124 results on '"Alhasan, Khalid"'
Search Results
2. Common prognostic biomarkers and outcomes in patients with COVID-19 infection in Saudi Arabia
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Abujabal, Mashael, Shalaby, Mohamed A, Abdullah, Layla, Albanna, Amr S, Elzoghby, Mohamed, Alahmadi, Ghadeer Ghazi, Sethi, Sidharth Kumar, Temsah, Mohamad-Hani, Aljamaan, Fadi, Alhasan, Khalid, and Kari, Jameela A
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- 2023
3. Art or Artifact: Evaluating the Accuracy, Appeal, and Educational Value of AI-Generated Imagery in DALL·E 3 for Illustrating Congenital Heart Diseases
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Temsah, Mohamad-Hani, Alhuzaimi, Abdullah N., Almansour, Mohammed, Aljamaan, Fadi, Alhasan, Khalid, Batarfi, Munirah A., Altamimi, Ibraheem, Alharbi, Amani, Alsuhaibani, Adel Abdulaziz, Alwakeel, Leena, Alzahrani, Abdulrahman Abdulkhaliq, Alsulaim, Khaled B., Jamal, Amr, Khayat, Afnan, Alghamdi, Mohammed Hussien, Halwani, Rabih, Khan, Muhammad Khurram, Al-Eyadhy, Ayman, and Nazer, Rakan
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- 2024
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4. Use of furosemide in preterm neonates with acute kidney injury is associated with increased mortality: results from the TINKER registry
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Raina, Rupesh, Sethi, Sidharth Kumar, Agrawal, Gopal, Wazir, Sanjay, Bajaj, Naveen, Gupta, Naveen Parkash, Tibrewal, Abhishek, Vadhera, Ananya, Mirgunde, Shishir, Balachandran, Binesh, Sahoo, Jagdish, Afzal, Kamran, Shrivastava, Anubha, Bagla, Jyoti, Krishnegowda, Sushma, Konapur, Ananth, Soni, Kritika, Alhasan, Khalid, McCulloch, Mignon, and Bunchman, Timothy
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- 2024
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5. ChatGPT-3.5 System Usability Scale early assessment among Healthcare Workers: Horizons of adoption in medical practice
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Aljamaan, Fadi, Malki, Khalid H., Alhasan, Khalid, Jamal, Amr, Altamimi, Ibraheem, Khayat, Afnan, Alhaboob, Ali, Abdulmajeed, Naif, Alshahrani, Fatimah S., Saad, Khaled, Al-Eyadhy, Ayman, Al-Tawfiq, Jaffar A., and Temsah, Mohamad-Hani
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- 2024
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6. Clinical and molecular characterization of a large primary hyperoxaluria cohort from Saudi Arabia: a retrospective study
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Alfadhel, Majid, Umair, Muhammad, Alghamdi, Malak A., Al Fakeeh, Khalid, Al Qahtani, Abdullah T., Farahat, Afrah, Shalaby, Mohamed A., Kari, Jameela A., Raina, Rupesh, Cochat, Pierre, and Alhasan, Khalid A.
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- 2023
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7. Nutrition in critically ill children with acute kidney injury on continuous kidney replacement therapy: a 2023 executive summary
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Raina, Rupesh, Suchan, Andrew, Soundararajan, Anvitha, Brown, Ann-Marie, Davenport, Andrew, Shih, Weiwen V., Nada, Arwa, Irving, Sharon Y., Mannemuddhu, Sai Sudha, Vitale, Victoria S., Crugnale, Aylin S., Keller, Gerri L., Berry, Katarina G., Zieg, Jakub, Alhasan, Khalid, Guzzo, Isabella, Lussier, Natalie H., Yap, Hui Kim, Bunchman, Timothy E., and Sethi, Sidharth K.
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- 2024
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8. Risk factors, outcomes, and predictors of resolution of acute kidney injury in children with diabetic ketoacidosis
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Al Khalifah, Reem, Al-Eyadhy, Ayman, Musibeeh, Najd, Alshalawi, Anfal, Alanazi, Noor, Alhboob, Ayman, Hassan, Gamal, Temsah, Mohamad-Hani, Alhaboob, Ali A. N., Raina, Rupesh, and Alhasan, Khalid
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- 2023
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9. SARS-CoV-2 variants and the global pandemic challenged by vaccine uptake during the emergence of the Delta variant: A national survey seeking vaccine hesitancy causes
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AlJamaan, Fadi, Temsah, Mohamad-Hani, Alhasan, Khalid, Alenezi, Shuliweeh, Alhaboob, Ali, Alrabiaah, Abdulkarim, Batais, Mohammed, Alshahrani, Fatimah, Assiri, Rasha Asaad, Bafaqih, Hind, Alaraj, Ali, Al Qadrah, Bedoor, Alhaidary, Abdulilah, Saad, Khaled, Saddik, Basema, Halwani, Rabih, Rabaan, Ali A., Al-Subaie, Sarah, Barry, Mazin, and Al-Tawfiq, Jaffar A.
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- 2022
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10. Young Adults With Hereditary Tubular Diseases: Practical Aspects for Adult-Focused Colleagues
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Alhasan, Khalid, D'Alessandri-Silva, Cynthia, Mongia, Anil, Topaloglu, Rezan, Tasic, Velibor, and Filler, Guido
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- 2022
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11. Adherence to Cysteamine Therapy Among Patients Diagnosed with Cystinosis in Saudi Arabia: A Prospective Cohort Study.
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Algasem, Reem, Zainy, Nedaa, Alsabban, Essam, Almojalli, Hamad, Alhasan, Khalid, Ali, Tariq, Broering, Deiter, and Aleid, Hassan
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PATIENT compliance ,EYE drops ,ELECTRONIC health records ,SOCIAL skills ,CYSTEAMINE - Abstract
Cystinosis is a rare autosomal recessive disorder in which cystine crystals accumulate within the cellular lysosomes, causing damage to multiple organs. Due to challenges with the stringent cysteamine treatment regimen and side effects, adherence is often sub-optimal. This study aimed to assess the level of adherence to cysteamine therapy among cystinosis patients in Saudi Arabia and its impact on their quality of life. Electronic medical record data of 39 cystinosis patients from the Department of Nephrology at King Faisal Specialist Hospital and Research Center in Saudi Arabia were reviewed, and 25 patients were included in this study. Out of the 25 patients included in the final analysis, 64% (n = 16) were female. The mean age was 19.04 years. Almost all patients (23/25, 92%) were on oral IR cysteamine therapy, and 52% (13/25) were on topical cysteamine eye drop treatment. Of the 15 patients who responded to the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire, only 4 (26.7%) were highly adherent to cysteamine therapy. Most of the respondents (7/15, 46.7%) showed a medium level of treatment adherence. Based on the medication possession ratio for oral cysteamine, only 6 out of 23 patients (26.1%) were found to be 96–100% adherent. For the cysteamine eye drops, only 5/13 patients (38.4%) were 76–95% adherent. The 36-Item Short Form Health Survey (SF-36) used to assess patients' health-related outcomes showed that their quality of life was affected in the domains of 'social functioning' and 'energy/fatigue.' Despite a small sample size, this study shows sub-optimal adherence to cysteamine treatment in patients from Saudi Arabia. The possible reasons for low treatment adherence could be a high frequency of administration and treatment-related side effects. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Importance of clinical practice guidelines to practicing pediatric nephrologists and IPNA survey
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Hari, Pankaj, Alhasan, Khalid, Bagga, Arvind, Bonilla-Felix, Melvin, Coccia, Paula Alejandra, Duzova, Ali, and Ha, Ill-So
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Practice guidelines (Medicine) -- Evaluation ,Nephrologists -- Practice -- Surveys ,Pediatricians -- Practice -- Surveys ,Health - Abstract
Clinical practice guidelines (CPGs) are systematically developed statements backed by scientific evidence to assist practitioners in management in clinical practice. An international cross-sectional survey was conducted by the IPNA to examine the perceptions of pediatric nephrologists on guidelines and their usage and to identify important diseases for future clinical practice guidelines (CPGs). The survey found that the majority of pediatric nephrologists find CPGs useful in clinical practice and admitted to using them most of the time. Developing CPGs is challenging and there are standards available to develop trustworthy guidelines. While evidence-based global guidelines are ideal, pediatric nephrologists expressed the desire that they address regional differences. Most respondents (89.2%) to the survey agreed that adult guidelines did not cover the pediatric perspective adequately and 71.4% opined that consensus-based pediatric guidelines can be developed when evidence for the pediatric population is lacking. The development of high-quality practice guidelines requires substantial resources and may not be feasible in resource-poor countries. Adaptation of an existing guideline has been suggested as an alternative and the ADAPTE collaboration provides a systematic approach to adapting guidelines. Several diseases where pediatric guidelines are needed as a priority including IgA and C3 glomerulopathy were identified in the survey. Implementation of guideline-based care is challenging and the survey found that lack of availability of guidelines (43%) and resources (22.8%) are important reasons for poor implementation in lower-middle and low-income countries. Perceived complexity of guidelines, physician attitudes, and lack of training also contribute to non-adherence to guidelines., Author(s): Pankaj Hari [sup.1] , Khalid Alhasan [sup.2] , Arvind Bagga [sup.1] , Melvin Bonilla-Felix [sup.3] , Paula Alejandra Coccia [sup.4] , Ali Duzova [sup.5] , Ill-So Ha [sup.6] , [...]
