Objective: To investigate the correlation of serum γ-glutamyl transferase(GGT) level with the influencing factors of coronary heart disease and the severity of patients with vascular disease. Methods: 61 patients diagnosed as coronary heart disease(CHD)from July 2013 to October 2017 in our hospital through coronary angiography were selected as the experimental group, which were divided into stable angina pectoris group(hereinafter referred to as A group, 20 cases), unstable angina(group B, 21 cases) and acute myocardial infarction(group C, 20 cases) according to their clinical symptoms. In the same period, thirty patients without coronary heart disease were selected as the control group. The levels of fasting blood glucose(FBG), total cholesterol(TC), triglyceride(TG), systolic blood pressure(SBP), diastolic blood pressure(DBP) and uric acid in the four groups were measured and compared. The correlation of coronary Gensini score. Finally, the GGT and Gensini scores of four groups of patients were analyzed. Results:(1) The FBG, serum TC,TG, SBP, DBP and uric acid levels in the four groups were significantly different(Group C>Group B>Group A>Control group, P<0.05);(2)The level of GGT was positively correlated with the above risk factors(r=0.236, 0.351, 0.316, 0.239, 0.301, 0.395, P=0.035, 0.000,0.000, 0.0034, 0.001, 0.000);(3)Both GGT and Gensini scores in the four groups were changed according to the trend of Group C>Group B>Group A>Control group(P<0.05);(4) The serum GGT level of patients with coronary heart disease was positively correlated with Gensini score(r=0.681, P=0.000). Conclusion: The serum GGT levels of CHD patients were positively correlated with the serum levels of FBG, TC, TG, SBP, DBP, uric acid levels and the severity of the vascular lesions, it may be used to predict the severity of lesion in CHD patients. [ABSTRACT FROM AUTHOR]