioli, Cinzia, Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Abbadessa, Gianmarco, Lavorgna, Luigi, Maniscalco, Giorgia Teresa, Curti, Erica, Lorefice, Lorena, Cocco, Eleonora, Nociti, Viviana, Mirabella, Massimiliano, Baroncini, Damiano, Mataluni, Giorgia, Landi, Doriana, Petruzzo, Martina, Lanzillo, Roberta, Gandoglia, Ilaria, Laroni, Alice, Frangiamore, Rita, Sartori, Arianna, Cavalla, Paola, Costantini, Gianfranco, Capra, Ruggero, Sormani, Maria Pia, and Clerico, Marinella

Published
2021
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31. Exit Strategies in Natalizumab-Treated RRMS at High Risk of Progressive Multifocal Leukoencephalopathy: a Multicentre Comparison Study

Author

Zanghì, Aurora, Gallo, Antonio, Avolio, Carlo, Capuano, Rocco, Lucchini, Matteo, Petracca, Maria, Bonavita, Simona, Lanzillo, Roberta, Ferraro, Diana, Curti, Erica, Buccafusca, Maria, Callari, Graziella, Barone, Stefania, Pontillo, Giuseppe, Abbadessa, Gianmarco, Di Francescantonio, Valeria, Signoriello, Elisabetta, Lus, Giacomo, Sola, Patrizia, Granella, Franco, Valentino, Paola, Mirabella, Massimiliano, Patti, Francesco, and D’Amico, Emanuele

Published
2021
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32. Impact of COVID-19 on pregnancy and fetal outcomes in women with multiple sclerosis.

Author

Aprea, Maria Grazia, Schiavetti, Irene, Portaccio, Emilio, Ballerini, Chiara, Bonavita, Simona, Buscarinu, Maria, Calabrese, Massimiliano, Cavalla, Paola, Cellerino, Maria, Cordioli, Cinzia, Dattola, Vincenzo, De Biase, Stefano, De Meo, Ermelinda, Fantozzi, Roberta, Gallo, Antonio, Iasevoli, Luigi, Karabudak, Rana, Landi, Doriana, Lorefice, Lorena, and Moiola, Lucia

Subjects
PREGNANCY outcomes, COVID-19 pandemic, PREGNANT women, MULTIPLE sclerosis, PREGNANCY complications
Abstract

Background: In the general population, maternal COVID-19 is associated with worse maternal and fetal outcomes. Two previous studies have assessed COVID-19 clinical outcomes in pregnant women with multiple sclerosis (MS), but there are no data about maternal and fetal outcomes. Objectives: In this multicenter study, we aimed to assess maternal and fetal outcomes in pregnant women with MS and COVID-19 infection. Methods: We recruited pregnant patients with MS who contracted COVID-19 and were followed up in Italian and Turkish Centers, during 2020–2022. A control group was extracted from a previous Italian cohort. Associations between group (COVID-19 or healthy patients) and clinical outcomes (maternal complications, fetal malformations, and spontaneous abortion) were investigated with a weighted logistic regression where propensity score–based inverse probability of treatment weighting (IPTW) approach was applied for adjusting for difference in baseline confounders. Results: In the multivariable analysis, COVID-19 during pregnancy was associated with a higher risk of maternal complications (odd ratio (OR) = 2.12; 95% confidence interval (CI) = 1.32–3.48; p = 0.002), while it was not associated with higher risk of spontaneous abortion and fetal malformations. Conclusion: Our data indicate that COVID-19 during pregnancy increases the risk of maternal complications, while it seems to have no significant impact on fetal outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Efficacy of different rituximab therapeutic strategies in patients with neuromyelitis optica spectrum disorders

Author

Novi, Giovanni, Bovis, Francesca, Capobianco, Marco, Frau, Jessica, Mataluni, Giorgia, Curti, Erica, Zuliani, Luigi, Cavalla, Paola, Brambilla, Laura, Annovazzi, Pietro, Repice, Anna Maria, Lanzillo, Roberta, Esposito, Sabrina, Benedetti, Luana, Maietta, Ilaria, Sica, Francesco, Buttari, Fabio, Malucchi, Simona, Fenu, Giuseppe, Landi, Doriana, Bosa, Chiara, Realmuto, Sabrina, Malentacchi, Maria, Granella, Franco, Signori, Alessio, Bonavita, Simona, Uccelli, Antonio, and Sormani, Maria Pia