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- 2021
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13. COVID-19 vaccine uptake among healthcare workers in the fourth country to authorize BNT162b2 during the first month of rollout
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Barry, Mazin, Temsah, Mohamad-Hani, Aljamaan, Fadi, Saddik, Basema, Al-Eyadhy, Ayman, Alenezi, Shuliweeh, Alamro, Nurah, Alhuzaimi, Abdullah N, Alhaboob, Ali, Alhasan, Khalid, Alsohime, Fahad, Alaraj, Ali, Halwani, Rabih, Jamal, Amr, Temsah, Omar, Alzamil, Fahad, Somily, Ali, and Al-Tawfiq, Jaffar A.
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- 2021
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14. Coronavirus disease in children: A multicentre study from the Kingdom of Saudi Arabia
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Kari, Jameela A., Shalaby, Mohamed A., Albanna, Amr S., Alahmadi, Turki S, Sukkar, Samaher A., MohamedNur, Hanan A.H., AlGhamdi, Manar S., Basri, Afnan H., Shagal, Reem A., Alnajar, Abeer, Badawi, Mazen, Safdar, Osama Y., Zaher, Zaher F., Temsah, Mohamad-Hani, and Alhasan, Khalid A.
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- 2021
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15. Prevention of dialysis disequilibrium syndrome in children with advanced uremia with a structured hemodialysis protocol: A quality improvement initiative study.
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Sethi, Sidharth Kumar, Luyckx, Valerie, Bunchman, Timothy, Nair, Aishwarya, Bansal, Shyam Bihari, Pember, Bryce, Soni, Kritika, Savita, Yadav, Dinesh Kumar, Sharma, Vivek, Alhasan, Khalid, and Raina, Rupesh
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SYNDROMES in children ,DIALYSIS (Chemistry) ,HEMODIALYSIS ,UREMIA ,CHILD patients - Abstract
Background: Dialysis disequilibrium syndrome (DDS) is a rare but significant concern in adult and pediatric patients undergoing dialysis initiation with advanced uremia or if done after an interval. It is imperative to gain insights into the epidemiological patterns, pathophysiological mechanisms, and preventive strategies aimed at averting the onset of this ailment. Design: Prospective observational quality improvement initiative cohort study. Setting and Participants: A prospective single‐center study involving 50 pediatric patients under 18 years recently diagnosed with chronic kidney disease stage V with blood urea ≥200 mg/dL, admitted to our tertiary care center for dialysis initiation from January 2017 to October 2023. Quality Improvement Plan: A standardized protocol was developed and followed for hemodialysis in pediatric patients with advanced uremia. This protocol included measures such as lower urea reduction ratios (targeted at 20%–30%) with shorter dialysis sessions and linear dialysate sodium profiling. Prophylactic administration of mannitol and 25% dextrose was also done to prevent the incidence of dialysis disequilibrium syndrome. Measures: Incidence of dialysis disequilibrium syndrome and severe dialysis disequilibrium syndrome, mortality, urea reduction ratios (URRs), neurological outcome at discharge, and development of complications such as infection and hypotension. Long‐term outcomes were assessed at the 1‐year follow‐up including adherence to dialysis, renal transplantation, death, and loss to follow‐up. Results: The median serum creatinine and urea levels at presentation were 7.93 and 224 mg/dL, respectively. A total of 20% of patients had neurological symptoms attributable to advanced uremia at the time of presentation. The incidence of dialysis disequilibrium syndrome was 4% (n = 2) with severe dialysis disequilibrium syndrome only 2% (n = 1). Overall mortality was 8% (n = 4) but none of the deaths were attributed to dialysis disequilibrium syndrome. The mean urea reduction ratios for the first, second, and third dialysis sessions were 23.45%, 34.56%, and 33.50%, respectively. The patients with dialysis disequilibrium syndrome were discharged with normal neurological status. Long‐term outcomes showed 88% adherence to dialysis and 38% renal transplantation. Limitations: This study is characterized by a single‐center design, nonrandomized approach, and limited sample size. Conclusions: Our structured protocol served as a framework for standardizing procedures contributing to low incidence rates of dialysis disequilibrium syndrome. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Remote interviews for medical residency selection during the initial COVID-19 crisis: a national survey
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Temsah, Mohamad-Hani, Alkhattabi, Fadiah, Aljamaan, Fadi, Alhasan, Khalid, Alherbish, Adi, Philby, Mona, Alsohime, Fahad, Alobaylan, Mohamad, Alabdulkarim, Hayfa, Almosned, Badr, Gashgarey, Deema, Felimban, Ghadah, Alkathiri, Ziyad, Almaghrabi, Randa, Jamal, Amr, Barry, Mazin, Alhaider, Sami A., Alsaywid, Basim, and Bashiri, Fahad A.
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- 2021
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17. Acute kidney injury in children with COVID-19: a retrospective study
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Kari, Jameela Abdulaziz, Shalaby, Mohamed A, Albanna, Amr S, Alahmadi, Turki S, Alherbish, Adi, and Alhasan, Khalid A
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- 2021
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18. Rituximab versus cyclophosphamide as first steroid-sparing agent in childhood frequently relapsing and steroid-dependent nephrotic syndrome
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Kari, Jameela A., Alhasan, Khalid A., Albanna, Amr S., Safdar, Osama Y., Shalaby, Mohamed A., Bockenhauer, Detlef, and El-Desoky, Sherif M.
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Cyclophosphamide -- Comparative analysis -- Usage ,Diseases -- Relapse ,Nephrotic syndrome -- Drug therapy ,Pediatric research -- Comparative analysis -- Usage ,Health - Abstract
Background Approximately 50% of children with steroid-sensitive nephrotic syndrome (SSNS) will suffer from frequent relapses or steroid dependency, prompting the use of so-called steroid-sparing drugs. In this pilot study, we compare the efficacy and safety of rituximab to oral cyclophosphamide as first-line steroid-sparing medications. Methods A prospective open-label non-randomized study of children with frequent relapsing or steroid-dependant SSNS. Exclusion criteria were steroid-resistant disease, prescription of immunosuppressive agents other than prednisolone or levamisole, evidence of impaired kidney function, leucopenia, or active infection. The recruited children were allocated either to the oral cyclophosphamide (3 mg/kg/day for 8 weeks) or intravenous rituximab treatment (two doses of 375 mg/m.sup.2/dose, 2 weeks apart) and were monitored for relapses and side effects for 12 months. Results Forty-six subjects were included from two centers; 27 received cyclophosphamide and 19 received rituximab. One-year relapse-free survival was reached in 17 (58.6%) patients treated with cyclophosphamide compared to 16 (84.2%) with rituximab (adjusted HR 0.36; 95% CI 0.09-1.45; p = 0.151). The mean interval to relapse was 6.9 months in the cyclophosphamide group (N = 10) and 6.3 months in the rituximab group (N = 3). Both treatments were associated with a significant (p < 0.001) reduction in prescribed dose of oral alternate-day steroid from 1.02 to 0.36 mg/kg (cyclophosphamide) and 0.86 to 0.08 mg/kg (rituximab). Importantly, a significantly (p = 0.003) higher percentage of patients achieved complete withdrawal of steroid within 3 months of commencing study treatment in the rituximab (73.7%) versus cyclophosphamide (29.6%) group. Transient leucopenia was the most frequent adverse effect observed in the cyclophosphamide group (18.5%) and one patient (3.4%) had acute hepatotoxicity besides severe leucopenia and neutropenia in the 7th week of treatment with complete recovery with the withdrawal of cyclophosphamide and maintenance of remission. A minor infusion-related reaction in the form of a generalized macular skin rash was observed in one patient (5%) in the rituximab group. Conclusions Rituximab is non-inferior to cyclophosphamide and safe as a first-line steroid-sparing agent in children with SSNS. A larger multicenter study is required to assess superiority over cyclophosphamide., Author(s): Jameela A. Kari [sup.1] [sup.2] , Khalid A. Alhasan [sup.3] , Amr S. Albanna [sup.4] , Osama Y. Safdar [sup.1] [sup.2] , Mohamed A. Shalaby [sup.1] [sup.2] , Detlef [...]
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- 2020
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19. Genetics of congenital and infantile nephrotic syndrome
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Sharief, Sara Nawfal, Hefni, Nada Abdullatif, Alzahrani, Walaa Ali, Nazer, Iman Ibrahim, Bayazeed, Marwa Abdullah, Alhasan, Khalid A., Safdar, Osama Y., El-Desoky, Sherif M., and Kari, Jameela Abdulaziz
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- 2019
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20. Awareness, Attitudes, and Willingness: A Cross-Sectional Study of Organ Donation in Saudi Arabia.
