1. [Establishment of a glioma orthotopic xenograft model based on imaging technology].
- Author
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Ji M, Wang LY, Lü YH, Lai FF, and Chen XG
- Subjects
- Animals, Antineoplastic Agents, Alkylating pharmacology, Cell Line, Tumor, Dacarbazine analogs & derivatives, Dacarbazine pharmacology, Heterografts, Humans, Magnetic Resonance Imaging, Mice, Mice, Inbred BALB C, Mice, Nude, Temozolomide, Xenograft Model Antitumor Assays, Brain Neoplasms diagnostic imaging, Disease Models, Animal, Glioma diagnostic imaging
- Abstract
Orthotopic xenograft model of human brain cancer cells is a good preclinical model for evaluation of antitumor compounds. In the present study, an orthotopic xenograft model of U87MG-m Cherry-luc was established in Balb/c nude mice and the tumor growth was monitored via imaging technology including magnetic resonance imaging (MRI), in vivo imaging (IVI) and micro-CT. Furthermore, the model was evaluated with a positive drug temozolomide. Our data suggest that integrated imaging technology including MRI, IVI and micro-CT in orthotopic xenograft model can be used to facilitate monitoring of cancer progression and evaluate antitumor activity of drugs against glioma.
- Published
- 2016