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Background: The societal burden of chronic pain and the contribution-in-part to the opioid crisis, is a strong motivation to improve and expand nonaddictive treatments, including spinal cord stimulation (SCS). For several decades standard SCS has consisted in delivery of tonic pulses with static parameter settings in frequency, pulse width, and amplitude. These static parameters have limited ability to personalize the quality of paresthesia, the dermatomal coverage, and thus may affect SCS efficacy. Further, static settings may contribute to the build-up of tolerance or loss of efficacy of the therapy over time in some patients. Methods: We conducted an acute exploratory study to evaluate the effects of SCS using time-dynamic pulses as compared to time-static (conventional tonic) stimulation pulses, with the hypotheses that dynamic pulse SCS may enable beneficial tailoring of the sensation and the patient's expectation for better pain relief with SCS. During a single clinic visit, consented subjects undergoing a standard SCS trial had their implanted leads temporarily connected to an investigational external stimulator capable of delivering timestatic and six categories of time-dynamic pulse sequences, each characterized by continuously varying a stimulation parameter. Study subjects provided several assessments while blinded to the stimulation pattern, including: drawing of paresthesia maps, descriptions of sensation, and ratings for comfort and helpfulness to pain relief. Results: Even without optimization of the field location, a majority of subjects rated sensations from dynamic stimulation as better or equal to that of static stimulation for comfortableness and for helpfulness to pain relief. The initial data showed a gender and/or pain dermatomal location related preference to a stimulation pattern. In particular, female subjects and subjects with pain at higher dermatomes tended to rank the sensation from dynamic stimulation better. Dynamic stimulation produced greater pain coverage without optimization; in 70% (9/13) of subjects, maximal pain coverage was achieved with a dynamic stimulation pattern. There was also greater variety in the words used by patients to describe stimulation sensation in the free text and free form verbal descriptions associated with dynamic stimulation. Conclusions: With the same electrode configuration and comparable parameter settings, acute SCS using dynamic pulses produced more positive ratings, expanded paresthesia coverage, and greater variation in sensation as compared to SCS using static pulses, suggesting that dynamic stimulation has the potential to improve capabilities of SCS for the treatment of chronic pain. Further study is warranted. [ABSTRACT FROM AUTHOR]

Our memory for common, easily recognizable logos, like the Apple logo, is surprisingly poor because of attentional saturation, where we stop attending to details of frequently encountered objects. This lack of attention to details may leave us susceptible to misinformation effects. Across four experiments, we tested recognition memory for the Apple logo after incidentally encoding an accurate or altered version of the logo (Experiments 1–3), or after no incidental encounter of the logo prior to the surprise test (Experiment 4). Additionally, participants rated how much they liked the logo as a measure of processing fluency. Results demonstrated that incidentally viewing an altered version of the Apple logo can disrupt subsequent recognition of the correct logo, but this effect may diminish following a short delay. Considering our frequent exposure to everyday stimuli, we show conditions in which memory for a ubiquitous stimulus can be disrupted when incidentally presented with inaccurate information. [ABSTRACT FROM AUTHOR]

Research has shown that climate change creates warmer temperatures and drier conditions, leading to longer wildfire seasons and increased wildfire risks in the United States. These factors have, in turn, led to increases in the frequency, extent, and severity of wildfires in recent years. Given the danger posed by wildland fires to people, property, wildlife, and the environment, there is an urgent need to provide tools for effective wildfire management. Early detection of wildfires is essential to minimizing potentially catastrophic destruction. To that end, in this paper, we present our work on integrating multiple data sources into SmokeyNet, a deep learning model using spatiotemporal information to detect smoke from wildland fires. We present Multimodal SmokeyNet and SmokeyNet Ensemble for multimodal wildland fire smoke detection using satellite-based fire detections, weather sensor measurements, and optical camera images. An analysis is provided to compare these multimodal approaches to the baseline SmokeyNet in terms of accuracy metrics, as well as time-to-detect, which is important for the early detection of wildfires. Our results show that incorporating weather data in SmokeyNet improves performance numerically in terms of both F1 and time-to-detect over the baseline with a single data source. With a time-to-detect of only a few minutes, SmokeyNet can be used for automated early notification of wildfires, providing a useful tool in the fight against destructive wildfires. [ABSTRACT FROM AUTHOR]

This study examined the development of joint attention in 95 infants assessed between 9 and 18 months of age. Infants displayed significant test-retest reliability on measures of following gaze and gestures (responding to joint attention, RJA) and in their use of eye contact to establish social attention coordination (initiating joint attention, IJA). Infants displayed a linear, increasing pattern of age-related growth on most joint attention measures. However, IJA was characterized by a significant cubic developmental pattern. Infants with different rates of cognitive development exhibited different frequencies of joint attention acts at each age, but did not exhibit different age-related patterns of development. Finally, 12-month RJA and 18-month IJA predicted 24-month language after controlling for general aspects of cognitive development.

