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Background: Epstein-Barr virus (EBV) is a gamma herpes virus that infects 95% of the human population. Primary infection is often asymptomatic but results in lifelong infection, when immune is compromised EBV is associated with lymph proliferative diseases and malignancies such as Burkitt´s lymphoma, Nasopharyngeal Carcinoma, and Hodgkin’s lymphoma. This study was designed to determine the prevalence of EBV in Human immune-deficient virus (HIV)-infected individuals in Katsina State, Nigeria. Materials and Methods: Two hundred and seventy- three (273) consented HIV-infected individuals were screened for EBV antigens, for the period of five months (November 2018- March 2019). The sera of individuals were subjected to antigen serological assay by enzyme-linked immunosorbent assay. Results: Out of 273 subjects that were tested 89(32.6%) were EBV antigen positive and 184(67.4%) were EBV antigen negative, prevalence of EBV antigen was higher in females with 61(22.3%), age group 35-44 years 30(10%), CD4+ 425-524 cells/µl 20(7.4%), and viral load 48(18.6%) with less than 1000 count. Conclusion: This study has contributed baseline data and provided insights in EBV-HIV co-infection in Katsina Northwestern Nigeria This would undoubtedly serve as a basis for further studies on EBV in the general population.