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Alhasan, Khalid, Aljamaan, Fadi, Ajlan, Aziza, Aleid, Hassan, Al Ghoufi, Talal, Alabbad, Saleh I., AlDhaferi, Rezqah F., Almaiman, Weiam, Ali, Tariq, Hakami, Alaa Abdullah, Hakami, Rafeef Abdullah, Alqarni, Baraah S., Alrashed, Alhanouf S., Alsharidi, Tarfa R., Almousa, Hamad A., Altamimi, Ibraheem, Alhaboob, Ali, Jamal, Amr, Shalaby, Mohamed A., and Kari, Jameela A.
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ISLAM ,CULTURE ,CONFIDENCE intervals ,CROSS-sectional method ,AGE distribution ,CONSUMER attitudes ,REGRESSION analysis ,HEALTH literacy ,SEX distribution ,PSYCHOSOCIAL factors ,DESCRIPTIVE statistics ,DATA analysis software ,ORGAN donation ,ORGAN donors ,EDUCATIONAL attainment - Abstract
Background: Organ transplantation is inherently dependent on the availability of organ donors. There is a noticeable paucity of literature addressing the rates of organ donation registration and the awareness of Islamic regulations (Fatwa) regarding organ donation within Saudi Arabia. Our study aimed to evaluate the level of organ donation registration, awareness of Islamic regulations, and knowledge of the Saudi Center for Organ Transplantation (SCOT) within the Saudi society. Methods: We conducted a cross-sectional survey from 30 March to 9 April 2023. This survey aimed to assess the awareness of Islamic (Fatwa) guidance on organ donation, the role of SCOT, and the rate of organ donation registration facilitated through the Tawakkalna app, the official health passport application in Saudi Arabia. Results: Out of 2329 respondents, 21% had registered as potential deceased organ donors, despite 87% acknowledging the importance of organ donation. Awareness of the Islamic Fatwa regarding organ donation was reported by 54.7% of respondents, and 37% recognized the Fatwa's acceptance of brain death criteria. The likelihood of registration as organ donors was higher among Saudi citizens under 45 years of age, females, healthcare workers (HCWs), individuals with higher education, relatives of patients awaiting organ donations, those informed about the Islamic Fatwas, and those willing to donate organs to friends. Conversely, being over the age of 25, Saudi nationality, employment as an HCW, awareness of SCOT, and prior organ donation registration were predictive of a heightened awareness of Islamic Fatwas. However, perceiving the importance of organ donation correlated with a lower awareness of the Fatwas. Significant positive correlations were found between awareness of SCOT, awareness of Fatwas, and registration for organ donation. Conclusions: While the Saudi population exhibits a high regard for the importance of organ donation, this recognition is not adequately translated into registration rates. The discrepancy may be attributable to limited awareness of SCOT and the relevant Islamic Fatwas. It is imperative to initiate organ donation awareness campaigns that focus on religious authorization to boost organ donation rates and rectify prevalent misconceptions. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Adapting Clinical Practice Guidelines for Chronic Kidney Disease: Blood Pressure Management and Kidney Replacement Therapy in Adults and Children in the Saudi Arabian Context Using the Grading of Recommendations Assessment, Development, and...
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Alhasan, Khalid A., José Yepes-Nuñez, Juan, Askandarani, Sumayah, Amer, Yasser S., Al-Jelaify, Muneera, Almatham, Khalid I., Al-Ghonaim, Mohammed, Al Dalbhi, Sultan, Kari, Jameela A., Mitwalli, Ahmed, Memish, Ziad A., Valson, Joanna Sara, Alvira, Ximena, Bilimoria, Khushnam, Chawla, Ruchi, Feit, Sheila, Bickett, Skye, and Brunnhuber, Klara
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- 2023
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22. Outcome of pediatric acute kidney injury: a multicenter prospective cohort study
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Kari, Jameela A., Alhasan, Khalid A., Shalaby, Mohamed A., Khathlan, Norah, Safdar, Osama Y., Al Rezgan, Suleman A., and El Desoky, Sherif
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Acute kidney failure -- Patient outcomes ,Intensive care units -- Management ,Epidemiology -- Analysis ,Company business management ,Health - Abstract
Background Acute kidney injury (AKI) is a common problem encountered in critically ill children with an increasing incidence and evolving epidemiology. AKI carries a serious morbidity and mortality in patients requiring admission to a pediatric intensive care unit (PICU). Methods We undertook a prospective cohort study of PICU admissions at three tertiary care hospitals in the Kingdom of Saudi Arabia over 2 years. The Kidney Disease Improving Global Outcomes (KDIGO) definition was used to diagnose AKI. Results A total of 1367 pediatrics PICU admissions were included in the study. AKI affected 511 children (37.4%), with 243 children (17.8%) classified as stage I (mild), 168 patients (12.3%) stage II (moderate), and 100 children (7.3%) were classified as stage III (severe). After adjustment for age, sex, and underlying diagnosis, in-hospital mortality was six times more likely among patients with AKI as compared to patients with normal renal function (adjusted OR: 6.5, 95% CI: 4.2-10). AKI was also a risk factor for hypertension (adjusted OR: 4.1, 95% CI: 2.8-5.9) and prolonged stay in the PICU and hospital, as it increased the average number of admission days by 10 (95% CI: 8.6-11) days in the PICU and 12 (95% CI: 10-14) days in the hospital. Conclusions One-third of PICU admissions were complicated with AKI. AKI was associated with increased hospital mortality and the length of stay in both PICU and hospital., Author(s): Jameela A. Kari [sup.1] , Khalid A. Alhasan [sup.2] , Mohamed A. Shalaby [sup.1] , Norah Khathlan [sup.3] , Osama Y. Safdar [sup.1] , Suleman A. Al Rezgan [sup.4] [...]
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- 2018
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23. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum cystatin C measurements for early diagnosis of acute kidney injury in children admitted to PICU
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Kari, Jameela Abdulaziz, Shalaby, Mohamed Ahmed, Sofyani, Kholoud, Sanad, Ahmad Saleh, Ossra, Albaraa Fuad, Halabi, Rayan Smeer, Aljuhani, Maha Hassan, Toffaha, Wael Mohammad, Moria, Feras Aymen, Sabry, Samar, Ahmed, Hanan AbdelAziz, Alhasan, Khalid Abdulaziz, Sharief, Sara, and Safdar, Osama
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- 2018
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24. Short-term outcome associated with disease severity and electrolyte abnormalities among critically ill children with acute kidney injury
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Safder, Osama Y., Alhasan, Khalid A., Shalaby, Mohamed A., Khathlan, Norah, Al Rezgan, Suleman A., Albanna, Amr S., and Kari, Jameela A.
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- 2019
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25. Combining human and AI could predict nephrologies future, but should be handled with care.
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Alhasan, Khalid, Raina, Rupesh, Jamal, Amr, and Temsah, Mohamad‐Hani
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NEPHROLOGISTS , *ARTIFICIAL intelligence , *CHATGPT , *MACHINE learning - Abstract
AI algorithms can help identify patients at risk of kidney disease, predict the progression of kidney disease and personalise treatment plans based on individual patient data. ChatGPT answer 2: Artificial intelligence (AI) has the potential to revolutionise kidney care by helping clinicians better predict, diagnose and treat kidney diseases. AI and kidney care ChatGPT answer 1: Artificial intelligence (AI) has the potential to revolutionise kidney care by providing more accurate and timely diagnosis, treatment, and monitoring of kidney diseases. Keywords: AI; ChatGPT EN AI ChatGPT 1844 1848 5 08/10/23 20230901 NES 230901 Abbreviations AI artificial intelligence Rapid advances have been made in artificial intelligence (AI) and researchers are constantly increasing their use of this technology. [Extracted from the article]
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- 2023
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26. ChatGPT and the Future of Digital Health: A Study on Healthcare Workers' Perceptions and Expectations.
