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158 results on '"Abenhaim, Lucien"'

5. Dronedarone, amiodarone and other antiarrhythmic drugs, and acute liver injuries: a case-referent study

Author

Andersen, Matthias, Berg, Thomas, Cordes, Hans-Jörg, Diepolder, Helmut, Fähndrich, Martin, Geier, Andreas, Göbel, Uwe, Grümmer, Harald, Jamali, Seyed Hamid, Kahl, Matthias, Krummenerl, Thomas, Lammertink, Jan, Langmann, Peter, Lohse, Ansgar W., Morgera, Ulrike, Niederau, Claus Ulrich, Pelster, Gregor, Plauth, Mathias, Reiser, Markus, Rufle, Walter, Schiefke, Ingolf, Schlenker, Thorsten, Schott, Eckart, Schwarze, Oliver, Schwerdtfeger, Michael, Seelhoff, Alexander, Spengler, Ulrich, Strohbach, Matthias, Tebbe, Johannes, Thomsen, Thomas, Treml, Oliver, von Aretin, Andreas, Wedemeyer, Heiner, Wiegand, Johannes, Wiese, Manfred, Wruck, Ullrich, Grimaldi-Bensouda, Lamiae, Benichou, Jacques, Rossignol, Michel, Larrey, Dominique, Abenhaim, Lucien, and Poynard, Thierry

Published
2018
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16. A case-control study to assess the risk of immune thrombocytopenia associated with vaccines

Author

Grimaldi-Bensouda, Lamiae, Michel, Marc, Aubrun, Elodie, Leighton, Pamela, Viallard, Jean-Francois, Adoue, Daniel, Magy-Bertrand, Nadine, Tisserand, Guillaume, Khellaf, Mehdi, Durand, Jean-Marc, Quittet, Philippe, Fain, Olivier, Bonnotte, Bernard, Morin, Anne Sophie, Limal, Nicolas, Costedoat-Chalumeau, Nathalie, Morel, Nathalie, Pan-Petesch, Brigitte, Decaux, Olivier, Mahevas, Matthieu, Ruel, Michel, Sacre, Karim, Lefrere, Francois, Abenhaim, Lucien, and Godeau, Bertrand

Published
2012
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29. International cohort study on the effectiveness of dronedarone and other antiarrhythmic drugs for atrial fibrillation in real-world practice (EFFECT-AF).

Author

Khachatryan, Artak, Merino, Jose L, Abajo, Francisco Jose de, Botto, Giovanni L, Kirchhof, Paulus, Breithardt, Guenter, Stambler, Bruce, Abenhaim, Lucien, Grimaldi-Bensouda, Lamiae, and de Abajo, Francisco Jose

Subjects
ATRIAL fibrillation diagnosis, MYOCARDIAL depressants, ATRIAL fibrillation, AMIODARONE, RESEARCH funding, LONGITUDINAL method
Abstract

Aims: To evaluate the effectiveness and safety of dronedarone compared with other commonly used antiarrhythmic drugs (AADs) for preventing atrial fibrillation (AF) recurrences.Methods and Results: An international observational cohort study in Germany, Spain, Italy, and the USA enrolling patients with AF receiving AAD therapy. Patients with New York Heart Association (NYHA) Class IV heart failure were excluded. Participants were followed for up to 18 months, regardless of discontinuation or subsequent AAD switches. Atrial fibrillation recurrence was captured by hospitalization, emergency room visit, or electrocardiogram-based documentation of AF. Confounding bias was controlled for in the analysis of AF recurrence using multivariate models of 19 variables for adjustment. A total of 1009 participants [mean age 67.2 (10.8) years, male to female ratio 1.3] were recruited from 170 centres, 693 (69%) of which were from across Europe and the remaining 316 (31%) from the USA. At the time of enrolment, participants were taking dronedarone (51%) or other AADs (49%) [flecainide or propafenone (42%), sotalol (11%), and amiodarone (47%)]. No significant differences in the risk of first confirmed AF recurrence with dronedarone vs. other AADs [crude hazard ratio (HR) 1.10 (95% confidence interval 0.85-1.42); adjusted HR 1.16 (0.87-1.55)] were found, irrespective of whether univariate or multivariate models were used. Reported safety events were in accordance with the known safety profile of dronedarone.Conclusion: In this population of patients from either Europe or the USA receiving dronedarone or another AAD, the effectiveness of dronedarone was comparable to that observed for other AADs in preventing first AF recurrence. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Temporal trends and drug exposures in pulmonary hypertension: an American experience

Author

Walker, Alexander M., Langleben, Daid, Korelitz, James J., Rich, Stuart, Rubin, Lewis J., Strom, Brian L., Gonin, Rene, Keast, Susan, Badesch, David, Barst, Robyn J., Bourge, Robert C., Channick, Richard, Frost, Adaani, Gaine, Sean, McGoon, Michael, McLaughlin, Vallerie, Murali, Srinivas, Oudiz, Ronald J., Robbins, Ivan M., Tapson, Victor, Abenhaim, Lucien, and Constantine, Ginger