Background: Preterm infants suffer from respiratory morbidity especially during the first year of life.Objective: To investigate the association of air quality and sociodemographic indicators on hospital admission rates for respiratory causes.Methods: This is a retrospective cohort study. We identified all live-born preterm infants in California from 2007 to 2012 in a population-based administrative data set and linked them to a data set measuring several air quality and sociodemographic indicators at the census tract level. All sociodemographic and air quality predictors were divided into quartiles (first quartile most favourable to the fourth quartile least favourable). Mixed effect logistic models to account for clustering at the census tract level were used to investigate associations between chronic air quality and sociodemographic indicators respiratory hospital admission during the first year of life.Results: Of 205 178 preterm infants, 5.9% (n = 12 033) were admitted to the hospital for respiratory causes during the first year. In the univariate analysis, comparing the first to the fourth quartile of chronic ozone (risk ratio [RR] 1.29, 95% confidence interval [CI] 1.21, 1.37), diesel (RR 1.10, 95% CI 1.02, 1.17) and particulate matter 2.5 (RR 1.07, 95% CI 1.01, 1.14) exposure were associated with hospital admission during the first year. Following adjustment for confounders, the risk ratios for hospital admission during the first year were 1.53 (95% CI 1.37, 1.72) in relation to educational attainment (per cent of the population over age 25 with less than a high school education) and 1.23 (95% CI 1.09, 1.38) for poverty (per cent of the population living below two times the federal poverty level).Conclusions: Among preterm infants, respiratory hospital admissions in the first year in California are associated with socioeconomic characteristics of the neighbourhood an individual is living in. [ABSTRACT FROM AUTHOR]

Mediation training standards are inconsistent and fail to focus on the pivotal skill set of addressing, understanding, and working with underlying emotions that shape conflict and may prevent mutual goal attainment. The purpose of this article is to explore skills essential to counseling and mediation and advocate for the potential benefits of formally training counselors to facilitate the process of mediation and conflict resolution. [ABSTRACT FROM AUTHOR]

Wildfires are critical for ecosystems in many geographical regions. However, our current urbanized existence in these environments is inducing the ecological balance to evolve into a different dynamic leading to the biggest fires in history. Wildfire wind speeds and directions change in an instant, and first responders can only be effective if they take action as quickly as the conditions change. What is lacking in disaster management today is a system integration of real-time sensor networks, satellite imagery, near-real time data management tools, wildfire simulation tools, and connectivity to emergency command centers before, during and after a wildfire. As a first time example of such an integrated system, the WIFIRE project is building an end-to-end cyberinfrastructure for real-time and data-driven simulation, prediction and visualization of wildfire behavior. This paper summarizes the approach and early results of the WIFIRE project to integrate networked observations, e.g., heterogeneous satellite data and real-time remote sensor data with computational techniques in signal processing, visualization, modeling and data assimilation to provide a scalable, technological, and educational solution to monitor weather patterns to predict a wildfire's Rate of Spread. [ABSTRACT FROM AUTHOR]

The goal of the structural health monitoring community has been to endow physical systems with a nervous system not unlike those commonly found in living organisms. Typically, the structural health monitoring community has attempted to do this by instrumenting structures with a variety of sensors and then applying various signal processing and classification procedures to the data in order to detect the presence of damage, the location of damage, the severity of damage, and to estimate the remaining useful life of the structure. This procedure has had some success, but we are still a long way from achieving the performance of nervous systems found in biology. This is primarily because contemporary classification algorithms do not have the performance required. In many cases, expert judgment is superior to automated classification. This work introduces a new paradigm. We propose interfacing the human nervous system to the distributed sensor network located on the structure and developing new techniques to enable human–machine cooperation. The results from the field of sensory substitution suggest this should be possible. This study investigates a vibro-haptic human–machine interface for structural health monitoring. The investigation was performed using a surrogate three-story structure. The structure features three nonlinearity-inducing bumpers to simulate damage. Accelerometers are placed on each floor to measure the response of the structure to a harmonic base excitation. The accelerometer measurements are preprocessed. The preprocessed data are then encoded as a vibro-tactile stimulus. Human subjects were then subjected to the vibro-tactile stimulus and asked to characterize the damage in the structure. [ABSTRACT FROM AUTHOR]

The article looks at the decision of the U.S. Court of Appeals for the First Circuit in the case EEOC v. Kohl's Department Stores Inc. regarding the work in night shift by a employee who is having type 1 diabetes as a violation of the Americans with Disabilities Act (ADA).