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Temsah, Mohamad-Hani, Aljamaan, Fadi, Malki, Khalid H., Alhasan, Khalid, Altamimi, Ibraheem, Aljarbou, Razan, Bazuhair, Faisal, Alsubaihin, Abdulmajeed, Abdulmajeed, Naif, Alshahrani, Fatimah S., Temsah, Reem, Alshahrani, Turki, Al-Eyadhy, Lama, Alkhateeb, Serin Mohammed, Saddik, Basema, Halwani, Rabih, Jamal, Amr, Al-Tawfiq, Jaffar A., and Al-Eyadhy, Ayman
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CONFIDENCE intervals ,ATTITUDES of medical personnel ,NATURAL language processing ,CROSS-sectional method ,DIGITAL health ,ARTIFICIAL intelligence ,INTELLECT ,DESCRIPTIVE statistics ,ODDS ratio ,DATA analysis software - Abstract
This study aimed to assess the knowledge, attitudes, and intended practices of healthcare workers (HCWs) in Saudi Arabia towards ChatGPT, an artificial intelligence (AI) Chatbot, within the first three months after its launch. We also aimed to identify potential barriers to AI Chatbot adoption among healthcare professionals. A cross-sectional survey was conducted among 1057 HCWs in Saudi Arabia, distributed electronically via social media channels from 21 February to 6 March 2023. The survey evaluated HCWs' familiarity with ChatGPT-3.5, their satisfaction, intended future use, and perceived usefulness in healthcare practice. Of the respondents, 18.4% had used ChatGPT for healthcare purposes, while 84.1% of non-users expressed interest in utilizing AI Chatbots in the future. Most participants (75.1%) were comfortable with incorporating ChatGPT into their healthcare practice. HCWs perceived the Chatbot to be useful in various aspects of healthcare, such as medical decision-making (39.5%), patient and family support (44.7%), medical literature appraisal (48.5%), and medical research assistance (65.9%). A majority (76.7%) believed ChatGPT could positively impact the future of healthcare systems. Nevertheless, concerns about credibility and the source of information provided by AI Chatbots (46.9%) were identified as the main barriers. Although HCWs recognize ChatGPT as a valuable addition to digital health in the early stages of adoption, addressing concerns regarding accuracy, reliability, and medicolegal implications is crucial. Therefore, due to their unreliability, the current forms of ChatGPT and other Chatbots should not be used for diagnostic or treatment purposes without human expert oversight. Ensuring the trustworthiness and dependability of AI Chatbots is essential for successful implementation in healthcare settings. Future research should focus on evaluating the clinical outcomes of ChatGPT and benchmarking its performance against other AI Chatbots. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Outcome of pediatric acute kidney injury: a multicenter prospective cohort study
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Kari, Jameela A., Alhasan, Khalid A., Shalaby, Mohamed A., Khathlan, Norah, Safdar, Osama Y., Al Rezgan, Suleman A., El Desoky, Sherif, and Albanna, Amr S.
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- 2017
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28. Living well with kidney disease
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McCarthy, Florencio, Cochat, Pierre, Alhasan, Khalid, and Bonilla-Felix, Melvin
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Children -- Diseases ,Chronic kidney failure -- Care and treatment ,Pediatric research ,Quality of life -- Health aspects ,Health - Abstract
Author(s): Florencio McCarthy [sup.1] , Pierre Cochat [sup.2] , Khalid Alhasan [sup.3] , Melvin Bonilla-Felix [sup.4] Author Affiliations: (1) grid.414610.6, 0000 0004 0571 4520, Hospital del Niño Dr. José Renán [...]
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- 2021
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29. Exploring Determinants of COVID-19 Vaccine Acceptance, Uptake, and Hesitancy in the Pediatric Population: A Study of Parents and Caregivers in Saudi Arabia during the Initial Vaccination Phase.
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Alhuzaimi, Abdullah N., Alrasheed, Abdullah A., Al-Eyadhy, Ayman, Aljamaan, Fadi, Alhasan, Khalid, Batais, Mohammed A., Jamal, Amr, Alshahrani, Fatimah S., Alenezi, Shuliweeh, Alhaboob, Ali, AlZamil, Fahad, Bashumeel, Yaser Y., Banaeem, Ahmad M., Aldawood, Abdulrahman, Halwani, Rabih, Barry, Mazin, Al-Tawfiq, Jaffar A., and Temsah, Mohamad-Hani
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VACCINATION ,PARENT attitudes ,COVID-19 ,SOCIAL determinants of health ,IMMUNIZATION ,PSYCHOLOGY of parents ,SAMPLE size (Statistics) ,CONFIDENCE intervals ,COVID-19 vaccines ,ATTITUDE (Psychology) ,CROSS-sectional method ,MULTIVARIATE analysis ,MULTIPLE regression analysis ,FEAR ,CRONBACH'S alpha ,T-test (Statistics) ,VACCINE hesitancy ,PSYCHOLOGY of caregivers ,DESCRIPTIVE statistics ,RESEARCH funding ,DATA analysis software ,CHILDREN - Abstract
Objectives: This study aims to assess COVID-19 vaccine acceptance, uptake, and hesitancy among parents and caregivers of children in Saudi Arabia during the initial rollout of pediatric COVID-19 vaccination. Methods: An electronic survey was used to collect data from participants who visited a COVID-19 vaccine center. The survey included demographic data, COVID-19 vaccine status among participants and their children, and reasons for vaccine acceptance or rejection. The Vaccine Hesitancy Scale (VHS) tool was also employed to assess vaccine hesitancy and attitudes toward the COVID-19 vaccine and routine childhood vaccination. Multivariate binary regression analysis was used to identify predictors of actual COVID-19 vaccine uptake among children. Results: Of the 873 respondents included in the analysis, 61.5% were parents and 38.5% were other caregivers. Of the participants, 96.9% had received the COVID-19 vaccine. Six hundred and ninety-four participants accepted the vaccine for their children, with the main reasons being an endorsement by the Saudi Ministry of Health (60%) and the importance of going back to school (55%). One hundred and seventy-nine participants would not vaccinate their children, with the most common reasons being fear of adverse effects (49%) and inadequate data about vaccine safety (48%). Factors such as age, COVID-19 vaccination status, self-rated family commitment level, attitudes toward routine children's vaccines, and participants' generalized anxiety disorder (GAD7) score did not significantly correlate with children's COVID-19 vaccination status. Parents were less likely to vaccinate their children compared to other caregivers, and participants with a higher socioeconomic status were more likely to vaccinate their children. Conclusion: Vaccine acceptance and uptake were high during the initial pediatric COVID-19 vaccination rollout in Saudi Arabia. Still, the ongoing endorsement of the Ministry of Health and healthcare authorities should continue to advocate for better vaccine uptake in children. [ABSTRACT FROM AUTHOR]
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- 2023
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30. IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome.
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Trautmann, Agnes, Boyer, Olivia, Hodson, Elisabeth, Bagga, Arvind, Gipson, Debbie S., Samuel, Susan, Wetzels, Jack, Alhasan, Khalid, Banerjee, Sushmita, Bhimma, Rajendra, Bonilla-Felix, Melvin, Cano, Francisco, Christian, Martin, Hahn, Deirdre, Kang, Hee Gyung, Nakanishi, Koichi, Safouh, Hesham, Trachtman, Howard, Xu, Hong, and Cook, Wendy
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DISEASE relapse ,THERAPEUTIC use of glucocorticoids ,NEPHROTIC syndrome diagnosis ,GLUCOCORTICOIDS ,NEPHROTIC syndrome ,STEROIDS ,DISEASES ,EVIDENCE-based medicine ,TREATMENT effectiveness ,MEDICAL protocols ,RESEARCH funding ,IMMUNOSUPPRESSIVE agents ,DISEASE management ,DRUG toxicity ,CHILDREN - Abstract
Idiopathic nephrotic syndrome is the most frequent pediatric glomerular disease, affecting from 1.15 to 16.9 per 100,000 children per year globally. It is characterized by massive proteinuria, hypoalbuminemia, and/or concomitant edema. Approximately 85–90% of patients attain complete remission of proteinuria within 4–6 weeks of treatment with glucocorticoids, and therefore, have steroid-sensitive nephrotic syndrome (SSNS). Among those patients who are steroid sensitive, 70–80% will have at least one relapse during follow-up, and up to 50% of these patients will experience frequent relapses or become dependent on glucocorticoids to maintain remission. The dose and duration of steroid treatment to prolong time between relapses remains a subject of much debate, and patients continue to experience a high prevalence of steroid-related morbidity. Various steroid-sparing immunosuppressive drugs have been used in clinical practice; however, there is marked practice variation in the selection of these drugs and timing of their introduction during the course of the disease. Therefore, international evidence-based clinical practice recommendations (CPRs) are needed to guide clinical practice and reduce practice variation. The International Pediatric Nephrology Association (IPNA) convened a team of experts including pediatric nephrologists, an adult nephrologist, and a patient representative to develop comprehensive CPRs on the diagnosis and management of SSNS in children. After performing a systematic literature review on 12 clinically relevant PICO (Patient or Population covered, Intervention, Comparator, Outcome) questions, recommendations were formulated and formally graded at several virtual consensus meetings. New definitions for treatment outcomes to help guide change of therapy and recommendations for important research questions are given. [ABSTRACT FROM AUTHOR]
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- 2023
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31. Mpox Perceptions and Vaccine Advocacy among the Healthcare Workers of Solid Organ Transplant Centers: A Multicenter, Cross-Sectional Survey in Saudi Arabia.
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Alhasan, Khalid, Sallam, Malik, Aljamaan, Fadi, Ali, Tariq, Al-jedai, Ahmed, Nazmi, Ahmed, Ajlan, Aziza, Aleid, Hassan, Karar, Enaam, Al-Awwami, Moheeb, Almojalli, Hamad, Shah, Yaser Zahir, Mohammed, Amir Eltayeb Ismail, Barry, Mazin, Alsubaie, Sarah, Altheaby, Abdulrahman, Almaghrabi, Reem S., Askandarani, Sumayah, Memish, Ziad A, and Al-Tawfiq, Jaffar A.
