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9. A global scientific strategy to cure hepatitis B

Author

Arbuthnot, Patrick, Boonstra, Andre, Chang, Kyong-Mi, Chen, Per-Jei, Glebe, Dieter, Guidotti, Luca G., Fellay, Jacques, Ferrari, Carlo, Jansen, Louis, Lau, Daryl T Y, Lok, Anna S, Maini, Mala K, Mason, William, Matthews, Gail, Paraskevis, Dimitrios, Petersen, Jörg, Rehermann, Barbara, Shin, Eui-Cheol, Thompson, Alex, van Bömmel, Florian, Wang, Fu-Sheng, Watashi, Koichi, Yang, Hung-Chih, Yuan, Zhenghong, Yuen, Man-Fung, Block, Timothy, Miller, Veronica, Protzer, Ulrike, Bréchot, Christian, Locarnini, Stephen, Peters, Marion G, Schinazi, Raymond F, Revill, Peter A, Chisari, Francis V, Block, Joan M, Dandri, Maura, Gehring, Adam J, Guo, Haitao, Hu, Jianming, Kramvis, Anna, Lampertico, Pietro, Janssen, Harry L A, Levrero, Massimo, Li, Wenhui, Liang, T Jake, Lim, Seng-Gee, Lu, Fengmin, Penicaud, M Capucine, Tavis, John E, Thimme, Robert, and Zoulim, Fabien

Published
2019
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12. A global scientific strategy to cure hepatitis B

Author

Revill, Peter A, primary, Chisari, Francis V, additional, Block, Joan M, additional, Dandri, Maura, additional, Gehring, Adam J, additional, Guo, Haitao, additional, Hu, Jianming, additional, Kramvis, Anna, additional, Lampertico, Pietro, additional, Janssen, Harry L A, additional, Levrero, Massimo, additional, Li, Wenhui, additional, Liang, T Jake, additional, Lim, Seng-Gee, additional, Lu, Fengmin, additional, Penicaud, M Capucine, additional, Tavis, John E, additional, Thimme, Robert, additional, Zoulim, Fabien, additional, Arbuthnot, Patrick, additional, Boonstra, Andre, additional, Chang, Kyong-Mi, additional, Chen, Per-Jei, additional, Glebe, Dieter, additional, Guidotti, Luca G., additional, Fellay, Jacques, additional, Ferrari, Carlo, additional, Jansen, Louis, additional, Lau, Daryl T Y, additional, Lok, Anna S, additional, Maini, Mala K, additional, Mason, William, additional, Matthews, Gail, additional, Paraskevis, Dimitrios, additional, Petersen, Jörg, additional, Rehermann, Barbara, additional, Shin, Eui-Cheol, additional, Thompson, Alex, additional, van Bömmel, Florian, additional, Wang, Fu-Sheng, additional, Watashi, Koichi, additional, Yang, Hung-Chih, additional, Yuan, Zhenghong, additional, Yuen, Man-Fung, additional, Block, Timothy, additional, Miller, Veronica, additional, Protzer, Ulrike, additional, Bréchot, Christian, additional, Locarnini, Stephen, additional, Peters, Marion G, additional, and Schinazi, Raymond F, additional

Published
2019
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13. Additional file 1: of Hepatitis B knowledge among key stakeholders in Haimen City, China: Implications for addressing chronic HBV infection

Author

Chari Cohen, Evans, Alison, Peixin Huang, W. London, Block, Joan, and Chen, Gang

Abstract

Healthcare provider pre/post-education questionnaire (knowledge questions only); and post-campaign questionnaire (knowledge questions only) for healthcare providers, city residents and chronically infected individuals. (DOCX 23 kb)

Published
2016
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14. Hepatitis-Associated Liver Cancer: Gaps and Opportunities to Improve Care

Author

McMahon, Brian, Block, Joan, Block, Timothy, Cohen, Chari, Evans, Alison A., Hosangadi, Anu, London, W. Thomas, and Sherman, Morris

Subjects
Primary Prevention, Carcinoma, Hepatocellular, Hepatitis B, Chronic, Non-alcoholic Fatty Liver Disease, Population Surveillance, Liver Neoplasms, Commentary, Biomarkers, Tumor, Humans, Hepatitis C, Chronic, Early Detection of Cancer, Neoplasm Staging
Abstract

The global burden of hepatocellular carcinoma (HCC; primary liver cancer) is increasing. HCC is often unaccompanied by clear symptomatology, causing patients to be unaware of their disease. Moreover, effective treatment for those with advanced disease is lacking. As such, effective surveillance and early detection of HCC are essential. However, current screening and surveillance guidelines are not being fully implemented. Some at-risk populations fall outside of the guidelines, and patients who are screened are often not diagnosed at an early enough stage for treatment to be effective. From March 17 to 19, 2015, the Hepatitis B Foundation sponsored a workshop to identify gaps and limitations in current approaches to the detection and treatment of HCC and to define research priorities and opportunities for advocacy. In this Commentary, we summarize areas for further research and action that were discussed throughout the workshop to improve the recognition of liver disease generally, improve the recognition of liver cancer risk, and improve the recognition that screening for HCC makes a life-saving difference. Participants agreed that primary prevention of HCC relies on prevention and treatment of viral hepatitis and other underlying etiologies. Earlier diagnosis (secondary prevention) needs to be substantially improved. Areas for attention include increasing practitioner awareness, better definition of at-risk populations, and improved performance of screening approaches (ultrasound, biomarkers for detection, risk stratification, targeted therapies). The heterogeneous nature of HCC makes it unlikely that a single therapeutic agent will be universally effective. Medical management will benefit from the development of new, targeted treatment approaches.