Published
2019
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36. Cardiovascular autonomic individual profile of relapsing-remitting multiple sclerosis patients and risk of extending cardiac monitoring after first dose fingolimod

Author

Vanoli, Emilio, Montano, Nicola, De Angelis, Giuseppe, Badilini, Fabio, Mirabella, Massimiliano, Bonavita, Simona, Patti, Francesco, Bianco, Assunta, Sparaco, Maddalena, Chisari, Clara, Laroni, Alice, Frigerio, Francesca, Bartezaghi, Marta, Rossi, Silvia, Turrini, Renato, and Mancardi, Gianluigi

Published
2019
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37. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author

Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi

Published
2022
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38. Extending the Interval of Natalizumab Dosing: Is Efficacy Preserved?

Author

Clerico, Marinella, De Mercanti, Stefania Federica, Signori, Alessio, Iudicello, Marco, Cordioli, Cinzia, Signoriello, Elisabetta, Lus, Giacomo, Bonavita, Simona, Lavorgna, Luigi, Maniscalco, Giorgia Teresa, Curti, Erica, Lorefice, Lorena, Cocco, Eleonora, Nociti, Viviana, Mirabella, Massimiliano, Baroncini, Damiano, Mataluni, Giorgia, Landi, Doriana, Petruzzo, Martina, Lanzillo, Roberta, Gandoglia, Ilaria, Laroni, Alice, Frangiamore, Rita, Sartori, Arianna, Cavalla, Paola, Costantini, Gianfranco, Sormani, Maria Pia, and Capra, Ruggero

Published
2020
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41. Vitamin D Supplementation: Effect on Cytokine Profile in Multiple Sclerosis.

Author

Sparaco, Maddalena and Bonavita, Simona

Subjects
*VITAMIN D, *DIETARY supplements, *TRANSFORMING growth factors, *MULTIPLE sclerosis, *CYTOKINES
Abstract

Vitamin D is known for its role in modulating calcium and phosphate homeostasis and is implicated both in bone mineralization and immune system regulation. The immune-modulatory role of vitamin D and its impact on multiple sclerosis (MS) courses are still debated. The aim of this review was to check the effect of vitamin D supplementation on cytokine profile regulation in people with MS. A significant increase in serum concentrations of interleukin (IL)-10 and Transforming growth factor (TGF)-β1 after vitamin D supplementation was demonstrated in most studies, with some of them reporting a reduction in disability scores after vitamin D supplementation and an inverse correlation between IL-10 levels and disability. The effect of vitamin D on the serum levels of IL-17 and IL-6 was controversial; different results across studies could be explained by a variability in the treatment duration, route, and frequency of administration, as well as the dosage of vitamin D supplementation, responses to vitamin D treatment and the serum levels reached with supplementation, including the methods used for cytokine analysis and the different cell types investigated, the MS phenotype, the disease phase (active vs. non-active) and duration, and concomitant treatment with disease-modifying therapies. Nevertheless, the significant increase in the serum concentrations of IL-10 and TGF-β1, demonstrated in most studies, suggests an anti-inflammatory effect of vitamin D supplementation. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Cost-Analysis of Telemedicine Interventions Compared with Traditional Care in the Management of Chronic Neurological Diseases: A Systematic Review.

Author

Maida, Elisabetta, Bresciamorra, Vincenzo, Triassi, Maria, Lanzillo, Roberta, Bonavita, Simona, and Lavorgna, Luigi

Subjects
NATIONAL health services, NEUROLOGICAL disorders, CHRONIC diseases, TELEMEDICINE, COGNITIVE therapy
Abstract