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VACCINATION ,RESEARCH ,PROFESSIONS ,IMMUNIZATION ,RESEARCH evaluation ,CONFIDENCE intervals ,ATTITUDE (Psychology) ,ATTITUDES of medical personnel ,CROSS-sectional method ,MULTIPLE regression analysis ,MONKEYPOX ,SENSORY perception ,MEDICAL personnel ,IMMUNOSUPPRESSION ,CROSS infection ,SURVEYS ,CRONBACH'S alpha ,PSYCHOSOCIAL factors ,EPIDEMICS ,EMPLOYEES' workload ,DESCRIPTIVE statistics ,ODDS ratio ,DATA analysis software ,TRANSPLANTATION of organs, tissues, etc. ,LABORATORY personnel ,INFECTIOUS disease transmission - Abstract
Background: In response to the global Mpox outbreaks, this survey aimed to assess the knowledge, perceptions, and advocacy of Mpox vaccines among solid organ transplant healthcare workers (HCWs) in Saudi Arabia. Methods: A cross-sectional survey was conducted among solid organ transplant HCWs in Saudi Arabia from 15 August to 5 September 2022. A total of 199 responses were received from participants primarily working in the kidney (54.8%) and liver (14.6%) transplant units. Results: The survey found that most participants were aware of the 2022 Mpox outbreak, but the majority were more concerned about COVID-19 than Mpox. While the majority of participants thought laboratory personnel and HCWs in direct contact with Mpox patients should receive the vaccine, less than 60% believed that all HCWs should be vaccinated. Additionally, over half of the participants lacked knowledge of animal–human transmission of the virus. Conclusion: The results highlight the need for increased education on Mpox among transplant HCWs in Saudi Arabia, particularly regarding the virus's transmission dynamics and vaccines. This education is crucial to improve HCWs' understanding of this emerging disease, especially given their vulnerability during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Monkeypox Disease (MPOX) Perceptions among Healthcare Workers versus General Population during the First Month of the WHO Alert: Cross-Sectional Survey in Saudi Arabia.
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Temsah, Mohamad-Hani, Aljamaan, Fadi, Alenezi, Shuliweeh, Abouammoh, Noura, Alhasan, Khalid, Dasuqi, Shereen A., Alhaboob, Ali, Hamad, Mohammed A., Halwani, Rabih, Alrabiaah, Abdulkarim, Alsubaie, Sarah, Alshahrani, Fatimah S., AlZamil, Fahad, Memish, Ziad A., Barry, Mazin, and Al-Tawfiq, Jaffar A.
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MEDICAL personnel ,MONKEYPOX ,EMERGING infectious diseases ,INFORMATION-seeking behavior ,SYMPTOMS - Abstract
Background: Monkeypox disease (MPOX) recently re-emerged in May 2022, causing international outbreaks in multiple non-endemic countries. This study demonstrates a novel comparison between the knowledge and perceptions of Saudi healthcare workers (HCWs) and the general public regarding MPOX. Methods: An online survey, conducted from 27 May to 5 June 2022, assessing participants' MPOX and monkeypox virus (MPV) knowledge in terms of transmission, vaccination, isolation precautions, and their attitudes toward seeking more information. Results: A total of 1546 members of the public and 1130 HCWs completed the survey. Briefly, 61.3% of the public and 74.2% of HCWs showed interest in seeking more information about MPOX. Both groups had average overall mean MPOX knowledge scores. Members of the public holding university degrees and those showing high levels of worry regarding MPOX had significantly higher knowledge scores. However, HCWs showed a poor vaccination knowledge score, while only 57% recognized that MPOX can present similarly to COVID-19 in the early stages. Female HCWs and those with high self-rated MPOX awareness had significantly high knowledge scores. HCWs in secondary and tertiary centers had significantly higher knowledge scores. Conclusion: Both groups showed a decent attitude in terms of seeking more MPOX knowledge, which correlated positively with their worry about and awareness of the disease. These observations are mostly as a consequence of the ongoing COVID-19 pandemic, which encouraged the public and HCW to acquire more information about any novel emerging disease. Policymakers should make the most of this attitude in their awareness campaigns to prevent the spread of the disease and encourage vaccination in cases where it is needed. The knowledge gaps among HCWs were most evident in terms of clinical presentation and vaccinations; this problem needs addressing if we are to avoid further emerging MPOX cases. [ABSTRACT FROM AUTHOR]
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- 2022
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33. A Multicenter Study Evaluating the Discontinuation of Eculizumab Therapy in Children with Atypical Hemolytic Uremic Syndrome.
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AlZabali, Saeed, AlBatati, Sawsan, Rahim, Khawla, Faqeehi, Hassan, Osman, Abubaker, Bamhraz, Abdulaziz, Saleh, Mohammed A., Kari, Jameela A., Aloufi, Majed, Eid, Loai, Nasser, Haydar, Imam, Abubakr, AlHammadi, Entesar, Alkandari, Omar, Al Riyami, Mohammed, Sethi, Sidharth, Licht, Christoph, Alhasan, Khalid A., and AlAnazi, Abdulkarim
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THERAPEUTIC use of monoclonal antibodies ,RESEARCH ,STATISTICS ,CONFIDENCE intervals ,RETROSPECTIVE studies ,FISHER exact test ,DISEASE relapse ,RISK assessment ,DESCRIPTIVE statistics ,KAPLAN-Meier estimator ,HEMOLYTIC-uremic syndrome ,TERMINATION of treatment ,DATA analysis software ,DATA analysis ,DISEASE risk factors ,CHILDREN - Abstract
Background: Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening thrombotic microangiopathy (TMA), which has been treated successfully with eculizumab. The optimal duration of eculizumab in treating patients with aHUS remains poorly defined. Methods: We conducted a multicenter retrospective study in the Arabian Gulf region for children of less than 18 years of age who were diagnosed with aHUS and who discontinued eculizumab between June 2013 and June 2021 to assess the rate and risk factors of aHUS recurrence. Results: We analyzed 28 patients with a clinical diagnosis of aHUS who had discontinued eculizumab. The most common reason for the discontinuation of eculizumab was renal and hematological remission (71.4%), followed by negative genetic testing (28.6%). During a median follow-up period of 24 months after discontinuation, 8 patients (28.5%) experienced HUS relapse. The risk factors of recurrence were positive genetic mutations (p = 0.020). On the other hand, there was no significant relationship between the relapse and age of presentation, the need for acute dialysis, the duration of eculizumab therapy before discontinuation, or the timing of eculizumab after the presentation. Regarding the renal outcomes after discontinuation, 23 patients were in remission with normal renal function, while 4 patients had chronic kidney disease (CKD) (three of them had pre-existing chronic kidney disease (CKD) before discontinuation, and one case developed a new CKD after discontinuation) and one patient underwent transplantation. Conclusions: The discontinuation of eculizumab in patients with aHUS is not without risk; it can result in HUS recurrence. Eculizumab discontinuation can be performed with close monitoring of the patients. It is essential to assess risk the factors for relapse before eculizumab discontinuation, in particular in children with a positive complement variant and any degree of residual CKD, as HUS relapse may lead to additional loss of kidney function. Resuming eculizumab promptly after relapse is effective in most patients. [ABSTRACT FROM AUTHOR]
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- 2022
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34. PCRRT-ICONIC critical care pediatric nephrology course: the global prevalence of COVID-19 and associated sequelae.
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Raina, Rupesh, Vijayvargiya, Nina, Kalra, Riti, Hui-Kim Yap, Nair, Nikhil, Alhasan, Khalid, Montini, Giovanni, Narang, Aarushi, McCulloch, Mignon, Bonilla-Felix, Melvin, Bagga, Arvind, Mok, Quen, de Sousa Tavares, Marcelo, Koch, Vera, Schaefer, Franz, Felipe, Cavagnaro, Bunchman, Tim, and Sethi, Sidharth
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- 2022
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35. Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome.
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Altassan, Ruqaiah, Qudair, Ahmad, Alokaili, Riyadh, Alhasan, Khalid, Faqeih, Eissa A., Alhashem, Amal, Alowain, Muhammed, Alsayed, Moeanaldeen, Rahbeeni, Zuhair, Albadi, Lama, Alkuraya, Fowzan S., Anderson, Eric N., Rajan, Deepa, and Pandey, Udai Bhan
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Pathogenic variants in GEMIN4 have recently been linked to an inherited autosomal recessive neurodevelopmental disorder characterized with microcephaly, cataracts, and renal abnormalities (NEDMCR syndrome). This report provides a retrospective review of 16 patients from 11 unrelated Saudi consanguineous families with GEMIN4 mutations. The cohort comprises 11 new and unpublished clinical details from five previously described patients. Only two missense, homozygous, pathogenic variants were found in all affected patients, suggesting a founder effect. All patients shared global developmental delay with variable ophthalmological, renal, and skeletal manifestations. In addition, we knocked down endogenous Drosophila GEMIN4 in neurons to further investigate the mechanism of the functional defects in affected patients. Our fly model findings demonstrated developmental defects and motor dysfunction suggesting that loss of GEMIN4 function is detrimental in vivo; likely similar to human patients. To date, this study presents the largest cohort of patients affected with GEMIN4 mutations. Considering that identifying GEMIN4 defects in patients presenting with neurodevelopmental delay and congenital cataract will help in early diagnosis, appropriate management and prevention plans that can be made for affected families. [ABSTRACT FROM AUTHOR]
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- 2022
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36. Healthcare Workers' Worries and Monkeypox Vaccine Advocacy during the First Month of the WHO Monkeypox Alert: Cross-Sectional Survey in Saudi Arabia.