Published
2015

21. The role of primary care physician assistants in managing chronic hepatitis B.

Author

Beckett, Geoff A., Block, Joan M., Cohen, Chari, and McMahon, Brian J.

Subjects
ANTIVIRAL agents, HEPATOCELLULAR carcinoma, ALGORITHMS, PATIENT aftercare, IMMUNIZATION, CIRRHOSIS of the liver, PHYSICIANS' assistants, PRIMARY health care, CHRONIC hepatitis B, DIAGNOSIS
Abstract

This article informs physician assistants of an algorithm designed for primary care practice to guide the screening of patients for hepatitis B virus infection. The algorithm also provides guidance on evaluation, follow-up, and referral of patients who screen positive. The algorithm is a synthesis of several published, evidence-based practice guidelines and reports. [ABSTRACT FROM AUTHOR]

Published
2014
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23. Hepatitis-Associated Liver Cancer: Gaps and Opportunities to Improve Care.

Author

McMahon B, Block J, Block T, Cohen C, Evans AA, Hosangadi A, London WT, and Sherman M

Subjects
Carcinoma, Hepatocellular diagnosis, Carcinoma, Hepatocellular metabolism, Carcinoma, Hepatocellular virology, Humans, Liver Neoplasms diagnosis, Liver Neoplasms metabolism, Liver Neoplasms virology, Neoplasm Staging, Non-alcoholic Fatty Liver Disease complications, Primary Prevention methods, Biomarkers, Tumor metabolism, Carcinoma, Hepatocellular prevention & control, Early Detection of Cancer, Hepatitis B, Chronic complications, Hepatitis C, Chronic complications, Liver Neoplasms prevention & control, Population Surveillance methods
Abstract

The global burden of hepatocellular carcinoma (HCC; primary liver cancer) is increasing. HCC is often unaccompanied by clear symptomatology, causing patients to be unaware of their disease. Moreover, effective treatment for those with advanced disease is lacking. As such, effective surveillance and early detection of HCC are essential. However, current screening and surveillance guidelines are not being fully implemented. Some at-risk populations fall outside of the guidelines, and patients who are screened are often not diagnosed at an early enough stage for treatment to be effective. From March 17 to 19, 2015, the Hepatitis B Foundation sponsored a workshop to identify gaps and limitations in current approaches to the detection and treatment of HCC and to define research priorities and opportunities for advocacy. In this Commentary, we summarize areas for further research and action that were discussed throughout the workshop to improve the recognition of liver disease generally, improve the recognition of liver cancer risk, and improve the recognition that screening for HCC makes a life-saving difference. Participants agreed that primary prevention of HCC relies on prevention and treatment of viral hepatitis and other underlying etiologies. Earlier diagnosis (secondary prevention) needs to be substantially improved. Areas for attention include increasing practitioner awareness, better definition of at-risk populations, and improved performance of screening approaches (ultrasound, biomarkers for detection, risk stratification, targeted therapies). The heterogeneous nature of HCC makes it unlikely that a single therapeutic agent will be universally effective. Medical management will benefit from the development of new, targeted treatment approaches., (© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)

Published
2015
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24. The role of primary care physician assistants in managing chronic hepatitis B.

Author

Beckett GA, Block JM, Cohen C, and McMahon BJ

Subjects
Algorithms, Humans, Hepatitis B, Chronic therapy, Physician Assistants, Primary Health Care methods, Role
Abstract

This article informs physician assistants of an algorithm designed for primary care practice to guide the screening of patients for hepatitis B virus infection. The algorithm also provides guidance on evaluation, follow-up, and referral of patients who screen positive. The algorithm is a synthesis of several published, evidence-based practice guidelines and reports.

Published
2014
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25. Transforming strategies for the prevention of chronic HBV and HCV infections.

Author

Ward JW, Hu DJ, Alter MJ, Kanwal F, Taylor C, Block JM, Caballero JB, Chase D, Saly M, Sandt L, and Swan T

Subjects
Emigrants and Immigrants statistics & numerical data, Hepatitis B, Chronic epidemiology, Hepatitis B, Chronic transmission, Hepatitis C, Chronic epidemiology, Humans, Mass Vaccination, Quality Indicators, Health Care, Quality of Health Care, Risk Factors, Substance Abuse, Intravenous prevention & control, Substance Abuse, Intravenous virology, United States epidemiology, Hepatitis B, Chronic prevention & control, Hepatitis C, Chronic prevention & control
Published
2010

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