Subjects
Pulmonary hypertension -- Forecasts and trends, Pulmonary hypertension -- Risk factors, Pulmonary hypertension -- Research, Appetite depressants -- Complications and side effects, Appetite depressants -- Research, Market trend/market analysis, Health
Published
2006

40. Appetite-suppressant drugs and the risk of primary pulmonary hypertension

Author

Abenhaim, Lucien, Moride, Yola, Brenot, Francois, Rich, Stuart, Benichou, Jacques, Kurz, Xavier, Higenbottam, Tim, Oakley, Celia, Wouters, Emil, Aubier, Michel, Simonneau, Gerald, and Begaud, Bernard

Subjects
Pulmonary hypertension -- Risk factors, Weight reducing preparations -- Health aspects, Fenfluramine -- Adverse and side effects, Dexfenfluramine -- Adverse and side effects
Abstract

Long-term use of diet pills containing fenfluramine or its derivatives may increase the risk of pulmonary hypertension. This lung disease is characterized by high blood pressure in the blood vessels of the lungs. Researchers compared the use of fenfluramine and its derivatives by 95 people with pulmonary hypertension and 355 healthy volunteers. Use of fenfluramine and its derivatives led to a six-fold increased risk of pulmonary hypertension. Those who took the drugs for more than three months had 23 times the risk.

Published
1996

45. Who seeks primary care for musculoskeletal disorders (MSDs) with physicians prescribing homeopathic and other complementary medicine? Results from the EPI3-LASER survey in France

Author

Magnier Anne-Marie, Guillemot Didier, Duru Gérard, Massol Jacques, Bénichou Jacques, Rouillon Frédéric, Lert France, Bégaud Bernard, Avouac Bernard, Rossignol Michel, Grimaldi-Bensouda Lamiae, and Abenhaim Lucien

Subjects
Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background There is a paucity of information describing patients with musculoskeletal disorders (MSDs) using complementary and alternative medicines (CAMs) and almost none distinguishing homeopathy from other CAMs. The objective of this study was to describe and compare patients with MSDs who consulted primary care physicians, either certified homeopaths (Ho) or regular prescribers of CAMs in a mixed practice (Mx), to those consulting physicians who strictly practice conventional medicine (CM), with regard to the severity of their MSD expressed as chronicity, co-morbidity and quality of life (QOL). Methods The EPI3-LASER study was a nationwide observational survey of a representative sample of general practitioners and their patients in France. The sampling strategy ensured a sufficient number of GPs in each of the three groups to allow comparison of their patients. Patients completed a questionnaire on socio-demographics, lifestyle and QOL using the Short Form 12 (SF-12) questionnaire. Chronicity of MSDs was defined as more than twelve weeks duration of the current episode. Diagnoses and co-morbidities were recorded by the physician. Results A total of 825 GPs included 1,692 MSD patients (predominantly back pain and osteoarthritis) were included, 21.6% in the CM group, 32.4% Ho and 45.9% Mx. Patients in the Ho group had more often a chronic MSD (62.1%) than the CM (48.6%) or Mx (50.3%) groups, a result that was statistically significant after controlling for patients' characteristics (Odds ratio = 1.43; 95% confidence interval (CI): 1.07 - 1.89). Patients seen by homeopaths or mixed practice physicians who were not the regular treating physician, had more often a chronic MSD than those seen in conventional medicine (Odds ratios were1.75; 95% CI: 1.22 - 2.50 and 1.48; 95% CI: 1.06 - 2.12, respectively). Otherwise patients in the three groups did not differ for co-morbidities and QOL. Conclusion MSD patients consulting primary care physicians who prescribed homeopathy and CAMs differed from those seen in conventional medicine. Chronic MSD patients represented a greater proportion of the clientele in physicians offering alternatives to conventional medicine. In addition, these physicians treated chronic patients as consulting rather than regular treating physicians, with potentially important impacts upon professional health care practices and organisation.

Published
2011
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48. New coronavirus pandemic: an analysis paralysis?

Author

Abenhaim, Lucien

Subjects
*COVID-19 pandemic, *PANDEMICS, *COVID-19, *INFLUENZA pandemic, 1918-1919, *PARALYSIS
Abstract

Keywords: containement measures; coronavirus; epidemiology history; pandemic; pandemic management; SARS-cov-2 outbreak EN containement measures coronavirus epidemiology history pandemic pandemic management SARS-cov-2 outbreak 1 6 6 06/23/20 20200502 NES 200502 In 1854, Dr. John Snow laid the foundations of epidemiology by applying statistical thinking to the investigation of the cholera epidemic in London, but also by acting on it despite the great uncertainty that reigned ([5]). No one could say with certainty that the COVID-19 epidemic would finally "blow up" to millions of cases in Europe and America: nearly 2 months had gone by since the first case was allegedly reported in Wuhan at this point. It should be noted that in the SARS-CoV-2 pandemic, the closest-to-reality "predictive model" was, in the absence of mitigation measures, the one simply using the transmission rate derived from the Chinese experience at the epicenter of this pandemic. Containement measures, coronavirus, epidemiology history, pandemic, pandemic management, SARS-cov-2 outbreak. [Extracted from the article]

Published
2020
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