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Ajman, Fadi, Alenezi, Shuliweeh, Alhasan, Khalid, Saddik, Basema, Alhaboob, Ali, Altawil, Esraa S., Alshahrani, Fatimah, Alrabiaah, Abdulkarim, Alaraj, Ali, Alkriadees, Khaled, Alshamlani, Yousef, Alharbi, Homood, Jamal, Amr, Halwani, Rabih, AlZamil, Fahad, Al-Subaie, Sarah, Barry, Mazin, Memish, Ziad A., Al-Tawfiq, Jaffar A., and Temsah, Mohamad-Hani
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MONKEYPOX ,MONKEYPOX vaccines ,INFECTION prevention ,COVID-19 - Abstract
Background: Monkeypox virus re-surged in May 2022 as a new potential global health threat, with outbreaks bursting in multiple countries across different continents. This study was conducted in Saudi Arabia during the first month following the WHO announcement of the Monkeypox outbreak, to assess healthcare workers (HCWs) perceptions of, worries concerning, and vaccine acceptance for, Monkeypox, in light of the resolving COVID-19 pandemic. Methods: A national cross-sectional survey was conducted between 27 May and 10 June 2022, in Saudi Arabia. Data were collected on: HCWs' sociodemographic and job-related characteristics; COVID-19 infection status; and worries concerning Monkeypox, compared to COVID-19 and its sources; as well as their perceptions and awareness of, and advocacy for, supporting Monkeypox vaccination. Results: A total of 1130 HCWs completed the survey, of which 41.6% have already developed COVID-19. However, 56.5% were more concerned about COVID-19 compared to Monkeypox, while the rest were more worried about Monkeypox disease. The main cause for concern among 68.8% of the participants was the development of another worldwide pandemic, post-COVID-19, followed by their concern of either themselves or their families contracting the infection (49.6%). Most HCWs (60%) rated their level of self-awareness of Monkeypox disease as moderate to high. Males, and those who had previously developed COVID-19, were significantly less likely to worry about Monkeypox. The worry about Monkeypox developing into a pandemic, and the perception of Monkeypox being a severe disease, correlated significantly positively with the odds of high worry concerning the disease. The major predictors of participants' advocacy for vaccination against Monkeypox disease were: those who had developed COVID-19 previously; and those who supported tighter infection control measures (than those currently used) to combat the disease. A total of 74.2% of the surveyed HCWs perceived that they needed to read more about Monkeypox disease. Conclusions: Approximately half of the HCWs in this study were more concerned about Monkeypox disease than COVID-19, particularly regarding its possible progression into a new pandemic, during the first month following the WHO's Monkeypox international alert. In addition, the majority of participants were in favor of applying tighter infection prevention measures to combat the disease. The current study highlights areas requiring attention for healthcare administrators regarding HCWs' perceptions and preparedness for Monkeypox, especially in the event of a local or international pandemic. [ABSTRACT FROM AUTHOR]
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- 2022
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37. Risk factors and outcomes of neonates with acute kidney injury needing peritoneal dialysis: Results from the prospective TINKER (The Indian PCRRT-ICONIC Neonatal Kidney Educational Registry) study.
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Sethi, Sidharth Kumar, Wazir, Sanjay, Sahoo, Jagdish, Agrawal, Gopal, Bajaj, Naveen, Gupta, Naveen Parkash, Mirgunde, Shishir, Balachandran, Binesh, Afzal, Kamran, Shrivastava, Anubha, Bagla, Jyoti, Krishnegowda, Sushma, Konapur, Ananth, Sultana, Azmeri, Soni, Kritika, Nair, Nikhil, Sharma, Divya, Khooblall, Prajit, Pandey, Avisha, and Alhasan, Khalid
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- 2022
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38. Hypermanganesemia with Dystonia Type 2: A Potentially Treatable Neurodegenerative Disorder: A Case Series in a Tertiary University Hospital.
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Alhasan, Khalid A., Alshuaibi, Walaa, Hamad, Muddathir H., Salim, Suha, Jamjoom, Dima Z., Alhashim, Aqeela H., AlGhamdi, Malak Ali, Kentab, Amal Y., and Bashiri, Fahad A.
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TREATMENT of dystonia ,TREATMENT of neurodegeneration ,CHELATION therapy ,GENETIC mutation ,ACADEMIC medical centers ,DYSTONIA ,GENETIC testing ,RETROSPECTIVE studies ,ACQUISITION of data ,MANGANESE ,CASE studies ,MEDICAL records ,NEURODEGENERATION - Abstract
Importance: Hypermanganesemia with dystonia type 2 is a rare autosomal recessive neurodegenerative disorder characterized by the loss of previously acquired milestones, dystonia, parkinsonian features, a high serum manganese level, and characteristic neuroimaging findings such as bilateral and symmetrically increased T1 and decreased T2/fluid-attenuated inversion recovery signal intensity in the basal ganglia. This condition is secondary to a mutation in the SLC39A14 gene. Objective: To present a series of three cases of hypermanganesemia with dystonia type 2, which was genetically confirmed secondary to a mutation in the SLC39A14 gene, and to describe the treatment and clinical course in these cases. Design: A retrospective case series. Setting: University, Tertiary hospital. Participants: Three unrelated pediatric patients with hypermanganesemia with dystonia type 2, genetically confirmed to be secondary to a mutation in the SLC39A14 gene. Exposures: Chelation therapy using calcium disodium edetate. Main outcome(s) and measure(s): The response to chelation therapy based on clinical improvements in motor and cognition developments. Results: All three patients were started on chelation therapy using calcium disodium edetate, and two of them showed an improvement in their clinical course. The chelation therapy could alter the course of the disease and prevent deterioration in the clinical setting. Conclusions and Relevance: Early diagnosis and intervention with chelating agents, such as calcium disodium edetate, will help change the outcome in patients with hypermanganesemia with dystonia type 2. This finding highlights the importance of early diagnosis and treatment in improving the outcomes of patients with treatable neurodegenerative disorders. [ABSTRACT FROM AUTHOR]
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- 2022
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39. The outcome of rituximab in treating steroid dependent nephrotic syndrome.
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Al Salloum, Abdullah A., Al Herbish, Adi J., Al Hissi, Mohammed A., Abdallah, Mohammed S., Salim, Suha B., Farhat, Afrah H., Shagal, Reem A., Othman, Abduldafaee, Alshaiban, Abdulelah, Temsah, Mohamad-Hani A., Al-Eyadhy, Ayman A., and Alhasan, Khalid A.
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NEPHROTIC syndrome ,TREATMENT effectiveness ,IMMUNOGLOBULIN M ,RENAL biopsy ,RITUXIMAB - Abstract
Objectives: To present our experience of treating steroid-dependent nephrotic syndrome (SDNS) in children with repeated doses of rituximab (RTX) with a relatively long follow-up, and to discuss the role of the histopathology type and previous immune-suppressor (IS) drugs on the outcome of these patients. Methods: The patients included in this prospective study were children with SDNS who were in remission on a high-dose steroid or with additional IS drugs. All patients underwent renal biopsy before RTX treatment. Intravenous RTX was administered monthly at 375 mg/m² for 4 doses. Response to treatment was defined as maintaining remission with no steroid-sparing agents or prednisone for one year. Results: Seventeen (14 males) patients were enrolled. Approximately 76% had minimal change disease (MCD) and 3 (18%) patients had immunoglobulin M (IgM) nephropathy. Approximately 85% of MCD and 33% of IgM nephropathy showed complete response to RTX. Conclusion: Compared to other IS used to treat SDNS, RTX showed a significant decrease in relapse rate with fewer side effects. The dose and interval should be modified according to the patient’s characteristics, such as medical history, pathology type, and previous IS agents. [ABSTRACT FROM AUTHOR]
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- 2022
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40. Kidney transplants in small children: Weighing the pros and cons.
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Alhasan, Khalid A., Sethi, Sidharth Kumar, and Broering, Dieter Clemens
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KIDNEY transplantation , *KIDNEY transplant complications , *CHRONIC kidney failure - Abstract
Kidney transplantation is the most effective treatment for pediatric kidney failure. The ideal age and weight for very young children, especially infants and toddlers, is a topic of debate among specialists. Early kidney transplantation offers benefits such as improved growth, cognitive development, psychosocial outcomes, and overall quality of life. It also reduces the need for prolonged dialysis and associated complications. However, there are challenges such as limited donor availability and surgical complexity. A recent study found that kidney transplantation in children under the age of two is associated with enhanced patient survival and reduced exposure to dialysis compared to waiting until the age of two or older. However, the study has limitations, including a restricted follow-up duration and potential selection bias. Overall, early kidney transplantation shows promise but further research is needed to refine selection criteria and improve post-transplant care. [Extracted from the article]
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- 2024
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41. Genomic, Proteomic, and Phenotypic Spectrum of Novel O-Sialoglycoprotein Endopeptidase Variant in Four Affected Individuals With Galloway-Mowat Syndrome.