This study examined the development of joint attention in 95 infants assessed between 9 and 18 months of age. Infants displayed significant test-retest reliability on measures of following gaze and gestures (responding to joint attention, RJA) and in their use of eye contact to establish social attention coordination (initiating joint attention, IJA). Infants displayed a linear, increasing pattern of age-related growth on most joint attention measures. However, IJA was characterized by a significant cubic developmental pattern. Infants with different rates of cognitive development exhibited different frequencies of joint attention acts at each age, but did not exhibit different age-related patterns of development. Finally, 12-month RJA and 18-month IJA predicted 24-month language after controlling for general aspects of cognitive development. [ABSTRACT FROM AUTHOR]

Infant joint attention has been observed to be related to social-emotional outcomes in at-risk children. To address whether this relation is also evident in typically developing children, 52 children were tested at 12, 15, 24, and 30 months to examine associations between infant joint attention and social outcomes. Twelve-month initiating and responding to joint attention were related to 30-month social competence and externalizing behavior, even when accounting for 15-month temperament ratings, 24-month cognition and language, and demographic variables. These results suggest that, in addition to associations with language and cognition, infant joint attention reflects robust aspects of development that are related to individual differences in the emergence of social and behavioral competence in childhood. [ABSTRACT FROM AUTHOR]

Little is known about variables that may contribute to individual differences in infant joint attention, or the coordination of visual attention with a social partner. Therefore, this study examined the contributions of caregiver behavior and temperament to infant joint attention development between 9 and 12 months. Data were collected from 57 infants using a caregiver-infant paradigm, an infant-tester paradigm, and a parent report of infant temperament. Nine-month measures of caregiver scaffolding and infant initiating joint attention (IJA) with testers were significantly related to 12-month infant IJA with testers. A temperament measure of positive emotional reactivity was related to 9-month IJA, and a measure of negative emotional reactivity was related to 12-month IJA. Temperament and caregiver scaffolding measures, however, were not associated with the development of infant responding to joint attention. These results further the understanding of the multiple processes that contribute to joint attention development in infancy, and support the hypothesis that initiating and responding measures tap different aspects of joint attention development. [ABSTRACT FROM AUTHOR]

A goal of the Precision Medicine Initiative All of Us Research Program (AoURP) is recruitment of participants who reflect the diversity of the US. Recruitment from among blood bank donors, which may better reflect the demographic makeup of local communities, is one proposed strategy. We evaluated this strategy by analyzing the results of a survey of San Diego Blood Bank donors conducted in November 2015. Whites were more likely than nonwhites to respond to the survey (7.1 percent versus 3.9 percent). However, race was not a significant predictor of interest in participating in precision medicine research. Using census data linked to donors' ZIP codes, we also found that people who indicated interest in research participation were more likely to come from regions with higher educational attainment. Although blood banks represent a viable recruitment strategy for AoURP, our findings indicate that bias toward inclusion of whites and more highly educated people persists. [ABSTRACT FROM AUTHOR]

Objective: To assess the relationship between infertility, marital benefit, and coping in a sample of men and women undergoing unsuccessful fertility treatments. Design: Prospective longitudinal cohort design using multilevel modeling. Setting: Danish public and private hospitals (n = 5) specializing in treating fertility patients. Patient(s): Participants were Danish men and women about to start a cycle of medically assisted reproduction treatment who were followed for a 5-year period of unsuccessful treatments. Intervention(s): None. Main Outcome Measure(s): The Copenhagen Multicenter Psychosocial Infertility research program Coping Strategy Scales and Marital Benefit Measure. Result(s): Compared with men, a greater percentage of women reported high levels of marital benefit. For active-avoidance coping, there was a significant partner effect by gender interaction. Meaning-based strategies increased between 1 and 5 years for men and women. The use of meaning-based coping had a significant positive actor effect with marital benefit for both men and women. Conclusion(s): Approximately one-third of participants undergoing unsuccessful fertility treatments reported high marital benefit as a positive consequence of the infertility experience. Partner effects for men and women related to active-avoidance coping may be related to the degree of emotional support that each spouse can offer the other, whereas differences in meaning-based coping indicate a possible timing effect related to gender. [ABSTRACT FROM AUTHOR]