Background: Telemedicine has proven successful in relieving the burden of chronic neurological disorders from the national health care systems by ensuring a highly customized and effective management plan. Although many studies focus on assessing telemedicine effectiveness, little is known about the economic implications of telemedicine applications in chronic neurological diseases (CNDs). This issue could account for a lack of widespread implementation. Objective: Our study attempted to fill this gap by systematically reviewing scientific literature on the economic evaluation of telemedicine compared with traditional care in the management of CNDs. Methods: We performed a literature search on PubMed, Google Scholar, Scopus, Embase, and Medline. The inclusion criteria were as follows: (1) studies with a full cost-analysis; (2) randomized controlled trials; (3) studies comparing telemedicine interventions with traditional care; (4) articles focusing only on CNDs. Conversely, the exclusion criteria were as follows: (1) studies focusing on acute neurological conditions or other diseases and (2) study protocols, case report, duplicate articles, abstract only, books, letters to editors, and review articles. Results: Ten articles met the inclusion criteria. Three different approaches of telemedicine intervention could be identified: digital cognitive-behavioral therapy (CBT), motor telerehabilitation, and home monitoring and assessment devices. Conclusion: Cost-analysis showed an overall benefit in terms of both cost and effectiveness from the application of telemedicine instead of in-presence management in CNDs. Among the identified interventions, digital CBT proved to be the most cost-saving. However, promising results were also found in monitoring and assessment devices and in telerehabilitation. Definitely, however, more thorough, comprehensive, and high-quality economic evaluation studies are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Cladribine vs other drugs in MS: Merging randomized trial with real-life data

Author

Signori, Alessio, Saccà, Francesco, Lanzillo, Roberta, Maniscalco, Giorgia Teresa, Signoriello, Elisabetta, Repice, Anna Maria, Annovazzi, Pietro, Baroncini, Damiano, Clerico, Marinella, Binello, Eleonora, Cerqua, Raffaella, Mataluni, Giorgia, Perini, Paola, Bonavita, Simona, Lavorgna, Luigi, Zarbo, Ignazio Roberto, Laroni, Alice, Pareja-Gutierrez, Lorena, La Gioia, Sara, Frigeni, Barbara, Barcella, Valeria, Frau, Jessica, Cocco, Eleonora, Fenu, Giuseppe, Clerici, Valentina Torri, Sartori, Arianna, Rasia, Sarah, Cordioli, Cinzia, Stromillo, Maria Laura, Di Sapio, Alessia, Pontecorvo, Simona, Grasso, Roberta, Barone, Stefania, Barrilà, Caterina, Russo, Cinzia Valeria, Esposito, Sabrina, Ippolito, Domenico, Landi, Doriana, Visconti, Andrea, and Sormani, Maria Pia

Published
2020
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48. Exploring Circulating Long Non-Coding RNAs in Mild Cognitive Impairment Patients' Blood.

Author

De Felice, Bruna, Coppola, Cinzia, Bonavita, Simona, Signoriello, Elisabetta, Montanino, Concetta, and Farinella, Federica

Subjects
LINCRNA, MILD cognitive impairment, AMNESTIC mild cognitive impairment, NON-coding RNA, ALZHEIMER'S disease, EPIGENOMICS
Abstract

Mild cognitive impairment (MCI) is a transitional clinical stage prior to dementia. Patients with amnestic MCI have a high risk of progression toward Alzheimer's disease. Both amnestic mild cognitive impairment and sporadic Alzheimer's disease are multifactorial disorders consequential from a multifaceted cross-talk among molecular and biological processes. Non-coding RNAs play an important role in the regulation of gene expression, mainly long non-coding RNAs (lncRNAs), that regulate other RNA transcripts through binding microRNAs. Cross-talk between RNAs, including coding RNAs and non-coding RNAs, produces a significant regulatory network all through the transcriptome. The relationship of genes and non-coding RNAs could improve the knowledge of the genetic factors contributing to the predisposition and pathophysiology of MCI. The objective of this study was to identify the expression patterns and relevant lncRNA-associated miRNA regulatory axes in the blood of MCI patients, which includes lncRNA-SNHG16, lncRNA-H19, and lncRNA-NEAT1. Microarray investigations have demonstrated modifications in the expression of long non-coding RNAs (lncRNA) in the blood of patients with MCI compared with control samples. This is the first study to explore lncRNA profiles in mild cognitive impairment blood. Our study proposes RNAs targets involved in molecular pathways connected to the pathogenesis of MCI. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Repetitive Transcranial Magnetic Stimulation (rTMS) in Mild Cognitive Impairment: Effects on Cognitive Functions—A Systematic Review.