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Ali Alghamdi, Malak, Benabdelkamel, Hicham, Masood, Afshan, Saheb Sharif-Askari, Narjes, Hachim, Mahmood Y., Alsheikh, Hamad, Hamad, Muddathir H., Salih, Mustafa A., Bashiri, Fahad A., Alhasan, Khalid, Kashour, Tarek, Guatibonza Moreno, Pilar, Schröder, Sabine, Karageorgou, Vasiliki, Bertoli-Avella, Aida M., Alkhalidi, Hisham, Jamjoom, Dima Z., Alorainy, Ibrahim A., Alfadda, Assim A., and Halwani, Rabih
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PROTEOMICS ,NEPHROTIC syndrome ,MISCARRIAGE ,BRAIN abnormalities ,SYNDROMES - Abstract
Galloway-Mowat syndrome is a rare autosomal recessive disease characterized by a unique combination of renal and neurological manifestations, including early-onset steroid-resistant nephrotic syndrome, microcephaly, psychomotor delay, and gyral abnormalities of the brain. Most patients die during early childhood. Here, we identified a novel homozygous O-sialoglycoprotein endopeptidase (OSGEP) variant, NM_017807.3:c.973C>G (p.Arg325Gly), in four affected individuals in an extended consanguineous family from Saudi Arabia. We have described the detailed clinical characterization, brain imaging results, and muscle biopsy findings. The described phenotype varied from embryonic lethality to early pregnancy loss or death at the age of 9. Renal disease is often the cause of death. Protein modeling of this OSGEP variant confirmed its pathogenicity. In addition, proteomic analysis of the affected patients proposed a link between the KEOPS complex function and human pathology and suggested potential pathogenic mechanisms. [ABSTRACT FROM AUTHOR]
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- 2022
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42. Acute kidney injury in pediatric hematopoietic cell transplantation: critical appraisal and consensus.
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Raina, Rupesh, Abu-Arja, Rolla, Sethi, Sidharth, Dua, Richa, Chakraborty, Ronith, Dibb, James T., Basu, Rajit K., Bissler, John, Felix, Melvin Bonilla, Brophy, Patrick, Bunchman, Timothy, Alhasan, Khalid, Haffner, Dieter, Kim, Yap Hui, Licht, Christopher, McCulloch, Mignon, Menon, Shina, Onder, Ali Mirza, Khooblall, Prajit, and Khooblall, Amrit
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CONSENSUS (Social sciences) ,ONLINE information services ,MEDICAL databases ,CONFIDENCE intervals ,MEDICAL information storage & retrieval systems ,META-analysis ,SYSTEMATIC reviews ,CARCINOGENESIS ,PEDIATRICS ,METABOLIC disorders ,DESCRIPTIVE statistics ,HEMATOPOIETIC stem cells ,ODDS ratio ,MEDLINE ,DATA analysis software ,ACUTE kidney failure ,CELL transplantation ,DISEASE risk factors - Abstract
Hematopoietic cell transplantation (HCT) is a common therapy for the treatment of neoplastic and metabolic disorders, hematological diseases, and fatal immunological deficiencies. HCT can be subcategorized as autologous or allogeneic, with each modality being associated with their own benefits, risks, and post-transplant complications. One of the most common complications includes acute kidney injury (AKI). However, diagnosing HCT patients with AKI early on remains quite difficult. Therefore, this evidence-based guideline, compiled by the Pediatric Continuous Renal Replacement Therapy (PCRRT) working group, presents the various factors that contribute to AKI and recommendations regarding optimization of therapy with minimal complications in HCT patients. [ABSTRACT FROM AUTHOR]
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- 2022
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43. In-Person Schooling Amidst Children's COVID-19 Vaccination: Exploring Parental Perceptions Just after Omicron Variant Announcement.
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Aljamaan, Fadi, Alhaboob, Ali, Saddik, Basema, Bassrawi, Rolan, Assiri, Rasha, Saeed, Elshazaly, Alhasan, Khalid, Alenezi, Shuliweeh, Alarabi, Mohammed, Alrabiaah, Abdulkarim, Alkriadees, Yazed, Al-Saud, Nora, Alenazi, Badi, Rabaan, Ali A., Halwani, Rabih, AlZamil, Fahad, Barry, Mazin, Memish, Ziad A., Al-Tawfiq, Jaffar A., and Temsah, Mohamad-Hani
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SARS-CoV-2 Omicron variant ,PARENT attitudes ,SARS-CoV-2 Delta variant ,COVID-19 vaccines ,SCHOOL children ,ATTITUDE (Psychology) - Abstract
Background: The SARS-CoV-2 Omicron spread fast globally and became the predominant variant in many countries. Resumption of public regular life activities, including in-person schooling, presented parents with new sources of worry. Thus, it is important to study parental worry about the Omicron variant, willingness to vaccinate their children, and knowledge about school-based COVID-19 precautionary measures. Methods: A national, cross-sectional, pilot-validated online questionnaire targeting parents in the Kingdom of Saudi Arabia (KSA) was distributed between 31 December 2021, and 7 January 2022. The survey included sociodemographic, COVID-19 infection data, parental and children vaccination status, attitudes towards booster vaccine, parents' Omicron-related perceptions and worries, and attitude towards in-person schooling. Results: A total of 1340 participants completed the survey, most (65.3%) of whom were mothers. Of the parents, 96.3% either received two or three doses of the COVID-19 vaccine. Only 32.1% of the parents were willing to vaccinate their young children (5–11 years of age). In relation to their children 12–18 years of age, 48% had already had them vaccinated, 31% were planning to vaccinate them, and 42.8% were willing to administer a booster dose. Only 16% were more worried about the Omicron variant compared to the Delta variant. Residents of western KSA were more worried about Omicron compared to Delta. Parents worried about the Omicron variant and male participants were significantly less aware of school-based COVID-19 precautionary measures. Parents with post-graduate degrees and those having more children were significantly more inclined to send their children to school even if COVID-19 outbreaks could occur in schools, while parents who were more worried about the Omicron variant and were more committed to infection prevention measures were significantly less inclined to do so. Conclusions: Overall, parents had lower worry levels about the Omicron variant compared to the Delta variant. They had a higher willingness to vaccinate their older children compared to the younger ones. In addition, our cohort of parents showed high willingness to send their children to schools and trusted the school-based preventative measures. These findings can inform policy makers when considering school related decisions during the current or future public health crises. [ABSTRACT FROM AUTHOR]
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- 2022
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44. Childhood nephrolithiasis and nephrocalcinosis caused by metabolic diseases and renal tubulopathy: A retrospective study from 2 tertiary centers.
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Kari, Jameela A., Shalaby, Mohamed A., Qari, Faiza A., Albanna, Amr S., and Alhasan, Khalid A.
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KIDNEY stones ,KIDNEY diseases ,KIDNEY calcification ,METABOLIC disorders ,PEDIATRIC nephrology ,CHRONIC kidney failure - Abstract
Copyright of Saudi Medical Journal is the property of Saudi Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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45. COVID-19 vaccine confidence and hesitancy among health care workers: A cross-sectional survey from a MERS-CoV experienced nation.
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Barry, Mazin, Temsah, Mohamad-Hani, Alhuzaimi, Abdullah, Alamro, Nurah, Al-Eyadhy, Ayman, Aljamaan, Fadi, Saddik, Basema, Alhaboob, Ali, Alsohime, Fahad, Alhasan, Khalid, Alrabiaah, Abdulkarim, Alaraj, Ali, Halwani, Rabih, Jamal, Amr, Alsubaie, Sarah, Al-Shahrani, Fatimah S., Memish, Ziad A., and Al-Tawfiq, Jaffar A.
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MEDICAL personnel ,COVID-19 vaccines ,VACCINE hesitancy ,COVID-19 ,MERS coronavirus ,VACCINATION ,VACCINE safety - Abstract
Objectives: This study aimed to identify coronavirus disease 2019 (COVID-19) vaccine perception, acceptance, confidence, hesitancy, and barriers among health care workers (HCWs). Methods: An online national cross-sectional pilot-validated questionnaire was self-administered by HCWs in Saudi Arabia, which is a nation with MERS-CoV experience. The main outcome variable was HCWs' acceptance of COVID-19 vaccine candidates. The factors associated with vaccination acceptance were identified through a logistic regression analysis, and the level of anxiety was measured using a validated instrument to measure general anxiety levels. Results: Out of the 1512 HCWs who completed the study questionnaire—of which 62.4% were women—70% were willing to receive COVID-19 vaccines. A logistic regression analysis revealed that male HCWs (ORa = 1.551, 95% CI: 1.122–2.144), HCWs who believe in vaccine safety (ORa = 2.151; 95% CI: 1.708–2.708), HCWs who believe that COVID vaccines are the most likely way to stop the pandemic (ORa = 1.539; 95% CI: 1.259–1.881), and HCWs who rely on the Centers for Disease Control and Prevention website for COVID 19 updates (ORa = 1.505, 95% CI: 1.125–2.013) were significantly associated with reporting a willingness to be vaccinated. However, HCWs who believed that the vaccines were rushed without evidence-informed testing were found to be 60% less inclined to accept COVID-19 vaccines (ORa = 0.394, 95% CI: 0.298–0.522). Conclusion: Most HCWs are willing to receive COVID-19 vaccines once they are available; the satisfactoriness of COVID-19 vaccination among HCWs is crucial because health professionals' knowledge and confidence toward vaccines are important determining factors for not only their own vaccine acceptance but also recommendation for such vaccines to their patients. [ABSTRACT FROM AUTHOR]
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- 2021
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46. Cinacalcet for Severe Secondary Hyperparathyroidism in Children with End-stage Kidney Disease.
