405 results on '"Bohlooly‐Y, Mohammad"'
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2. Extracellular vesicles transport RNA between cells: Unraveling their dual role in diagnostics and therapeutics
3. A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo
4. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
5. IDOL regulates systemic energy balance through control of neuronal VLDLR expression
6. TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis
7. Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis
8. Aging AdipoR2‐deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty acids.
9. Mouse Models to Study Inherited Cardiomyopathy
10. Universal toxin-based selection for precise genome engineering in human cells
11. Author Correction: Universal toxin-based selection for precise genome engineering in human cells
12. Rapid target validation in a Cas9-inducible hiPSC derived kidney model
13. Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
14. Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice
15. AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue
16. Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery
17. In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model
18. Mouse Models to Study Inherited Cardiomyopathy
19. In vivo CRISPR editing with no detectable genome-wide off-target mutations
20. Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin Signaling.
21. ELEVATED ADIPOCYTE MEMBRANE PHOSPHOLIPID SATURATION DOES NOT COMPROMISE INSULIN SIGNALING
22. Elevated Adipocyte Membrane Phospholipid Saturation Does not Compromise Insulin Signaling
23. Simultaneous inhibition of DNA-PK and Polϴ improves integration efficiency and precision of genome editing
24. Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes
25. Selecting the right therapeutic target for kidney disease
26. Effects of Pharmacological AMP Deaminase Inhibition and Ampd1 Deletion on Nucleotide Levels and AMPK Activation in Contracting Skeletal Muscle
27. Mitochondria are required for pro‐ageing features of the senescent phenotype
28. The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
29. A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation
30. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells
31. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
32. Exploring the Mechanisms of Recovery in Anorexia Nervosa through a Translational Approach: From Original Ecological Measurements in Human to Brain Tissue Analyses in Mice
33. Human genetic evidence supports MAP3K15 inhibition as a therapeutic strategy for diabetes
34. Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype
35. Human rare variant and zebrafish CRISPR/Cas9-mediated mutant analyses reveal novel functions for API5, HSPB7, and LMO2 in heart failure
36. Sphingosine 1-Phosphate Mediates Adiponectin Receptor Signaling Essential For Lipid Homeostasis And Embryogenesis
37. Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects
38. PCSK9 rs11591147 R46L loss‐of‐function variant protects against liver damage in individuals with NAFLD
39. Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects
40. Allostatic hypermetabolic response in PGC1 alpha/beta heterozygote mouse despite mitochondrial defects
41. Universal toxin-based selection for precise genome engineering in human cells
42. Over-expression of Adamts1 in mice alters bone mineral density
43. Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice
44. Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids
45. Effect of Growth Hormone Secretagogue Receptor Deletion on Growth, Pulsatile Growth Hormone Secretion, and Meal Pattern in Male and Female Mice
46. 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors Still Improve Metabolic Phenotype in Male 11β-HSD1 Knockout Mice Suggesting Off-Target Mechanisms
47. Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice
48. Mice with experimental colitis show an altered metabolism with decreased metabolic rate
49. Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice
50. Network Analyses Links Epicardial Fat Metabolism to Human Coronary Heart Disease
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