Author

Sharbafshaaer, Minoo, Gigi, Ilaria, Lavorgna, Luigi, Esposito, Sabrina, Bonavita, Simona, Tedeschi, Gioacchino, Esposito, Fabrizio, and Trojsi, Francesca

Subjects
TRANSCRANIAL magnetic stimulation, MILD cognitive impairment, FUNCTIONAL magnetic resonance imaging, COGNITIVE ability, DEFAULT mode network, COGNITION disorders
Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique also used as a non-pharmacological intervention against cognitive impairment. The purpose of the present review was to summarize what is currently known about the effectiveness of rTMS intervention on different cognitive domains in patients with mild cognitive impairment (MCI) and to address potential neuromodulation approaches in combination with electroencephalography (EEG) and neuroimaging, especially functional magnetic resonance imaging (fMRI). In this systematic review, we consulted three main databases (PubMed, Science Direct, and Scopus), and Google Scholar was selected for the gray literature search. The PRISMA flowchart drove the studies' inclusion. The selection process ensured that only high-quality studies were included; after removing duplicate papers, explicit ratings were given based on the quality classification as high (A), moderate (B), or low (C), considering factors such as risks of bias, inaccuracies, inconsistencies, lack of direction, and publication bias. Seven full-text articles fulfilled the stated inclusion, reporting five double-blind, randomized, sham-controlled studies, a case study, and a randomized crossover trial. The results of the reviewed studies suggested that rTMS in MCI patients is safe and effective for enhancing cognitive functions, thus making it a potential therapeutic approach for MCI patients. Changes in functional connectivity within the default mode network (DMN) after targeted rTMS could represent a valuable indicator of treatment response. Finally, high-frequency rTMS over the dorsolateral prefrontal cortex (DLPFC) has been shown to significantly enhance cognitive functions, such as executive performance, together with the increase of functional connectivity within frontoparietal networks. The main limitations were the number of included studies and the exclusion of studies using intermittent theta-burst stimulation, used in studies on Alzheimer's disease. Therefore, neuroimaging techniques in combination with rTMS have been shown to be useful for future network-based, fMRI-guided therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Assisted Reproductive Technology and Disease Management in Infertile Women with Multiple Sclerosis.

Author

Sparaco, Maddalena, Carbone, Luigi, Landi, Doriana, Ingrasciotta, Ylenia, Di Girolamo, Raffaella, Vitturi, Giacomo, Marfia, Girolama Alessandra, Alviggi, Carlo, and Bonavita, Simona

Subjects
REPRODUCTIVE technology, DISEASE management, MULTIPLE sclerosis, INDUCED ovulation, NATALIZUMAB, WOMEN executives, TECHNOLOGY management, LUTEINIZING hormone releasing hormone, CATTLE fertility
Abstract

Multiple sclerosis (MS) predominantly affects women of fertile age. Various aspects of MS could impact on fertility, such as sexual dysfunction, endocrine alterations, autoimmune imbalances, and disease-modifying therapies (DMTs). The proportion of women with MS (wMS) requesting infertility management and assisted reproductive technology (ART) is increasing over time. In this review, we report on data regarding ART in wMS and address safety issues. We also discuss the clinical aspects to consider when planning a course of treatment for infertility, and provide updated recommendations to guide neurologists in the management of wMS undergoing ART, with the goal of reducing the risk of disease activation after this procedure. According to most studies, there is an increase in relapse rate and magnetic resonance imaging activity after ART. Therefore, to reduce the risk of relapse, ART should be considered in wMS with stable disease. In wMS, especially those with high disease activity, fertility issues should be discussed early as the choice of DMT, and fertility preservation strategies might be proposed in selected cases to ensure both disease control and a safe pregnancy. For patients with stable disease taking DMTs compatible with pregnancy, treatment should not be interrupted before ART. If the ongoing therapy is contraindicated in pregnancy, then it should be switched to a compatible therapy. Prior to beginning fertility treatments in wMS, it would be reasonable to assess vitamin D serum levels, thyroid function and its antibody serum levels; start folic acid supplementation; and ensure smoking and alcohol cessation, adequate sleep, and food hygiene. Cervico-vaginal swabs for Ureaplasma urealyticum, Mycoplasma hominis, and Chlamydia trachomatis, as well as serology for viral hepatitis, HIV, syphilis, and cytomegalovirus, should be performed. Steroids could be administered under specific indications. Although the available data do not clearly show a definite raised relapse risk associated with a specific ART protocol, it seems reasonably safe to prefer the use of gonadotropin-releasing hormone (GnRH) antagonists for ovarian stimulation. Close clinical and radiological monitoring is reasonably recommended, particularly after hormonal stimulation and in case of pregnancy failure. [ABSTRACT FROM AUTHOR]

Published
2023
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