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Sheerah, Areej Adel, Al-Ahmed, Rafif Ali, El-Desoky, Sherif M., Alhasan, Khalid Abdulaziz, Albanna, Amr S., Shalaby, Mohamed A., and Kari, Jameela Abdulaziz
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- 2021
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47. Lethal variants in humans: lessons learned from a large molecular autopsy cohort.
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Shamseldin, Hanan E., AlAbdi, Lama, Maddirevula, Sateesh, Alsaif, Hessa S., Alzahrani, Fatema, Ewida, Nour, Hashem, Mais, Abdulwahab, Firdous, Abuyousef, Omar, Kuwahara, Hiroyuki, Gao, Xin, Molecular Autopsy Consortium, Aldhalaan, Hesham, Alfaifi, Abdullah, Alhashem, Amal, Alhasan, Khalid, Alnemer, Maha, Alsahan, Nada, Alyamani, Suad, and Alzaidan, Hamad
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SUDDEN death ,CAUSES of death ,AUTOPSY ,POPULATION genetics ,LEARNING ,HUMAN genome - Abstract
Background: Molecular autopsy refers to DNA-based identification of the cause of death. Despite recent attempts to broaden its scope, the term remains typically reserved to sudden unexplained death in young adults. In this study, we aim to showcase the utility of molecular autopsy in defining lethal variants in humans. Methods: We describe our experience with a cohort of 481 cases in whom the cause of premature death was investigated using DNA from the index or relatives (molecular autopsy by proxy). Molecular autopsy tool was typically exome sequencing although some were investigated using targeted approaches in the earlier stages of the study; these include positional mapping, targeted gene sequencing, chromosomal microarray, and gene panels. Results: The study includes 449 cases from consanguineous families and 141 lacked family history (simplex). The age range was embryos to 18 years. A likely causal variant (pathogenic/likely pathogenic) was identified in 63.8% (307/481), a much higher yield compared to the general diagnostic yield (43%) from the same population. The predominance of recessive lethal alleles allowed us to implement molecular autopsy by proxy in 55 couples, and the yield was similarly high (63.6%). We also note the occurrence of biallelic lethal forms of typically non-lethal dominant disorders, sometimes representing a novel bona fide biallelic recessive disease trait. Forty-six disease genes with no OMIM phenotype were identified in the course of this study. The presented data support the candidacy of two other previously reported novel disease genes (FAAH2 and MSN). The focus on lethal phenotypes revealed many examples of interesting phenotypic expansion as well as remarkable variability in clinical presentation. Furthermore, important insights into population genetics and variant interpretation are highlighted based on the results. Conclusions: Molecular autopsy, broadly defined, proved to be a helpful clinical approach that provides unique insights into lethal variants and the clinical annotation of the human genome. [ABSTRACT FROM AUTHOR]
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- 2021
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48. Kidney involvement in multisystem inflammatory syndrome in children: a pediatric nephrologist's perspective.
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Sethi, Sidharth Kumar, Rana, Abhyuday, Adnani, Harsha, McCulloch, Mignon, Alhasan, Khalid, Sultana, Azmeri, Safadi, Rama, Agrawal, Nirav, and Raina, Rupesh
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MULTISYSTEM inflammatory syndrome in children ,COVID-19 ,ACUTE kidney failure ,VIRAL tropism ,KIDNEYS - Abstract
The initial report of the multisystem inflammatory syndrome in children (MIS-C) was from the UK in April 2020; since then, cases have been reported worldwide. Renal involvement has been seen commonly, ranging from 10% to 46%. Kidney involvement following severe acute respiratory syndrome coronavirus 2 infection in children with MIS-C is more common than initially thought and is associated with higher morbidity and mortality. There are several reports of a direct viral tropism of coronavirus disease 2019 and MIS-C-associated renal damage. This study's objective was to systematically review the current understanding of kidney involvement in children suffering from MIS-C. Based on our systemic literature search, 19 studies have either partially or fully discussed kidney involvement in MIS-C patients. Furthermore, we discuss the multifactorial pathogenesis contributing to acute kidney injury (AKI) development in MIS-C. The current review gives a pediatric nephrologist's perspective of the renal involvement in MIS-C, the incidence of AKI, the pathophysiology of AKI in MIS-C and the proposed therapeutic regimens available, including the need for kidney replacement therapy for a child with AKI associated with MIS-C. As the disease is rapidly evolving, more detailed clinical prospective studies are required to understand MIS-C and its role in AKI better. [ABSTRACT FROM AUTHOR]
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- 2021
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49. Predictors and Direct Cost Estimation of Long Stays in Pediatric Intensive Care Units in Saudi Arabia: A Mixed Methods Study.
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Temsah, Mohamad-Hani, Abouammoh, Noura, Al-Eyadhy, Ayman, AlRuthia, Yazed, Hassounah, Marwah, Alsohime, Fahad, Alhaboob, Ali, Almazyad, Mohammed, Alabdulhafid, Majed, Aljamaan, Fadi, Alhasan, Khalid, and Jamal, Amr
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INTENSIVE care units ,PEDIATRIC intensive care ,CORONARY care units ,LENGTH of stay in hospitals ,DIRECT costing ,FORECASTING - Abstract
Background: Several factors influence patients' length of stay (LOS) in pediatric intensive care units (PICUs). This study explored the factors and cost associated with long LOS among pediatric patient population across various PICUs and pediatric surgical cardiac intensive care units (SCICUs). Methods: This is a multi-center concurrent mixed-methods study that was conducted in different PICUs and SCICUs in Riyadh, Saudi Arabia. The units' leaders were qualitatively interviewed to explore the potential factors contributing to long LOSs in PICUs and SCICUs, and deductive content analysis was used. Microcosting was utilized to estimate the inpatient costs for a sample of long-stay patients (LSPs) and the potential cost savings if those patients were transferred to step-down care units (SDUs) for those who stayed ≥ 60 days. Results: Ten (90%) leaders of PICUs and SCICUs who were invited had participated. Changing the admission criteria, patient transfer to SDUs, family engagement in the decision-making process, and adopting a national do-not-resuscitate (DNR) policy were factors contributing to short LOSs. On the other hand, administrative constraints, staff avoidance of code status decisions, lack of palliative care resources, and complex patient characteristics were factors associated with long LOSs. The mean inpatient cost per patient was SAR 3.63 million (USD 0.97 million), and the total cost for the 48 patients was SAR 172.95 million (USD 46.12 million). Conclusion: If the recommendation to transfer LSPs after a 60-day PICU stay to SDUs is taken, the estimated cost savings among this sample of patients alone can be as high as SAR 109.47 million (USD 29.19 million). Therefore, future studies should examine the factors contributing to long LOSs in PICUs and SCICUs as well as the effectiveness of different policies aimed at improving the resource allocation and management using more robust study designs and diverse patient population. [ABSTRACT FROM AUTHOR]
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- 2021
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50. Virtual Handover of Patients in the Pediatric Intensive Care Unit During the Covid-19 Crisis.
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Temsah, Mohamad-Hani, Abouammoh, Noura, Ashry, Ahmed, Al-Eyadhy, Ayman, Alhaboob, Ali, Alsohime, Fahad, Almazyad, Mohammed, Alabdulhafid, Majed, Temsah, Reem, Aljamaan, Fadi, Jamal, Amr, Halwani, Rabih, Alhasan, Khalid, Al-Tawfiq, Jaffar A, and Barry, Mazin
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COVID-19 pandemic ,INTENSIVE care patients ,SIMULATED patients ,PHYSICIANS ,SOCIAL distancing - Abstract
abstraction. Main Results: All 37 PICU physicians who participated in the handover completed the survey. The participants comprised six attendings, nine specialists, and 22 residents. While 20 (54.1%) physicians reported attending 1– 5 Zoom handovers by the time of the study, some (n. 6, 16.2%) had more than ten virtual handovers. They had variable previous teleconferencing experiences. Most physicians (78.4%) were comfortable conducting a remote handover. Most found that Situation–Background–Assessment–Recommendation handover elements were properly achieved through this remote handover process. The perceived advantages of online handover included fewer interruptions, time efficiency, and facilitation of social distancing. The perceived disadvantages were the paucity of nonverbal communication and teaching during virtual meetings. Conclusion: Video-conferencing applications for online handovers could supplement traditional face-to-face intensive care unit patient handover during outbreaks of infectious diseases. The use of video streaming and more emphasis on teaching should be encouraged to optimize the users' experience. [ABSTRACT FROM AUTHOR]
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- 2021
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