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This paper demonstrates the performance of a potential design of a paper substrate-based flexible antenna for intrabody telemedicine systems in the 2.4 GHz industrial, scientific, and medical radio (ISM) bands. The antenna was fabricated using 0.54 mm thick flexible photo paper and 0.03 mm copper strips as radiating elements. Design and performance analyses of the antenna were performed using Computer Simulation Technology (CST) Microwave Studio software. The antenna performances were investigated based on the reflection coefficient in normal and bent conditions. The total dimensions of the proposed antenna are 40 × 35 × 0.6 mm3. The antenna operates at 2.33–2.53 GHz in the normal condition. More than an 8% fractional bandwidth is expressed by the antenna. Computational analysis was performed at different flexible curvatures by bending the antenna. The minimum fractional bandwidth deviation is 5.04% and the maximum is 24.97%. Moreover, it was mounted on a homogeneous phantom muscle and a four-layer human tissue phantom. Up to a 70% radiation efficiency with a 2 dB gain was achieved by the antenna. Finally, the performance of the antenna with a homogeneous phantom muscle was measured and found reliable for wearable telemedicine applications. [ABSTRACT FROM AUTHOR]